Protein phosphatase 1 regulatory subunit 21

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X2P1_LEIDO

TriTrypDb:

LdBPK_292360.1 , LdCL_290029700 , LDHU3_29.3490

Length:

707

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X2P1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2P1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.448
CLV_C14_Caspase3-7	325	329	PF00656	0.439
CLV_C14_Caspase3-7	531	535	PF00656	0.534
CLV_NRD_NRD_1	178	180	PF00675	0.570
CLV_NRD_NRD_1	408	410	PF00675	0.638
CLV_NRD_NRD_1	67	69	PF00675	0.495
CLV_PCSK_KEX2_1	178	180	PF00082	0.664
CLV_PCSK_KEX2_1	414	416	PF00082	0.428
CLV_PCSK_PC1ET2_1	414	416	PF00082	0.428
CLV_PCSK_SKI1_1	206	210	PF00082	0.606
CLV_PCSK_SKI1_1	271	275	PF00082	0.524
CLV_PCSK_SKI1_1	533	537	PF00082	0.440
CLV_PCSK_SKI1_1	68	72	PF00082	0.533
CLV_PCSK_SKI1_1	680	684	PF00082	0.457
DEG_APCC_DBOX_1	532	540	PF00400	0.436
DEG_SCF_FBW7_2	474	481	PF00400	0.485
DOC_CYCLIN_RxL_1	268	278	PF00134	0.522
DOC_MAPK_gen_1	25	31	PF00069	0.462
DOC_MAPK_gen_1	303	310	PF00069	0.417
DOC_MAPK_gen_1	316	323	PF00069	0.426
DOC_MAPK_MEF2A_6	275	284	PF00069	0.491
DOC_MAPK_MEF2A_6	303	310	PF00069	0.435
DOC_MAPK_MEF2A_6	370	377	PF00069	0.509
DOC_MAPK_MEF2A_6	619	627	PF00069	0.530
DOC_MAPK_NFAT4_5	370	378	PF00069	0.512
DOC_USP7_MATH_1	152	156	PF00917	0.514
DOC_USP7_MATH_1	262	266	PF00917	0.508
DOC_USP7_MATH_1	395	399	PF00917	0.708
DOC_USP7_MATH_1	515	519	PF00917	0.472
DOC_USP7_MATH_1	547	551	PF00917	0.593
DOC_USP7_MATH_1	575	579	PF00917	0.634
DOC_USP7_MATH_1	582	586	PF00917	0.655
DOC_USP7_MATH_1	633	637	PF00917	0.612
DOC_USP7_MATH_1	682	686	PF00917	0.577
DOC_USP7_UBL2_3	158	162	PF12436	0.643
DOC_USP7_UBL2_3	410	414	PF12436	0.425
DOC_WW_Pin1_4	121	126	PF00397	0.586
DOC_WW_Pin1_4	444	449	PF00397	0.605
DOC_WW_Pin1_4	474	479	PF00397	0.797
DOC_WW_Pin1_4	577	582	PF00397	0.694
DOC_WW_Pin1_4	600	605	PF00397	0.623
DOC_WW_Pin1_4	702	707	PF00397	0.708
LIG_14-3-3_CanoR_1	114	123	PF00244	0.626
LIG_14-3-3_CanoR_1	130	138	PF00244	0.499
LIG_14-3-3_CanoR_1	140	146	PF00244	0.577
LIG_14-3-3_CanoR_1	178	182	PF00244	0.651
LIG_14-3-3_CanoR_1	275	280	PF00244	0.425
LIG_14-3-3_CanoR_1	293	297	PF00244	0.558
LIG_14-3-3_CanoR_1	305	309	PF00244	0.357
LIG_14-3-3_CanoR_1	409	418	PF00244	0.584
LIG_14-3-3_CanoR_1	41	49	PF00244	0.581
LIG_14-3-3_CanoR_1	514	523	PF00244	0.475
LIG_14-3-3_CanoR_1	595	604	PF00244	0.540
LIG_14-3-3_CanoR_1	632	638	PF00244	0.614
LIG_14-3-3_CanoR_1	68	74	PF00244	0.587
LIG_Actin_WH2_2	163	180	PF00022	0.565
LIG_Actin_WH2_2	248	266	PF00022	0.448
LIG_APCC_ABBA_1	306	311	PF00400	0.466
LIG_APCC_ABBA_1	373	378	PF00400	0.312
LIG_APCC_ABBAyCdc20_2	305	311	PF00400	0.509
LIG_BIR_II_1	1	5	PF00653	0.566
LIG_BRCT_BRCA1_1	590	594	PF00533	0.752
LIG_CtBP_PxDLS_1	486	490	PF00389	0.589
LIG_EH1_1	207	215	PF00400	0.542
LIG_FHA_1	172	178	PF00498	0.606
LIG_FHA_1	226	232	PF00498	0.676
LIG_FHA_1	392	398	PF00498	0.631
LIG_FHA_1	475	481	PF00498	0.773
LIG_FHA_1	51	57	PF00498	0.559
