Kinesin, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Kinesin, putative

Gene product:

kinesin, putative (fragment)

Species:

Leishmania donovani

UniProt:

A0A3S7X2P9_LEIDO

TriTrypDb:

LdBPK_292500.1 , LdCL_290031000 , LDHU3_29.3690

Length:

588

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 30

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005871	kinesin complex	3	1
GO:0005874	microtubule	6	1
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X2P9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2P9

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	14
GO:0007018	microtubule-based movement	3	14
GO:0009987	cellular process	1	14

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	14
GO:0003774	cytoskeletal motor activity	1	14
GO:0003777	microtubule motor activity	2	14
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	14
GO:0005515	protein binding	2	14
GO:0005524	ATP binding	5	14
GO:0008017	microtubule binding	5	14
GO:0008092	cytoskeletal protein binding	3	14
GO:0015631	tubulin binding	4	14
GO:0016787	hydrolase activity	2	7
GO:0017076	purine nucleotide binding	4	14
GO:0030554	adenyl nucleotide binding	5	14
GO:0032553	ribonucleotide binding	3	14
GO:0032555	purine ribonucleotide binding	4	14
GO:0032559	adenyl ribonucleotide binding	5	14
GO:0035639	purine ribonucleoside triphosphate binding	4	14
GO:0036094	small molecule binding	2	14
GO:0043167	ion binding	2	14
GO:0043168	anion binding	3	14
GO:0097159	organic cyclic compound binding	2	14
GO:0097367	carbohydrate derivative binding	2	14
GO:0140657	ATP-dependent activity	1	14
GO:1901265	nucleoside phosphate binding	3	14
GO:1901363	heterocyclic compound binding	2	14
GO:0016462	pyrophosphatase activity	5	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	398	402	PF00656	0.436
CLV_C14_Caspase3-7	413	417	PF00656	0.353
CLV_NRD_NRD_1	171	173	PF00675	0.339
CLV_NRD_NRD_1	281	283	PF00675	0.279
CLV_NRD_NRD_1	554	556	PF00675	0.374
CLV_PCSK_FUR_1	45	49	PF00082	0.355
CLV_PCSK_KEX2_1	171	173	PF00082	0.339
CLV_PCSK_KEX2_1	47	49	PF00082	0.394
CLV_PCSK_KEX2_1	554	556	PF00082	0.374
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.404
CLV_PCSK_SKI1_1	115	119	PF00082	0.440
CLV_PCSK_SKI1_1	148	152	PF00082	0.305
CLV_PCSK_SKI1_1	16	20	PF00082	0.519
CLV_PCSK_SKI1_1	394	398	PF00082	0.594
CLV_PCSK_SKI1_1	415	419	PF00082	0.500
CLV_PCSK_SKI1_1	523	527	PF00082	0.493
CLV_PCSK_SKI1_1	554	558	PF00082	0.415
CLV_PCSK_SKI1_1	69	73	PF00082	0.267
DEG_SCF_FBW7_1	524	530	PF00400	0.435
DOC_CKS1_1	524	529	PF01111	0.436
DOC_CYCLIN_RxL_1	112	120	PF00134	0.440
DOC_CYCLIN_RxL_1	391	401	PF00134	0.420
DOC_CYCLIN_yClb5_NLxxxL_5	475	484	PF00134	0.516
DOC_MAPK_gen_1	19	30	PF00069	0.515
DOC_MAPK_gen_1	6	15	PF00069	0.538
DOC_MAPK_MEF2A_6	213	222	PF00069	0.305
DOC_MAPK_MEF2A_6	6	15	PF00069	0.406
DOC_PP2B_LxvP_1	150	153	PF13499	0.305
DOC_PP2B_LxvP_1	462	465	PF13499	0.442
DOC_USP7_MATH_1	22	26	PF00917	0.497
DOC_USP7_MATH_1	275	279	PF00917	0.291
DOC_USP7_MATH_1	417	421	PF00917	0.572
