Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7X2R9_LEIDO

TriTrypDb:

LdBPK_292540.1 , LdCL_290031500 , LDHU3_29.3780

Length:

764

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X2R9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2R9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.706
CLV_C14_Caspase3-7	250	254	PF00656	0.691
CLV_C14_Caspase3-7	263	267	PF00656	0.586
CLV_C14_Caspase3-7	510	514	PF00656	0.676
CLV_C14_Caspase3-7	56	60	PF00656	0.563
CLV_NRD_NRD_1	113	115	PF00675	0.663
CLV_NRD_NRD_1	186	188	PF00675	0.606
CLV_NRD_NRD_1	282	284	PF00675	0.640
CLV_NRD_NRD_1	312	314	PF00675	0.702
CLV_NRD_NRD_1	394	396	PF00675	0.661
CLV_NRD_NRD_1	413	415	PF00675	0.493
CLV_NRD_NRD_1	503	505	PF00675	0.610
CLV_NRD_NRD_1	543	545	PF00675	0.636
CLV_NRD_NRD_1	705	707	PF00675	0.697
CLV_NRD_NRD_1	710	712	PF00675	0.605
CLV_NRD_NRD_1	86	88	PF00675	0.594
CLV_PCSK_FUR_1	501	505	PF00082	0.586
CLV_PCSK_KEX2_1	113	115	PF00082	0.663
CLV_PCSK_KEX2_1	141	143	PF00082	0.522
CLV_PCSK_KEX2_1	282	284	PF00082	0.640
CLV_PCSK_KEX2_1	312	314	PF00082	0.617
CLV_PCSK_KEX2_1	363	365	PF00082	0.578
CLV_PCSK_KEX2_1	394	396	PF00082	0.663
CLV_PCSK_KEX2_1	413	415	PF00082	0.493
CLV_PCSK_KEX2_1	503	505	PF00082	0.610
CLV_PCSK_KEX2_1	542	544	PF00082	0.639
CLV_PCSK_KEX2_1	590	592	PF00082	0.684
CLV_PCSK_KEX2_1	615	617	PF00082	0.701
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.557
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.578
CLV_PCSK_PC1ET2_1	590	592	PF00082	0.684
CLV_PCSK_PC1ET2_1	615	617	PF00082	0.701
CLV_PCSK_SKI1_1	322	326	PF00082	0.631
CLV_PCSK_SKI1_1	523	527	PF00082	0.693
CLV_PCSK_SKI1_1	607	611	PF00082	0.600
CLV_PCSK_SKI1_1	663	667	PF00082	0.588
CLV_PCSK_SKI1_1	706	710	PF00082	0.699
CLV_PCSK_SKI1_1	79	83	PF00082	0.643
CLV_Separin_Metazoa	719	723	PF03568	0.587
DEG_SCF_FBW7_1	376	382	PF00400	0.607
DEG_SCF_FBW7_1	694	700	PF00400	0.639
DEG_SCF_FBW7_2	196	202	PF00400	0.641
DEG_SIAH_1	349	357	PF03145	0.556
DOC_CKS1_1	128	133	PF01111	0.588
DOC_CKS1_1	196	201	PF01111	0.641
DOC_CKS1_1	323	328	PF01111	0.535
DOC_CKS1_1	376	381	PF01111	0.639
DOC_CKS1_1	573	578	PF01111	0.640
DOC_CKS1_1	694	699	PF01111	0.638
DOC_CYCLIN_RxL_1	164	175	PF00134	0.586
DOC_MAPK_DCC_7	578	586	PF00069	0.665
DOC_MAPK_RevD_3	730	744	PF00069	0.540
