Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X2J5_LEIDO

TriTrypDb:

LdBPK_291540.1 , LdCL_290020900 , LDHU3_29.2240

Length:

539

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X2J5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2J5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	221	223	PF00675	0.372
CLV_NRD_NRD_1	469	471	PF00675	0.607
CLV_NRD_NRD_1	512	514	PF00675	0.573
CLV_NRD_NRD_1	520	522	PF00675	0.551
CLV_NRD_NRD_1	53	55	PF00675	0.668
CLV_PCSK_KEX2_1	138	140	PF00082	0.412
CLV_PCSK_KEX2_1	176	178	PF00082	0.541
CLV_PCSK_KEX2_1	221	223	PF00082	0.401
CLV_PCSK_KEX2_1	520	522	PF00082	0.600
CLV_PCSK_KEX2_1	53	55	PF00082	0.678
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.397
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.564
CLV_PCSK_PC7_1	516	522	PF00082	0.565
CLV_PCSK_SKI1_1	191	195	PF00082	0.554
CLV_PCSK_SKI1_1	375	379	PF00082	0.366
CLV_PCSK_SKI1_1	382	386	PF00082	0.442
CLV_PCSK_SKI1_1	521	525	PF00082	0.634
CLV_PCSK_SKI1_1	54	58	PF00082	0.564
CLV_PCSK_SKI1_1	6	10	PF00082	0.524
DEG_APCC_DBOX_1	221	229	PF00400	0.496
DEG_APCC_DBOX_1	374	382	PF00400	0.463
DEG_ODPH_VHL_1	385	397	PF01847	0.439
DEG_SCF_FBW7_1	474	479	PF00400	0.576
DOC_ANK_TNKS_1	265	272	PF00023	0.457
DOC_CKS1_1	182	187	PF01111	0.606
DOC_CKS1_1	78	83	PF01111	0.588
DOC_CYCLIN_yCln2_LP_2	78	84	PF00134	0.564
DOC_MAPK_gen_1	138	144	PF00069	0.463
DOC_MAPK_gen_1	191	199	PF00069	0.572
DOC_MAPK_gen_1	221	229	PF00069	0.441
DOC_MAPK_MEF2A_6	138	146	PF00069	0.397
DOC_MAPK_MEF2A_6	221	229	PF00069	0.441
DOC_MAPK_NFAT4_5	139	147	PF00069	0.395
DOC_MAPK_NFAT4_5	222	230	PF00069	0.443
DOC_PP1_RVXF_1	532	539	PF00149	0.570
DOC_PP2B_LxvP_1	197	200	PF13499	0.498
DOC_PP2B_LxvP_1	524	527	PF13499	0.518
DOC_USP7_MATH_1	128	132	PF00917	0.476
DOC_USP7_MATH_1	15	19	PF00917	0.511
DOC_USP7_MATH_1	365	369	PF00917	0.633
DOC_USP7_MATH_1	98	102	PF00917	0.629
DOC_WW_Pin1_4	11	16	PF00397	0.510
DOC_WW_Pin1_4	181	186	PF00397	0.580
DOC_WW_Pin1_4	238	243	PF00397	0.419
DOC_WW_Pin1_4	310	315	PF00397	0.492
DOC_WW_Pin1_4	388	393	PF00397	0.564
DOC_WW_Pin1_4	472	477	PF00397	0.547
DOC_WW_Pin1_4	527	532	PF00397	0.655
DOC_WW_Pin1_4	77	82	PF00397	0.627
DOC_WW_Pin1_4	84	89	PF00397	0.618
LIG_14-3-3_CanoR_1	16	20	PF00244	0.709
LIG_14-3-3_CanoR_1	274	283	PF00244	0.407
LIG_14-3-3_CanoR_1	367	374	PF00244	0.569
LIG_14-3-3_CanoR_1	415	423	PF00244	0.386
LIG_14-3-3_CanoR_1	425	433	PF00244	0.361
LIG_14-3-3_CanoR_1	462	469	PF00244	0.527
LIG_14-3-3_CanoR_1	53	59	PF00244	0.603
LIG_14-3-3_CanoR_1	66	73	PF00244	0.528
LIG_14-3-3_CanoR_1	99	103	PF00244	0.809
LIG_Actin_WH2_2	366	384	PF00022	0.431
LIG_AP2alpha_1	209	213	PF02296	0.482
LIG_APCC_ABBA_1	206	211	PF00400	0.526
LIG_APCC_ABBA_1	254	259	PF00400	0.375
LIG_APCC_ABBA_1	506	511	PF00400	0.508
LIG_BIR_II_1	1	5	PF00653	0.630
LIG_BIR_III_4	334	338	PF00653	0.620
LIG_deltaCOP1_diTrp_1	112	121	PF00928	0.497
LIG_deltaCOP1_diTrp_1	161	170	PF00928	0.601
LIG_EVH1_2	246	250	PF00568	0.368
LIG_EVH1_2	393	397	PF00568	0.483
LIG_EVH1_2	43	47	PF00568	0.567
LIG_FHA_1	102	108	PF00498	0.640
LIG_FHA_1	239	245	PF00498	0.360
LIG_FHA_1	284	290	PF00498	0.324
LIG_FHA_1	473	479	PF00498	0.643
LIG_FHA_1	53	59	PF00498	0.747
LIG_FHA_2	337	343	PF00498	0.605
LIG_Integrin_RGD_1	215	217	PF01839	0.485
LIG_LIR_Gen_1	112	119	PF02991	0.489
LIG_LIR_Gen_1	161	170	PF02991	0.642
LIG_LIR_Gen_1	420	431	PF02991	0.504
LIG_LIR_Nem_3	112	118	PF02991	0.488
LIG_LIR_Nem_3	161	167	PF02991	0.638
LIG_LIR_Nem_3	324	329	PF02991	0.497
LIG_LIR_Nem_3	420	426	PF02991	0.540
LIG_NRBOX	224	230	PF00104	0.439
LIG_NRP_CendR_1	537	539	PF00754	0.597
LIG_Pex14_2	209	213	PF04695	0.536
LIG_PTB_Apo_2	444	451	PF02174	0.409
LIG_PTB_Phospho_1	444	450	PF10480	0.407
LIG_SH2_GRB2like	445	448	PF00017	0.400
LIG_SH2_GRB2like	486	489	PF00017	0.534
LIG_SH2_SRC	198	201	PF00017	0.559
LIG_SH2_SRC	445	448	PF00017	0.442
LIG_SH2_STAT5	174	177	PF00017	0.627
LIG_SH2_STAT5	198	201	PF00017	0.497
LIG_SH2_STAT5	231	234	PF00017	0.567
LIG_SH2_STAT5	405	408	PF00017	0.446
LIG_SH2_STAT5	429	432	PF00017	0.451
LIG_SH2_STAT5	435	438	PF00017	0.439
LIG_SH2_STAT5	445	448	PF00017	0.499
LIG_SH2_STAT5	486	489	PF00017	0.649
LIG_SH3_1	525	531	PF00018	0.550
LIG_SH3_3	179	185	PF00018	0.674
LIG_SH3_3	196	202	PF00018	0.396
LIG_SH3_3	241	247	PF00018	0.355
LIG_SH3_3	37	43	PF00018	0.527
LIG_SH3_3	525	531	PF00018	0.578
LIG_SH3_3	78	84	PF00018	0.602
LIG_SH3_3	92	98	PF00018	0.761
LIG_SH3_CIN85_PxpxPR_1	94	99	PF14604	0.594
LIG_SUMO_SIM_anti_2	315	322	PF11976	0.408
LIG_SUMO_SIM_par_1	315	322	PF11976	0.408
LIG_TRAF2_1	322	325	PF00917	0.472
LIG_UBA3_1	227	233	PF00899	0.424
MOD_CDK_SPK_2	11	16	PF00069	0.510
MOD_CDK_SPK_2	86	91	PF00069	0.644
MOD_CDK_SPxxK_3	527	534	PF00069	0.578
MOD_CDK_SPxxK_3	84	91	PF00069	0.643
MOD_CK1_1	101	107	PF00069	0.656
MOD_CK1_1	11	17	PF00069	0.510
MOD_CK1_1	172	178	PF00069	0.577
MOD_CK1_1	277	283	PF00069	0.339
MOD_CK1_1	318	324	PF00069	0.530
MOD_CK1_1	83	89	PF00069	0.823
MOD_CK2_1	110	116	PF00069	0.565
MOD_CK2_1	318	324	PF00069	0.539
MOD_CK2_1	336	342	PF00069	0.662
MOD_Cter_Amidation	136	139	PF01082	0.435
MOD_GlcNHglycan	10	13	PF01048	0.517
MOD_GlcNHglycan	276	279	PF01048	0.368
MOD_GlcNHglycan	369	372	PF01048	0.518
MOD_GlcNHglycan	459	462	PF01048	0.614
MOD_GlcNHglycan	74	77	PF01048	0.594
MOD_GSK3_1	101	108	PF00069	0.645
MOD_GSK3_1	11	18	PF00069	0.509
MOD_GSK3_1	110	117	PF00069	0.560
MOD_GSK3_1	147	154	PF00069	0.529
MOD_GSK3_1	277	284	PF00069	0.443
MOD_GSK3_1	315	322	PF00069	0.476
MOD_GSK3_1	329	336	PF00069	0.492
MOD_GSK3_1	356	363	PF00069	0.729
MOD_GSK3_1	472	479	PF00069	0.554
MOD_GSK3_1	480	487	PF00069	0.439
MOD_GSK3_1	72	79	PF00069	0.628
MOD_GSK3_1	80	87	PF00069	0.719
MOD_N-GLC_1	496	501	PF02516	0.652
MOD_NEK2_1	169	174	PF00069	0.594
MOD_NEK2_1	496	501	PF00069	0.626
MOD_PIKK_1	277	283	PF00454	0.366
MOD_PIKK_1	462	468	PF00454	0.610
MOD_PKA_2	15	21	PF00069	0.512
MOD_PKA_2	424	430	PF00069	0.391
MOD_PKA_2	52	58	PF00069	0.624
MOD_PKA_2	98	104	PF00069	0.677
MOD_Plk_1	341	347	PF00069	0.601
MOD_Plk_4	110	116	PF00069	0.611
MOD_Plk_4	147	153	PF00069	0.534
MOD_Plk_4	15	21	PF00069	0.509
MOD_Plk_4	302	308	PF00069	0.551
MOD_ProDKin_1	11	17	PF00069	0.510
MOD_ProDKin_1	181	187	PF00069	0.579
MOD_ProDKin_1	238	244	PF00069	0.421
MOD_ProDKin_1	310	316	PF00069	0.483
MOD_ProDKin_1	388	394	PF00069	0.570
MOD_ProDKin_1	472	478	PF00069	0.546
MOD_ProDKin_1	527	533	PF00069	0.655
MOD_ProDKin_1	77	83	PF00069	0.629
MOD_ProDKin_1	84	90	PF00069	0.618
TRG_DiLeu_BaEn_1	223	228	PF01217	0.455
TRG_DiLeu_BaLyEn_6	188	193	PF01217	0.578
TRG_DiLeu_BaLyEn_6	412	417	PF01217	0.420
TRG_ENDOCYTIC_2	210	213	PF00928	0.526
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	310	315	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	415	420	PF00026	0.318
TRG_Pf-PMV_PEXEL_1	467	472	PF00026	0.641

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P950	Leptomonas seymouri	39%	96%
A0A3Q8IAB6	Leishmania donovani	26%	100%
A0A3R7KFA4	Trypanosoma rangeli	31%	100%
A4H889	Leishmania braziliensis	26%	100%
A4HHF5	Leishmania braziliensis	81%	100%
A4HWL2	Leishmania infantum	26%	100%
A4I4K3	Leishmania infantum	100%	100%
C9ZL87	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AE02	Leishmania major	94%	100%
E9ALT0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9AQB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
Q4QF55	Leishmania major	25%	100%