Nodulin-like/Major Facilitator Superfamily, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

major facilitator superfamily, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X2K5_LEIDO

TriTrypDb:

LdBPK_291610.1 , LdCL_290021900 , LDHU3_29.2360

Length:

586

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 36

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 114
NetGPI	no	yes: 0, no: 114

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	108
GO:0110165	cellular anatomical entity	1	108
GO:0005737	cytoplasm	2	3

Expansion

Sequence features

A0A3S7X2K5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2K5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	52
GO:0022857	transmembrane transporter activity	2	52

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	146	148	PF00675	0.260
CLV_NRD_NRD_1	547	549	PF00675	0.355
CLV_NRD_NRD_1	566	568	PF00675	0.374
CLV_NRD_NRD_1	97	99	PF00675	0.568
CLV_PCSK_FUR_1	545	549	PF00082	0.260
CLV_PCSK_KEX2_1	145	147	PF00082	0.253
CLV_PCSK_KEX2_1	246	248	PF00082	0.574
CLV_PCSK_KEX2_1	329	331	PF00082	0.344
CLV_PCSK_KEX2_1	547	549	PF00082	0.366
CLV_PCSK_KEX2_1	566	568	PF00082	0.368
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.410
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.383
CLV_PCSK_SKI1_1	146	150	PF00082	0.325
CLV_PCSK_SKI1_1	246	250	PF00082	0.618
CLV_PCSK_SKI1_1	458	462	PF00082	0.289
CLV_PCSK_SKI1_1	494	498	PF00082	0.566
CLV_PCSK_SKI1_1	548	552	PF00082	0.405
CLV_PCSK_SKI1_1	79	83	PF00082	0.375
DEG_Nend_Nbox_1	1	3	PF02207	0.455
DOC_CYCLIN_RxL_1	455	464	PF00134	0.396
DOC_MAPK_DCC_7	35	43	PF00069	0.181
DOC_MAPK_gen_1	135	144	PF00069	0.466
DOC_MAPK_gen_1	329	335	PF00069	0.491
DOC_MAPK_MEF2A_6	194	203	PF00069	0.294
DOC_MAPK_MEF2A_6	35	43	PF00069	0.318
DOC_PP2B_LxvP_1	426	429	PF13499	0.409
DOC_PP2B_PxIxI_1	404	410	PF00149	0.388
DOC_USP7_MATH_1	187	191	PF00917	0.306
DOC_USP7_MATH_1	351	355	PF00917	0.510
DOC_USP7_MATH_1	412	416	PF00917	0.382
DOC_USP7_MATH_1	429	433	PF00917	0.371
DOC_USP7_UBL2_3	223	227	PF12436	0.735
DOC_USP7_UBL2_3	277	281	PF12436	0.599
DOC_USP7_UBL2_3	365	369	PF12436	0.265
DOC_USP7_UBL2_3	463	467	PF12436	0.498
DOC_WW_Pin1_4	506	511	PF00397	0.446
LIG_14-3-3_CanoR_1	145	154	PF00244	0.490
LIG_14-3-3_CanoR_1	194	200	PF00244	0.345
LIG_14-3-3_CanoR_1	310	320	PF00244	0.646
LIG_14-3-3_CanoR_1	386	390	PF00244	0.291
LIG_14-3-3_CanoR_1	98	106	PF00244	0.360
LIG_AP2alpha_1	440	444	PF02296	0.198
LIG_deltaCOP1_diTrp_1	332	338	PF00928	0.505
LIG_EH1_1	105	113	PF00400	0.444
LIG_FHA_1	115	121	PF00498	0.383
LIG_FHA_1	196	202	PF00498	0.374
LIG_FHA_1	38	44	PF00498	0.319
LIG_FHA_1	401	407	PF00498	0.584
LIG_FHA_1	532	538	PF00498	0.394
LIG_FHA_1	55	61	PF00498	0.320
LIG_FHA_2	250	256	PF00498	0.749
LIG_GBD_Chelix_1	202	210	PF00786	0.349
LIG_LIR_Apic_2	4	8	PF02991	0.469
LIG_LIR_Gen_1	101	112	PF02991	0.299
LIG_LIR_Gen_1	175	184	PF02991	0.358
LIG_LIR_Gen_1	322	333	PF02991	0.511
LIG_LIR_Gen_1	372	381	PF02991	0.313
LIG_LIR_Gen_1	539	549	PF02991	0.360
LIG_LIR_Nem_3	101	107	PF02991	0.268
