MIZ/SP-RING zinc finger containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MIZ/SP-RING zinc finger, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X2U8_LEIDO

TriTrypDb:

LdBPK_292630.1 , LdCL_290032400 , LDHU3_29.3900

Length:

402

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X2U8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0008270	zinc ion binding	6	7
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	325	329	PF00656	0.611
CLV_NRD_NRD_1	183	185	PF00675	0.392
CLV_NRD_NRD_1	20	22	PF00675	0.524
CLV_NRD_NRD_1	354	356	PF00675	0.624
CLV_NRD_NRD_1	390	392	PF00675	0.651
CLV_NRD_NRD_1	95	97	PF00675	0.352
CLV_PCSK_FUR_1	183	187	PF00082	0.496
CLV_PCSK_FUR_1	352	356	PF00082	0.615
CLV_PCSK_KEX2_1	183	185	PF00082	0.392
CLV_PCSK_KEX2_1	20	22	PF00082	0.533
CLV_PCSK_KEX2_1	354	356	PF00082	0.588
CLV_PCSK_KEX2_1	389	391	PF00082	0.597
CLV_PCSK_KEX2_1	95	97	PF00082	0.370
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.498
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.619
CLV_PCSK_SKI1_1	346	350	PF00082	0.476
DOC_ANK_TNKS_1	378	385	PF00023	0.576
DOC_CKS1_1	137	142	PF01111	0.526
DOC_CKS1_1	155	160	PF01111	0.521
DOC_CKS1_1	216	221	PF01111	0.546
DOC_CKS1_1	237	242	PF01111	0.548
DOC_CKS1_1	371	376	PF01111	0.810
DOC_CYCLIN_yCln2_LP_2	155	161	PF00134	0.336
DOC_CYCLIN_yCln2_LP_2	216	222	PF00134	0.552
DOC_MAPK_gen_1	255	264	PF00069	0.454
DOC_MAPK_gen_1	388	394	PF00069	0.609
DOC_MAPK_HePTP_8	290	302	PF00069	0.447
DOC_MAPK_MEF2A_6	293	302	PF00069	0.450
DOC_PP2B_LxvP_1	66	69	PF13499	0.559
DOC_PP4_FxxP_1	137	140	PF00568	0.521
DOC_USP7_MATH_1	289	293	PF00917	0.476
DOC_USP7_MATH_1	309	313	PF00917	0.297
DOC_USP7_MATH_1	319	323	PF00917	0.522
DOC_USP7_MATH_1	359	363	PF00917	0.738
DOC_USP7_MATH_1	372	376	PF00917	0.680
DOC_USP7_MATH_1	50	54	PF00917	0.528
DOC_USP7_MATH_1	78	82	PF00917	0.531
DOC_WW_Pin1_4	136	141	PF00397	0.452
DOC_WW_Pin1_4	154	159	PF00397	0.455
DOC_WW_Pin1_4	215	220	PF00397	0.537
DOC_WW_Pin1_4	236	241	PF00397	0.540
DOC_WW_Pin1_4	370	375	PF00397	0.754
LIG_14-3-3_CanoR_1	102	108	PF00244	0.463
LIG_14-3-3_CanoR_1	20	28	PF00244	0.501
LIG_14-3-3_CanoR_1	277	283	PF00244	0.506
LIG_14-3-3_CanoR_1	346	351	PF00244	0.614
LIG_14-3-3_CanoR_1	354	364	PF00244	0.710
LIG_14-3-3_CanoR_1	40	46	PF00244	0.221
LIG_AP2alpha_2	221	223	PF02296	0.588
LIG_BIR_II_1	1	5	PF00653	0.605
LIG_BIR_III_2	328	332	PF00653	0.589
LIG_BIR_III_4	381	385	PF00653	0.565
LIG_Clathr_ClatBox_1	264	268	PF01394	0.496
LIG_FHA_1	118	124	PF00498	0.510
LIG_FHA_1	129	135	PF00498	0.519
LIG_FHA_1	137	143	PF00498	0.376
LIG_FHA_1	150	156	PF00498	0.442
LIG_FHA_1	204	210	PF00498	0.442
LIG_FHA_1	23	29	PF00498	0.496
LIG_FHA_1	232	238	PF00498	0.580
LIG_FHA_1	279	285	PF00498	0.507
LIG_FHA_1	292	298	PF00498	0.560
LIG_FHA_1	302	308	PF00498	0.429
LIG_FHA_1	345	351	PF00498	0.616
LIG_FHA_1	40	46	PF00498	0.491
LIG_FHA_2	104	110	PF00498	0.536
LIG_FHA_2	148	154	PF00498	0.494
LIG_FHA_2	216	222	PF00498	0.504
LIG_FHA_2	225	231	PF00498	0.568
LIG_LIR_Gen_1	104	113	PF02991	0.539
LIG_LIR_Gen_1	278	287	PF02991	0.592
LIG_LIR_Gen_1	63	72	PF02991	0.637
LIG_LIR_Nem_3	104	110	PF02991	0.535
LIG_LIR_Nem_3	278	282	PF02991	0.532
LIG_LIR_Nem_3	30	35	PF02991	0.573
LIG_LIR_Nem_3	63	68	PF02991	0.647
LIG_NRBOX	190	196	PF00104	0.501
