Transmembrane 9 superfamily member

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endomembrane protein 70, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X2L7_LEIDO

TriTrypDb:

LdBPK_291730.1 , LdCL_290022900 , LDHU3_29.2500

Length:

681

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 13, no: 1
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	15
GO:0110165	cellular anatomical entity	1	15

Expansion

Sequence features

A0A3S7X2L7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2L7

Function

Biological processes
Term	Name	Level	Count
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0033036	macromolecule localization	2	1
GO:0051179	localization	1	1
GO:0051641	cellular localization	2	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0072657	protein localization to membrane	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	138	140	PF00675	0.521
CLV_NRD_NRD_1	234	236	PF00675	0.456
CLV_NRD_NRD_1	414	416	PF00675	0.442
CLV_NRD_NRD_1	672	674	PF00675	0.284
CLV_PCSK_KEX2_1	138	140	PF00082	0.488
CLV_PCSK_KEX2_1	234	236	PF00082	0.365
CLV_PCSK_KEX2_1	414	416	PF00082	0.442
CLV_PCSK_KEX2_1	672	674	PF00082	0.366
CLV_PCSK_SKI1_1	143	147	PF00082	0.489
CLV_PCSK_SKI1_1	183	187	PF00082	0.516
CLV_PCSK_SKI1_1	205	209	PF00082	0.520
CLV_PCSK_SKI1_1	271	275	PF00082	0.542
CLV_PCSK_SKI1_1	276	280	PF00082	0.520
CLV_PCSK_SKI1_1	300	304	PF00082	0.516
CLV_PCSK_SKI1_1	415	419	PF00082	0.456
CLV_PCSK_SKI1_1	450	454	PF00082	0.223
DEG_APCC_DBOX_1	18	26	PF00400	0.427
DEG_APCC_KENBOX_2	293	297	PF00400	0.217
DOC_MAPK_gen_1	151	159	PF00069	0.273
DOC_MAPK_gen_1	179	187	PF00069	0.285
DOC_MAPK_gen_1	234	241	PF00069	0.324
DOC_MAPK_gen_1	54	64	PF00069	0.379
DOC_MAPK_gen_1	672	680	PF00069	0.498
DOC_MAPK_MEF2A_6	19	27	PF00069	0.496
DOC_MAPK_MEF2A_6	234	243	PF00069	0.296
DOC_PP1_RVXF_1	244	251	PF00149	0.304
DOC_PP2B_LxvP_1	195	198	PF13499	0.273
DOC_PP4_FxxP_1	375	378	PF00568	0.429
DOC_PP4_FxxP_1	409	412	PF00568	0.213
DOC_PP4_FxxP_1	457	460	PF00568	0.394
DOC_PP4_FxxP_1	46	49	PF00568	0.373
DOC_PP4_FxxP_1	85	88	PF00568	0.231
DOC_USP7_MATH_1	530	534	PF00917	0.460
DOC_USP7_UBL2_3	117	121	PF12436	0.212
DOC_USP7_UBL2_3	143	147	PF12436	0.274
DOC_USP7_UBL2_3	179	183	PF12436	0.276
DOC_USP7_UBL2_3	54	58	PF12436	0.374
DOC_WW_Pin1_4	38	43	PF00397	0.530
DOC_WW_Pin1_4	408	413	PF00397	0.213
