LeishMANIAdb
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Protein kinase domain family protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain family protein
Gene product:
5'-AMP-activated protein kinase catalytic subunit alpha, putative
Species:
Leishmania donovani
UniProt:
A0A3S7X2Q3_LEIDO
TriTrypDb:
LdBPK_292140.1 , LdCL_290027400 , LDHU3_29.3050
Length:
815

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Annotations by Jardim et al.

Protein kinase, serine/threonine kinase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 462
Promastigote: 502, 679, 682
Promastigote/Amastigote: 192, 193

Expansion

Sequence features

A0A3S7X2Q3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2Q3

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 11
GO:0006793 phosphorus metabolic process 3 11
GO:0006796 phosphate-containing compound metabolic process 4 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009987 cellular process 1 11
GO:0016310 phosphorylation 5 11
GO:0019538 protein metabolic process 3 11
GO:0036211 protein modification process 4 11
GO:0043170 macromolecule metabolic process 3 11
GO:0043412 macromolecule modification 4 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0071704 organic substance metabolic process 2 11
GO:1901564 organonitrogen compound metabolic process 3 11
GO:0007165 signal transduction 2 1
GO:0035556 intracellular signal transduction 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0004672 protein kinase activity 3 11
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0016301 kinase activity 4 11
GO:0016740 transferase activity 2 11
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 11
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 11
GO:0017076 purine nucleotide binding 4 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11
GO:0004674 protein serine/threonine kinase activity 4 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 444 448 PF00656 0.763
CLV_NRD_NRD_1 329 331 PF00675 0.481
CLV_NRD_NRD_1 353 355 PF00675 0.419
CLV_NRD_NRD_1 504 506 PF00675 0.711
CLV_NRD_NRD_1 534 536 PF00675 0.671
CLV_NRD_NRD_1 615 617 PF00675 0.569
CLV_NRD_NRD_1 671 673 PF00675 0.708
CLV_NRD_NRD_1 811 813 PF00675 0.457
CLV_PCSK_FUR_1 351 355 PF00082 0.497
CLV_PCSK_FUR_1 669 673 PF00082 0.685
CLV_PCSK_KEX2_1 320 322 PF00082 0.428
CLV_PCSK_KEX2_1 351 353 PF00082 0.428
