Actin-like protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

actin-like protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X2U7_LEIDO

TriTrypDb:

LdBPK_292850.1 , LdCL_290034600 , LDHU3_29.4170

Length:

323

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005869	dynactin complex	3	1
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1

Expansion

Sequence features

A0A3S7X2U7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2U7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.373
CLV_NRD_NRD_1	23	25	PF00675	0.622
CLV_NRD_NRD_1	34	36	PF00675	0.425
CLV_PCSK_KEX2_1	272	274	PF00082	0.404
CLV_PCSK_KEX2_1	34	36	PF00082	0.568
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.270
CLV_PCSK_PC7_1	268	274	PF00082	0.289
CLV_PCSK_SKI1_1	277	281	PF00082	0.471
DEG_APCC_DBOX_1	272	280	PF00400	0.279
DEG_COP1_1	180	188	PF00400	0.470
DEG_Nend_UBRbox_2	1	3	PF02207	0.353
DEG_SPOP_SBC_1	237	241	PF00917	0.457
DOC_CYCLIN_RxL_1	268	280	PF00134	0.468
DOC_MAPK_DCC_7	181	190	PF00069	0.460
DOC_MAPK_gen_1	21	31	PF00069	0.526
DOC_MAPK_HePTP_8	178	190	PF00069	0.450
DOC_MAPK_MEF2A_6	181	190	PF00069	0.460
DOC_MAPK_MEF2A_6	24	31	PF00069	0.568
DOC_MAPK_MEF2A_6	61	70	PF00069	0.515
DOC_PP2B_LxvP_1	188	191	PF13499	0.423
DOC_USP7_MATH_1	191	195	PF00917	0.559
DOC_USP7_UBL2_3	21	25	PF12436	0.509
LIG_14-3-3_CanoR_1	142	147	PF00244	0.473
LIG_14-3-3_CanoR_1	201	210	PF00244	0.389
LIG_APCC_ABBA_1	195	200	PF00400	0.444
LIG_BRCT_BRCA1_1	232	236	PF00533	0.544
LIG_FHA_1	111	117	PF00498	0.414
LIG_FHA_1	146	152	PF00498	0.443
LIG_FHA_1	165	171	PF00498	0.524
LIG_FHA_1	216	222	PF00498	0.384
LIG_FHA_1	238	244	PF00498	0.437
LIG_FHA_1	65	71	PF00498	0.429
LIG_FHA_2	187	193	PF00498	0.368
LIG_FHA_2	200	206	PF00498	0.379
LIG_Integrin_RGD_1	160	162	PF01839	0.222
LIG_LIR_Gen_1	239	250	PF02991	0.350
LIG_LIR_Gen_1	83	92	PF02991	0.482
LIG_LIR_Nem_3	13	19	PF02991	0.359
LIG_LIR_Nem_3	239	245	PF02991	0.322
LIG_LIR_Nem_3	304	309	PF02991	0.479
LIG_LIR_Nem_3	83	89	PF02991	0.464
LIG_NRBOX	154	160	PF00104	0.483
LIG_NRBOX	67	73	PF00104	0.504
LIG_SH2_CRK	16	20	PF00017	0.409
LIG_SH2_STAP1	101	105	PF00017	0.503
LIG_SH2_STAT5	101	104	PF00017	0.450
LIG_SH2_STAT5	41	44	PF00017	0.435
LIG_SH2_STAT5	5	8	PF00017	0.422
LIG_SUMO_SIM_anti_2	63	70	PF11976	0.450
LIG_SUMO_SIM_par_1	67	74	PF11976	0.458
LIG_TRAF2_1	62	65	PF00917	0.504
LIG_TYR_ITIM	14	19	PF00017	0.391
LIG_UBA3_1	289	297	PF00899	0.367
LIG_WRC_WIRS_1	72	77	PF05994	0.555