LIG_LIR_Nem_3	161	167	PF02991	0.511
LIG_LIR_Nem_3	175	179	PF02991	0.311
LIG_LIR_Nem_3	322	328	PF02991	0.520
LIG_LIR_Nem_3	372	377	PF02991	0.339
LIG_LIR_Nem_3	539	544	PF02991	0.332
LIG_LIR_Nem_3	80	84	PF02991	0.351
LIG_LYPXL_yS_3	157	160	PF13949	0.388
LIG_NRBOX	421	427	PF00104	0.403
LIG_Pex14_2	163	167	PF04695	0.337
LIG_Pex14_2	440	444	PF04695	0.351
LIG_PTB_Apo_2	360	367	PF02174	0.342
LIG_PTB_Apo_2	90	97	PF02174	0.314
LIG_PTB_Phospho_1	360	366	PF10480	0.394
LIG_REV1ctd_RIR_1	94	103	PF16727	0.288
LIG_SH2_CRK	186	190	PF00017	0.317
LIG_SH2_CRK	26	30	PF00017	0.275
LIG_SH2_CRK	358	362	PF00017	0.303
LIG_SH2_CRK	374	378	PF00017	0.368
LIG_SH2_CRK	5	9	PF00017	0.457
LIG_SH2_GRB2like	186	189	PF00017	0.354
LIG_SH2_NCK_1	186	190	PF00017	0.316
LIG_SH2_SRC	186	189	PF00017	0.363
LIG_SH2_STAP1	374	378	PF00017	0.364
LIG_SH2_STAP1	492	496	PF00017	0.309
LIG_SH2_STAT3	153	156	PF00017	0.450
LIG_SH2_STAT3	492	495	PF00017	0.364
LIG_SH2_STAT5	153	156	PF00017	0.463
LIG_SH2_STAT5	164	167	PF00017	0.323
LIG_SH2_STAT5	176	179	PF00017	0.315
LIG_SH2_STAT5	267	270	PF00017	0.546
LIG_SH2_STAT5	473	476	PF00017	0.380
LIG_SH3_1	227	233	PF00018	0.685
LIG_SH3_3	227	233	PF00018	0.669
LIG_SH3_3	245	251	PF00018	0.597
LIG_SH3_3	507	513	PF00018	0.365
LIG_SUMO_SIM_anti_2	117	122	PF11976	0.381
LIG_SUMO_SIM_anti_2	198	204	PF11976	0.308
LIG_SUMO_SIM_anti_2	87	93	PF11976	0.439
LIG_SUMO_SIM_par_1	169	175	PF11976	0.299
LIG_SUMO_SIM_par_1	375	382	PF11976	0.335
LIG_TRAF2_1	252	255	PF00917	0.755
LIG_TYR_ITIM	174	179	PF00017	0.353
LIG_TYR_ITIM	24	29	PF00017	0.289
LIG_TYR_ITSM	370	377	PF00017	0.348
LIG_UBA3_1	425	433	PF00899	0.392
LIG_WRC_WIRS_1	179	184	PF05994	0.385
LIG_WRC_WIRS_1	237	242	PF05994	0.490
LIG_WRC_WIRS_1	441	446	PF05994	0.397
LIG_WRC_WIRS_1	78	83	PF05994	0.379
MOD_CK1_1	283	289	PF00069	0.750
MOD_CK1_1	37	43	PF00069	0.337
MOD_CK1_1	379	385	PF00069	0.345
MOD_CK1_1	54	60	PF00069	0.355
MOD_CK2_1	249	255	PF00069	0.635
MOD_CK2_1	282	288	PF00069	0.779
MOD_CMANNOS	334	337	PF00535	0.361
MOD_Cter_Amidation	278	281	PF01082	0.503
MOD_Cter_Amidation	516	519	PF01082	0.474
MOD_GlcNHglycan	191	194	PF01048	0.382
MOD_GlcNHglycan	353	356	PF01048	0.371
MOD_GlcNHglycan	374	377	PF01048	0.329
MOD_GlcNHglycan	381	384	PF01048	0.320
MOD_GSK3_1	13	20	PF00069	0.381
MOD_GSK3_1	279	286	PF00069	0.723
MOD_GSK3_1	320	327	PF00069	0.449
MOD_GSK3_1	372	379	PF00069	0.368
MOD_GSK3_1	446	453	PF00069	0.356
MOD_GSK3_1	50	57	PF00069	0.351
MOD_GSK3_1	63	70	PF00069	0.327
MOD_N-GLC_1	531	536	PF02516	0.296
MOD_N-GLC_1	92	97	PF02516	0.343
MOD_NEK2_1	17	22	PF00069	0.273
MOD_NEK2_1	195	200	PF00069	0.285
MOD_NEK2_1	324	329	PF00069	0.395
MOD_NEK2_1	440	445	PF00069	0.357
MOD_NEK2_1	50	55	PF00069	0.343
MOD_NEK2_1	84	89	PF00069	0.382
MOD_PIKK_1	152	158	PF00454	0.353
MOD_PKA_1	146	152	PF00069	0.414
MOD_PKA_1	280	286	PF00069	0.482
MOD_PKA_2	146	152	PF00069	0.326
MOD_PKA_2	385	391	PF00069	0.313
MOD_PKA_2	97	103	PF00069	0.429
MOD_Plk_1	133	139	PF00069	0.430
MOD_Plk_1	531	537	PF00069	0.312
MOD_Plk_1	92	98	PF00069	0.374