CLV_PCSK_KEX2_1 504 506 PF00082 0.675
CLV_PCSK_KEX2_1 615 617 PF00082 0.569
CLV_PCSK_KEX2_1 671 673 PF00082 0.708
CLV_PCSK_PC1ET2_1 320 322 PF00082 0.417
CLV_PCSK_SKI1_1 137 141 PF00082 0.287
CLV_PCSK_SKI1_1 158 162 PF00082 0.271
CLV_PCSK_SKI1_1 577 581 PF00082 0.508
DEG_MDM2_SWIB_1 579 586 PF02201 0.457
DEG_SPOP_SBC_1 480 484 PF00917 0.747
DEG_SPOP_SBC_1 752 756 PF00917 0.634
DOC_ANK_TNKS_1 634 641 PF00023 0.579
DOC_CKS1_1 103 108 PF01111 0.289
DOC_MAPK_gen_1 158 167 PF00069 0.271
DOC_MAPK_gen_1 306 315 PF00069 0.520
DOC_MAPK_gen_1 327 335 PF00069 0.378
DOC_MAPK_gen_1 781 790 PF00069 0.485
DOC_MAPK_gen_1 79 90 PF00069 0.272
DOC_MAPK_HePTP_8 205 217 PF00069 0.289
DOC_MAPK_MEF2A_6 208 217 PF00069 0.289
DOC_MAPK_MEF2A_6 306 315 PF00069 0.520
DOC_MAPK_MEF2A_6 391 399 PF00069 0.518
DOC_PP1_RVXF_1 172 179 PF00149 0.271
DOC_PP1_RVXF_1 206 212 PF00149 0.289
DOC_PP2B_LxvP_1 277 280 PF13499 0.289
DOC_PP4_FxxP_1 91 94 PF00568 0.271
DOC_USP7_MATH_1 252 256 PF00917 0.352
DOC_USP7_MATH_1 454 458 PF00917 0.777
DOC_USP7_MATH_1 459 463 PF00917 0.649
DOC_USP7_MATH_1 676 680 PF00917 0.591
DOC_USP7_MATH_1 712 716 PF00917 0.684
DOC_USP7_MATH_1 728 732 PF00917 0.663
DOC_USP7_MATH_1 751 755 PF00917 0.690
DOC_USP7_UBL2_3 383 387 PF12436 0.664
DOC_USP7_UBL2_3 580 584 PF12436 0.375
DOC_WW_Pin1_4 102 107 PF00397 0.289
DOC_WW_Pin1_4 193 198 PF00397 0.271
DOC_WW_Pin1_4 399 404 PF00397 0.526
DOC_WW_Pin1_4 584 589 PF00397 0.442
DOC_WW_Pin1_4 735 740 PF00397 0.735
DOC_WW_Pin1_4 743 748 PF00397 0.637
DOC_WW_Pin1_4 761 766 PF00397 0.633
LIG_14-3-3_CanoR_1 276 280 PF00244 0.466
LIG_14-3-3_CanoR_1 295 305 PF00244 0.344
LIG_14-3-3_CanoR_1 309 314 PF00244 0.389
LIG_14-3-3_CanoR_1 594 602 PF00244 0.541
LIG_14-3-3_CanoR_1 610 619 PF00244 0.678
LIG_Actin_RPEL_3 147 166 PF02755 0.404
LIG_Actin_WH2_2 59 75 PF00022 0.314
LIG_BIR_II_1 1 5 PF00653 0.675
LIG_BIR_III_3 1 5 PF00653 0.683
LIG_BRCT_BRCA1_1 771 775 PF00533 0.486
LIG_FHA_1 597 603 PF00498 0.573
LIG_FHA_1 619 625 PF00498 0.729
LIG_FHA_1 753 759 PF00498 0.711
LIG_FHA_2 103 109 PF00498 0.271
LIG_FHA_2 387 393 PF00498 0.527
LIG_FHA_2 431 437 PF00498 0.694
LIG_FHA_2 539 545 PF00498 0.491
LIG_GBD_Chelix_1 798 806 PF00786 0.404
LIG_LIR_Apic_2 196 202 PF02991 0.271
LIG_LIR_Gen_1 107 116 PF02991 0.271
LIG_LIR_Gen_1 120 126 PF02991 0.271
LIG_LIR_Gen_1 570 581 PF02991 0.425
LIG_LIR_Gen_1 58 67 PF02991 0.404
LIG_LIR_Gen_1 598 604 PF02991 0.473
