Poly(A) polymerase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Download

Quick info

Protein:

Gene product:

poly(A) polymerase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X2S4_LEIDO

TriTrypDb:

LdBPK_292710.1 , LdCL_290033200 , LDHU3_29.3990

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S7X2S4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2S4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0031123	RNA 3'-end processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071076	RNA 3' uridylation	8	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004652	obsolete polynucleotide adenylyltransferase activity	6	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016779	nucleotidyltransferase activity	4	2
GO:0050265	RNA uridylyltransferase activity	4	2
GO:0070566	adenylyltransferase activity	5	2
GO:0070569	uridylyltransferase activity	5	2
GO:0140098	catalytic activity, acting on RNA	3	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	75	79	PF00656	0.493
CLV_NRD_NRD_1	156	158	PF00675	0.378
CLV_NRD_NRD_1	163	165	PF00675	0.374
CLV_NRD_NRD_1	30	32	PF00675	0.326
CLV_PCSK_FUR_1	161	165	PF00082	0.372
CLV_PCSK_KEX2_1	156	158	PF00082	0.378
CLV_PCSK_KEX2_1	163	165	PF00082	0.374
CLV_PCSK_KEX2_1	30	32	PF00082	0.326
CLV_PCSK_PC7_1	159	165	PF00082	0.370
CLV_PCSK_SKI1_1	11	15	PF00082	0.321
CLV_PCSK_SKI1_1	30	34	PF00082	0.331
CLV_PCSK_SKI1_1	49	53	PF00082	0.302
CLV_Separin_Metazoa	43	47	PF03568	0.502
DEG_APCC_DBOX_1	48	56	PF00400	0.502
DEG_Nend_UBRbox_2	1	3	PF02207	0.565
DOC_CDC14_PxL_1	238	246	PF14671	0.369
DOC_CKS1_1	185	190	PF01111	0.575
DOC_CKS1_1	231	236	PF01111	0.361
DOC_CYCLIN_RxL_1	46	53	PF00134	0.499
DOC_CYCLIN_yCln2_LP_2	123	129	PF00134	0.571
DOC_CYCLIN_yCln2_LP_2	185	191	PF00134	0.575
DOC_MAPK_MEF2A_6	98	106	PF00069	0.564
DOC_PP2B_LxvP_1	189	192	PF13499	0.576
DOC_PP4_FxxP_1	107	110	PF00568	0.573
DOC_PP4_FxxP_1	180	183	PF00568	0.568
DOC_USP7_MATH_1	23	27	PF00917	0.504
DOC_USP7_MATH_1	58	62	PF00917	0.523
DOC_USP7_MATH_1	92	96	PF00917	0.533
DOC_WW_Pin1_4	106	111	PF00397	0.573
DOC_WW_Pin1_4	122	127	PF00397	0.576
DOC_WW_Pin1_4	179	184	PF00397	0.567
DOC_WW_Pin1_4	190	195	PF00397	0.572
DOC_WW_Pin1_4	230	235	PF00397	0.357
DOC_WW_Pin1_4	250	255	PF00397	0.360
LIG_14-3-3_CanoR_1	145	152	PF00244	0.608
LIG_14-3-3_CanoR_1	30	38	PF00244	0.537
LIG_APCC_ABBA_1	86	91	PF00400	0.487
LIG_BIR_III_2	12	16	PF00653	0.526
LIG_BRCT_BRCA1_1	124	128	PF00533	0.570
LIG_BRCT_BRCA1_1	219	223	PF00533	0.199
LIG_BRCT_BRCA1_1	95	99	PF00533	0.551