MOD_Plk_2-3	236	242	PF00069	0.694
MOD_Plk_4	13	19	PF00069	0.293
MOD_Plk_4	172	178	PF00069	0.326
MOD_Plk_4	195	201	PF00069	0.369
MOD_Plk_4	320	326	PF00069	0.419
MOD_Plk_4	369	375	PF00069	0.290
MOD_Plk_4	537	543	PF00069	0.277
MOD_Plk_4	56	62	PF00069	0.327
MOD_Plk_4	84	90	PF00069	0.373
MOD_Plk_4	92	98	PF00069	0.380
MOD_ProDKin_1	506	512	PF00069	0.564
MOD_SUMO_rev_2	239	248	PF00179	0.693
MOD_SUMO_rev_2	304	309	PF00179	0.572
MOD_SUMO_rev_2	362	370	PF00179	0.478
TRG_DiLeu_BaLyEn_6	7	12	PF01217	0.376
TRG_ENDOCYTIC_2	104	107	PF00928	0.282
TRG_ENDOCYTIC_2	128	131	PF00928	0.358
TRG_ENDOCYTIC_2	157	160	PF00928	0.393
TRG_ENDOCYTIC_2	164	167	PF00928	0.357
TRG_ENDOCYTIC_2	176	179	PF00928	0.294
TRG_ENDOCYTIC_2	26	29	PF00928	0.399
TRG_ENDOCYTIC_2	358	361	PF00928	0.365
TRG_ENDOCYTIC_2	374	377	PF00928	0.309
TRG_ENDOCYTIC_2	469	472	PF00928	0.324
TRG_ENDOCYTIC_2	488	491	PF00928	0.429
TRG_ENDOCYTIC_2	546	549	PF00928	0.397
TRG_ENDOCYTIC_2	94	97	PF00928	0.344
TRG_ER_diArg_1	144	147	PF00400	0.340
TRG_ER_diArg_1	546	548	PF00400	0.450
TRG_ER_diArg_1	566	568	PF00400	0.446
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	566	570	PF00026	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G0	Leptomonas seymouri	28%	92%
A0A0N1HZC2	Leptomonas seymouri	30%	93%
A0A0N1IKC5	Leptomonas seymouri	31%	96%
A0A0N1PAX2	Leptomonas seymouri	25%	100%
A0A0N1PB63	Leptomonas seymouri	26%	89%
A0A0N1PD04	Leptomonas seymouri	25%	91%
A0A0N1PFR4	Leptomonas seymouri	33%	89%
A0A1X0NKK0	Trypanosomatidae	30%	97%
A0A1X0NM09	Trypanosomatidae	29%	96%
A0A1X0NRW5	Trypanosomatidae	26%	84%
A0A1X0NV13	Trypanosomatidae	31%	90%
A0A1X0NV19	Trypanosomatidae	33%	98%
A0A1X0NV27	Trypanosomatidae	32%	98%
A0A1X0NVF9	Trypanosomatidae	23%	88%
A0A1X0NVH8	Trypanosomatidae	29%	89%
A0A1X0NVM7	Trypanosomatidae	29%	91%
A0A1X0NWQ1	Trypanosomatidae	33%	91%
A0A1X0NZE6	Trypanosomatidae	29%	98%
A0A1X0NZU2	Trypanosomatidae	32%	91%
A0A1X0NZU5	Trypanosomatidae	54%	100%
A0A1X0NZW1	Trypanosomatidae	31%	97%
A0A1X0P0M7	Trypanosomatidae	28%	99%
A0A381MMW5	Leishmania infantum	97%	100%
A0A3Q8IEC4	Leishmania donovani	97%	100%
A0A3Q8IF95	Leishmania donovani	28%	100%
A0A3Q8IIT5	Leishmania donovani	31%	100%
A0A3Q8ISY9	Leishmania donovani	28%	100%
A0A3R7JPZ0	Trypanosoma rangeli	28%	100%
A0A3R7JSQ9	Trypanosoma rangeli	30%	100%
A0A3R7KKN8	Trypanosoma rangeli	32%	98%
A0A3R7MAQ7	Trypanosoma rangeli	27%	83%
A0A3R7N3S6	Trypanosoma rangeli	25%	91%
A0A3R7N415	Trypanosoma rangeli	31%	98%
A0A3R7N921	Trypanosoma rangeli	28%	100%
A0A3R7R443	Trypanosoma rangeli	31%	98%
A0A3R7R6N6	Trypanosoma rangeli	28%	100%
A0A3S7WRJ4	Leishmania donovani	30%	100%
A0A3S7WRJ5	Leishmania donovani	32%	100%
A0A3S7WRS3	Leishmania donovani	25%	100%
A0A3S7WSR4	Leishmania donovani	30%	100%
A0A3S7WWU1	Leishmania donovani	26%	100%
A0A3S7X2G0	Leishmania donovani	98%	100%
A0A3S7XB11	Leishmania donovani	29%	97%
A0A422MSE4	Trypanosoma rangeli	33%	100%
A0A422MSP6	Trypanosoma rangeli	49%	100%
A0A422MST9	Trypanosoma rangeli	29%	98%
A0A422MU68	Trypanosoma rangeli	29%	100%
