Nucleosome_assembly_protein_(NAP)_putative/Pfam:P F00956

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleosome assembly protein (NAP), putative

Species:

Leishmania donovani

UniProt:

A0A3S7X2Q8_LEIDO

TriTrypDb:

LdBPK_292450.1 , LdCL_290030500 , LDHU3_29.3650

Length:

184

Annotations

Annotations by Jardim et al.

Histone/chromosome structure, nucleosome assembly (NAP), putative

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0000785	chromatin	2	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S7X2Q8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2Q8

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	10
GO:0006334	nucleosome assembly	7	10
GO:0006338	chromatin remodeling	5	10
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0022607	cellular component assembly	4	10
GO:0034728	nucleosome organization	6	10
GO:0043933	protein-containing complex organization	4	10
GO:0065003	protein-containing complex assembly	5	10
GO:0065004	protein-DNA complex assembly	6	10
GO:0071824	protein-DNA complex subunit organization	5	10
GO:0071840	cellular component organization or biogenesis	2	10

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0042393	histone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.568
CLV_NRD_NRD_1	22	24	PF00675	0.575
CLV_NRD_NRD_1	47	49	PF00675	0.615
CLV_PCSK_KEX2_1	47	49	PF00082	0.568
CLV_PCSK_SKI1_1	102	106	PF00082	0.673
CLV_PCSK_SKI1_1	48	52	PF00082	0.605
CLV_PCSK_SKI1_1	83	87	PF00082	0.577
DEG_APCC_DBOX_1	47	55	PF00400	0.596
DEG_Nend_UBRbox_2	1	3	PF02207	0.564
DEG_SCF_FBW7_1	65	71	PF00400	0.570
DOC_CKS1_1	65	70	PF01111	0.650
DOC_PP1_RVXF_1	99	106	PF00149	0.613
DOC_USP7_UBL2_3	98	102	PF12436	0.565
DOC_WW_Pin1_4	61	66	PF00397	0.541
LIG_14-3-3_CanoR_1	142	151	PF00244	0.590
LIG_14-3-3_CanoR_1	83	91	PF00244	0.562
LIG_14-3-3_CanoR_1	93	100	PF00244	0.537
LIG_AP2alpha_2	176	178	PF02296	0.549
LIG_APCC_ABBAyCdc20_2	108	114	PF00400	0.541
LIG_CaM_IQ_9	85	100	PF13499	0.622
LIG_Clathr_ClatBox_1	18	22	PF01394	0.548
LIG_FHA_1	126	132	PF00498	0.559
LIG_FHA_1	13	19	PF00498	0.497
LIG_FHA_1	165	171	PF00498	0.569
LIG_LIR_Apic_2	171	177	PF02991	0.505
LIG_LIR_Gen_1	146	156	PF02991	0.648
LIG_LIR_Gen_1	176	183	PF02991	0.484
LIG_LIR_Gen_1	86	94	PF02991	0.613
LIG_LIR_Nem_3	145	151	PF02991	0.534
LIG_LIR_Nem_3	176	181	PF02991	0.480
LIG_LIR_Nem_3	55	61	PF02991	0.525
LIG_LIR_Nem_3	86	91	PF02991	0.594
LIG_Pex14_2	148	152	PF04695	0.637
LIG_SH2_CRK	100	104	PF00017	0.608
LIG_SH2_SRC	174	177	PF00017	0.628
LIG_SH3_3	62	68	PF00018	0.564
LIG_SUMO_SIM_par_1	15	22	PF11976	0.493
LIG_WRC_WIRS_1	104	109	PF05994	0.652
MOD_CK1_1	12	18	PF00069	0.518
MOD_CK1_1	64	70	PF00069	0.610
MOD_CK2_1	135	141	PF00069	0.655
MOD_CK2_1	155	161	PF00069	0.420
MOD_CK2_1	35	41	PF00069	0.572
MOD_CK2_1	60	66	PF00069	0.585
MOD_GlcNHglycan	137	140	PF01048	0.641
MOD_GlcNHglycan	58	61	PF01048	0.530
MOD_GSK3_1	121	128	PF00069	0.611
MOD_GSK3_1	150	157	PF00069	0.624
MOD_GSK3_1	52	59	PF00069	0.589
MOD_GSK3_1	60	67	PF00069	0.590
MOD_N-GLC_1	154	159	PF02516	0.523
MOD_N-GLC_1	73	78	PF02516	0.521
MOD_NEK2_1	1	6	PF00069	0.550
MOD_NEK2_1	126	131	PF00069	0.583
MOD_NEK2_2	169	174	PF00069	0.622
MOD_PIKK_1	1	7	PF00454	0.520
MOD_PKA_2	92	98	PF00069	0.605
MOD_PKB_1	142	150	PF00069	0.588
MOD_Plk_1	27	33	PF00069	0.590
MOD_Plk_2-3	17	23	PF00069	0.506
MOD_Plk_4	144	150	PF00069	0.508
MOD_Plk_4	169	175	PF00069	0.620
MOD_Plk_4	68	74	PF00069	0.540
MOD_ProDKin_1	61	67	PF00069	0.543
MOD_SUMO_rev_2	119	129	PF00179	0.591
MOD_SUMO_rev_2	95	99	PF00179	0.584
TRG_DiLeu_BaEn_1	46	51	PF01217	0.600
TRG_DiLeu_BaEn_4	27	33	PF01217	0.634
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.623
TRG_ENDOCYTIC_2	100	103	PF00928	0.693

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I131	Leptomonas seymouri	77%	100%
A0A0S4JW42	Bodo saltans	37%	92%
A0A1X0P944	Trypanosomatidae	45%	99%
A0A422MX53	Trypanosoma rangeli	45%	99%
A4HHN3	Leishmania braziliensis	84%	100%
A4I4U8	Leishmania infantum	100%	100%
C9ZLJ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AE96	Leishmania major	95%	100%
E9ALJ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q8LC68	Arabidopsis thaliana	25%	72%