DOC_USP7_MATH_1	453	457	PF00917	0.467
DOC_USP7_MATH_1	527	531	PF00917	0.500
DOC_USP7_MATH_1	573	577	PF00917	0.531
DOC_USP7_UBL2_3	537	541	PF12436	0.420
DOC_WW_Pin1_4	314	319	PF00397	0.321
DOC_WW_Pin1_4	523	528	PF00397	0.423
LIG_14-3-3_CanoR_1	176	181	PF00244	0.440
LIG_14-3-3_CanoR_1	200	207	PF00244	0.440
LIG_14-3-3_CanoR_1	23	30	PF00244	0.532
LIG_14-3-3_CanoR_1	274	280	PF00244	0.305
LIG_14-3-3_CanoR_1	554	564	PF00244	0.497
LIG_14-3-3_CanoR_1	8	14	PF00244	0.435
LIG_14-3-3_CterR_2	585	588	PF00244	0.529
LIG_Actin_WH2_2	60	75	PF00022	0.266
LIG_APCC_ABBA_1	140	145	PF00400	0.305
LIG_APCC_ABBA_1	163	168	PF00400	0.305
LIG_BIR_II_1	1	5	PF00653	0.611
LIG_BRCT_BRCA1_1	222	226	PF00533	0.440
LIG_BRCT_BRCA1_1	284	288	PF00533	0.420
LIG_BRCT_BRCA1_1	300	304	PF00533	0.305
LIG_BRCT_BRCA1_1	512	516	PF00533	0.463
LIG_EH1_1	456	464	PF00400	0.490
LIG_eIF4E_1	457	463	PF01652	0.494
LIG_FHA_1	130	136	PF00498	0.436
LIG_FHA_1	24	30	PF00498	0.559
LIG_FHA_1	295	301	PF00498	0.305
LIG_FHA_1	308	314	PF00498	0.305
LIG_FHA_1	322	328	PF00498	0.305
LIG_FHA_1	44	50	PF00498	0.259
LIG_FHA_1	459	465	PF00498	0.389
LIG_FHA_1	505	511	PF00498	0.490
LIG_FHA_1	524	530	PF00498	0.440
LIG_FHA_1	548	554	PF00498	0.404
LIG_FHA_1	92	98	PF00498	0.305
LIG_FHA_2	248	254	PF00498	0.391
LIG_FHA_2	396	402	PF00498	0.420
LIG_FHA_2	411	417	PF00498	0.603
LIG_LIR_Gen_1	223	234	PF02991	0.391
LIG_LIR_Gen_1	285	296	PF02991	0.323
LIG_LIR_Gen_1	351	360	PF02991	0.460
LIG_LIR_Gen_1	560	569	PF02991	0.423
LIG_LIR_Gen_1	62	72	PF02991	0.299
LIG_LIR_Gen_1	94	101	PF02991	0.391
LIG_LIR_LC3C_4	461	464	PF02991	0.486
LIG_LIR_Nem_3	223	229	PF02991	0.339
LIG_LIR_Nem_3	285	291	PF02991	0.323
LIG_LIR_Nem_3	351	357	PF02991	0.486
LIG_LIR_Nem_3	560	566	PF02991	0.393
LIG_LIR_Nem_3	62	67	PF02991	0.299
LIG_LIR_Nem_3	74	79	PF02991	0.290
LIG_LIR_Nem_3	94	98	PF02991	0.210
LIG_NRBOX	295	301	PF00104	0.339
LIG_NRBOX	479	485	PF00104	0.337
LIG_Pex14_2	52	56	PF04695	0.294
LIG_PTB_Apo_2	532	539	PF02174	0.481
LIG_Rb_pABgroove_1	112	120	PF01858	0.440
LIG_Rb_pABgroove_1	461	469	PF01858	0.433
LIG_SH2_CRK	467	471	PF00017	0.523
LIG_SH2_CRK	95	99	PF00017	0.440
LIG_SH2_NCK_1	467	471	PF00017	0.570
LIG_SH2_SRC	363	366	PF00017	0.345
LIG_SH2_STAP1	332	336	PF00017	0.303
LIG_SH2_STAP1	354	358	PF00017	0.428
LIG_SH2_STAP1	378	382	PF00017	0.407
LIG_SH2_STAT3	378	381	PF00017	0.458
LIG_SH2_STAT5	174	177	PF00017	0.305
LIG_SH2_STAT5	363	366	PF00017	0.429
LIG_SH2_STAT5	544	547	PF00017	0.407
LIG_SH2_STAT5	563	566	PF00017	0.441
LIG_SH3_3	467	473	PF00018	0.593
LIG_SH3_3	521	527	PF00018	0.455
LIG_SUMO_SIM_anti_2	489	495	PF11976	0.457
LIG_SUMO_SIM_par_1	235	242	PF11976	0.339
LIG_SUMO_SIM_par_1	395	402	PF11976	0.543
LIG_SUMO_SIM_par_1	489	495	PF11976	0.462
LIG_TYR_ITIM	352	357	PF00017	0.526
LIG_TYR_ITIM	561	566	PF00017	0.438
LIG_UBA3_1	189	195	PF00899	0.339
LIG_WRC_WIRS_1	276	281	PF05994	0.291
MOD_CK1_1	211	217	PF00069	0.289
MOD_CK1_1	294	300	PF00069	0.302
MOD_CK1_1	326	332	PF00069	0.416
MOD_CK1_1	377	383	PF00069	0.488