DOC_PP1_RVXF_1	165	172	PF00149	0.591
DOC_PP2B_LxvP_1	240	243	PF13499	0.551
DOC_PP2B_LxvP_1	292	295	PF13499	0.656
DOC_PP2B_LxvP_1	324	327	PF13499	0.531
DOC_PP2B_LxvP_1	358	361	PF13499	0.578
DOC_PP2B_LxvP_1	384	387	PF13499	0.652
DOC_PP2B_LxvP_1	46	49	PF13499	0.626
DOC_PP2B_LxvP_1	633	636	PF13499	0.559
DOC_PP4_FxxP_1	422	425	PF00568	0.515
DOC_USP7_MATH_1	15	19	PF00917	0.615
DOC_USP7_MATH_1	153	157	PF00917	0.596
DOC_USP7_MATH_1	206	210	PF00917	0.693
DOC_USP7_MATH_1	247	251	PF00917	0.665
DOC_USP7_MATH_1	400	404	PF00917	0.601
DOC_USP7_MATH_1	406	410	PF00917	0.598
DOC_USP7_MATH_1	517	521	PF00917	0.625
DOC_USP7_MATH_1	55	59	PF00917	0.596
DOC_USP7_MATH_1	628	632	PF00917	0.679
DOC_USP7_MATH_1	649	653	PF00917	0.752
DOC_USP7_MATH_1	658	662	PF00917	0.627
DOC_USP7_MATH_1	683	687	PF00917	0.707
DOC_USP7_MATH_1	96	100	PF00917	0.657
DOC_USP7_UBL2_3	562	566	PF12436	0.652
DOC_USP7_UBL2_3	703	707	PF12436	0.648
DOC_USP7_UBL2_3	750	754	PF12436	0.585
DOC_WW_Pin1_4	121	126	PF00397	0.768
DOC_WW_Pin1_4	127	132	PF00397	0.608
DOC_WW_Pin1_4	186	191	PF00397	0.585
DOC_WW_Pin1_4	192	197	PF00397	0.617
DOC_WW_Pin1_4	266	271	PF00397	0.660
DOC_WW_Pin1_4	322	327	PF00397	0.517
DOC_WW_Pin1_4	372	377	PF00397	0.726
DOC_WW_Pin1_4	385	390	PF00397	0.596
DOC_WW_Pin1_4	526	531	PF00397	0.665
DOC_WW_Pin1_4	554	559	PF00397	0.696
DOC_WW_Pin1_4	568	573	PF00397	0.551
DOC_WW_Pin1_4	599	604	PF00397	0.630
DOC_WW_Pin1_4	615	620	PF00397	0.669
DOC_WW_Pin1_4	647	652	PF00397	0.654
DOC_WW_Pin1_4	665	670	PF00397	0.652
DOC_WW_Pin1_4	693	698	PF00397	0.679
DOC_WW_Pin1_4	754	759	PF00397	0.601
LIG_14-3-3_CanoR_1	129	139	PF00244	0.601
LIG_14-3-3_CanoR_1	260	270	PF00244	0.672
LIG_14-3-3_CanoR_1	312	320	PF00244	0.789
LIG_14-3-3_CanoR_1	342	350	PF00244	0.634
LIG_14-3-3_CanoR_1	542	551	PF00244	0.628
LIG_14-3-3_CanoR_1	607	612	PF00244	0.573
LIG_14-3-3_CanoR_1	706	713	PF00244	0.651
LIG_14-3-3_CanoR_1	87	95	PF00244	0.648
LIG_BRCT_BRCA1_1	285	289	PF00533	0.593
LIG_FHA_1	134	140	PF00498	0.654
LIG_FHA_1	196	202	PF00498	0.610
LIG_FHA_1	367	373	PF00498	0.606
LIG_FHA_1	41	47	PF00498	0.556
LIG_FHA_1	437	443	PF00498	0.562
LIG_FHA_1	555	561	PF00498	0.681
LIG_FHA_2	170	176	PF00498	0.565
LIG_FHA_2	54	60	PF00498	0.769
LIG_FHA_2	569	575	PF00498	0.699
LIG_FHA_2	75	81	PF00498	0.614
