IMD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X2T0_LEIDO

TriTrypDb:

LdBPK_292440.1 , LdCL_290030400 , LDHU3_29.3640

Length:

368

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X2T0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2T0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	185	187	PF00675	0.445
CLV_NRD_NRD_1	227	229	PF00675	0.545
CLV_NRD_NRD_1	299	301	PF00675	0.490
CLV_NRD_NRD_1	67	69	PF00675	0.422
CLV_NRD_NRD_1	88	90	PF00675	0.396
CLV_PCSK_FUR_1	182	186	PF00082	0.535
CLV_PCSK_KEX2_1	138	140	PF00082	0.443
CLV_PCSK_KEX2_1	184	186	PF00082	0.458
CLV_PCSK_KEX2_1	298	300	PF00082	0.462
CLV_PCSK_KEX2_1	58	60	PF00082	0.467
CLV_PCSK_KEX2_1	67	69	PF00082	0.389
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.443
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.491
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.542
CLV_PCSK_SKI1_1	138	142	PF00082	0.407
CLV_PCSK_SKI1_1	299	303	PF00082	0.537
CLV_PCSK_SKI1_1	68	72	PF00082	0.448
DEG_APCC_DBOX_1	66	74	PF00400	0.429
DEG_APCC_KENBOX_2	189	193	PF00400	0.561
DEG_Nend_UBRbox_3	1	3	PF02207	0.527
DOC_CYCLIN_RxL_1	65	75	PF00134	0.429
DOC_MAPK_gen_1	67	73	PF00069	0.496
DOC_PP2B_LxvP_1	337	340	PF13499	0.499
DOC_USP7_MATH_1	115	119	PF00917	0.571
DOC_USP7_MATH_1	167	171	PF00917	0.375
DOC_USP7_MATH_1	222	226	PF00917	0.548
DOC_USP7_MATH_1	327	331	PF00917	0.601
DOC_USP7_MATH_1	343	347	PF00917	0.689
DOC_USP7_UBL2_3	160	164	PF12436	0.371
DOC_USP7_UBL2_3	285	289	PF12436	0.503
DOC_USP7_UBL2_3	86	90	PF12436	0.358
DOC_WW_Pin1_4	338	343	PF00397	0.646
LIG_14-3-3_CanoR_1	200	207	PF00244	0.538
LIG_14-3-3_CanoR_1	348	352	PF00244	0.740
LIG_AP2alpha_1	140	144	PF02296	0.365
LIG_BRCT_BRCA1_1	255	259	PF00533	0.392
LIG_FHA_1	147	153	PF00498	0.480
LIG_FHA_1	34	40	PF00498	0.581
LIG_FHA_1	5	11	PF00498	0.558
LIG_FHA_1	82	88	PF00498	0.460
LIG_FHA_2	148	154	PF00498	0.460
LIG_FHA_2	17	23	PF00498	0.615
LIG_FHA_2	176	182	PF00498	0.420
LIG_FHA_2	200	206	PF00498	0.526
LIG_FHA_2	314	320	PF00498	0.439
LIG_FHA_2	49	55	PF00498	0.578
LIG_FXI_DFP_1	177	181	PF00024	0.536
LIG_GBD_Chelix_1	314	322	PF00786	0.424
LIG_GBD_Chelix_1	87	95	PF00786	0.387
LIG_LIR_Nem_3	43	48	PF02991	0.569
LIG_LIR_Nem_3	75	80	PF02991	0.361
LIG_Pex14_2	140	144	PF04695	0.388
LIG_SH2_SRC	230	233	PF00017	0.519
LIG_SH2_STAT3	126	129	PF00017	0.418
LIG_SH2_STAT5	126	129	PF00017	0.418
LIG_SH2_STAT5	15	18	PF00017	0.544
LIG_SH2_STAT5	230	233	PF00017	0.560