MOD_CK1_1	448	454	PF00069	0.410
MOD_CK1_1	91	97	PF00069	0.339
MOD_CK2_1	135	141	PF00069	0.305
MOD_CK2_1	247	253	PF00069	0.290
MOD_CK2_1	287	293	PF00069	0.472
MOD_CK2_1	399	405	PF00069	0.519
MOD_DYRK1A_RPxSP_1	523	527	PF00069	0.428
MOD_GlcNHglycan	184	187	PF01048	0.440
MOD_GlcNHglycan	253	257	PF01048	0.423
MOD_GlcNHglycan	557	560	PF01048	0.542
MOD_GlcNHglycan	56	59	PF01048	0.392
MOD_GlcNHglycan	570	573	PF01048	0.496
MOD_GlcNHglycan	90	93	PF01048	0.339
MOD_GSK3_1	129	136	PF00069	0.369
MOD_GSK3_1	207	214	PF00069	0.304
MOD_GSK3_1	243	250	PF00069	0.288
MOD_GSK3_1	287	294	PF00069	0.305
MOD_GSK3_1	312	319	PF00069	0.313
MOD_GSK3_1	321	328	PF00069	0.291
MOD_GSK3_1	395	402	PF00069	0.514
MOD_GSK3_1	417	424	PF00069	0.532
MOD_GSK3_1	441	448	PF00069	0.408
MOD_GSK3_1	519	526	PF00069	0.454
MOD_N-GLC_1	207	212	PF02516	0.291
MOD_N-GLC_1	265	270	PF02516	0.305
MOD_N-GLC_1	321	326	PF02516	0.305
MOD_N-GLC_1	345	350	PF02516	0.465
MOD_N-GLC_1	399	404	PF02516	0.583
MOD_N-GLC_2	80	82	PF02516	0.305
MOD_NEK2_1	207	212	PF00069	0.305
MOD_NEK2_1	218	223	PF00069	0.305
MOD_NEK2_1	291	296	PF00069	0.305
MOD_NEK2_1	300	305	PF00069	0.305
MOD_NEK2_1	312	317	PF00069	0.295
MOD_NEK2_1	323	328	PF00069	0.300
MOD_NEK2_1	337	342	PF00069	0.446
MOD_NEK2_1	364	369	PF00069	0.571
MOD_NEK2_1	399	404	PF00069	0.515
MOD_NEK2_1	441	446	PF00069	0.425
MOD_NEK2_2	129	134	PF00069	0.440
MOD_NEK2_2	287	292	PF00069	0.278
MOD_OFUCOSY	440	445	PF10250	0.424
MOD_PIKK_1	220	226	PF00454	0.305
MOD_PIKK_1	377	383	PF00454	0.552
MOD_PIKK_1	399	405	PF00454	0.602
MOD_PK_1	176	182	PF00069	0.440
MOD_PKA_1	282	288	PF00069	0.420
MOD_PKA_2	199	205	PF00069	0.339
MOD_PKA_2	22	28	PF00069	0.475
MOD_PKA_2	247	253	PF00069	0.290
MOD_PKA_2	291	297	PF00069	0.305
MOD_PKA_2	510	516	PF00069	0.469
MOD_Plk_1	129	135	PF00069	0.440
MOD_Plk_1	265	271	PF00069	0.305
MOD_Plk_1	399	405	PF00069	0.496
MOD_Plk_1	573	579	PF00069	0.653
MOD_Plk_2-3	159	165	PF00069	0.336
MOD_Plk_2-3	395	401	PF00069	0.417
MOD_Plk_2-3	410	416	PF00069	0.606
MOD_Plk_4	135	141	PF00069	0.305
MOD_Plk_4	236	242	PF00069	0.353
MOD_Plk_4	265	271	PF00069	0.305
MOD_Plk_4	307	313	PF00069	0.305
MOD_Plk_4	458	464	PF00069	0.372
MOD_Plk_4	510	516	PF00069	0.408
MOD_Plk_4	93	99	PF00069	0.304
MOD_ProDKin_1	314	320	PF00069	0.321
MOD_ProDKin_1	523	529	PF00069	0.421
MOD_SUMO_rev_2	2	7	PF00179	0.461
MOD_SUMO_rev_2	255	265	PF00179	0.298
MOD_SUMO_rev_2	278	285	PF00179	0.441
MOD_SUMO_rev_2	290	297	PF00179	0.436
TRG_DiLeu_BaEn_1	353	358	PF01217	0.562
TRG_DiLeu_BaEn_1	414	419	PF01217	0.490
TRG_DiLeu_BaEn_1	458	463	PF01217	0.489
TRG_DiLeu_BaLyEn_6	295	300	PF01217	0.339
TRG_DiLeu_BaLyEn_6	471	476	PF01217	0.408
TRG_ENDOCYTIC_2	354	357	PF00928	0.535
TRG_ENDOCYTIC_2	467	470	PF00928	0.506
TRG_ENDOCYTIC_2	563	566	PF00928	0.441
TRG_ENDOCYTIC_2	76	79	PF00928	0.470
TRG_ENDOCYTIC_2	95	98	PF00928	0.173
TRG_ER_diArg_1	13	16	PF00400	0.539
TRG_ER_diArg_1	153	156	PF00400	0.305
TRG_ER_diArg_1	171	173	PF00400	0.339
TRG_ER_diArg_1	358	361	PF00400	0.538