LIG_SH2_CRK	13	17	PF00017	0.523
LIG_SH2_CRK	32	36	PF00017	0.323
LIG_SH2_NCK_1	107	111	PF00017	0.545
LIG_SH2_NCK_1	313	317	PF00017	0.637
LIG_SH2_SRC	107	110	PF00017	0.551
LIG_SH2_STAP1	313	317	PF00017	0.637
LIG_SH2_STAT3	126	129	PF00017	0.501
LIG_SH2_STAT3	190	193	PF00017	0.488
LIG_SH2_STAT5	105	108	PF00017	0.558
LIG_SH2_STAT5	190	193	PF00017	0.501
LIG_SH2_STAT5	65	68	PF00017	0.660
LIG_SH3_2	371	376	PF14604	0.770
LIG_SH3_3	216	222	PF00018	0.519
LIG_SH3_3	234	240	PF00018	0.552
LIG_SH3_3	281	287	PF00018	0.593
LIG_SH3_3	368	374	PF00018	0.785
LIG_SH3_3	66	72	PF00018	0.619
LIG_SUMO_SIM_anti_2	347	352	PF11976	0.591
LIG_SUMO_SIM_par_1	208	215	PF11976	0.526
LIG_TRAF2_1	358	361	PF00917	0.651
LIG_WRC_WIRS_1	267	272	PF05994	0.437
MOD_CDK_SPxK_1	236	242	PF00069	0.549
MOD_CDK_SPxK_1	370	376	PF00069	0.763
MOD_CK1_1	228	234	PF00069	0.537
MOD_CK1_1	278	284	PF00069	0.557
MOD_CK1_1	322	328	PF00069	0.669
MOD_CK1_1	70	76	PF00069	0.526
MOD_CK2_1	208	214	PF00069	0.427
MOD_CK2_1	224	230	PF00069	0.566
MOD_CK2_1	355	361	PF00069	0.703
MOD_Cter_Amidation	352	355	PF01082	0.615
MOD_GlcNHglycan	1	4	PF01048	0.645
MOD_GlcNHglycan	123	126	PF01048	0.539
MOD_GlcNHglycan	357	360	PF01048	0.649
MOD_GlcNHglycan	361	364	PF01048	0.721
MOD_GlcNHglycan	72	75	PF01048	0.577
MOD_GSK3_1	117	124	PF00069	0.515
MOD_GSK3_1	147	154	PF00069	0.514
MOD_GSK3_1	208	215	PF00069	0.454
MOD_GSK3_1	224	231	PF00069	0.483
MOD_GSK3_1	232	239	PF00069	0.460
MOD_GSK3_1	319	326	PF00069	0.665
MOD_GSK3_1	340	347	PF00069	0.570
MOD_GSK3_1	355	362	PF00069	0.586
MOD_N-GLC_1	212	217	PF02516	0.531
MOD_NEK2_1	101	106	PF00069	0.420
MOD_NEK2_1	160	165	PF00069	0.522
MOD_NEK2_1	212	217	PF00069	0.460
MOD_NEK2_1	38	43	PF00069	0.544
MOD_NEK2_2	117	122	PF00069	0.544
MOD_NEK2_2	291	296	PF00069	0.504
MOD_PIKK_1	203	209	PF00454	0.531
MOD_PIKK_1	243	249	PF00454	0.550
MOD_PIKK_1	78	84	PF00454	0.508
MOD_PKA_2	101	107	PF00069	0.521
MOD_PKA_2	22	28	PF00069	0.581
MOD_PKA_2	39	45	PF00069	0.379
MOD_Plk_1	212	218	PF00069	0.463
MOD_Plk_1	228	234	PF00069	0.526
MOD_Plk_1	359	365	PF00069	0.684
MOD_Plk_4	245	251	PF00069	0.464
MOD_Plk_4	266	272	PF00069	0.406
MOD_Plk_4	346	352	PF00069	0.487
MOD_Plk_4	61	67	PF00069	0.436
MOD_Plk_4	84	90	PF00069	0.357
MOD_ProDKin_1	136	142	PF00069	0.455
MOD_ProDKin_1	154	160	PF00069	0.453
MOD_ProDKin_1	215	221	PF00069	0.543
MOD_ProDKin_1	236	242	PF00069	0.536
MOD_ProDKin_1	370	376	PF00069	0.755
TRG_ENDOCYTIC_2	107	110	PF00928	0.547
TRG_ENDOCYTIC_2	13	16	PF00928	0.613
TRG_ENDOCYTIC_2	32	35	PF00928	0.446
TRG_ENDOCYTIC_2	65	68	PF00928	0.660
TRG_ER_diArg_1	183	186	PF00400	0.377
TRG_ER_diArg_1	19	21	PF00400	0.551
TRG_ER_diArg_1	351	354	PF00400	0.614
TRG_ER_diArg_1	390	392	PF00400	0.644
TRG_ER_diArg_1	95	97	PF00400	0.370
TRG_NLS_MonoCore_2	387	392	PF00514	0.667
TRG_NLS_MonoExtC_3	387	393	PF00514	0.660
TRG_NLS_MonoExtN_4	183	188	PF00514	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I530	Leptomonas seymouri	55%	99%
A0A1X0P9D0	Trypanosomatidae	25%	100%
A0A3R7LU18	Trypanosoma rangeli	29%	100%
A4HHQ1	Leishmania braziliensis	78%	100%
A4I4W6	Leishmania infantum	99%	100%
C9ZKZ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AEB4	Leishmania major	92%	100%
E9ALH2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5C220	Trypanosoma cruzi	27%	100%