LIG_LIR_Apic_2	420	425	PF02991	0.518
LIG_LIR_Apic_2	502	508	PF02991	0.663
LIG_LIR_Gen_1	286	295	PF02991	0.581
LIG_LIR_Gen_1	318	327	PF02991	0.588
LIG_LIR_Gen_1	401	411	PF02991	0.652
LIG_LIR_Nem_3	162	168	PF02991	0.675
LIG_LIR_Nem_3	286	292	PF02991	0.587
LIG_LIR_Nem_3	318	323	PF02991	0.617
LIG_LIR_Nem_3	401	407	PF02991	0.654
LIG_LIR_Nem_3	80	86	PF02991	0.625
LIG_SH2_CRK	165	169	PF00017	0.563
LIG_SH2_CRK	320	324	PF00017	0.603
LIG_SH2_PTP2	505	508	PF00017	0.657
LIG_SH2_SRC	505	508	PF00017	0.657
LIG_SH2_STAP1	237	241	PF00017	0.565
LIG_SH2_STAP1	320	324	PF00017	0.603
LIG_SH2_STAT5	332	335	PF00017	0.586
LIG_SH2_STAT5	440	443	PF00017	0.567
LIG_SH2_STAT5	505	508	PF00017	0.593
LIG_SH2_STAT5	746	749	PF00017	0.572
LIG_SH3_1	193	199	PF00018	0.583
LIG_SH3_1	210	216	PF00018	0.574
LIG_SH3_1	590	596	PF00018	0.562
LIG_SH3_2	573	578	PF14604	0.574
LIG_SH3_3	122	128	PF00018	0.596
LIG_SH3_3	154	160	PF00018	0.628
LIG_SH3_3	193	199	PF00018	0.671
LIG_SH3_3	210	216	PF00018	0.668
LIG_SH3_3	224	230	PF00018	0.552
LIG_SH3_3	292	298	PF00018	0.606
LIG_SH3_3	304	310	PF00018	0.537
LIG_SH3_3	320	326	PF00018	0.564
LIG_SH3_3	347	353	PF00018	0.618
LIG_SH3_3	373	379	PF00018	0.779
LIG_SH3_3	463	469	PF00018	0.641
LIG_SH3_3	527	533	PF00018	0.641
LIG_SH3_3	545	551	PF00018	0.634
LIG_SH3_3	570	576	PF00018	0.592
LIG_SH3_3	590	596	PF00018	0.569
LIG_SH3_3	602	608	PF00018	0.600
LIG_SH3_3	622	628	PF00018	0.734
LIG_SH3_3	633	639	PF00018	0.561
LIG_SH3_3	692	698	PF00018	0.664
LIG_SUMO_SIM_anti_2	56	68	PF11976	0.553
LIG_SUMO_SIM_par_1	369	375	PF11976	0.557
LIG_SUMO_SIM_par_1	496	502	PF11976	0.590
LIG_SUMO_SIM_par_1	607	614	PF11976	0.682
LIG_TRAF2_1	172	175	PF00917	0.553
LIG_TRAF2_1	508	511	PF00917	0.591
LIG_TRAF2_1	525	528	PF00917	0.659
MOD_CDK_SPK_2	186	191	PF00069	0.556
MOD_CDK_SPK_2	754	759	PF00069	0.601
MOD_CDK_SPxK_1	572	578	PF00069	0.609
MOD_CDK_SPxxK_3	186	193	PF00069	0.585
MOD_CDK_SPxxK_3	754	761	PF00069	0.547
MOD_CK1_1	115	121	PF00069	0.687
MOD_CK1_1	189	195	PF00069	0.630
MOD_CK1_1	259	265	PF00069	0.622
MOD_CK1_1	272	278	PF00069	0.650
MOD_CK1_1	285	291	PF00069	0.505
MOD_CK1_1	343	349	PF00069	0.629
MOD_CK1_1	375	381	PF00069	0.633
MOD_CK1_1	417	423	PF00069	0.558
MOD_CK1_1	444	450	PF00069	0.583
MOD_CK1_1	650	656	PF00069	0.691
MOD_CK1_1	74	80	PF00069	0.757
