Phosphodiesterase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Phosphodiesterase

Gene product:

3'5'-cyclic nucleotide phosphodiesterase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X2R6_LEIDO

TriTrypDb:

LdBPK_292550.1 , LdCL_290031600 , LDHU3_29.3790

Length:

724

Annotations

LeishMANIAdb annotations

Phosphodiesterase, with probable N-terminal lipidation signal. Not embedded in membrane, like its homologs.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	5
GO:0005737	cytoplasm	2	1
GO:0020016	ciliary pocket	2	1

Expansion

Sequence features

A0A3S7X2R6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2R6

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	14
GO:0009987	cellular process	1	14
GO:0050789	regulation of biological process	2	14
GO:0050794	regulation of cellular process	3	14
GO:0065007	biological regulation	1	14

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0004112	cyclic-nucleotide phosphodiesterase activity	6	14
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	7	14
GO:0005488	binding	1	14
GO:0008081	phosphoric diester hydrolase activity	5	14
GO:0016787	hydrolase activity	2	14
GO:0016788	hydrolase activity, acting on ester bonds	3	14
GO:0042578	phosphoric ester hydrolase activity	4	14
GO:0043167	ion binding	2	14
GO:0043169	cation binding	3	14
GO:0046872	metal ion binding	4	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	184	188	PF00656	0.540
CLV_NRD_NRD_1	184	186	PF00675	0.539
CLV_NRD_NRD_1	304	306	PF00675	0.547
CLV_NRD_NRD_1	379	381	PF00675	0.549
CLV_NRD_NRD_1	446	448	PF00675	0.517
CLV_NRD_NRD_1	706	708	PF00675	0.585
CLV_PCSK_KEX2_1	304	306	PF00082	0.551
CLV_PCSK_KEX2_1	446	448	PF00082	0.517
CLV_PCSK_KEX2_1	706	708	PF00082	0.568
CLV_PCSK_PC7_1	300	306	PF00082	0.651
CLV_PCSK_SKI1_1	107	111	PF00082	0.541
CLV_PCSK_SKI1_1	220	224	PF00082	0.496
CLV_PCSK_SKI1_1	304	308	PF00082	0.610
CLV_PCSK_SKI1_1	356	360	PF00082	0.406
CLV_PCSK_SKI1_1	446	450	PF00082	0.386
CLV_PCSK_SKI1_1	530	534	PF00082	0.318
CLV_PCSK_SKI1_1	582	586	PF00082	0.336
CLV_PCSK_SKI1_1	605	609	PF00082	0.376
CLV_PCSK_SKI1_1	92	96	PF00082	0.520
CLV_Separin_Metazoa	543	547	PF03568	0.397
DEG_APCC_DBOX_1	445	453	PF00400	0.459
DEG_SCF_FBW7_1	13	20	PF00400	0.667
DEG_SPOP_SBC_1	76	80	PF00917	0.663
DOC_CYCLIN_RxL_1	643	653	PF00134	0.438
DOC_MAPK_gen_1	446	452	PF00069	0.509
DOC_MAPK_gen_1	600	608	PF00069	0.397
DOC_MAPK_gen_1	646	652	PF00069	0.447
DOC_MAPK_MEF2A_6	600	608	PF00069	0.330
DOC_PP4_FxxP_1	117	120	PF00568	0.513
DOC_PP4_FxxP_1	204	207	PF00568	0.553
