Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X2K3_LEIDO

TriTrypDb:

LdBPK_292030.1 , LdCL_290026200 , LDHU3_29.2900

Length:

459

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X2K3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2K3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.599
CLV_C14_Caspase3-7	336	340	PF00656	0.704
CLV_NRD_NRD_1	207	209	PF00675	0.480
CLV_NRD_NRD_1	322	324	PF00675	0.707
CLV_NRD_NRD_1	367	369	PF00675	0.412
CLV_NRD_NRD_1	377	379	PF00675	0.427
CLV_NRD_NRD_1	436	438	PF00675	0.540
CLV_NRD_NRD_1	70	72	PF00675	0.566
CLV_PCSK_FUR_1	375	379	PF00082	0.512
CLV_PCSK_KEX2_1	207	209	PF00082	0.491
CLV_PCSK_KEX2_1	215	217	PF00082	0.428
CLV_PCSK_KEX2_1	324	326	PF00082	0.770
CLV_PCSK_KEX2_1	367	369	PF00082	0.412
CLV_PCSK_KEX2_1	377	379	PF00082	0.425
CLV_PCSK_KEX2_1	70	72	PF00082	0.529
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.470
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.770
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.547
CLV_PCSK_PC7_1	375	381	PF00082	0.520
CLV_PCSK_PC7_1	66	72	PF00082	0.557
CLV_PCSK_SKI1_1	175	179	PF00082	0.409
CLV_PCSK_SKI1_1	216	220	PF00082	0.552
CLV_PCSK_SKI1_1	360	364	PF00082	0.559
CLV_PCSK_SKI1_1	371	375	PF00082	0.493
CLV_PCSK_SKI1_1	402	406	PF00082	0.526
CLV_PCSK_SKI1_1	70	74	PF00082	0.480
CLV_Separin_Metazoa	372	376	PF03568	0.541
DOC_CYCLIN_RxL_1	10	24	PF00134	0.377
DOC_CYCLIN_yCln2_LP_2	178	184	PF00134	0.414
DOC_MAPK_gen_1	173	180	PF00069	0.475
DOC_MAPK_gen_1	95	101	PF00069	0.771
DOC_PP1_RVXF_1	14	21	PF00149	0.382
DOC_PP2B_LxvP_1	178	181	PF13499	0.481
DOC_PP4_FxxP_1	259	262	PF00568	0.521
DOC_PP4_FxxP_1	41	44	PF00568	0.517
DOC_USP7_MATH_1	135	139	PF00917	0.655
DOC_USP7_MATH_1	270	274	PF00917	0.651
DOC_USP7_MATH_1	91	95	PF00917	0.695
DOC_USP7_UBL2_3	401	405	PF12436	0.572
DOC_WW_Pin1_4	101	106	PF00397	0.734
DOC_WW_Pin1_4	188	193	PF00397	0.525
LIG_14-3-3_CanoR_1	325	333	PF00244	0.804
LIG_14-3-3_CanoR_1	378	386	PF00244	0.496
LIG_Actin_WH2_2	159	177	PF00022	0.483
LIG_BIR_II_1	1	5	PF00653	0.582
LIG_deltaCOP1_diTrp_1	283	289	PF00928	0.550
LIG_FHA_1	53	59	PF00498	0.427
LIG_FHA_2	324	330	PF00498	0.730
LIG_FHA_2	385	391	PF00498	0.447
LIG_FHA_2	394	400	PF00498	0.422
LIG_FHA_2	410	416	PF00498	0.585
LIG_HCF-1_HBM_1	392	395	PF13415	0.540
LIG_LIR_Apic_2	256	262	PF02991	0.507
LIG_LIR_Apic_2	40	44	PF02991	0.520
LIG_LIR_Gen_1	283	289	PF02991	0.479
LIG_LIR_Nem_3	283	287	PF02991	0.476
LIG_Pex14_2	193	197	PF04695	0.391
LIG_PTB_Apo_2	226	233	PF02174	0.605
LIG_SH2_NCK_1	395	399	PF00017	0.565
LIG_SH2_STAP1	158	162	PF00017	0.529
LIG_SH2_STAT5	361	364	PF00017	0.502
LIG_SH2_STAT5	395	398	PF00017	0.466
LIG_SH3_3	146	152	PF00018	0.430
LIG_SH3_3	178	184	PF00018	0.556
LIG_SH3_3	254	260	PF00018	0.393
LIG_TRAF2_1	109	112	PF00917	0.691
