Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7X2N6_LEIDO

TriTrypDb:

LdBPK_292400.1 , LdCL_290030000 , LDHU3_29.3550

Length:

412

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X2N6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2N6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	27	31	PF00656	0.667
CLV_NRD_NRD_1	8	10	PF00675	0.577
CLV_PCSK_KEX2_1	8	10	PF00082	0.577
CLV_PCSK_SKI1_1	186	190	PF00082	0.663
CLV_PCSK_SKI1_1	8	12	PF00082	0.601
DEG_APCC_DBOX_1	183	191	PF00400	0.662
DEG_Nend_Nbox_1	1	3	PF02207	0.621
DEG_SCF_FBW7_1	55	62	PF00400	0.685
DEG_SPOP_SBC_1	343	347	PF00917	0.609
DOC_CKS1_1	145	150	PF01111	0.668
DOC_CKS1_1	46	51	PF01111	0.671
DOC_CYCLIN_yCln2_LP_2	230	236	PF00134	0.652
DOC_MAPK_FxFP_2	23	26	PF00069	0.563
DOC_PP2B_LxvP_1	399	402	PF13499	0.549
DOC_PP2B_LxvP_1	47	50	PF13499	0.634
DOC_PP4_FxxP_1	11	14	PF00568	0.604
DOC_PP4_FxxP_1	142	145	PF00568	0.707
DOC_PP4_FxxP_1	23	26	PF00568	0.549
DOC_PP4_FxxP_1	376	379	PF00568	0.557
DOC_PP4_MxPP_1	108	111	PF00568	0.640
DOC_USP7_MATH_1	100	104	PF00917	0.790
DOC_USP7_MATH_1	122	126	PF00917	0.587
DOC_USP7_MATH_1	14	18	PF00917	0.687
DOC_USP7_MATH_1	195	199	PF00917	0.595
DOC_USP7_MATH_1	214	218	PF00917	0.683
DOC_USP7_MATH_1	24	28	PF00917	0.581
DOC_USP7_MATH_1	300	304	PF00917	0.632
DOC_USP7_MATH_1	325	329	PF00917	0.645
DOC_USP7_MATH_1	381	385	PF00917	0.558
DOC_USP7_MATH_1	50	54	PF00917	0.655
DOC_USP7_MATH_1	59	63	PF00917	0.634
DOC_WW_Pin1_4	127	132	PF00397	0.710
DOC_WW_Pin1_4	144	149	PF00397	0.691
DOC_WW_Pin1_4	164	169	PF00397	0.481
DOC_WW_Pin1_4	177	182	PF00397	0.543
DOC_WW_Pin1_4	197	202	PF00397	0.467
DOC_WW_Pin1_4	229	234	PF00397	0.693
DOC_WW_Pin1_4	235	240	PF00397	0.617
DOC_WW_Pin1_4	255	260	PF00397	0.449
DOC_WW_Pin1_4	265	270	PF00397	0.694
DOC_WW_Pin1_4	292	297	PF00397	0.672
DOC_WW_Pin1_4	311	316	PF00397	0.542
DOC_WW_Pin1_4	336	341	PF00397	0.635
DOC_WW_Pin1_4	345	350	PF00397	0.657
DOC_WW_Pin1_4	359	364	PF00397	0.549
DOC_WW_Pin1_4	45	50	PF00397	0.673
DOC_WW_Pin1_4	55	60	PF00397	0.571
DOC_WW_Pin1_4	91	96	PF00397	0.643
LIG_14-3-3_CanoR_1	123	132	PF00244	0.624
LIG_14-3-3_CanoR_1	134	140	PF00244	0.657
LIG_14-3-3_CanoR_1	274	279	PF00244	0.601
LIG_14-3-3_CanoR_1	374	379	PF00244	0.612
LIG_BRCT_BRCA1_1	168	172	PF00533	0.660