DOC_PP4_FxxP_1	506	509	PF00568	0.358
DOC_SPAK_OSR1_1	224	228	PF12202	0.479
DOC_SPAK_OSR1_1	447	451	PF12202	0.509
DOC_USP7_MATH_1	286	290	PF00917	0.600
DOC_USP7_MATH_1	451	455	PF00917	0.483
DOC_USP7_MATH_2	347	353	PF00917	0.536
DOC_USP7_UBL2_3	632	636	PF12436	0.456
DOC_USP7_UBL2_3	86	90	PF12436	0.564
DOC_WW_Pin1_4	11	16	PF00397	0.721
DOC_WW_Pin1_4	213	218	PF00397	0.588
DOC_WW_Pin1_4	334	339	PF00397	0.693
DOC_WW_Pin1_4	359	364	PF00397	0.527
DOC_WW_Pin1_4	65	70	PF00397	0.720
DOC_WW_Pin1_4	650	655	PF00397	0.318
LIG_14-3-3_CanoR_1	140	147	PF00244	0.486
LIG_14-3-3_CanoR_1	590	597	PF00244	0.432
LIG_14-3-3_CanoR_1	605	611	PF00244	0.376
LIG_APCC_ABBA_1	114	119	PF00400	0.513
LIG_APCC_ABBA_1	652	657	PF00400	0.358
LIG_BRCT_BRCA1_1	634	638	PF00533	0.358
LIG_CSL_BTD_1	335	338	PF09270	0.693
LIG_CtBP_PxDLS_1	207	211	PF00389	0.568
LIG_eIF4E_1	423	429	PF01652	0.392
LIG_FHA_1	111	117	PF00498	0.422
LIG_FHA_1	132	138	PF00498	0.535
LIG_FHA_1	167	173	PF00498	0.478
LIG_FHA_1	229	235	PF00498	0.532
LIG_FHA_1	266	272	PF00498	0.642
LIG_FHA_1	407	413	PF00498	0.474
LIG_FHA_1	422	428	PF00498	0.365
LIG_FHA_1	539	545	PF00498	0.451
LIG_FHA_1	690	696	PF00498	0.476
LIG_FHA_1	71	77	PF00498	0.755
LIG_FHA_1	8	14	PF00498	0.762
LIG_FHA_2	141	147	PF00498	0.456
LIG_FHA_2	177	183	PF00498	0.540
LIG_FHA_2	267	273	PF00498	0.630
LIG_FHA_2	553	559	PF00498	0.380
LIG_FHA_2	565	571	PF00498	0.285
LIG_IBAR_NPY_1	459	461	PF08397	0.408
LIG_IRF3_LxIS_1	648	653	PF10401	0.424
LIG_LIR_Apic_2	201	207	PF02991	0.566
LIG_LIR_Apic_2	505	509	PF02991	0.318
LIG_LIR_Gen_1	187	198	PF02991	0.507
LIG_LIR_Gen_1	394	402	PF02991	0.413
LIG_LIR_Gen_1	406	415	PF02991	0.357
LIG_LIR_Gen_1	424	434	PF02991	0.331
LIG_LIR_Gen_1	541	550	PF02991	0.379
LIG_LIR_Nem_3	159	163	PF02991	0.406
LIG_LIR_Nem_3	187	193	PF02991	0.477
LIG_LIR_Nem_3	199	205	PF02991	0.467
LIG_LIR_Nem_3	221	226	PF02991	0.488
LIG_LIR_Nem_3	394	399	PF02991	0.393
LIG_LIR_Nem_3	406	410	PF02991	0.401
LIG_LIR_Nem_3	424	429	PF02991	0.351
LIG_LIR_Nem_3	492	498	PF02991	0.421
LIG_LIR_Nem_3	541	545	PF02991	0.399
LIG_LIR_Nem_3	671	675	PF02991	0.320
LIG_LIR_Nem_3	96	100	PF02991	0.567
LIG_LYPXL_yS_3	202	205	PF13949	0.491
LIG_Pex14_1	160	164	PF04695	0.377
LIG_PTB_Apo_2	544	551	PF02174	0.397
LIG_PTB_Apo_2	698	705	PF02174	0.530
LIG_PTB_Phospho_1	544	550	PF10480	0.421
LIG_PTB_Phospho_1	698	704	PF10480	0.531
LIG_Rb_pABgroove_1	317	325	PF01858	0.687
LIG_REV1ctd_RIR_1	161	169	PF16727	0.389
LIG_SH2_CRK	407	411	PF00017	0.417
LIG_SH2_CRK	97	101	PF00017	0.560
LIG_SH2_GRB2like	437	440	PF00017	0.497
LIG_SH2_GRB2like	461	464	PF00017	0.330