LIG_WRC_WIRS_1	286	291	PF05994	0.557
MOD_CK1_1	309	315	PF00069	0.721
MOD_CK1_1	382	388	PF00069	0.599
MOD_CK1_1	414	420	PF00069	0.536
MOD_CK2_1	118	124	PF00069	0.767
MOD_CK2_1	316	322	PF00069	0.738
MOD_CK2_1	382	388	PF00069	0.458
MOD_CK2_1	393	399	PF00069	0.411
MOD_CK2_1	409	415	PF00069	0.570
MOD_GlcNHglycan	137	140	PF01048	0.632
MOD_GlcNHglycan	268	271	PF01048	0.747
MOD_GlcNHglycan	273	276	PF01048	0.535
MOD_GlcNHglycan	303	306	PF01048	0.720
MOD_GlcNHglycan	308	311	PF01048	0.700
MOD_GlcNHglycan	313	317	PF01048	0.675
MOD_GlcNHglycan	333	336	PF01048	0.697
MOD_GSK3_1	130	137	PF00069	0.682
MOD_GSK3_1	139	146	PF00069	0.582
MOD_GSK3_1	223	230	PF00069	0.551
MOD_GSK3_1	266	273	PF00069	0.715
MOD_GSK3_1	308	315	PF00069	0.720
MOD_GSK3_1	52	59	PF00069	0.524
MOD_GSK3_1	91	98	PF00069	0.680
MOD_N-GLC_1	188	193	PF02516	0.341
MOD_N-GLC_1	228	233	PF02516	0.622
MOD_N-GLC_1	270	275	PF02516	0.730
MOD_N-GLC_1	301	306	PF02516	0.764
MOD_NEK2_1	21	26	PF00069	0.500
MOD_NEK2_1	228	233	PF00069	0.563
MOD_NEK2_1	99	104	PF00069	0.757
MOD_NEK2_2	444	449	PF00069	0.537
MOD_PIKK_1	316	322	PF00454	0.822
MOD_PKA_1	323	329	PF00069	0.796
MOD_PKA_1	379	385	PF00069	0.497
MOD_PKA_1	95	101	PF00069	0.677
MOD_PKA_2	331	337	PF00069	0.799
MOD_PKA_2	379	385	PF00069	0.482
MOD_PKA_2	433	439	PF00069	0.568
MOD_PKB_1	323	331	PF00069	0.800
MOD_Plk_1	129	135	PF00069	0.729
MOD_Plk_1	228	234	PF00069	0.612
MOD_Plk_1	382	388	PF00069	0.601
MOD_Plk_4	223	229	PF00069	0.528
MOD_Plk_4	43	49	PF00069	0.505
MOD_Plk_4	95	101	PF00069	0.713
MOD_ProDKin_1	101	107	PF00069	0.734
MOD_ProDKin_1	188	194	PF00069	0.517
MOD_SUMO_for_1	347	350	PF00179	0.509
MOD_SUMO_rev_2	212	217	PF00179	0.538
MOD_SUMO_rev_2	319	326	PF00179	0.784
TRG_DiLeu_BaEn_1	399	404	PF01217	0.522
TRG_DiLeu_BaEn_1	78	83	PF01217	0.432
TRG_DiLeu_BaEn_2	414	420	PF01217	0.613
TRG_ER_diArg_1	172	175	PF00400	0.427
TRG_ER_diArg_1	206	208	PF00400	0.490
TRG_ER_diArg_1	366	368	PF00400	0.412
TRG_ER_diArg_1	378	381	PF00400	0.483
TRG_ER_diArg_1	69	71	PF00400	0.552
TRG_ER_FFAT_1	414	425	PF00635	0.439
TRG_NLS_Bipartite_1	367	382	PF00514	0.403
TRG_NLS_MonoExtC_3	323	329	PF00514	0.748
TRG_NLS_MonoExtC_3	377	383	PF00514	0.504
TRG_NLS_MonoExtN_4	323	328	PF00514	0.806
TRG_NLS_MonoExtN_4	375	382	PF00514	0.515
TRG_Pf-PMV_PEXEL_1	360	364	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	70	75	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB34	Leptomonas seymouri	49%	88%
A0A0S4JH57	Bodo saltans	26%	86%
A0A1X0P158	Trypanosomatidae	31%	100%
A0A3R7MJJ2	Trypanosoma rangeli	31%	100%
A4HHJ1	Leishmania braziliensis	75%	100%
A4I4P9	Leishmania infantum	100%	100%
C9ZLD7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AE52	Leishmania major	92%	100%
E9ALN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BGH3	Trypanosoma cruzi	30%	100%