LIG_LIR_Nem_3 120 125 PF02991 0.271
LIG_LIR_Nem_3 46 50 PF02991 0.288
LIG_LIR_Nem_3 570 576 PF02991 0.388
LIG_LIR_Nem_3 58 64 PF02991 0.271
LIG_LIR_Nem_3 587 592 PF02991 0.436
LIG_LIR_Nem_3 772 778 PF02991 0.566
LIG_LIR_Nem_3 789 793 PF02991 0.334
LIG_MAD2 154 162 PF02301 0.404
LIG_MLH1_MIPbox_1 771 775 PF16413 0.486
LIG_NRBOX 223 229 PF00104 0.289
LIG_NRBOX 801 807 PF00104 0.443
LIG_OCRL_FandH_1 774 786 PF00620 0.498
LIG_PCNA_yPIPBox_3 767 781 PF02747 0.570
LIG_Pex14_2 579 583 PF04695 0.402
LIG_REV1ctd_RIR_1 773 781 PF16727 0.483
LIG_SH2_CRK 122 126 PF00017 0.349
LIG_SH2_CRK 225 229 PF00017 0.271
LIG_SH2_CRK 251 255 PF00017 0.289
LIG_SH2_CRK 344 348 PF00017 0.294
LIG_SH2_CRK 573 577 PF00017 0.367
LIG_SH2_NCK_1 100 104 PF00017 0.271
LIG_SH2_NCK_1 199 203 PF00017 0.271
LIG_SH2_NCK_1 251 255 PF00017 0.404
LIG_SH2_PTP2 61 64 PF00017 0.404
LIG_SH2_SRC 115 118 PF00017 0.289
LIG_SH2_SRC 122 125 PF00017 0.289
LIG_SH2_SRC 251 254 PF00017 0.311
LIG_SH2_SRC 485 488 PF00017 0.572
LIG_SH2_STAP1 122 126 PF00017 0.289
LIG_SH2_STAP1 298 302 PF00017 0.493
LIG_SH2_STAT3 124 127 PF00017 0.341
LIG_SH2_STAT3 138 141 PF00017 0.204
LIG_SH2_STAT5 110 113 PF00017 0.276
LIG_SH2_STAT5 115 118 PF00017 0.278
LIG_SH2_STAT5 124 127 PF00017 0.289
LIG_SH2_STAT5 138 141 PF00017 0.225
LIG_SH2_STAT5 149 152 PF00017 0.271
LIG_SH2_STAT5 210 213 PF00017 0.271
LIG_SH2_STAT5 36 39 PF00017 0.278
LIG_SH2_STAT5 540 543 PF00017 0.491
LIG_SH2_STAT5 61 64 PF00017 0.404
LIG_SH2_STAT5 700 703 PF00017 0.707
LIG_SH2_STAT5 774 777 PF00017 0.421
LIG_SH2_STAT5 786 789 PF00017 0.395
LIG_SH3_1 23 29 PF00018 0.473
LIG_SH3_3 23 29 PF00018 0.667
LIG_SH3_3 267 273 PF00018 0.271
LIG_SH3_3 582 588 PF00018 0.453
LIG_SH3_3 736 742 PF00018 0.789
LIG_SH3_3 762 768 PF00018 0.694
LIG_SUMO_SIM_anti_2 801 809 PF11976 0.518
LIG_SUMO_SIM_anti_2 84 89 PF11976 0.404
LIG_SUMO_SIM_par_1 267 272 PF11976 0.274
LIG_SUMO_SIM_par_1 404 413 PF11976 0.629
LIG_SUMO_SIM_par_1 767 772 PF11976 0.602
LIG_SUMO_SIM_par_1 801 809 PF11976 0.411
LIG_TRAF2_1 541 544 PF00917 0.508
LIG_TYR_ITIM 223 228 PF00017 0.271
LIG_TYR_ITIM 342 347 PF00017 0.291
LIG_UBA3_1 242 250 PF00899 0.271
LIG_WRC_WIRS_1 460 465 PF05994 0.691
LIG_WRC_WIRS_1 576 581 PF05994 0.431
MOD_CDC14_SPxK_1 587 590 PF00782 0.510
MOD_CDK_SPK_2 735 740 PF00069 0.598
MOD_CDK_SPxK_1 584 590 PF00069 0.502
MOD_CK1_1 104 110 PF00069 0.314
