LeishMANIAdb
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C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
C2H2-type domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X2P5_LEIDO
TriTrypDb:
LdBPK_291990.1 * , LdCL_290025800 , LDHU3_29.2840
Length:
107

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 7
GO:0005737 cytoplasm 2 7
GO:0043226 organelle 2 7
GO:0043227 membrane-bounded organelle 3 7
GO:0043229 intracellular organelle 3 7
GO:0043231 intracellular membrane-bounded organelle 4 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

A0A3S7X2P5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2P5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 16 18 PF00675 0.490
CLV_NRD_NRD_1 35 37 PF00675 0.444
DOC_CDC14_PxL_1 52 60 PF14671 0.391
DOC_PP1_RVXF_1 60 66 PF00149 0.484
DOC_USP7_MATH_1 41 45 PF00917 0.385
DOC_USP7_UBL2_3 101 105 PF12436 0.566
DOC_USP7_UBL2_3 45 49 PF12436 0.430
LIG_APCC_ABBA_1 61 66 PF00400 0.412
LIG_FHA_1 88 94 PF00498 0.450
LIG_FHA_2 71 77 PF00498 0.463
LIG_FHA_2 9 15 PF00498 0.442
LIG_LIR_Gen_1 76 86 PF02991 0.433
LIG_LIR_Nem_3 76 82 PF02991 0.458
LIG_OCRL_FandH_1 78 90 PF00620 0.429
MOD_CK2_1 70 76 PF00069 0.458
MOD_CK2_1 8 14 PF00069 0.470
MOD_GlcNHglycan 29 32 PF01048 0.461
MOD_GSK3_1 8 15 PF00069 0.467
MOD_N-GLC_1 70 75 PF02516 0.449
MOD_NEK2_1 21 26 PF00069 0.463
MOD_Plk_1 70 76 PF00069 0.481
TRG_ER_diLys_1 103 107 PF00400 0.591

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PB71 Leptomonas seymouri 86% 100%
A4HHI7 Leishmania braziliensis 90% 100%
A4I4P5 Leishmania infantum 98% 100%
E9AE48 Leishmania major 98% 100%
E9ALN7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q9FFD8 Arabidopsis thaliana 48% 100%
Q9M8S0 Arabidopsis thaliana 47% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS