NOL1/NOP2/sun family, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X2L4_LEIDO

TriTrypDb:

LdBPK_292120.1 , LdCL_290027200 , LDHU3_29.3030

Length:

701

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X2L4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2L4

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	10
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009451	RNA modification	5	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0032259	methylation	2	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0043414	macromolecule methylation	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0008168	methyltransferase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016741	transferase activity, transferring one-carbon groups	3	10
GO:0003676	nucleic acid binding	3	5
GO:0003723	RNA binding	4	5
GO:0005488	binding	1	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	305	309	PF00656	0.514
CLV_C14_Caspase3-7	498	502	PF00656	0.588
CLV_NRD_NRD_1	122	124	PF00675	0.590
CLV_NRD_NRD_1	198	200	PF00675	0.446
CLV_NRD_NRD_1	448	450	PF00675	0.587
CLV_NRD_NRD_1	48	50	PF00675	0.442
CLV_NRD_NRD_1	548	550	PF00675	0.292
CLV_NRD_NRD_1	577	579	PF00675	0.515
CLV_NRD_NRD_1	619	621	PF00675	0.602
CLV_PCSK_KEX2_1	124	126	PF00082	0.591
CLV_PCSK_KEX2_1	318	320	PF00082	0.437
CLV_PCSK_KEX2_1	335	337	PF00082	0.511
CLV_PCSK_KEX2_1	47	49	PF00082	0.444
CLV_PCSK_KEX2_1	548	550	PF00082	0.287
CLV_PCSK_KEX2_1	577	579	PF00082	0.628
CLV_PCSK_KEX2_1	619	621	PF00082	0.602
CLV_PCSK_KEX2_1	683	685	PF00082	0.392
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.522
CLV_PCSK_PC1ET2_1	318	320	PF00082	0.447
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.575
CLV_PCSK_PC1ET2_1	683	685	PF00082	0.392
CLV_PCSK_SKI1_1	318	322	PF00082	0.374
CLV_PCSK_SKI1_1	39	43	PF00082	0.567
CLV_PCSK_SKI1_1	548	552	PF00082	0.231
CLV_PCSK_SKI1_1	577	581	PF00082	0.350
CLV_PCSK_SKI1_1	93	97	PF00082	0.403
DEG_APCC_DBOX_1	137	145	PF00400	0.413
DEG_APCC_DBOX_1	618	626	PF00400	0.344
DEG_SPOP_SBC_1	327	331	PF00917	0.696
DEG_SPOP_SBC_1	387	391	PF00917	0.590
DEG_SPOP_SBC_1	505	509	PF00917	0.487
DOC_ANK_TNKS_1	431	438	PF00023	0.503
DOC_CYCLIN_yCln2_LP_2	583	589	PF00134	0.467
DOC_MAPK_DCC_7	680	690	PF00069	0.402
DOC_MAPK_gen_1	199	207	PF00069	0.488
DOC_MAPK_gen_1	47	53	PF00069	0.426
DOC_MAPK_gen_1	577	584	PF00069	0.482
DOC_MAPK_gen_1	669	678	PF00069	0.409
DOC_MAPK_gen_1	680	690	PF00069	0.538
DOC_MAPK_MEF2A_6	133	141	PF00069	0.505
DOC_MAPK_MEF2A_6	459	467	PF00069	0.498
DOC_MAPK_MEF2A_6	683	692	PF00069	0.496
DOC_PP2B_LxvP_1	420	423	PF13499	0.548
DOC_PP4_FxxP_1	163	166	PF00568	0.440
DOC_USP7_MATH_1	117	121	PF00917	0.610
DOC_USP7_MATH_1	148	152	PF00917	0.418
DOC_USP7_MATH_1	170	174	PF00917	0.352
DOC_USP7_MATH_1	379	383	PF00917	0.701
DOC_USP7_MATH_1	407	411	PF00917	0.414
DOC_USP7_MATH_1	480	484	PF00917	0.677
DOC_USP7_MATH_1	486	490	PF00917	0.795
DOC_USP7_MATH_1	503	507	PF00917	0.570
DOC_USP7_MATH_1	512	516	PF00917	0.534
DOC_USP7_MATH_1	534	538	PF00917	0.502
DOC_USP7_MATH_1	8	12	PF00917	0.623
DOC_WW_Pin1_4	235	240	PF00397	0.535
DOC_WW_Pin1_4	352	357	PF00397	0.671
DOC_WW_Pin1_4	388	393	PF00397	0.646
DOC_WW_Pin1_4	501	506	PF00397	0.684
DOC_WW_Pin1_4	85	90	PF00397	0.539
LIG_14-3-3_CanoR_1	108	118	PF00244	0.678
LIG_14-3-3_CanoR_1	260	264	PF00244	0.456
LIG_14-3-3_CanoR_1	290	294	PF00244	0.385
LIG_14-3-3_CanoR_1	432	436	PF00244	0.616
LIG_14-3-3_CanoR_1	577	585	PF00244	0.340
LIG_14-3-3_CanoR_1	669	678	PF00244	0.420
LIG_14-3-3_CanoR_1	80	89	PF00244	0.542
LIG_14-3-3_CanoR_1	93	99	PF00244	0.607
LIG_Actin_WH2_2	510	528	PF00022	0.454
LIG_BIR_II_1	1	5	PF00653	0.600
LIG_Clathr_ClatBox_1	182	186	PF01394	0.407
LIG_CSL_BTD_1	156	159	PF09270	0.469
LIG_EVH1_2	31	35	PF00568	0.444
LIG_FHA_1	578	584	PF00498	0.488
LIG_FHA_1	687	693	PF00498	0.510
LIG_FHA_1	81	87	PF00498	0.652
LIG_FHA_2	110	116	PF00498	0.611
LIG_FHA_2	125	131	PF00498	0.448
LIG_FHA_2	312	318	PF00498	0.376
LIG_FHA_2	569	575	PF00498	0.712
LIG_LIR_Gen_1	535	546	PF02991	0.559
LIG_LIR_Gen_1	641	649	PF02991	0.543
LIG_LIR_Gen_1	673	681	PF02991	0.325
LIG_LIR_LC3C_4	243	247	PF02991	0.343
LIG_LIR_Nem_3	519	525	PF02991	0.469
LIG_LIR_Nem_3	535	541	PF02991	0.476
LIG_LIR_Nem_3	632	636	PF02991	0.484
LIG_LIR_Nem_3	641	646	PF02991	0.535
LIG_LIR_Nem_3	664	670	PF02991	0.470
LIG_LIR_Nem_3	673	678	PF02991	0.326
LIG_MAD2	203	211	PF02301	0.448
LIG_NRBOX	621	627	PF00104	0.341
LIG_Pex14_1	667	671	PF04695	0.423
LIG_Pex14_2	163	167	PF04695	0.385
LIG_Pex14_2	671	675	PF04695	0.362
LIG_PTB_Apo_2	171	178	PF02174	0.397
LIG_SH2_CRK	522	526	PF00017	0.434
LIG_SH2_CRK	538	542	PF00017	0.434
LIG_SH2_CRK	633	637	PF00017	0.509
LIG_SH2_PTP2	50	53	PF00017	0.361
LIG_SH2_SRC	643	646	PF00017	0.532
LIG_SH2_STAP1	589	593	PF00017	0.620
LIG_SH2_STAT5	50	53	PF00017	0.348
LIG_SH2_STAT5	540	543	PF00017	0.514
LIG_SH2_STAT5	545	548	PF00017	0.511
LIG_SH2_STAT5	645	648	PF00017	0.682
LIG_SH2_STAT5	677	680	PF00017	0.454
LIG_SH3_3	233	239	PF00018	0.710
LIG_SH3_3	358	364	PF00018	0.547
LIG_SH3_3	389	395	PF00018	0.642
LIG_SH3_3	579	585	PF00018	0.503
LIG_Sin3_3	579	586	PF02671	0.341
LIG_SUMO_SIM_par_1	687	693	PF11976	0.510
LIG_TRAF2_1	88	91	PF00917	0.609
LIG_UBA3_1	510	516	PF00899	0.391
MOD_CDC14_SPxK_1	391	394	PF00782	0.477
MOD_CDK_SPxK_1	388	394	PF00069	0.479
MOD_CK1_1	111	117	PF00069	0.715
MOD_CK1_1	235	241	PF00069	0.539
MOD_CK1_1	292	298	PF00069	0.533
MOD_CK1_1	349	355	PF00069	0.678
MOD_CK1_1	440	446	PF00069	0.627
MOD_CK1_1	481	487	PF00069	0.615
MOD_CK1_1	504	510	PF00069	0.638
MOD_CK1_1	603	609	PF00069	0.459
MOD_CK2_1	311	317	PF00069	0.372
MOD_CK2_1	471	477	PF00069	0.711
MOD_CK2_1	487	493	PF00069	0.558
MOD_CK2_1	568	574	PF00069	0.556
MOD_CK2_1	652	658	PF00069	0.578
MOD_CK2_1	85	91	PF00069	0.624
MOD_Cter_Amidation	121	124	PF01082	0.514
MOD_GlcNHglycan	17	20	PF01048	0.565
MOD_GlcNHglycan	294	297	PF01048	0.485
MOD_GlcNHglycan	304	307	PF01048	0.423
MOD_GlcNHglycan	340	343	PF01048	0.732
MOD_GlcNHglycan	433	436	PF01048	0.739
MOD_GlcNHglycan	439	442	PF01048	0.705
MOD_GlcNHglycan	480	483	PF01048	0.691
MOD_GlcNHglycan	493	496	PF01048	0.658
MOD_GlcNHglycan	654	657	PF01048	0.681
MOD_GSK3_1	104	111	PF00069	0.626
MOD_GSK3_1	327	334	PF00069	0.625
MOD_GSK3_1	352	359	PF00069	0.623
MOD_GSK3_1	386	393	PF00069	0.687
MOD_GSK3_1	407	414	PF00069	0.393
MOD_GSK3_1	427	434	PF00069	0.461
MOD_GSK3_1	435	442	PF00069	0.731
MOD_GSK3_1	487	494	PF00069	0.804
MOD_GSK3_1	501	508	PF00069	0.635
MOD_GSK3_1	532	539	PF00069	0.291
MOD_GSK3_1	81	88	PF00069	0.664
MOD_GSK3_1	94	101	PF00069	0.619
MOD_N-GLC_1	325	330	PF02516	0.497
MOD_NEK2_1	256	261	PF00069	0.494
MOD_NEK2_1	300	305	PF00069	0.539
MOD_NEK2_1	487	492	PF00069	0.658
MOD_NEK2_1	671	676	PF00069	0.317
MOD_NEK2_1	81	86	PF00069	0.613
MOD_NEK2_1	94	99	PF00069	0.505
MOD_NEK2_2	444	449	PF00069	0.580
MOD_PIKK_1	117	123	PF00454	0.660
MOD_PIKK_1	272	278	PF00454	0.546
MOD_PIKK_1	379	385	PF00454	0.544
MOD_PIKK_1	471	477	PF00454	0.704
MOD_PIKK_1	481	487	PF00454	0.677
MOD_PKA_1	124	130	PF00069	0.467
MOD_PKA_1	577	583	PF00069	0.393
MOD_PKA_2	107	113	PF00069	0.654
MOD_PKA_2	124	130	PF00069	0.620
MOD_PKA_2	259	265	PF00069	0.509
MOD_PKA_2	289	295	PF00069	0.368
MOD_PKA_2	431	437	PF00069	0.533
MOD_PKA_2	568	574	PF00069	0.556
MOD_PKA_2	577	583	PF00069	0.355
MOD_PKA_2	671	677	PF00069	0.390
MOD_PKB_1	336	344	PF00069	0.678
MOD_Plk_1	249	255	PF00069	0.415
MOD_Plk_1	603	609	PF00069	0.484
MOD_Plk_1	686	692	PF00069	0.486
MOD_Plk_4	178	184	PF00069	0.468
MOD_Plk_4	356	362	PF00069	0.434
MOD_Plk_4	506	512	PF00069	0.537
MOD_Plk_4	527	533	PF00069	0.311
MOD_Plk_4	536	542	PF00069	0.311
MOD_Plk_4	671	677	PF00069	0.481
MOD_Plk_4	82	88	PF00069	0.592
MOD_ProDKin_1	235	241	PF00069	0.527
MOD_ProDKin_1	352	358	PF00069	0.652
MOD_ProDKin_1	388	394	PF00069	0.645
MOD_ProDKin_1	501	507	PF00069	0.680
MOD_ProDKin_1	85	91	PF00069	0.536
MOD_SUMO_rev_2	588	598	PF00179	0.514
TRG_DiLeu_BaLyEn_6	316	321	PF01217	0.316
TRG_DiLeu_BaLyEn_6	394	399	PF01217	0.426
TRG_DiLeu_BaLyEn_6	621	626	PF01217	0.520
TRG_ENDOCYTIC_2	50	53	PF00928	0.367
TRG_ENDOCYTIC_2	522	525	PF00928	0.270
TRG_ENDOCYTIC_2	538	541	PF00928	0.270
TRG_ENDOCYTIC_2	633	636	PF00928	0.477
TRG_ENDOCYTIC_2	643	646	PF00928	0.525
TRG_ER_diArg_1	336	339	PF00400	0.642
TRG_ER_diArg_1	46	49	PF00400	0.488
TRG_ER_diArg_1	547	549	PF00400	0.351
TRG_NLS_Bipartite_1	318	339	PF00514	0.586
TRG_NLS_MonoExtC_3	334	339	PF00514	0.575
TRG_Pf-PMV_PEXEL_1	319	324	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	402	406	PF00026	0.340

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5B6	Leptomonas seymouri	44%	100%
A0A1X0P1I1	Trypanosomatidae	30%	100%
A0A422NNK7	Trypanosoma rangeli	32%	100%
A4HHJ9	Leishmania braziliensis	69%	100%
C9ZLE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AE62	Leishmania major	90%	100%
E9ALM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5DCM2	Trypanosoma cruzi	30%	100%