Pentatricopeptide repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X2T2_LEIDO

TriTrypDb:

LdBPK_292130.1 , LdCL_290027300 , LDHU3_29.3040

Length:

698

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X2T2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2T2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	340	344	PF00656	0.606
CLV_NRD_NRD_1	118	120	PF00675	0.529
CLV_NRD_NRD_1	182	184	PF00675	0.424
CLV_NRD_NRD_1	2	4	PF00675	0.682
CLV_NRD_NRD_1	25	27	PF00675	0.636
CLV_NRD_NRD_1	444	446	PF00675	0.396
CLV_NRD_NRD_1	463	465	PF00675	0.256
CLV_NRD_NRD_1	539	541	PF00675	0.494
CLV_NRD_NRD_1	609	611	PF00675	0.612
CLV_NRD_NRD_1	81	83	PF00675	0.449
CLV_PCSK_KEX2_1	182	184	PF00082	0.422
CLV_PCSK_KEX2_1	2	4	PF00082	0.687
CLV_PCSK_KEX2_1	25	27	PF00082	0.585
CLV_PCSK_KEX2_1	444	446	PF00082	0.396
CLV_PCSK_KEX2_1	463	465	PF00082	0.256
CLV_PCSK_KEX2_1	470	472	PF00082	0.447
CLV_PCSK_KEX2_1	539	541	PF00082	0.518
CLV_PCSK_KEX2_1	609	611	PF00082	0.599
CLV_PCSK_KEX2_1	81	83	PF00082	0.490
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.557
CLV_PCSK_PC1ET2_1	470	472	PF00082	0.474
CLV_PCSK_PC7_1	440	446	PF00082	0.389
CLV_PCSK_SKI1_1	119	123	PF00082	0.467
CLV_PCSK_SKI1_1	314	318	PF00082	0.332
CLV_PCSK_SKI1_1	539	543	PF00082	0.644
CLV_PCSK_SKI1_1	57	61	PF00082	0.547
CLV_PCSK_SKI1_1	609	613	PF00082	0.594
CLV_PCSK_SKI1_1	94	98	PF00082	0.560
CLV_Separin_Metazoa	211	215	PF03568	0.333
DEG_APCC_DBOX_1	313	321	PF00400	0.343
DEG_Nend_UBRbox_1	1	4	PF02207	0.626
DEG_SCF_FBW7_2	541	546	PF00400	0.601
DOC_CKS1_1	520	525	PF01111	0.604
DOC_CYCLIN_RxL_1	116	127	PF00134	0.528
DOC_CYCLIN_yCln2_LP_2	657	663	PF00134	0.544
DOC_MAPK_DCC_7	668	677	PF00069	0.530
DOC_MAPK_gen_1	116	124	PF00069	0.521
DOC_MAPK_gen_1	463	469	PF00069	0.490
DOC_MAPK_gen_1	81	90	PF00069	0.386
DOC_MAPK_MEF2A_6	203	212	PF00069	0.422
DOC_MAPK_MEF2A_6	647	656	PF00069	0.564
DOC_MAPK_MEF2A_6	668	677	PF00069	0.530
DOC_PP1_RVXF_1	118	125	PF00149	0.521
DOC_PP2B_LxvP_1	304	307	PF13499	0.417
DOC_PP2B_LxvP_1	657	660	PF13499	0.493
DOC_PP4_MxPP_1	670	673	PF00568	0.514
DOC_USP7_MATH_1	36	40	PF00917	0.544
DOC_USP7_MATH_1	435	439	PF00917	0.322
DOC_USP7_MATH_1	556	560	PF00917	0.781
DOC_USP7_MATH_1	99	103	PF00917	0.526
DOC_WW_Pin1_4	44	49	PF00397	0.494
DOC_WW_Pin1_4	496	501	PF00397	0.589
DOC_WW_Pin1_4	516	521	PF00397	0.460
DOC_WW_Pin1_4	539	544	PF00397	0.686
DOC_WW_Pin1_4	604	609	PF00397	0.533
LIG_14-3-3_CanoR_1	2	6	PF00244	0.693
LIG_14-3-3_CanoR_1	224	228	PF00244	0.420
LIG_14-3-3_CanoR_1	609	615	PF00244	0.473
LIG_14-3-3_CanoR_1	616	624	PF00244	0.383
LIG_APCC_ABBA_1	191	196	PF00400	0.432
LIG_BRCT_BRCA1_1	418	422	PF00533	0.466
LIG_FHA_1	172	178	PF00498	0.434