A4H6J0	Leishmania braziliensis	30%	100%
A4H6J1	Leishmania braziliensis	33%	100%
A4H6Q5	Leishmania braziliensis	27%	100%
A4HC19	Leishmania braziliensis	26%	100%
A4HHG2	Leishmania braziliensis	30%	100%
A4HHG3	Leishmania braziliensis	80%	100%
A4HHG4	Leishmania braziliensis	76%	100%
A4HJW3	Leishmania braziliensis	28%	100%
A4HPE2	Leishmania braziliensis	29%	100%
A4HUX5	Leishmania infantum	30%	100%
A4HUX6	Leishmania infantum	32%	100%
A4HV40	Leishmania infantum	25%	100%
A4HZF5	Leishmania infantum	28%	100%
A4HZJ4	Leishmania infantum	25%	100%
A4I4L2	Leishmania infantum	31%	100%
A4I7C5	Leishmania infantum	27%	100%
A4ICI3	Leishmania infantum	29%	100%
C9ZL97	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	98%
C9ZL98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZL99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	98%
C9ZLA0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZLA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	98%
C9ZTR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	98%
C9ZTR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	97%
C9ZTR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZTR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	98%
C9ZTR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
C9ZTS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	98%
C9ZUT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	99%
D0A7B1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	91%
D0A7H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0AAQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	86%
E8NHE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9AE01	Leishmania major	89%	100%
E9AE09	Leishmania major	30%	100%
E9AE10	Leishmania major	30%	100%
E9AE11	Leishmania major	94%	100%
E9AGK5	Leishmania infantum	30%	100%
E9AHJ0	Leishmania infantum	97%	100%
E9AHJ1	Leishmania infantum	100%	100%
E9ALS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9ALS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9ANL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9ANL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9ANS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9APJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AT53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AVF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AVF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B2B8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
Q4Q1E4	Leishmania major	28%	100%
Q4Q5T8	Leishmania major	27%	100%
Q4QC27	Leishmania major	25%	100%
Q4QC28	Leishmania major	26%	100%
Q4QFY5	Leishmania major	30%	100%
Q4QGU8	Leishmania major	26%	100%
Q4QH14	Leishmania major	31%	100%
Q4QH15	Leishmania major	30%	100%
V5B647	Trypanosoma cruzi	31%	93%
V5B983	Trypanosoma cruzi	46%	100%
V5BBB1	Trypanosoma cruzi	29%	99%
V5BFV8	Trypanosoma cruzi	32%	87%
V5BQY6	Trypanosoma cruzi	30%	83%
V5BVP0	Trypanosoma cruzi	30%	99%
V5BWJ7	Trypanosoma cruzi	22%	100%
V5DT25	Trypanosoma cruzi	30%	95%