ATP-binding cassette protein subfamily H, member 2, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-binding cassette protein subfamily H, member 2, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X2I8_LEIDO

TriTrypDb:

LdBPK_291780.1 , LdCL_290023400 , LDHU3_29.2550

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X2I8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2I8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0009987	cellular process	1	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8
GO:0005215	transporter activity	1	1
GO:0015399	primary active transmembrane transporter activity	4	1
GO:0022804	active transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0042626	ATPase-coupled transmembrane transporter activity	2	1
GO:0140657	ATP-dependent activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.597
CLV_NRD_NRD_1	126	128	PF00675	0.351
CLV_NRD_NRD_1	288	290	PF00675	0.460
CLV_PCSK_KEX2_1	126	128	PF00082	0.351
CLV_PCSK_KEX2_1	288	290	PF00082	0.460
CLV_PCSK_SKI1_1	222	226	PF00082	0.339
CLV_PCSK_SKI1_1	320	324	PF00082	0.518
CLV_PCSK_SKI1_1	344	348	PF00082	0.501
CLV_PCSK_SKI1_1	41	45	PF00082	0.518
CLV_PCSK_SKI1_1	88	92	PF00082	0.447
DEG_APCC_DBOX_1	221	229	PF00400	0.292
DOC_CYCLIN_RxL_1	178	189	PF00134	0.266
DOC_CYCLIN_RxL_1	218	226	PF00134	0.351
DOC_CYCLIN_yCln2_LP_2	118	124	PF00134	0.492
DOC_CYCLIN_yCln2_LP_2	413	419	PF00134	0.603
DOC_MAPK_gen_1	126	133	PF00069	0.351
DOC_MAPK_gen_1	218	227	PF00069	0.294
DOC_MAPK_gen_1	288	297	PF00069	0.367
DOC_PP1_RVXF_1	179	186	PF00149	0.292
DOC_PP2B_LxvP_1	118	121	PF13499	0.545
DOC_PP2B_LxvP_1	413	416	PF13499	0.716
DOC_PP4_FxxP_1	23	26	PF00568	0.551
DOC_USP7_MATH_1	381	385	PF00917	0.620
DOC_USP7_MATH_1	402	406	PF00917	0.634
DOC_USP7_MATH_1	445	449	PF00917	0.664
DOC_USP7_MATH_1	95	99	PF00917	0.710
DOC_USP7_UBL2_3	211	215	PF12436	0.296
DOC_WW_Pin1_4	14	19	PF00397	0.623
DOC_WW_Pin1_4	27	32	PF00397	0.525
DOC_WW_Pin1_4	6	11	PF00397	0.746
LIG_14-3-3_CanoR_1	222	228	PF00244	0.388
LIG_14-3-3_CanoR_1	288	297	PF00244	0.378
LIG_14-3-3_CanoR_1	55	59	PF00244	0.428
LIG_14-3-3_CanoR_1	8	14	PF00244	0.769
LIG_BIR_II_1	1	5	PF00653	0.601
LIG_BRCT_BRCA1_1	19	23	PF00533	0.583
LIG_FHA_1	108	114	PF00498	0.683
LIG_FHA_1	140	146	PF00498	0.292
LIG_FHA_1	156	162	PF00498	0.297
LIG_FHA_1	187	193	PF00498	0.328
LIG_FHA_1	266	272	PF00498	0.382
LIG_FHA_1	274	280	PF00498	0.361
LIG_FHA_1	290	296	PF00498	0.361
LIG_FHA_1	334	340	PF00498	0.520
LIG_FHA_2	195	201	PF00498	0.292
LIG_FHA_2	31	37	PF00498	0.648
LIG_FHA_2	89	95	PF00498	0.462
LIG_Integrin_isoDGR_2	162	164	PF01839	0.335
LIG_LIR_Apic_2	20	26	PF02991	0.553
LIG_LIR_Gen_1	129	136	PF02991	0.311
LIG_LIR_Gen_1	189	198	PF02991	0.334
LIG_LIR_Gen_1	321	330	PF02991	0.481
LIG_LIR_Gen_1	347	355	PF02991	0.564
LIG_LIR_Nem_3	129	133	PF02991	0.311
LIG_LIR_Nem_3	189	193	PF02991	0.334
LIG_LIR_Nem_3	321	326	PF02991	0.482
LIG_LIR_Nem_3	333	338	PF02991	0.520
LIG_LIR_Nem_3	347	352	PF02991	0.590
LIG_LIR_Nem_3	74	78	PF02991	0.559
LIG_LYPXL_yS_3	75	78	PF13949	0.355
LIG_PTB_Apo_2	179	186	PF02174	0.313
LIG_SH2_STAP1	306	310	PF00017	0.326
LIG_SH2_STAP1	335	339	PF00017	0.446
LIG_SH2_STAT5	312	315	PF00017	0.377
LIG_SH2_STAT5	335	338	PF00017	0.439
LIG_SH3_2	121	126	PF14604	0.432
LIG_SH3_3	118	124	PF00018	0.497
LIG_SH3_3	199	205	PF00018	0.292
LIG_SH3_3	406	412	PF00018	0.585
LIG_SH3_3	437	443	PF00018	0.534
LIG_SUMO_SIM_anti_2	260	266	PF11976	0.292
LIG_SUMO_SIM_anti_2	276	281	PF11976	0.356
LIG_SUMO_SIM_par_1	260	266	PF11976	0.292
LIG_SUMO_SIM_par_1	275	281	PF11976	0.358
LIG_SUMO_SIM_par_1	80	89	PF11976	0.468
LIG_TRAF2_1	33	36	PF00917	0.620
LIG_UBA3_1	208	215	PF00899	0.351
LIG_UBA3_1	282	291	PF00899	0.427
LIG_WRC_WIRS_1	187	192	PF05994	0.292
MOD_CK1_1	150	156	PF00069	0.336
MOD_CK1_1	17	23	PF00069	0.472
MOD_CK1_1	2	8	PF00069	0.686
MOD_CK1_1	239	245	PF00069	0.292
MOD_CK1_1	30	36	PF00069	0.548
MOD_CK1_1	395	401	PF00069	0.783
MOD_CK1_1	425	431	PF00069	0.573
MOD_CK1_1	438	444	PF00069	0.545
MOD_CK1_1	51	57	PF00069	0.600
MOD_CK2_1	150	156	PF00069	0.342
MOD_CK2_1	194	200	PF00069	0.295
MOD_CK2_1	239	245	PF00069	0.331
MOD_CK2_1	30	36	PF00069	0.633
MOD_CK2_1	386	392	PF00069	0.556
MOD_CK2_1	46	52	PF00069	0.460
MOD_CK2_1	88	94	PF00069	0.443
MOD_GlcNHglycan	136	139	PF01048	0.292
MOD_GlcNHglycan	19	22	PF01048	0.605
MOD_GlcNHglycan	212	215	PF01048	0.291
MOD_GlcNHglycan	240	244	PF01048	0.292
MOD_GlcNHglycan	394	397	PF01048	0.792
MOD_GlcNHglycan	406	409	PF01048	0.599
MOD_GlcNHglycan	424	427	PF01048	0.503
MOD_GlcNHglycan	448	451	PF01048	0.561
MOD_GlcNHglycan	98	101	PF01048	0.641
MOD_GSK3_1	17	24	PF00069	0.518
MOD_GSK3_1	2	9	PF00069	0.604
MOD_GSK3_1	247	254	PF00069	0.292
MOD_GSK3_1	388	395	PF00069	0.621
MOD_GSK3_1	427	434	PF00069	0.746
MOD_GSK3_1	54	61	PF00069	0.543
MOD_GSK3_1	96	103	PF00069	0.574
MOD_N-GLC_1	27	32	PF02516	0.603
MOD_N-GLC_1	333	338	PF02516	0.490
MOD_N-GLC_1	381	386	PF02516	0.590
MOD_NEK2_1	192	197	PF00069	0.292
MOD_NEK2_1	446	451	PF00069	0.597
MOD_PIKK_1	101	107	PF00454	0.658
MOD_PIKK_1	425	431	PF00454	0.630
MOD_PKA_2	247	253	PF00069	0.292
MOD_PKA_2	287	293	PF00069	0.375
MOD_PKA_2	361	367	PF00069	0.642
MOD_PKA_2	54	60	PF00069	0.400
MOD_Plk_1	381	387	PF00069	0.534
MOD_Plk_1	46	52	PF00069	0.650
MOD_Plk_1	88	94	PF00069	0.451
MOD_Plk_4	140	146	PF00069	0.292
MOD_Plk_4	170	176	PF00069	0.404
MOD_Plk_4	204	210	PF00069	0.351
MOD_Plk_4	223	229	PF00069	0.351
MOD_Plk_4	257	263	PF00069	0.339
MOD_Plk_4	395	401	PF00069	0.600
MOD_Plk_4	54	60	PF00069	0.563
MOD_ProDKin_1	14	20	PF00069	0.621
MOD_ProDKin_1	27	33	PF00069	0.527
MOD_ProDKin_1	6	12	PF00069	0.746
MOD_SUMO_rev_2	167	173	PF00179	0.337
TRG_DiLeu_BaEn_1	278	283	PF01217	0.411
TRG_ENDOCYTIC_2	75	78	PF00928	0.355
TRG_ER_diArg_1	125	127	PF00400	0.351
TRG_ER_diArg_1	217	220	PF00400	0.292
TRG_ER_diArg_1	230	233	PF00400	0.292

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICD4	Leptomonas seymouri	76%	99%
A0A0S4J9X9	Bodo saltans	58%	100%
A4HHH8	Leishmania braziliensis	68%	96%
A4I4M8	Leishmania infantum	99%	100%
E9AE26	Leishmania major	89%	100%
E9ALQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%