LIG_FHA_1	690	696	PF00498	0.579
LIG_FHA_2	145	151	PF00498	0.550
LIG_FHA_2	225	231	PF00498	0.714
LIG_FHA_2	293	299	PF00498	0.534
LIG_FHA_2	467	473	PF00498	0.751
LIG_FHA_2	655	661	PF00498	0.530
LIG_GBD_Chelix_1	280	288	PF00786	0.555
LIG_LIR_Gen_1	618	627	PF02991	0.632
LIG_LIR_Gen_1	636	646	PF02991	0.607
LIG_LIR_Nem_3	364	368	PF02991	0.435
LIG_LIR_Nem_3	389	393	PF02991	0.479
LIG_LIR_Nem_3	449	455	PF02991	0.610
LIG_LIR_Nem_3	473	479	PF02991	0.575
LIG_LIR_Nem_3	618	623	PF02991	0.642
LIG_NRBOX	319	325	PF00104	0.475
LIG_NRBOX	488	494	PF00104	0.603
LIG_Pex14_2	204	208	PF04695	0.457
LIG_SH2_CRK	427	431	PF00017	0.553
LIG_SH2_SRC	643	646	PF00017	0.503
LIG_SH2_STAP1	393	397	PF00017	0.537
LIG_SH2_STAP1	427	431	PF00017	0.553
LIG_SH2_STAP1	616	620	PF00017	0.637
LIG_SH2_STAT3	637	640	PF00017	0.495
LIG_SH2_STAT5	143	146	PF00017	0.581
LIG_SH2_STAT5	195	198	PF00017	0.564
LIG_SH2_STAT5	322	325	PF00017	0.543
LIG_SH2_STAT5	390	393	PF00017	0.533
LIG_SH2_STAT5	538	541	PF00017	0.513
LIG_SH2_STAT5	638	641	PF00017	0.544
LIG_SH2_STAT5	643	646	PF00017	0.495
LIG_SH3_3	228	234	PF00018	0.734
LIG_SH3_3	461	467	PF00018	0.632
LIG_SUMO_SIM_anti_2	278	284	PF11976	0.404
LIG_SUMO_SIM_anti_2	378	385	PF11976	0.415
LIG_SUMO_SIM_anti_2	685	692	PF11976	0.564
LIG_SUMO_SIM_par_1	27	32	PF11976	0.458
LIG_SUMO_SIM_par_1	518	525	PF11976	0.472
LIG_SUMO_SIM_par_1	621	628	PF11976	0.630
LIG_TRAF2_1	216	219	PF00917	0.597
LIG_TRAF2_1	3	6	PF00917	0.559
LIG_TRAF2_1	337	340	PF00917	0.667
LIG_TRAF2_1	549	552	PF00917	0.615
LIG_WRC_WIRS_1	142	147	PF05994	0.436
MOD_CK1_1	102	108	PF00069	0.667
MOD_CK1_1	239	245	PF00069	0.637
MOD_CK1_1	329	335	PF00069	0.547
MOD_CK1_1	398	404	PF00069	0.732
MOD_CK1_1	50	56	PF00069	0.621
MOD_CK1_1	505	511	PF00069	0.581
MOD_CK1_1	587	593	PF00069	0.691
MOD_CK1_1	636	642	PF00069	0.614
MOD_CK1_1	685	691	PF00069	0.587
MOD_CK1_1	82	88	PF00069	0.554
MOD_CK2_1	130	136	PF00069	0.487
MOD_CK2_1	144	150	PF00069	0.473
MOD_CK2_1	224	230	PF00069	0.729
MOD_CK2_1	466	472	PF00069	0.769
MOD_CK2_1	582	588	PF00069	0.750
MOD_CK2_1	654	660	PF00069	0.508
MOD_GlcNHglycan	107	110	PF01048	0.666
MOD_GlcNHglycan	115	118	PF01048	0.486
MOD_GlcNHglycan	155	158	PF01048	0.603
MOD_GlcNHglycan	241	244	PF01048	0.745
MOD_GlcNHglycan	257	260	PF01048	0.465
MOD_GlcNHglycan	264	267	PF01048	0.594
MOD_GlcNHglycan	331	334	PF01048	0.551
MOD_GlcNHglycan	342	345	PF01048	0.634
MOD_GlcNHglycan	397	400	PF01048	0.697
MOD_GlcNHglycan	50	53	PF01048	0.405
MOD_GlcNHglycan	627	630	PF01048	0.549
MOD_GlcNHglycan	82	85	PF01048	0.608
MOD_GSK3_1	101	108	PF00069	0.658
MOD_GSK3_1	115	122	PF00069	0.631
MOD_GSK3_1	262	269	PF00069	0.505
MOD_GSK3_1	340	347	PF00069	0.662
MOD_GSK3_1	391	398	PF00069	0.612
MOD_GSK3_1	429	436	PF00069	0.501
MOD_GSK3_1	466	473	PF00069	0.723
MOD_GSK3_1	501	508	PF00069	0.563
MOD_GSK3_1	583	590	PF00069	0.705
MOD_GSK3_1	595	602	PF00069	0.629
MOD_GSK3_1	685	692	PF00069	0.548
MOD_N-GLC_1	105	110	PF02516	0.691
MOD_N-GLC_1	474	479	PF02516	0.785
MOD_N-GLC_1	516	521	PF02516	0.529