LIG_FHA_1	2	8	PF00498	0.629
LIG_FHA_1	275	281	PF00498	0.507
LIG_FHA_1	347	353	PF00498	0.574
LIG_FHA_1	388	394	PF00498	0.476
LIG_FHA_1	39	45	PF00498	0.551
LIG_FHA_1	47	53	PF00498	0.518
LIG_FHA_1	510	516	PF00498	0.675
LIG_FHA_1	84	90	PF00498	0.533
LIG_FHA_2	418	424	PF00498	0.437
LIG_FHA_2	45	51	PF00498	0.599
LIG_FHA_2	610	616	PF00498	0.448
LIG_IRF3_LxIS_1	672	678	PF10401	0.555
LIG_LIR_Gen_1	102	112	PF02991	0.371
LIG_LIR_Gen_1	263	273	PF02991	0.381
LIG_LIR_Gen_1	419	429	PF02991	0.397
LIG_LIR_Nem_3	102	108	PF02991	0.377
LIG_LIR_Nem_3	310	316	PF02991	0.339
LIG_LIR_Nem_3	419	425	PF02991	0.392
LIG_LIR_Nem_3	430	436	PF02991	0.315
LIG_LIR_Nem_3	472	477	PF02991	0.488
LIG_NRBOX	464	470	PF00104	0.440
LIG_PCNA_yPIPBox_3	379	391	PF02747	0.533
LIG_PDZ_Class_1	693	698	PF00595	0.542
LIG_SH2_CRK	105	109	PF00017	0.366
LIG_SH2_CRK	246	250	PF00017	0.468
LIG_SH2_CRK	313	317	PF00017	0.339
LIG_SH2_CRK	429	433	PF00017	0.347
LIG_SH2_NCK_1	429	433	PF00017	0.475
LIG_SH2_STAP1	429	433	PF00017	0.332
LIG_SH2_STAP1	482	486	PF00017	0.454
LIG_SH2_STAT3	482	485	PF00017	0.456
LIG_SH2_STAT3	663	666	PF00017	0.539
LIG_SH2_STAT5	105	108	PF00017	0.368
LIG_SH2_STAT5	209	212	PF00017	0.336
LIG_SH2_STAT5	491	494	PF00017	0.461
LIG_SH3_3	165	171	PF00018	0.481
LIG_SH3_3	429	435	PF00018	0.420
LIG_SH3_3	494	500	PF00018	0.532
LIG_SH3_3	514	520	PF00018	0.453
LIG_SH3_3	658	664	PF00018	0.393
LIG_SH3_3	670	676	PF00018	0.500
LIG_SH3_3	683	689	PF00018	0.577
LIG_SUMO_SIM_par_1	349	355	PF11976	0.529
LIG_TRAF2_1	267	270	PF00917	0.328
LIG_TYR_ITIM	207	212	PF00017	0.458
LIG_TYR_ITSM	309	316	PF00017	0.485
LIG_UBA3_1	212	220	PF00899	0.475
LIG_WRC_WIRS_1	375	380	PF05994	0.430
MOD_CDC14_SPxK_1	607	610	PF00782	0.547
MOD_CDK_SPK_2	604	609	PF00069	0.466
MOD_CDK_SPxK_1	604	610	PF00069	0.534
MOD_CDK_SPxxK_3	44	51	PF00069	0.502
MOD_CK1_1	276	282	PF00069	0.439
MOD_CK1_1	39	45	PF00069	0.493
MOD_CK1_1	519	525	PF00069	0.727
MOD_CK1_1	587	593	PF00069	0.633
MOD_CK2_1	264	270	PF00069	0.479
MOD_CK2_1	417	423	PF00069	0.431
MOD_CK2_1	44	50	PF00069	0.554
MOD_CK2_1	609	615	PF00069	0.430
MOD_Cter_Amidation	23	26	PF01082	0.553
MOD_GlcNHglycan	395	398	PF01048	0.594
MOD_GlcNHglycan	530	533	PF01048	0.595
MOD_GlcNHglycan	557	561	PF01048	0.767
MOD_GSK3_1	235	242	PF00069	0.553
MOD_GSK3_1	346	353	PF00069	0.455
MOD_GSK3_1	417	424	PF00069	0.435
MOD_GSK3_1	583	590	PF00069	0.618
MOD_GSK3_1	634	641	PF00069	0.460
MOD_N-GLC_1	638	643	PF02516	0.423
MOD_N-GLC_2	179	181	PF02516	0.334
MOD_NEK2_1	1	6	PF00069	0.657
MOD_NEK2_1	142	147	PF00069	0.427
MOD_NEK2_1	264	269	PF00069	0.427
MOD_NEK2_1	348	353	PF00069	0.462
MOD_NEK2_1	393	398	PF00069	0.602
MOD_NEK2_1	417	422	PF00069	0.510