LIG_SH2_NCK_1	236	240	PF00017	0.581
LIG_SH2_NCK_1	407	411	PF00017	0.433
LIG_SH2_SRC	323	326	PF00017	0.625
LIG_SH2_STAP1	138	142	PF00017	0.484
LIG_SH2_STAP1	423	427	PF00017	0.331
LIG_SH2_STAP1	627	631	PF00017	0.397
LIG_SH2_STAT3	675	678	PF00017	0.421
LIG_SH2_STAT5	142	145	PF00017	0.595
LIG_SH2_STAT5	270	273	PF00017	0.626
LIG_SH2_STAT5	423	426	PF00017	0.374
LIG_SH2_STAT5	437	440	PF00017	0.426
LIG_SH2_STAT5	476	479	PF00017	0.309
LIG_SH2_STAT5	522	525	PF00017	0.330
LIG_SH2_STAT5	639	642	PF00017	0.403
LIG_SH2_STAT5	675	678	PF00017	0.318
LIG_SH2_STAT5	93	96	PF00017	0.446
LIG_SH3_3	12	18	PF00018	0.699
LIG_SH3_3	223	229	PF00018	0.541
LIG_SH3_3	357	363	PF00018	0.419
LIG_SH3_3	54	60	PF00018	0.752
LIG_SH3_3	63	69	PF00018	0.720
LIG_SH3_3	683	689	PF00018	0.400
LIG_SUMO_SIM_anti_2	682	688	PF11976	0.255
LIG_SUMO_SIM_par_1	448	454	PF11976	0.495
LIG_TRAF2_1	143	146	PF00917	0.583
LIG_TRAF2_1	342	345	PF00917	0.593
LIG_TRAF2_1	490	493	PF00917	0.376
LIG_TRFH_1	359	363	PF08558	0.435
LIG_TYR_ITIM	435	440	PF00017	0.478
LIG_TYR_ITSM	422	429	PF00017	0.396
LIG_WRC_WIRS_1	350	355	PF05994	0.432
LIG_WRC_WIRS_1	690	695	PF05994	0.391
MOD_CDK_SPxxK_3	213	220	PF00069	0.533
MOD_CDK_SPxxK_3	359	366	PF00069	0.530
MOD_CK1_1	133	139	PF00069	0.520
MOD_CK1_1	166	172	PF00069	0.380
MOD_CK1_1	174	180	PF00069	0.438
MOD_CK1_1	212	218	PF00069	0.518
MOD_CK1_1	241	247	PF00069	0.577
MOD_CK1_1	3	9	PF00069	0.728
MOD_CK1_1	368	374	PF00069	0.514
MOD_CK1_1	592	598	PF00069	0.435
MOD_CK1_1	68	74	PF00069	0.734
MOD_CK2_1	125	131	PF00069	0.399
MOD_CK2_1	140	146	PF00069	0.491
MOD_CK2_1	16	22	PF00069	0.778
MOD_CK2_1	241	247	PF00069	0.675
MOD_CK2_1	487	493	PF00069	0.362
MOD_CK2_1	528	534	PF00069	0.318
MOD_CK2_1	564	570	PF00069	0.349
MOD_CK2_1	596	602	PF00069	0.380
MOD_GlcNHglycan	2	5	PF01048	0.774
MOD_GlcNHglycan	240	243	PF01048	0.580
MOD_GlcNHglycan	26	29	PF01048	0.685
MOD_GlcNHglycan	283	287	PF01048	0.665
MOD_GlcNHglycan	369	373	PF01048	0.504
MOD_GlcNHglycan	37	40	PF01048	0.670
MOD_GlcNHglycan	453	456	PF01048	0.458
MOD_GlcNHglycan	80	83	PF01048	0.706
MOD_GSK3_1	121	128	PF00069	0.455
MOD_GSK3_1	13	20	PF00069	0.687
MOD_GSK3_1	177	184	PF00069	0.483
MOD_GSK3_1	188	195	PF00069	0.405
MOD_GSK3_1	209	216	PF00069	0.551
MOD_GSK3_1	261	268	PF00069	0.602
MOD_GSK3_1	282	289	PF00069	0.581
MOD_GSK3_1	3	10	PF00069	0.755
MOD_GSK3_1	327	334	PF00069	0.698
MOD_GSK3_1	592	599	PF00069	0.397
MOD_N-GLC_1	188	193	PF02516	0.473
MOD_N-GLC_1	632	637	PF02516	0.394
MOD_N-GLC_1	648	653	PF02516	0.276
MOD_N-GLC_1	76	81	PF02516	0.790
MOD_N-GLC_2	696	698	PF02516	0.518