MOD_CK1_1	757	763	PF00069	0.546
MOD_CK1_1	89	95	PF00069	0.579
MOD_CK2_1	169	175	PF00069	0.571
MOD_CK2_1	211	217	PF00069	0.642
MOD_CK2_1	406	412	PF00069	0.655
MOD_CK2_1	424	430	PF00069	0.458
MOD_CK2_1	568	574	PF00069	0.655
MOD_CK2_1	628	634	PF00069	0.688
MOD_CK2_1	64	70	PF00069	0.583
MOD_CK2_1	683	689	PF00069	0.643
MOD_CK2_1	74	80	PF00069	0.665
MOD_Cter_Amidation	392	395	PF01082	0.621
MOD_DYRK1A_RPxSP_1	322	326	PF00069	0.553
MOD_GlcNHglycan	115	118	PF01048	0.550
MOD_GlcNHglycan	249	252	PF01048	0.733
MOD_GlcNHglycan	342	345	PF01048	0.595
MOD_GlcNHglycan	400	403	PF01048	0.648
MOD_GlcNHglycan	449	452	PF01048	0.573
MOD_GlcNHglycan	485	488	PF01048	0.586
MOD_GlcNHglycan	519	522	PF01048	0.615
MOD_GlcNHglycan	622	625	PF01048	0.625
MOD_GlcNHglycan	643	646	PF01048	0.655
MOD_GlcNHglycan	656	659	PF01048	0.642
MOD_GlcNHglycan	683	686	PF01048	0.679
MOD_GlcNHglycan	714	717	PF01048	0.672
MOD_GlcNHglycan	98	101	PF01048	0.755
MOD_GSK3_1	105	112	PF00069	0.747
MOD_GSK3_1	130	137	PF00069	0.572
MOD_GSK3_1	197	204	PF00069	0.716
MOD_GSK3_1	211	218	PF00069	0.768
MOD_GSK3_1	256	263	PF00069	0.671
MOD_GSK3_1	269	276	PF00069	0.766
MOD_GSK3_1	366	373	PF00069	0.591
MOD_GSK3_1	375	382	PF00069	0.656
MOD_GSK3_1	394	401	PF00069	0.586
MOD_GSK3_1	413	420	PF00069	0.702
MOD_GSK3_1	436	443	PF00069	0.579
MOD_GSK3_1	5	12	PF00069	0.540
MOD_GSK3_1	53	60	PF00069	0.621
MOD_GSK3_1	542	549	PF00069	0.688
MOD_GSK3_1	568	575	PF00069	0.654
MOD_GSK3_1	607	614	PF00069	0.705
MOD_GSK3_1	650	657	PF00069	0.623
MOD_GSK3_1	693	700	PF00069	0.663
MOD_GSK3_1	744	751	PF00069	0.463
MOD_GSK3_1	86	93	PF00069	0.599
MOD_GSK3_1	96	103	PF00069	0.661
MOD_LATS_1	710	716	PF00433	0.585
MOD_N-GLC_1	169	174	PF02516	0.628
MOD_N-GLC_1	340	345	PF02516	0.588
MOD_N-GLC_1	676	681	PF02516	0.631
MOD_N-GLC_1	74	79	PF02516	0.671
MOD_N-GLC_1	96	101	PF02516	0.616
MOD_NEK2_1	201	206	PF00069	0.717
MOD_NEK2_1	273	278	PF00069	0.651
MOD_NEK2_1	5	10	PF00069	0.565
MOD_NEK2_1	567	572	PF00069	0.620
MOD_NEK2_1	611	616	PF00069	0.810
MOD_NEK2_1	748	753	PF00069	0.460
MOD_NEK2_1	86	91	PF00069	0.651
MOD_NEK2_2	749	754	PF00069	0.481
MOD_OFUCOSY	421	428	PF10250	0.529
MOD_PIKK_1	201	207	PF00454	0.657
MOD_PIKK_1	229	235	PF00454	0.526
MOD_PIKK_1	441	447	PF00454	0.663
MOD_PIKK_1	9	15	PF00454	0.530