LIG_EVH1_1	191	195	PF00568	0.571
LIG_EVH1_2	194	198	PF00568	0.567
LIG_FHA_1	244	250	PF00498	0.373
LIG_FHA_1	39	45	PF00498	0.515
LIG_FHA_2	80	86	PF00498	0.504
LIG_GBD_Chelix_1	47	55	PF00786	0.303
LIG_IRF3_LxIS_1	176	182	PF10401	0.569
LIG_LIR_Apic_2	250	255	PF02991	0.360
LIG_LIR_Apic_2	87	92	PF02991	0.491
LIG_LIR_Gen_1	170	181	PF02991	0.566
LIG_LIR_Gen_1	222	232	PF02991	0.199
LIG_LIR_Nem_3	12	17	PF02991	0.527
LIG_LIR_Nem_3	170	176	PF02991	0.564
LIG_LIR_Nem_3	220	226	PF02991	0.199
LIG_LIR_Nem_3	96	102	PF02991	0.562
LIG_NRBOX	131	137	PF00104	0.585
LIG_NRBOX	51	57	PF00104	0.508
LIG_Pex14_1	219	223	PF04695	0.199
LIG_Pex14_1	66	70	PF04695	0.496
LIG_SH2_CRK	173	177	PF00017	0.567
LIG_SH2_CRK	252	256	PF00017	0.354
LIG_SH2_STAT5	252	255	PF00017	0.355
LIG_SH2_STAT5	70	73	PF00017	0.478
LIG_SH3_3	107	113	PF00018	0.574
LIG_SH3_3	115	121	PF00018	0.583
LIG_SH3_3	123	129	PF00018	0.571
LIG_SH3_3	189	195	PF00018	0.574
LIG_SH3_3	204	210	PF00018	0.400
LIG_SH3_3	239	245	PF00018	0.367
LIG_SH3_3	260	266	PF00018	0.366
LIG_SUMO_SIM_anti_2	6	12	PF11976	0.527
LIG_SUMO_SIM_par_1	213	218	PF11976	0.199
MOD_CDK_SPK_2	111	116	PF00069	0.578
MOD_CDK_SPxK_1	184	190	PF00069	0.572
MOD_CK1_1	131	137	PF00069	0.585
MOD_CK1_1	167	173	PF00069	0.563
MOD_CK1_1	250	256	PF00069	0.359
MOD_GlcNHglycan	219	222	PF01048	0.199
MOD_GlcNHglycan	59	63	PF01048	0.321
MOD_GlcNHglycan	74	77	PF01048	0.280
MOD_GSK3_1	127	134	PF00069	0.574
MOD_GSK3_1	163	170	PF00069	0.567
MOD_GSK3_1	190	197	PF00069	0.570
MOD_GSK3_1	215	222	PF00069	0.199
MOD_GSK3_1	226	233	PF00069	0.414
MOD_GSK3_1	236	243	PF00069	0.371
MOD_GSK3_1	30	37	PF00069	0.536
MOD_NEK2_1	236	241	PF00069	0.375
MOD_NEK2_1	72	77	PF00069	0.478
MOD_NEK2_2	219	224	PF00069	0.199
MOD_PIKK_1	64	70	PF00454	0.504
MOD_PKA_1	163	169	PF00069	0.568
MOD_PKA_1	30	36	PF00069	0.536
MOD_PKA_2	163	169	PF00069	0.568
MOD_PKA_2	30	36	PF00069	0.536
MOD_PKB_1	143	151	PF00069	0.605
MOD_PKB_1	161	169	PF00069	0.568
MOD_Plk_1	5	11	PF00069	0.528
MOD_Plk_2-3	34	40	PF00069	0.541
MOD_Plk_4	131	137	PF00069	0.585
MOD_Plk_4	194	200	PF00069	0.564
MOD_Plk_4	219	225	PF00069	0.199
MOD_Plk_4	5	11	PF00069	0.528
MOD_ProDKin_1	106	112	PF00069	0.572
MOD_ProDKin_1	122	128	PF00069	0.575
MOD_ProDKin_1	179	185	PF00069	0.567
MOD_ProDKin_1	190	196	PF00069	0.572
MOD_ProDKin_1	230	236	PF00069	0.361
MOD_ProDKin_1	250	256	PF00069	0.359
TRG_DiLeu_BaEn_1	43	48	PF01217	0.498
TRG_ENDOCYTIC_2	173	176	PF00928	0.567
TRG_ER_diArg_1	161	164	PF00400	0.572
TRG_ER_diArg_1	29	31	PF00400	0.528
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.302