Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X2N0_LEIDO

TriTrypDb:

LdBPK_291650.1 , LdCL_290022100 , LDHU3_29.2390

Length:

192

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X2N0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2N0

PDB structure(s): 7ane_g

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.419
CLV_NRD_NRD_1	151	153	PF00675	0.418
CLV_NRD_NRD_1	159	161	PF00675	0.486
CLV_NRD_NRD_1	58	60	PF00675	0.348
CLV_NRD_NRD_1	97	99	PF00675	0.403
CLV_PCSK_KEX2_1	159	161	PF00082	0.464
CLV_PCSK_KEX2_1	58	60	PF00082	0.365
CLV_PCSK_KEX2_1	96	98	PF00082	0.381
CLV_PCSK_SKI1_1	114	118	PF00082	0.360
DEG_Nend_UBRbox_3	1	3	PF02207	0.655
DOC_MAPK_DCC_7	159	169	PF00069	0.436
DOC_MAPK_HePTP_8	157	169	PF00069	0.434
DOC_MAPK_MEF2A_6	160	169	PF00069	0.416
DOC_PP4_FxxP_1	3	6	PF00568	0.434
DOC_WW_Pin1_4	2	7	PF00397	0.459
LIG_14-3-3_CanoR_1	159	165	PF00244	0.501
LIG_14-3-3_CanoR_1	16	24	PF00244	0.523
LIG_FHA_1	113	119	PF00498	0.360
LIG_FHA_1	2	8	PF00498	0.600
LIG_FHA_1	39	45	PF00498	0.442
LIG_LIR_Gen_1	106	113	PF02991	0.400
LIG_LIR_Gen_1	151	161	PF02991	0.428
LIG_LIR_Nem_3	106	110	PF02991	0.381
LIG_LIR_Nem_3	151	157	PF02991	0.451
LIG_Pex14_2	185	189	PF04695	0.384
LIG_PTB_Apo_2	179	186	PF02174	0.346
LIG_SH2_PTP2	154	157	PF00017	0.390
LIG_SH2_STAT5	154	157	PF00017	0.462
LIG_SH2_STAT5	63	66	PF00017	0.358
LIG_SH3_3	46	52	PF00018	0.511
LIG_SUMO_SIM_par_1	51	57	PF11976	0.416
MOD_CK1_1	18	24	PF00069	0.546
MOD_CK1_1	82	88	PF00069	0.419
MOD_GSK3_1	18	25	PF00069	0.413
MOD_LATS_1	15	21	PF00433	0.450
MOD_LATS_1	158	164	PF00433	0.445
MOD_N-GLC_1	38	43	PF02516	0.526
MOD_N-GLC_1	82	87	PF02516	0.407
MOD_NEK2_1	1	6	PF00069	0.576
MOD_NEK2_1	103	108	PF00069	0.383
MOD_NEK2_1	22	27	PF00069	0.453
MOD_NEK2_1	74	79	PF00069	0.386
MOD_PIKK_1	124	130	PF00454	0.514
MOD_PKA_2	15	21	PF00069	0.469
MOD_PKA_2	22	28	PF00069	0.466
MOD_Plk_1	38	44	PF00069	0.527
MOD_Plk_4	103	109	PF00069	0.387
MOD_ProDKin_1	2	8	PF00069	0.459
MOD_SUMO_rev_2	147	155	PF00179	0.468
MOD_SUMO_rev_2	82	89	PF00179	0.396
TRG_DiLeu_BaEn_1	121	126	PF01217	0.505
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.568
TRG_ENDOCYTIC_2	154	157	PF00928	0.479
TRG_ER_diArg_1	159	161	PF00400	0.454
TRG_ER_diArg_1	58	60	PF00400	0.361
TRG_ER_diArg_1	66	69	PF00400	0.381
TRG_ER_diArg_1	95	98	PF00400	0.382
TRG_Pf-PMV_PEXEL_1	117	121	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P947	Leptomonas seymouri	86%	100%
A0A0S4KFE4	Bodo saltans	59%	100%
A0A1X0P098	Trypanosomatidae	76%	99%
A0A422NEG3	Trypanosoma rangeli	79%	100%
A4HHG6	Leishmania braziliensis	91%	100%
A4I4L5	Leishmania infantum	99%	100%
C9ZLA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	99%
E9AE13	Leishmania major	97%	100%
E9ALS0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%