LIG_BRCT_BRCA1_1	19	23	PF00533	0.654
LIG_BRCT_BRCA1_1	246	250	PF00533	0.622
LIG_CSL_BTD_1	279	282	PF09270	0.615
LIG_CtBP_PxDLS_1	269	273	PF00389	0.498
LIG_FHA_1	225	231	PF00498	0.657
LIG_FHA_1	302	308	PF00498	0.632
LIG_IBAR_NPY_1	3	5	PF08397	0.609
LIG_LIR_Apic_2	20	26	PF02991	0.558
LIG_LIR_Gen_1	247	254	PF02991	0.609
LIG_LIR_Nem_3	130	135	PF02991	0.810
LIG_LIR_Nem_3	200	205	PF02991	0.615
LIG_LIR_Nem_3	247	253	PF02991	0.719
LIG_SH2_SRC	119	122	PF00017	0.670
LIG_SH2_STAT3	203	206	PF00017	0.660
LIG_SH2_STAT3	51	54	PF00017	0.604
LIG_SH2_STAT5	252	255	PF00017	0.560
LIG_SH2_STAT5	46	49	PF00017	0.678
LIG_SH3_1	46	52	PF00018	0.668
LIG_SH3_2	4	9	PF14604	0.592
LIG_SH3_3	1	7	PF00018	0.590
LIG_SH3_3	107	113	PF00018	0.641
LIG_SH3_3	142	148	PF00018	0.632
LIG_SH3_3	165	171	PF00018	0.621
LIG_SH3_3	198	204	PF00018	0.612
LIG_SH3_3	264	270	PF00018	0.637
LIG_SH3_3	276	282	PF00018	0.651
LIG_SH3_3	32	38	PF00018	0.674
LIG_SH3_3	385	391	PF00018	0.569
LIG_SH3_3	46	52	PF00018	0.567
LIG_SUMO_SIM_anti_2	101	106	PF11976	0.677
MOD_CDC14_SPxK_1	348	351	PF00782	0.651
MOD_CDK_SPxK_1	345	351	PF00069	0.649
MOD_CDK_SPxxK_3	127	134	PF00069	0.608
MOD_CDK_SPxxK_3	177	184	PF00069	0.640
MOD_CK1_1	115	121	PF00069	0.621
MOD_CK1_1	125	131	PF00069	0.642
MOD_CK1_1	17	23	PF00069	0.704
MOD_CK1_1	217	223	PF00069	0.685
MOD_CK1_1	225	231	PF00069	0.587
MOD_CK1_1	238	244	PF00069	0.548
MOD_CK1_1	268	274	PF00069	0.641
MOD_CK1_1	290	296	PF00069	0.642
MOD_CK1_1	311	317	PF00069	0.688
MOD_CK1_1	53	59	PF00069	0.702
MOD_CK1_1	62	68	PF00069	0.653
MOD_CK1_1	94	100	PF00069	0.585
MOD_CK2_1	374	380	PF00069	0.612
MOD_CK2_1	61	67	PF00069	0.683
MOD_GlcNHglycan	17	20	PF01048	0.597
MOD_GlcNHglycan	175	178	PF01048	0.612
MOD_GlcNHglycan	190	193	PF01048	0.637
MOD_GlcNHglycan	216	219	PF01048	0.691
MOD_GlcNHglycan	224	227	PF01048	0.596
MOD_GlcNHglycan	244	247	PF01048	0.596
MOD_GlcNHglycan	255	258	PF01048	0.518
MOD_GlcNHglycan	26	29	PF01048	0.647
MOD_GlcNHglycan	290	293	PF01048	0.818
MOD_GlcNHglycan	30	33	PF01048	0.691
MOD_GlcNHglycan	322	325	PF01048	0.646
MOD_GlcNHglycan	376	379	PF01048	0.603
MOD_GlcNHglycan	55	58	PF01048	0.669
MOD_GlcNHglycan	59	62	PF01048	0.666
MOD_GlcNHglycan	77	80	PF01048	0.709
MOD_GSK3_1	123	130	PF00069	0.595
MOD_GSK3_1	140	147	PF00069	0.652
MOD_GSK3_1	166	173	PF00069	0.756