LIG_14-3-3_CanoR_1	106	112	PF00244	0.272
LIG_14-3-3_CanoR_1	352	361	PF00244	0.495
LIG_14-3-3_CanoR_1	70	78	PF00244	0.318
LIG_APCC_ABBA_1	237	242	PF00400	0.260
LIG_BIR_II_1	1	5	PF00653	0.531
LIG_BRCT_BRCA1_1	507	511	PF00533	0.264
LIG_BRCT_BRCA1_1	571	575	PF00533	0.324
LIG_BRCT_BRCA1_1	624	628	PF00533	0.323
LIG_BRCT_BRCA1_1	666	670	PF00533	0.325
LIG_BRCT_BRCA1_1	72	76	PF00533	0.400
LIG_CaM_NSCaTE_8	305	312	PF13499	0.324
LIG_EH1_1	322	330	PF00400	0.399
LIG_eIF4E_1	435	441	PF01652	0.293
LIG_FHA_1	132	138	PF00498	0.276
LIG_FHA_1	144	150	PF00498	0.267
LIG_FHA_1	26	32	PF00498	0.424
LIG_FHA_1	286	292	PF00498	0.276
LIG_FHA_1	395	401	PF00498	0.283
LIG_FHA_1	418	424	PF00498	0.300
LIG_FHA_1	427	433	PF00498	0.244
LIG_FHA_1	478	484	PF00498	0.257
LIG_FHA_1	491	497	PF00498	0.268
LIG_FHA_1	577	583	PF00498	0.321
LIG_FHA_2	165	171	PF00498	0.260
LIG_FHA_2	226	232	PF00498	0.260
LIG_FHA_2	301	307	PF00498	0.210
LIG_FHA_2	485	491	PF00498	0.260
LIG_GBD_Chelix_1	553	561	PF00786	0.283
LIG_LIR_Apic_2	373	378	PF02991	0.406
LIG_LIR_Apic_2	44	49	PF02991	0.366
LIG_LIR_Apic_2	454	460	PF02991	0.265
LIG_LIR_Gen_1	233	243	PF02991	0.256
LIG_LIR_Gen_1	425	436	PF02991	0.368
LIG_LIR_Gen_1	493	502	PF02991	0.320
LIG_LIR_Gen_1	572	582	PF02991	0.281
LIG_LIR_Gen_1	79	88	PF02991	0.324
LIG_LIR_LC3C_4	28	32	PF02991	0.337
LIG_LIR_LC3C_4	547	552	PF02991	0.271
LIG_LIR_Nem_3	233	239	PF02991	0.231
LIG_LIR_Nem_3	284	289	PF02991	0.291
LIG_LIR_Nem_3	303	308	PF02991	0.186
LIG_LIR_Nem_3	349	353	PF02991	0.430
LIG_LIR_Nem_3	364	370	PF02991	0.339
LIG_LIR_Nem_3	425	431	PF02991	0.345
LIG_LIR_Nem_3	493	498	PF02991	0.320
LIG_LIR_Nem_3	572	578	PF02991	0.279
LIG_LIR_Nem_3	593	599	PF02991	0.281
LIG_NRBOX	22	28	PF00104	0.579
LIG_Pex14_1	152	156	PF04695	0.260
LIG_Pex14_1	383	387	PF04695	0.524
LIG_Pex14_1	449	453	PF04695	0.406
LIG_Pex14_1	607	611	PF04695	0.406
LIG_Pex14_2	453	457	PF04695	0.356
LIG_Pex14_2	540	544	PF04695	0.324
LIG_PTB_Apo_2	106	113	PF02174	0.256
LIG_PTB_Apo_2	147	154	PF02174	0.295
LIG_PTB_Phospho_1	106	112	PF10480	0.256
LIG_PTB_Phospho_1	147	153	PF10480	0.295
LIG_SH2_CRK	675	679	PF00017	0.477
LIG_SH2_GRB2like	156	159	PF00017	0.324
LIG_SH2_GRB2like	380	383	PF00017	0.514
LIG_SH2_GRB2like	443	446	PF00017	0.456
LIG_SH2_GRB2like	601	604	PF00017	0.456
LIG_SH2_PTP2	236	239	PF00017	0.286