MOD_CK1_1	145	151	PF00069	0.505
MOD_CK1_1	216	222	PF00069	0.469
MOD_CK1_1	77	83	PF00069	0.474
MOD_CK2_1	174	180	PF00069	0.463
MOD_CK2_1	199	205	PF00069	0.502
MOD_CK2_1	217	223	PF00069	0.490
MOD_CK2_1	301	307	PF00069	0.392
MOD_CK2_1	84	90	PF00069	0.513
MOD_GlcNHglycan	103	106	PF01048	0.297
MOD_GlcNHglycan	112	116	PF01048	0.227
MOD_GlcNHglycan	210	213	PF01048	0.347
MOD_GlcNHglycan	284	287	PF01048	0.310
MOD_GlcNHglycan	56	59	PF01048	0.257
MOD_GSK3_1	137	144	PF00069	0.527
MOD_GSK3_1	213	220	PF00069	0.398
MOD_GSK3_1	80	87	PF00069	0.490
MOD_LATS_1	275	281	PF00433	0.488
MOD_N-GLC_2	36	38	PF02516	0.519
MOD_N-GLC_2	96	98	PF02516	0.133
MOD_NEK2_1	1	6	PF00069	0.332
MOD_NEK2_1	137	142	PF00069	0.391
MOD_NEK2_1	213	218	PF00069	0.450
MOD_NEK2_1	71	76	PF00069	0.479
MOD_NEK2_1	84	89	PF00069	0.449
MOD_NEK2_1	99	104	PF00069	0.411
MOD_NEK2_2	10	15	PF00069	0.322
MOD_NEK2_2	191	196	PF00069	0.528
MOD_PIKK_1	288	294	PF00454	0.344
MOD_PIKK_1	74	80	PF00454	0.533
MOD_PK_1	142	148	PF00069	0.515
MOD_PKA_2	141	147	PF00069	0.504
MOD_Plk_1	1	7	PF00069	0.308
MOD_Plk_1	164	170	PF00069	0.475
MOD_Plk_1	186	192	PF00069	0.531
MOD_Plk_1	237	243	PF00069	0.416
MOD_Plk_1	64	70	PF00069	0.460
MOD_Plk_4	1	7	PF00069	0.399
MOD_Plk_4	174	180	PF00069	0.471
MOD_Plk_4	191	197	PF00069	0.484
MOD_Plk_4	238	244	PF00069	0.372
MOD_Plk_4	246	252	PF00069	0.341
MOD_Plk_4	64	70	PF00069	0.417
MOD_Plk_4	80	86	PF00069	0.385
TRG_DiLeu_BaEn_1	154	159	PF01217	0.515
TRG_DiLeu_BaEn_1	180	185	PF01217	0.613
TRG_DiLeu_BaEn_1	64	69	PF01217	0.521
TRG_DiLeu_BaEn_3	64	70	PF01217	0.503
TRG_DiLeu_LyEn_5	154	159	PF01217	0.454
TRG_ENDOCYTIC_2	16	19	PF00928	0.362
TRG_ENDOCYTIC_2	86	89	PF00928	0.500
TRG_NES_CRM1_1	292	305	PF08389	0.364
TRG_Pf-PMV_PEXEL_1	149	154	PF00026	0.228
TRG_Pf-PMV_PEXEL_1	157	162	PF00026	0.200

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Y8	Leptomonas seymouri	77%	100%
A0A0S4KG45	Bodo saltans	26%	89%
A0A1X0NIU0	Trypanosomatidae	22%	82%
A0A1X0NRG7	Trypanosomatidae	23%	83%
A0A1X0P9A3	Trypanosomatidae	36%	99%
A0A3S5IR27	Trypanosoma rangeli	37%	95%
A4HHT1	Leishmania braziliensis	84%	100%
A4I4Z1	Leishmania infantum	99%	100%
C9ZKK7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	99%
E9ALF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4FXC8	Leishmania major	95%	100%
Q4QR76	Rattus norvegicus	24%	77%
V5BDL0	Trypanosoma cruzi	24%	86%
V5C0Q2	Trypanosoma cruzi	24%	83%
V5DTX0	Trypanosoma cruzi	35%	99%