MOD_GSK3_1	225	232	PF00069	0.654
MOD_GSK3_1	234	241	PF00069	0.589
MOD_GSK3_1	24	31	PF00069	0.592
MOD_GSK3_1	288	295	PF00069	0.688
MOD_GSK3_1	332	339	PF00069	0.733
MOD_GSK3_1	53	60	PF00069	0.644
MOD_GSK3_1	62	69	PF00069	0.674
MOD_GSK3_1	80	87	PF00069	0.671
MOD_GSK3_1	91	98	PF00069	0.576
MOD_N-GLC_1	115	120	PF02516	0.685
MOD_N-GLC_1	374	379	PF02516	0.612
MOD_N-GLC_1	62	67	PF02516	0.663
MOD_NEK2_1	124	129	PF00069	0.723
MOD_NEK2_1	149	154	PF00069	0.662
MOD_NEK2_1	157	162	PF00069	0.688
MOD_NEK2_1	172	177	PF00069	0.580
MOD_NEK2_1	188	193	PF00069	0.544
MOD_NEK2_1	234	239	PF00069	0.589
MOD_NEK2_1	263	268	PF00069	0.651
MOD_NEK2_1	288	293	PF00069	0.769
MOD_NEK2_1	320	325	PF00069	0.717
MOD_NEK2_1	68	73	PF00069	0.753
MOD_PIKK_1	135	141	PF00454	0.636
MOD_PIKK_1	149	155	PF00454	0.586
MOD_PIKK_1	166	172	PF00454	0.599
MOD_PIKK_1	225	231	PF00454	0.657
MOD_PIKK_1	238	244	PF00454	0.548
MOD_PIKK_1	274	280	PF00454	0.629
MOD_PIKK_1	313	319	PF00454	0.742
MOD_PIKK_1	325	331	PF00454	0.639
MOD_PIKK_1	50	56	PF00454	0.595
MOD_PIKK_1	68	74	PF00454	0.747
MOD_PKA_2	122	128	PF00069	0.635
MOD_PKA_2	300	306	PF00069	0.652
MOD_Plk_1	115	121	PF00069	0.675
MOD_Plk_1	301	307	PF00069	0.619
MOD_Plk_4	100	106	PF00069	0.707
MOD_Plk_4	157	163	PF00069	0.588
MOD_Plk_4	268	274	PF00069	0.622
MOD_Plk_4	332	338	PF00069	0.645
MOD_ProDKin_1	127	133	PF00069	0.712
MOD_ProDKin_1	144	150	PF00069	0.691
MOD_ProDKin_1	164	170	PF00069	0.480
MOD_ProDKin_1	177	183	PF00069	0.539
MOD_ProDKin_1	197	203	PF00069	0.470
MOD_ProDKin_1	229	235	PF00069	0.696
MOD_ProDKin_1	255	261	PF00069	0.623
MOD_ProDKin_1	265	271	PF00069	0.693
MOD_ProDKin_1	292	298	PF00069	0.675
MOD_ProDKin_1	311	317	PF00069	0.542
MOD_ProDKin_1	336	342	PF00069	0.636
MOD_ProDKin_1	345	351	PF00069	0.661
MOD_ProDKin_1	359	365	PF00069	0.547
MOD_ProDKin_1	45	51	PF00069	0.672
MOD_ProDKin_1	55	61	PF00069	0.571
MOD_ProDKin_1	91	97	PF00069	0.641
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.632
TRG_ER_diArg_1	184	187	PF00400	0.670
TRG_ER_diArg_1	7	9	PF00400	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4C9	Leptomonas seymouri	34%	98%
A4HHM8	Leishmania braziliensis	81%	100%
A4I4U3	Leishmania infantum	100%	100%
E9AE91	Leishmania major	95%	100%
E9ALJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%