LIG_SH2_PTP2	467	470	PF00017	0.394
LIG_SH2_SRC	47	50	PF00017	0.370
LIG_SH2_SRC	601	604	PF00017	0.456
LIG_SH2_STAP1	112	116	PF00017	0.242
LIG_SH2_STAP1	289	293	PF00017	0.223
LIG_SH2_STAP1	380	384	PF00017	0.481
LIG_SH2_STAT3	559	562	PF00017	0.408
LIG_SH2_STAT5	112	115	PF00017	0.247
LIG_SH2_STAT5	236	239	PF00017	0.271
LIG_SH2_STAT5	308	311	PF00017	0.230
LIG_SH2_STAT5	435	438	PF00017	0.251
LIG_SH2_STAT5	443	446	PF00017	0.407
LIG_SH2_STAT5	467	470	PF00017	0.264
LIG_SH2_STAT5	47	50	PF00017	0.351
LIG_SH2_STAT5	559	562	PF00017	0.299
LIG_SH2_STAT5	597	600	PF00017	0.414
LIG_SH2_STAT5	611	614	PF00017	0.258
LIG_SH3_3	263	269	PF00018	0.325
LIG_SH3_3	371	377	PF00018	0.445
LIG_SH3_3	495	501	PF00018	0.337
LIG_SH3_3	540	546	PF00018	0.311
LIG_SUMO_SIM_anti_2	28	34	PF11976	0.420
LIG_SUMO_SIM_anti_2	327	332	PF11976	0.249
LIG_SUMO_SIM_par_1	22	28	PF11976	0.479
LIG_SUMO_SIM_par_1	550	556	PF11976	0.291
LIG_SUMO_SIM_par_1	588	593	PF11976	0.353
LIG_SxIP_EBH_1	475	489	PF03271	0.260
LIG_TRAF2_1	229	232	PF00917	0.318
LIG_TRAF2_1	89	92	PF00917	0.226
LIG_TYR_ITIM	465	470	PF00017	0.368
LIG_UBA3_1	342	348	PF00899	0.279
LIG_UBA3_1	468	475	PF00899	0.316
LIG_UBA3_1	75	82	PF00899	0.260
LIG_WRC_WIRS_1	570	575	PF05994	0.279
LIG_WRC_WIRS_1	635	640	PF05994	0.242
LIG_WW_1	377	380	PF00397	0.514
MOD_CDC14_SPxK_1	411	414	PF00782	0.242
MOD_CDK_SPxK_1	408	414	PF00069	0.242
MOD_CDK_SPxxK_3	408	415	PF00069	0.213
MOD_CK1_1	10	16	PF00069	0.663
MOD_CK1_1	110	116	PF00069	0.221
MOD_CK1_1	2	8	PF00069	0.742
MOD_CK1_1	223	229	PF00069	0.301
MOD_CK1_1	430	436	PF00069	0.323
MOD_CK1_1	631	637	PF00069	0.259
MOD_CK1_1	68	74	PF00069	0.238
MOD_CK2_1	164	170	PF00069	0.338
MOD_CK2_1	225	231	PF00069	0.260
MOD_CK2_1	484	490	PF00069	0.260
MOD_CK2_1	68	74	PF00069	0.352
MOD_CK2_1	94	100	PF00069	0.270
MOD_GlcNHglycan	335	338	PF01048	0.319
MOD_GlcNHglycan	43	46	PF01048	0.562
MOD_GlcNHglycan	432	435	PF01048	0.345
MOD_GlcNHglycan	639	642	PF01048	0.535
MOD_GSK3_1	139	146	PF00069	0.226
MOD_GSK3_1	164	171	PF00069	0.316
MOD_GSK3_1	220	227	PF00069	0.326
MOD_GSK3_1	244	251	PF00069	0.256
MOD_GSK3_1	281	288	PF00069	0.220
MOD_GSK3_1	418	425	PF00069	0.408
MOD_GSK3_1	426	433	PF00069	0.379
MOD_GSK3_1	451	458	PF00069	0.507
MOD_GSK3_1	496	503	PF00069	0.337
MOD_GSK3_1	633	640	PF00069	0.231
MOD_GSK3_1	65	72	PF00069	0.388
MOD_GSK3_1	7	14	PF00069	0.661