MOD_N-GLC_1	527	532	PF02516	0.540
MOD_N-GLC_1	553	558	PF02516	0.703
MOD_NEK2_1	209	214	PF00069	0.602
MOD_NEK2_1	224	229	PF00069	0.676
MOD_NEK2_1	247	252	PF00069	0.676
MOD_NEK2_1	368	373	PF00069	0.542
MOD_NEK2_1	376	381	PF00069	0.477
MOD_NEK2_1	480	485	PF00069	0.724
MOD_NEK2_1	487	492	PF00069	0.578
MOD_NEK2_1	509	514	PF00069	0.542
MOD_NEK2_1	516	521	PF00069	0.458
MOD_NEK2_1	553	558	PF00069	0.631
MOD_NEK2_1	689	694	PF00069	0.538
MOD_NEK2_2	266	271	PF00069	0.544
MOD_NEK2_2	502	507	PF00069	0.495
MOD_PIKK_1	171	177	PF00454	0.629
MOD_PIKK_1	326	332	PF00454	0.545
MOD_PIKK_1	368	374	PF00454	0.428
MOD_PIKK_1	40	46	PF00454	0.597
MOD_PIKK_1	480	486	PF00454	0.710
MOD_PIKK_1	50	56	PF00454	0.608
MOD_PIKK_1	636	642	PF00454	0.477
MOD_PIKK_1	682	688	PF00454	0.474
MOD_PIKK_1	689	695	PF00454	0.472
MOD_PK_1	275	281	PF00069	0.505
MOD_PKA_1	19	25	PF00069	0.545
MOD_PKA_1	316	322	PF00069	0.499
MOD_PKA_1	409	415	PF00069	0.520
MOD_PKA_2	113	119	PF00069	0.709
MOD_PKA_2	171	177	PF00069	0.561
MOD_PKA_2	219	225	PF00069	0.680
MOD_PKA_2	255	261	PF00069	0.536
MOD_PKA_2	292	298	PF00069	0.586
MOD_PKA_2	304	310	PF00069	0.349
MOD_PKA_2	40	46	PF00069	0.583
MOD_PKA_2	408	414	PF00069	0.603
MOD_PKA_2	509	515	PF00069	0.546
MOD_PKA_2	80	86	PF00069	0.631
MOD_Plk_1	487	493	PF00069	0.569
MOD_Plk_1	516	522	PF00069	0.265
MOD_Plk_1	587	593	PF00069	0.749
MOD_Plk_2-3	292	298	PF00069	0.645
MOD_Plk_4	209	215	PF00069	0.656
MOD_Plk_4	219	225	PF00069	0.513
MOD_Plk_4	269	275	PF00069	0.434
MOD_Plk_4	304	310	PF00069	0.439
MOD_Plk_4	316	322	PF00069	0.382
MOD_Plk_4	388	394	PF00069	0.527
MOD_Plk_4	488	494	PF00069	0.565
MOD_Plk_4	516	522	PF00069	0.488
MOD_Plk_4	633	639	PF00069	0.567
MOD_Plk_4	94	100	PF00069	0.565
MOD_ProDKin_1	121	127	PF00069	0.577
MOD_ProDKin_1	444	450	PF00069	0.607
MOD_ProDKin_1	474	480	PF00069	0.792
MOD_ProDKin_1	577	583	PF00069	0.697
MOD_ProDKin_1	600	606	PF00069	0.624
MOD_SUMO_rev_2	13	22	PF00179	0.499
MOD_SUMO_rev_2	672	679	PF00179	0.598
TRG_DiLeu_BaEn_1	364	369	PF01217	0.454
TRG_DiLeu_BaEn_1	6	11	PF01217	0.558
TRG_DiLeu_BaEn_2	218	224	PF01217	0.586
TRG_DiLeu_BaLyEn_6	127	132	PF01217	0.604
TRG_DiLeu_BaLyEn_6	475	480	PF01217	0.580
TRG_ENDOCYTIC_2	427	430	PF00928	0.557
TRG_ENDOCYTIC_2	620	623	PF00928	0.639
TRG_ENDOCYTIC_2	638	641	PF00928	0.400
TRG_ENDOCYTIC_2	643	646	PF00928	0.514
TRG_ER_diArg_1	177	179	PF00400	0.515
TRG_ER_diArg_1	594	597	PF00400	0.653
TRG_NES_CRM1_1	298	311	PF08389	0.498
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.593
TRG_Pf-PMV_PEXEL_1	441	445	PF00026	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYM6	Leptomonas seymouri	52%	95%
A0A0S4IKE2	Bodo saltans	26%	100%
A0A1X0P953	Trypanosomatidae	31%	100%
A0A3R7K9I4	Trypanosoma rangeli	31%	100%
A4HHM5	Leishmania braziliensis	75%	100%
A4I4T4	Leishmania infantum	99%	100%
C9ZLI5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AE87	Leishmania major	92%	100%
E9ALJ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BC22	Trypanosoma cruzi	31%	100%