MOD_NEK2_1	487	492	PF00069	0.544
MOD_NEK2_1	588	593	PF00069	0.660
MOD_NEK2_1	623	628	PF00069	0.379
MOD_NEK2_2	435	440	PF00069	0.335
MOD_PIKK_1	327	333	PF00454	0.512
MOD_PIKK_1	509	515	PF00454	0.565
MOD_PIKK_1	638	644	PF00454	0.473
MOD_PIKK_1	99	105	PF00454	0.489
MOD_PK_1	610	616	PF00069	0.557
MOD_PKA_1	609	615	PF00069	0.596
MOD_PKA_2	1	7	PF00069	0.619
MOD_PKA_2	115	121	PF00069	0.479
MOD_PKA_2	223	229	PF00069	0.339
MOD_PKA_2	561	567	PF00069	0.707
MOD_PKA_2	609	615	PF00069	0.470
MOD_Plk_1	235	241	PF00069	0.491
MOD_Plk_1	327	333	PF00069	0.494
MOD_Plk_1	638	644	PF00069	0.485
MOD_Plk_2-3	561	567	PF00069	0.772
MOD_Plk_4	158	164	PF00069	0.458
MOD_Plk_4	308	314	PF00069	0.424
MOD_Plk_4	39	45	PF00069	0.461
MOD_Plk_4	421	427	PF00069	0.363
MOD_Plk_4	428	434	PF00069	0.358
MOD_Plk_4	487	493	PF00069	0.451
MOD_Plk_4	511	517	PF00069	0.683
MOD_Plk_4	584	590	PF00069	0.654
MOD_Plk_4	69	75	PF00069	0.422
MOD_ProDKin_1	44	50	PF00069	0.500
MOD_ProDKin_1	496	502	PF00069	0.590
MOD_ProDKin_1	516	522	PF00069	0.459
MOD_ProDKin_1	539	545	PF00069	0.691
MOD_ProDKin_1	604	610	PF00069	0.535
MOD_SUMO_for_1	469	472	PF00179	0.545
MOD_SUMO_rev_2	127	134	PF00179	0.422
MOD_SUMO_rev_2	334	339	PF00179	0.499
MOD_SUMO_rev_2	34	39	PF00179	0.663
TRG_DiLeu_BaEn_1	211	216	PF01217	0.459
TRG_DiLeu_BaEn_1	400	405	PF01217	0.491
TRG_DiLeu_BaEn_1	511	516	PF01217	0.671
TRG_DiLeu_BaEn_4	472	478	PF01217	0.527
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.617
TRG_DiLeu_BaLyEn_6	437	442	PF01217	0.388
TRG_DiLeu_LyEn_5	211	216	PF01217	0.392
TRG_ENDOCYTIC_2	105	108	PF00928	0.368
TRG_ENDOCYTIC_2	209	212	PF00928	0.362
TRG_ENDOCYTIC_2	246	249	PF00928	0.468
TRG_ENDOCYTIC_2	313	316	PF00928	0.326
TRG_ENDOCYTIC_2	375	378	PF00928	0.548
TRG_ENDOCYTIC_2	429	432	PF00928	0.337
TRG_ER_diArg_1	1	3	PF00400	0.657
TRG_ER_diArg_1	182	184	PF00400	0.533
TRG_ER_diArg_1	443	445	PF00400	0.403
TRG_ER_diArg_1	462	464	PF00400	0.419
TRG_ER_diArg_1	538	540	PF00400	0.496
TRG_ER_diArg_1	608	610	PF00400	0.644
TRG_ER_diArg_1	80	82	PF00400	0.504
TRG_NES_CRM1_1	50	64	PF08389	0.558
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	402	406	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	504	508	PF00026	0.638
TRG_PTS1	695	698	PF00515	0.661

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5R0	Leptomonas seymouri	71%	97%
A0A0S4IQD8	Bodo saltans	36%	94%
A0A1X0P086	Trypanosomatidae	46%	100%
A0A422NKV6	Trypanosoma rangeli	45%	100%
A4HHK0	Leishmania braziliensis	87%	100%
A4I4Q8	Leishmania infantum	100%	100%
C9ZLE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AE63	Leishmania major	96%	100%
E9ALM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BGI2	Trypanosoma cruzi	47%	95%