MOD_N-GLC_1	143	148	PF02516	0.413
MOD_N-GLC_1	276	281	PF02516	0.497
MOD_NEK2_1	1	6	PF00069	0.699
MOD_NEK2_1	107	112	PF00069	0.313
MOD_NEK2_1	213	218	PF00069	0.277
MOD_NEK2_1	25	30	PF00069	0.463
MOD_NEK2_1	307	312	PF00069	0.261
MOD_NEK2_1	333	338	PF00069	0.289
MOD_NEK2_1	418	423	PF00069	0.329
MOD_NEK2_1	453	458	PF00069	0.376
MOD_NEK2_1	505	510	PF00069	0.272
MOD_NEK2_1	576	581	PF00069	0.375
MOD_NEK2_1	622	627	PF00069	0.281
MOD_NEK2_1	628	633	PF00069	0.265
MOD_NEK2_1	643	648	PF00069	0.197
MOD_NEK2_1	65	70	PF00069	0.341
MOD_NEK2_2	287	292	PF00069	0.303
MOD_OFUCOSY	587	594	PF10250	0.408
MOD_PIKK_1	169	175	PF00454	0.350
MOD_PIKK_1	2	8	PF00454	0.602
MOD_PIKK_1	220	226	PF00454	0.165
MOD_PIKK_1	255	261	PF00454	0.239
MOD_PIKK_1	276	282	PF00454	0.282
MOD_PIKK_1	528	534	PF00454	0.409
MOD_PK_1	244	250	PF00069	0.260
MOD_PK_1	94	100	PF00069	0.324
MOD_PKA_1	139	145	PF00069	0.226
MOD_PKA_2	69	75	PF00069	0.376
MOD_Plk_1	169	175	PF00069	0.324
MOD_Plk_1	213	219	PF00069	0.318
MOD_Plk_1	94	100	PF00069	0.319
MOD_Plk_4	107	113	PF00069	0.231
MOD_Plk_4	25	31	PF00069	0.473
MOD_Plk_4	281	287	PF00069	0.277
MOD_Plk_4	324	330	PF00069	0.286
MOD_Plk_4	418	424	PF00069	0.338
MOD_Plk_4	427	433	PF00069	0.249
MOD_Plk_4	484	490	PF00069	0.240
MOD_Plk_4	500	506	PF00069	0.181
MOD_Plk_4	530	536	PF00069	0.466
MOD_Plk_4	622	628	PF00069	0.267
MOD_Plk_4	649	655	PF00069	0.306
MOD_Plk_4	664	670	PF00069	0.370
MOD_ProDKin_1	38	44	PF00069	0.535
MOD_ProDKin_1	408	414	PF00069	0.213
MOD_SUMO_for_1	93	96	PF00179	0.336
MOD_SUMO_rev_2	118	123	PF00179	0.243
MOD_SUMO_rev_2	135	145	PF00179	0.326
MOD_SUMO_rev_2	60	65	PF00179	0.216
TRG_DiLeu_BaEn_2	59	65	PF01217	0.343
TRG_DiLeu_BaEn_3	232	238	PF01217	0.309
TRG_DiLeu_BaEn_3	60	66	PF01217	0.224
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.489
TRG_ENDOCYTIC_2	156	159	PF00928	0.253
TRG_ENDOCYTIC_2	236	239	PF00928	0.273
TRG_ENDOCYTIC_2	467	470	PF00928	0.337
TRG_ENDOCYTIC_2	558	561	PF00928	0.329
TRG_ENDOCYTIC_2	570	573	PF00928	0.164
TRG_ENDOCYTIC_2	596	599	PF00928	0.406
TRG_ENDOCYTIC_2	647	650	PF00928	0.232
TRG_ENDOCYTIC_2	675	678	PF00928	0.464
TRG_ENDOCYTIC_2	80	83	PF00928	0.231
TRG_ER_diArg_1	137	139	PF00400	0.321
TRG_ER_diArg_1	234	236	PF00400	0.165
TRG_ER_diArg_1	671	673	PF00400	0.558
TRG_NES_CRM1_1	105	119	PF08389	0.276
TRG_Pf-PMV_PEXEL_1	344	349	PF00026	0.215