LIG_SH3_3	339	345	PF00018	0.549
LIG_SH3_3	346	352	PF00018	0.731
LIG_TYR_ITIM	209	214	PF00017	0.424
LIG_UBA3_1	266	275	PF00899	0.541
LIG_UBA3_1	281	289	PF00899	0.427
MOD_CK1_1	118	124	PF00069	0.337
MOD_CK1_1	147	153	PF00069	0.546
MOD_CK1_1	199	205	PF00069	0.512
MOD_CK1_1	248	254	PF00069	0.366
MOD_CK1_1	268	274	PF00069	0.224
MOD_CK1_1	331	337	PF00069	0.682
MOD_CK1_1	350	356	PF00069	0.708
MOD_CK1_1	40	46	PF00069	0.493
MOD_CK2_1	16	22	PF00069	0.490
MOD_CK2_1	199	205	PF00069	0.644
MOD_CK2_1	313	319	PF00069	0.539
MOD_CK2_1	48	54	PF00069	0.502
MOD_Cter_Amidation	226	229	PF01082	0.537
MOD_GlcNHglycan	142	147	PF01048	0.541
MOD_GlcNHglycan	269	273	PF01048	0.472
MOD_GlcNHglycan	330	333	PF01048	0.633
MOD_GlcNHglycan	344	348	PF01048	0.643
MOD_GlcNHglycan	59	62	PF01048	0.495
MOD_GSK3_1	13	20	PF00069	0.523
MOD_GSK3_1	142	149	PF00069	0.390
MOD_GSK3_1	196	203	PF00069	0.494
MOD_GSK3_1	248	255	PF00069	0.397
MOD_GSK3_1	280	287	PF00069	0.508
MOD_GSK3_1	288	295	PF00069	0.549
MOD_GSK3_1	313	320	PF00069	0.574
MOD_GSK3_1	327	334	PF00069	0.433
MOD_GSK3_1	33	40	PF00069	0.316
MOD_GSK3_1	343	350	PF00069	0.675
MOD_N-GLC_1	63	68	PF02516	0.479
MOD_NEK2_1	13	18	PF00069	0.527
MOD_NEK2_1	144	149	PF00069	0.442
MOD_NEK2_1	238	243	PF00069	0.421
MOD_NEK2_1	245	250	PF00069	0.407
MOD_NEK2_1	3	8	PF00069	0.616
MOD_NEK2_1	33	38	PF00069	0.312
MOD_PIKK_1	118	124	PF00454	0.337
MOD_PIKK_1	132	138	PF00454	0.469
MOD_PIKK_1	284	290	PF00454	0.562
MOD_PKA_2	199	205	PF00069	0.525
MOD_PKA_2	347	353	PF00069	0.722
MOD_PKA_2	357	363	PF00069	0.418
MOD_Plk_1	118	124	PF00069	0.376
MOD_Plk_1	245	251	PF00069	0.405
MOD_Plk_1	268	274	PF00069	0.468
MOD_Plk_4	332	338	PF00069	0.693
MOD_Plk_4	37	43	PF00069	0.473
MOD_ProDKin_1	338	344	PF00069	0.649
TRG_DiLeu_BaEn_3	296	302	PF01217	0.506
TRG_ENDOCYTIC_2	211	214	PF00928	0.426
TRG_ER_diArg_1	182	185	PF00400	0.500
TRG_ER_diArg_1	299	301	PF00400	0.470
TRG_Pf-PMV_PEXEL_1	128	132	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.339
TRG_Pf-PMV_PEXEL_1	300	304	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAR2	Leptomonas seymouri	54%	94%
A0A0S4K0W0	Bodo saltans	24%	79%
A0A1X0P9E6	Trypanosomatidae	31%	100%
A0A3R7JW64	Trypanosoma rangeli	32%	100%
A4HHN2	Leishmania braziliensis	70%	100%
A4I4U7	Leishmania infantum	99%	100%
E9AE95	Leishmania major	90%	100%
E9ALJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BSJ0	Trypanosoma cruzi	32%	99%