5-demethoxyubiquinone hydroxylase, mitochondrial

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ubiquinone biosynthesis protein COQ7, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X2Q6_LEIDO

TriTrypDb:

LdBPK_292460.1 , LdCL_290030600 , LDHU3_29.3660

Length:

206

Annotations

LeishMANIAdb annotations

Very conserved, homologous to animal COQ7 proteins. Probably perimembrane protein.. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0019898	extrinsic component of membrane	2	10
GO:0031312	extrinsic component of organelle membrane	3	10
GO:0031314	extrinsic component of mitochondrial inner membrane	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0005743	mitochondrial inner membrane	5	1
GO:0016020	membrane	2	1
GO:0019866	organelle inner membrane	4	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1

Expansion

Sequence features

A0A3S7X2Q6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2Q6

Function

Biological processes
Term	Name	Level	Count
GO:0006743	ubiquinone metabolic process	5	10
GO:0006744	ubiquinone biosynthetic process	6	10
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0009987	cellular process	1	10
GO:0042180	cellular ketone metabolic process	3	10
GO:0042181	ketone biosynthetic process	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044281	small molecule metabolic process	2	10
GO:0044283	small molecule biosynthetic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:1901576	organic substance biosynthetic process	3	10
GO:1901661	quinone metabolic process	4	10
GO:1901663	quinone biosynthetic process	5	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004497	monooxygenase activity	3	10
GO:0005488	binding	1	10
GO:0008682	3-demethoxyubiquinol 3-hydroxylase activity	4	10
GO:0016491	oxidoreductase activity	2	10
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	10
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	4	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	204	206	PF00082	0.349
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.349
CLV_PCSK_SKI1_1	2	6	PF00082	0.561
CLV_Separin_Metazoa	27	31	PF03568	0.277
DEG_APCC_DBOX_1	43	51	PF00400	0.358
DEG_Nend_UBRbox_1	1	4	PF02207	0.506
DEG_SPOP_SBC_1	83	87	PF00917	0.306
DOC_MAPK_gen_1	21	31	PF00069	0.265
DOC_PP4_FxxP_1	16	19	PF00568	0.434
DOC_WW_Pin1_4	48	53	PF00397	0.242
LIG_14-3-3_CanoR_1	84	89	PF00244	0.247
LIG_BIR_III_2	55	59	PF00653	0.358
LIG_FHA_1	101	107	PF00498	0.143
LIG_FHA_1	58	64	PF00498	0.388
LIG_FHA_1	83	89	PF00498	0.337
LIG_FHA_2	84	90	PF00498	0.256
LIG_LIR_Apic_2	48	52	PF02991	0.358
LIG_LIR_Gen_1	151	161	PF02991	0.341
LIG_LIR_Nem_3	120	126	PF02991	0.360
LIG_LIR_Nem_3	151	156	PF02991	0.281
LIG_LRP6_Inhibitor_1	187	193	PF00058	0.246
LIG_LYPXL_yS_3	185	188	PF13949	0.242
LIG_PCNA_yPIPBox_3	21	29	PF02747	0.303
LIG_SH2_CRK	189	193	PF00017	0.242
LIG_SH2_STAT3	126	129	PF00017	0.242
LIG_SH2_STAT5	159	162	PF00017	0.294
LIG_SH3_3	180	186	PF00018	0.242
LIG_SUMO_SIM_anti_2	132	138	PF11976	0.252
LIG_TYR_ITIM	187	192	PF00017	0.242
MOD_CK2_1	143	149	PF00069	0.409
MOD_LATS_1	70	76	PF00433	0.337
MOD_PIKK_1	57	63	PF00454	0.458
MOD_PKA_2	138	144	PF00069	0.190
MOD_PKA_2	83	89	PF00069	0.242
MOD_Plk_1	118	124	PF00069	0.242
MOD_Plk_4	118	124	PF00069	0.341
MOD_Plk_4	155	161	PF00069	0.328
MOD_Plk_4	5	11	PF00069	0.432
MOD_ProDKin_1	48	54	PF00069	0.242
MOD_SUMO_rev_2	137	146	PF00179	0.382
MOD_SUMO_rev_2	149	158	PF00179	0.256
TRG_DiLeu_BaLyEn_6	183	188	PF01217	0.265
TRG_ENDOCYTIC_2	185	188	PF00928	0.261
TRG_ENDOCYTIC_2	189	192	PF00928	0.252
TRG_NES_CRM1_1	48	62	PF08389	0.349

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB42	Leptomonas seymouri	82%	100%
A0A1X0P9Z6	Trypanosomatidae	66%	100%
A0A3R7LIB4	Trypanosoma rangeli	66%	100%
A4HHN4	Leishmania braziliensis	86%	100%
A4I4U9	Leishmania infantum	100%	100%
C9ZLJ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9AE97	Leishmania major	93%	100%
E9ALI9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O74826	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	95%
P41735	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	88%
P48376	Caenorhabditis elegans	38%	100%
P97478	Mus musculus	36%	95%
Q2RNK3	Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1)	37%	97%
Q2TBW2	Bos taurus	36%	95%
Q54VB3	Dictyostelium discoideum	36%	95%
Q63619	Rattus norvegicus	37%	100%
Q99807	Homo sapiens	36%	95%