MOD_PIKK_1	90	96	PF00454	0.693
MOD_PKA_1	113	119	PF00069	0.666
MOD_PKA_1	282	288	PF00069	0.693
MOD_PKA_1	394	400	PF00069	0.599
MOD_PKA_1	413	419	PF00069	0.486
MOD_PKA_1	542	548	PF00069	0.631
MOD_PKA_1	706	712	PF00069	0.683
MOD_PKA_1	87	93	PF00069	0.630
MOD_PKA_2	112	118	PF00069	0.677
MOD_PKA_2	259	265	PF00069	0.615
MOD_PKA_2	282	288	PF00069	0.633
MOD_PKA_2	394	400	PF00069	0.610
MOD_PKA_2	413	419	PF00069	0.486
MOD_PKA_2	542	548	PF00069	0.631
MOD_PKA_2	86	92	PF00069	0.596
MOD_PKB_1	313	321	PF00069	0.619
MOD_Plk_1	79	85	PF00069	0.601
MOD_Plk_2-3	676	682	PF00069	0.609
MOD_Plk_4	15	21	PF00069	0.625
MOD_Plk_4	153	159	PF00069	0.661
MOD_Plk_4	315	321	PF00069	0.661
MOD_Plk_4	367	373	PF00069	0.589
MOD_Plk_4	59	65	PF00069	0.549
MOD_Plk_4	79	85	PF00069	0.707
MOD_ProDKin_1	121	127	PF00069	0.768
MOD_ProDKin_1	186	192	PF00069	0.587
MOD_ProDKin_1	195	201	PF00069	0.620
MOD_ProDKin_1	266	272	PF00069	0.659
MOD_ProDKin_1	322	328	PF00069	0.513
MOD_ProDKin_1	372	378	PF00069	0.728
MOD_ProDKin_1	385	391	PF00069	0.597
MOD_ProDKin_1	526	532	PF00069	0.665
MOD_ProDKin_1	554	560	PF00069	0.698
MOD_ProDKin_1	568	574	PF00069	0.555
MOD_ProDKin_1	599	605	PF00069	0.627
MOD_ProDKin_1	615	621	PF00069	0.668
MOD_ProDKin_1	647	653	PF00069	0.653
MOD_ProDKin_1	665	671	PF00069	0.653
MOD_ProDKin_1	693	699	PF00069	0.679
MOD_ProDKin_1	754	760	PF00069	0.547
MOD_SUMO_for_1	525	528	PF00179	0.705
MOD_SUMO_for_1	716	719	PF00179	0.590
MOD_SUMO_rev_2	66	74	PF00179	0.557
MOD_SUMO_rev_2	699	705	PF00179	0.641
TRG_DiLeu_BaEn_4	304	310	PF01217	0.600
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.630
TRG_ENDOCYTIC_2	165	168	PF00928	0.568
TRG_ENDOCYTIC_2	237	240	PF00928	0.611
TRG_ENDOCYTIC_2	320	323	PF00928	0.610
TRG_ER_diArg_1	190	193	PF00400	0.580
TRG_ER_diArg_1	281	283	PF00400	0.631
TRG_ER_diArg_1	312	315	PF00400	0.620
TRG_ER_diArg_1	413	415	PF00400	0.607
TRG_ER_diArg_1	500	503	PF00400	0.598
TRG_ER_diArg_1	541	544	PF00400	0.637
TRG_NLS_MonoExtC_3	702	707	PF00514	0.567
TRG_NLS_MonoExtN_4	702	707	PF00514	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0L3	Leptomonas seymouri	37%	88%
A4HHP2	Leishmania braziliensis	51%	98%
A4I4V7	Leishmania infantum	96%	100%
E9AEA5	Leishmania major	85%	100%
E9ALI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%