MOD_NEK2_1	110	115	PF00069	0.491
MOD_NEK2_1	163	168	PF00069	0.375
MOD_NEK2_1	331	336	PF00069	0.655
MOD_NEK2_1	421	426	PF00069	0.315
MOD_NEK2_1	606	611	PF00069	0.315
MOD_NEK2_1	648	653	PF00069	0.397
MOD_NEK2_2	188	193	PF00069	0.560
MOD_NEK2_2	255	260	PF00069	0.551
MOD_NEK2_2	522	527	PF00069	0.318
MOD_NMyristoyl	1	7	PF02799	0.671
MOD_PIKK_1	196	202	PF00454	0.488
MOD_PIKK_1	468	474	PF00454	0.376
MOD_PIKK_1	68	74	PF00454	0.782
MOD_PK_1	714	720	PF00069	0.453
MOD_PKA_1	706	712	PF00069	0.569
MOD_PKA_2	564	570	PF00069	0.331
MOD_PKA_2	589	595	PF00069	0.405
MOD_PKA_2	706	712	PF00069	0.561
MOD_Plk_1	122	128	PF00069	0.477
MOD_Plk_1	188	194	PF00069	0.430
MOD_Plk_1	255	261	PF00069	0.571
MOD_Plk_1	282	288	PF00069	0.584
MOD_Plk_1	468	474	PF00069	0.330
MOD_Plk_1	528	534	PF00069	0.321
MOD_Plk_1	648	654	PF00069	0.421
MOD_Plk_2-3	298	304	PF00069	0.601
MOD_Plk_4	110	116	PF00069	0.463
MOD_Plk_4	122	128	PF00069	0.440
MOD_Plk_4	133	139	PF00069	0.445
MOD_Plk_4	266	272	PF00069	0.581
MOD_Plk_4	331	337	PF00069	0.666
MOD_Plk_4	422	428	PF00069	0.329
MOD_Plk_4	522	528	PF00069	0.318
MOD_Plk_4	564	570	PF00069	0.330
MOD_Plk_4	668	674	PF00069	0.372
MOD_ProDKin_1	11	17	PF00069	0.712
MOD_ProDKin_1	213	219	PF00069	0.591
MOD_ProDKin_1	334	340	PF00069	0.690
MOD_ProDKin_1	359	365	PF00069	0.527
MOD_ProDKin_1	65	71	PF00069	0.722
MOD_ProDKin_1	650	656	PF00069	0.318
MOD_SUMO_rev_2	643	648	PF00179	0.451
TRG_DiLeu_BaEn_1	559	564	PF01217	0.468
TRG_DiLeu_BaEn_2	220	226	PF01217	0.455
TRG_DiLeu_BaLyEn_6	558	563	PF01217	0.430
TRG_ENDOCYTIC_2	202	205	PF00928	0.521
TRG_ENDOCYTIC_2	407	410	PF00928	0.379
TRG_ENDOCYTIC_2	426	429	PF00928	0.322
TRG_ENDOCYTIC_2	437	440	PF00928	0.364
TRG_ENDOCYTIC_2	475	478	PF00928	0.319
TRG_ENDOCYTIC_2	550	553	PF00928	0.335
TRG_ENDOCYTIC_2	97	100	PF00928	0.558
TRG_ER_diArg_1	304	306	PF00400	0.581
TRG_ER_diArg_1	445	447	PF00400	0.513
TRG_ER_diArg_1	705	707	PF00400	0.564
TRG_Pf-PMV_PEXEL_1	279	283	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	530	534	PF00026	0.330
TRG_Pf-PMV_PEXEL_1	561	566	PF00026	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Y4	Leptomonas seymouri	68%	100%
A0A0S4IPG9	Bodo saltans	43%	97%
A0A0S4IRJ2	Bodo saltans	46%	100%
A0A1X0P701	Trypanosomatidae	31%	100%
A0A1X0P936	Trypanosomatidae	54%	100%
A0A3R7KV25	Trypanosoma rangeli	54%	100%
A4HHP3	Leishmania braziliensis	82%	100%
A4I4V8	Leishmania infantum	100%	100%
C9ZL03	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AEA6	Leishmania major	94%	100%
E9ALI0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5DTU5	Trypanosoma cruzi	53%	100%