MOD_CK1_1 181 187 PF00069 0.349
MOD_CK1_1 193 199 PF00069 0.211
MOD_CK1_1 301 307 PF00069 0.533
MOD_CK1_1 430 436 PF00069 0.621
MOD_CK1_1 441 447 PF00069 0.569
MOD_CK1_1 479 485 PF00069 0.587
MOD_CK1_1 606 612 PF00069 0.573
MOD_CK1_1 620 626 PF00069 0.514
MOD_CK1_1 641 647 PF00069 0.751
MOD_CK1_1 679 685 PF00069 0.600
MOD_CK1_1 717 723 PF00069 0.688
MOD_CK1_1 733 739 PF00069 0.759
MOD_CK2_1 294 300 PF00069 0.412
MOD_CK2_1 301 307 PF00069 0.449
MOD_CK2_1 363 369 PF00069 0.537
MOD_CK2_1 386 392 PF00069 0.529
MOD_CK2_1 538 544 PF00069 0.502
MOD_CK2_1 592 598 PF00069 0.494
MOD_CK2_1 728 734 PF00069 0.718
MOD_GlcNHglycan 18 21 PF01048 0.741
MOD_GlcNHglycan 205 208 PF01048 0.289
MOD_GlcNHglycan 365 368 PF01048 0.610
MOD_GlcNHglycan 447 451 PF01048 0.754
MOD_GlcNHglycan 470 473 PF01048 0.655
MOD_GlcNHglycan 476 479 PF01048 0.569
MOD_GlcNHglycan 569 572 PF01048 0.505
MOD_GlcNHglycan 625 629 PF01048 0.659
MOD_GlcNHglycan 635 638 PF01048 0.731
MOD_GlcNHglycan 640 643 PF01048 0.764
MOD_GlcNHglycan 681 684 PF01048 0.635
MOD_GlcNHglycan 714 717 PF01048 0.721
MOD_GlcNHglycan 719 722 PF01048 0.616
MOD_GlcNHglycan 724 727 PF01048 0.627
MOD_GlcNHglycan 73 76 PF01048 0.404
MOD_GlcNHglycan 730 733 PF01048 0.687
MOD_GlcNHglycan 749 752 PF01048 0.527
MOD_GlcNHglycan 755 758 PF01048 0.695
MOD_GSK3_1 189 196 PF00069 0.271
MOD_GSK3_1 252 259 PF00069 0.473
MOD_GSK3_1 294 301 PF00069 0.425
MOD_GSK3_1 309 316 PF00069 0.402
MOD_GSK3_1 363 370 PF00069 0.596
MOD_GSK3_1 459 466 PF00069 0.615
MOD_GSK3_1 470 477 PF00069 0.537
MOD_GSK3_1 494 501 PF00069 0.744
MOD_GSK3_1 508 515 PF00069 0.630
MOD_GSK3_1 592 599 PF00069 0.410
MOD_GSK3_1 6 13 PF00069 0.664
MOD_GSK3_1 606 613 PF00069 0.489
MOD_GSK3_1 620 627 PF00069 0.601
MOD_GSK3_1 728 735 PF00069 0.738
MOD_GSK3_1 743 750 PF00069 0.559
MOD_N-GLC_1 181 186 PF02516 0.335
MOD_N-GLC_1 522 527 PF02516 0.592
MOD_N-GLC_1 610 615 PF02516 0.555
MOD_N-GLC_1 688 693 PF02516 0.558
MOD_N-GLC_2 95 97 PF02516 0.271
MOD_NEK2_1 166 171 PF00069 0.358
MOD_NEK2_1 178 183 PF00069 0.235
MOD_NEK2_1 189 194 PF00069 0.241
MOD_NEK2_1 241 246 PF00069 0.335
MOD_NEK2_1 294 299 PF00069 0.504
MOD_NEK2_1 32 37 PF00069 0.452
MOD_NEK2_1 397 402 PF00069 0.519
MOD_NEK2_1 463 468 PF00069 0.567
MOD_NEK2_1 474 479 PF00069 0.526
MOD_NEK2_1 508 513 PF00069 0.617
MOD_NEK2_1 592 597 PF00069 0.463
MOD_NEK2_1 603 608 PF00069 0.457
MOD_NEK2_1 688 693 PF00069 0.595