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P948	Leptomonas seymouri	63%	100%
A0A0N1I2B1	Leptomonas seymouri	29%	100%
A0A0N1I6Y7	Leptomonas seymouri	30%	100%
A0A0N1IME8	Leptomonas seymouri	20%	100%
A0A0S4IV41	Bodo saltans	32%	100%
A0A0S4J9X2	Bodo saltans	40%	100%
A0A0S4JBB1	Bodo saltans	34%	100%
A0A0S4JCH7	Bodo saltans	33%	99%
A0A0S4JEU5	Bodo saltans	27%	100%
A0A0S4JIF4	Bodo saltans	37%	100%
A0A0S4JWZ9	Bodo saltans	21%	100%
A0A0S4JZ31	Bodo saltans	26%	100%
A0A1X0NJN3	Trypanosomatidae	23%	100%
A0A1X0NK64	Trypanosomatidae	29%	100%
A0A1X0NZX5	Trypanosomatidae	48%	100%
A0A1X0P2G3	Trypanosomatidae	31%	100%
A0A1X0P6M4	Trypanosomatidae	29%	89%
A0A1X0PA12	Trypanosomatidae	34%	100%
A0A3Q8IBT4	Leishmania donovani	25%	100%
A0A3Q8IFM1	Leishmania donovani	30%	100%
A0A3Q8IHT3	Leishmania donovani	29%	100%
A0A3R7MBZ3	Trypanosoma rangeli	31%	100%
A0A422NED2	Trypanosoma rangeli	49%	100%
A0A422NMS9	Trypanosoma rangeli	30%	100%
A4H7C1	Leishmania braziliensis	25%	100%
A4HB85	Leishmania braziliensis	27%	98%
A4HHH4	Leishmania braziliensis	81%	100%
A4HHY3	Leishmania braziliensis	29%	100%
A4HVR6	Leishmania infantum	25%	100%
A4I4M3	Leishmania infantum	99%	100%
A4I563	Leishmania infantum	30%	100%
A4IAD3	Leishmania infantum	29%	100%
A4IFE9	Bos taurus	27%	100%
A5D7E2	Bos taurus	32%	100%
C9ZLB0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	93%
C9ZLW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZUX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AE21	Leishmania major	93%	100%
E9ALR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9APG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B0G0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B5F7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
F4HW17	Arabidopsis thaliana	25%	100%
F4JRE0	Arabidopsis thaliana	29%	100%
F4KIB2	Arabidopsis thaliana	32%	100%
O15321	Homo sapiens	27%	100%
P32802	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
P40071	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	96%
P58021	Mus musculus	30%	100%
Q04562	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
Q4KLL4	Rattus norvegicus	33%	100%
Q4Q2H8	Leishmania major	30%	100%
Q4Q7S3	Leishmania major	29%	97%
Q4QG16	Leishmania major	21%	90%
Q54ZW0	Dictyostelium discoideum	26%	100%
Q55FP0	Dictyostelium discoideum	31%	100%
Q5R8F1	Pongo abelii	27%	100%
Q5R8Y6	Pongo abelii	30%	100%
Q5RDY2	Pongo abelii	32%	100%
Q66HF2	Rattus norvegicus	27%	100%
Q66HG5	Rattus norvegicus	30%	100%
Q7YTA6	Dictyostelium discoideum	21%	100%
Q8BH24	Mus musculus	33%	100%
Q8RWW1	Arabidopsis thaliana	32%	100%
Q92544	Homo sapiens	32%	100%
Q940G0	Arabidopsis thaliana	26%	100%
Q940S0	Arabidopsis thaliana	27%	100%
Q99805	Homo sapiens	30%	100%
Q9C5N2	Arabidopsis thaliana	33%	100%
Q9C720	Arabidopsis thaliana	33%	100%
Q9DBU0	Mus musculus	27%	100%
Q9FHT4	Arabidopsis thaliana	27%	100%
Q9FYQ8	Arabidopsis thaliana	29%	100%
Q9LIC2	Arabidopsis thaliana	33%	100%
Q9Y819	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
Q9ZPS7	Arabidopsis thaliana	27%	100%
V5BCD5	Trypanosoma cruzi	32%	100%
V5BHS7	Trypanosoma cruzi	28%	100%
V5D9U0	Trypanosoma cruzi	48%	100%
V5DII3	Trypanosoma cruzi	22%	100%