TRG_ER_diArg_1	553	555	PF00400	0.366
TRG_NES_CRM1_1	233	247	PF08389	0.353
TRG_Pf-PMV_PEXEL_1	115	119	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	298	302	PF00026	0.305
TRG_Pf-PMV_PEXEL_1	372	376	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P569	Leptomonas seymouri	27%	67%
A0A0N1I0Y5	Leptomonas seymouri	29%	96%
A0A0N1PDD6	Leptomonas seymouri	31%	77%
A0A0S4IP49	Bodo saltans	27%	73%
A0A0S4J0Q2	Bodo saltans	35%	71%
A0A0S4JEF6	Bodo saltans	28%	88%
A0A0S4JJ54	Bodo saltans	32%	84%
A0A0S4JLW3	Bodo saltans	32%	100%
A0A0S4JXY6	Bodo saltans	31%	68%
A0A0S4KL43	Bodo saltans	29%	100%
A0A1X0NQ03	Trypanosomatidae	28%	71%
A0A1X0P0C2	Trypanosomatidae	32%	72%
A0A1X0P2B6	Trypanosomatidae	30%	96%
A0A1X0P728	Trypanosomatidae	27%	66%
A0A1X0P9E3	Trypanosomatidae	60%	99%
A0A1X0P9H3	Trypanosomatidae	33%	68%
A0A1X0P9T0	Trypanosomatidae	32%	100%
A0A1X0PAG9	Trypanosomatidae	50%	99%
A0A3Q8IHG6	Leishmania donovani	98%	100%
A0A3R7LY66	Trypanosoma rangeli	32%	72%
A0A3R7MDH9	Trypanosoma rangeli	28%	83%
A0A3R7R330	Trypanosoma rangeli	62%	100%
A0A3R7RD86	Trypanosoma rangeli	34%	73%
A0A422NE49	Trypanosoma rangeli	31%	66%
A0A422NEQ8	Trypanosoma rangeli	32%	78%
A4H4R6	Leishmania braziliensis	29%	67%
A4HAQ7	Leishmania braziliensis	27%	100%
A4HHN7	Leishmania braziliensis	88%	100%
A4HHY2	Leishmania braziliensis	28%	100%
A4HSA6	Leishmania infantum	33%	100%
A4I4V2	Leishmania infantum	98%	100%
B9G2X9	Oryza sativa subsp. japonica	33%	97%
C9ZK93	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	79%
C9ZL08	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	99%
C9ZL09	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
C9ZQI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	94%
C9ZU98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	73%
C9ZV26	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	78%
E9AEA0	Leishmania major	95%	100%
E9ALI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9ALI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9B0F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
P46870	Chlamydomonas reinhardtii	30%	76%
Q10E64	Oryza sativa subsp. japonica	34%	80%
Q1MTQ7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	93%
Q29DY1	Drosophila pseudoobscura pseudoobscura	35%	74%
Q2R2P7	Oryza sativa subsp. japonica	33%	92%
Q4QJ61	Leishmania major	26%	100%
Q5E913	Arabidopsis thaliana	27%	94%
Q5XI51	Rattus norvegicus	30%	89%
Q651Z7	Oryza sativa subsp. japonica	30%	68%
Q6H638	Oryza sativa subsp. japonica	31%	67%
Q7ZYL5	Xenopus laevis	28%	90%
Q8VWI7	Arabidopsis thaliana	28%	68%
Q8W5R6	Arabidopsis thaliana	30%	66%
Q965T6	Caenorhabditis elegans	35%	91%
Q9I869	Xenopus laevis	29%	90%
Q9SCJ4	Arabidopsis thaliana	33%	72%
Q9V877	Drosophila melanogaster	28%	94%
V5B8X9	Trypanosoma cruzi	28%	84%
V5BIC1	Trypanosoma cruzi	32%	92%
V5BK25	Trypanosoma cruzi	29%	82%
V5BMP0	Trypanosoma cruzi	32%	76%
V5D4P5	Trypanosoma cruzi	30%	95%
V5D733	Trypanosoma cruzi	32%	78%
V5DFA7	Trypanosoma cruzi	32%	100%
V5DTU1	Trypanosoma cruzi	49%	100%