MOD_NEK2_1 806 811 PF00069 0.350
MOD_NEK2_2 298 303 PF00069 0.467
MOD_NEK2_2 459 464 PF00069 0.692
MOD_PIKK_1 397 403 PF00454 0.524
MOD_PIKK_1 515 521 PF00454 0.692
MOD_PIKK_1 604 610 PF00454 0.645
MOD_PIKK_1 690 696 PF00454 0.633
MOD_PK_1 309 315 PF00069 0.493
MOD_PK_1 529 535 PF00069 0.575
MOD_PKA_1 615 621 PF00069 0.567
MOD_PKA_2 131 137 PF00069 0.404
MOD_PKA_2 275 281 PF00069 0.271
MOD_PKA_2 294 300 PF00069 0.393
MOD_PKA_2 38 44 PF00069 0.404
MOD_PKA_2 463 469 PF00069 0.685
MOD_PKA_2 593 599 PF00069 0.471
MOD_PKA_2 615 621 PF00069 0.631
MOD_Plk_1 235 241 PF00069 0.289
MOD_Plk_1 441 447 PF00069 0.662
MOD_Plk_4 298 304 PF00069 0.480
MOD_Plk_4 309 315 PF00069 0.358
MOD_Plk_4 32 38 PF00069 0.425
MOD_Plk_4 470 476 PF00069 0.707
MOD_Plk_4 806 812 PF00069 0.354
MOD_ProDKin_1 102 108 PF00069 0.289
MOD_ProDKin_1 193 199 PF00069 0.271
MOD_ProDKin_1 399 405 PF00069 0.527
MOD_ProDKin_1 584 590 PF00069 0.442
MOD_ProDKin_1 735 741 PF00069 0.735
MOD_ProDKin_1 743 749 PF00069 0.637
MOD_ProDKin_1 761 767 PF00069 0.631
MOD_SUMO_for_1 160 163 PF00179 0.271
MOD_SUMO_rev_2 74 81 PF00179 0.321
MOD_SUMO_rev_2 783 793 PF00179 0.567
TRG_DiLeu_BaEn_2 542 548 PF01217 0.500
TRG_DiLeu_BaEn_3 543 549 PF01217 0.496
TRG_DiLeu_BaLyEn_6 237 242 PF01217 0.404
TRG_DiLeu_BaLyEn_6 587 592 PF01217 0.437
TRG_ENDOCYTIC_2 100 103 PF00928 0.308
TRG_ENDOCYTIC_2 110 113 PF00928 0.271
TRG_ENDOCYTIC_2 122 125 PF00928 0.289
TRG_ENDOCYTIC_2 225 228 PF00928 0.271
TRG_ENDOCYTIC_2 344 347 PF00928 0.292
TRG_ENDOCYTIC_2 573 576 PF00928 0.342
TRG_ENDOCYTIC_2 61 64 PF00928 0.404
TRG_ER_diArg_1 351 354 PF00400 0.491
TRG_ER_diArg_1 503 505 PF00400 0.689
TRG_ER_diArg_1 669 672 PF00400 0.703
TRG_NES_CRM1_1 355 369 PF08389 0.562
TRG_NLS_MonoExtN_4 245 251 PF00514 0.349
TRG_NLS_MonoExtN_4 49 55 PF00514 0.349
TRG_Pf-PMV_PEXEL_1 137 141 PF00026 0.298
TRG_Pf-PMV_PEXEL_1 158 163 PF00026 0.271
TRG_Pf-PMV_PEXEL_1 262 266 PF00026 0.271

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I379 Leptomonas seymouri 70% 99%
A0A1X0P022 Trypanosomatidae 61% 100%
A0A3R7MPF2 Trypanosoma rangeli 61% 100%
A4HHK1 Leishmania braziliensis 86% 100%
A4I4Q9 Leishmania infantum 100% 100%
C9ZLF2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
E9AE64 Leishmania major 97% 100%
E9ALM1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
V5BL06 Trypanosoma cruzi 59% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS