LeishMANIAdb
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CPSF_A domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
CPSF_A domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X2G1_LEIDO
TriTrypDb:
LdBPK_291640.1 , LdCL_290022000 , LDHU3_29.2370
Length:
711

Annotations

LeishMANIAdb annotations

A tail-anchored beta-barrel protein family, mostly unique to Kinetoplastids

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A0A3S7X2G1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2G1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 145 149 PF00656 0.598
CLV_C14_Caspase3-7 200 204 PF00656 0.495
CLV_C14_Caspase3-7 262 266 PF00656 0.431
CLV_C14_Caspase3-7 676 680 PF00656 0.469
CLV_NRD_NRD_1 130 132 PF00675 0.433
CLV_NRD_NRD_1 151 153 PF00675 0.460
CLV_NRD_NRD_1 207 209 PF00675 0.584
CLV_NRD_NRD_1 286 288 PF00675 0.677
CLV_NRD_NRD_1 362 364 PF00675 0.642
CLV_NRD_NRD_1 441 443 PF00675 0.598
CLV_NRD_NRD_1 509 511 PF00675 0.637
CLV_NRD_NRD_1 58 60 PF00675 0.433
CLV_NRD_NRD_1 591 593 PF00675 0.662
CLV_NRD_NRD_1 709 711 PF00675 0.398
CLV_PCSK_FUR_1 359 363 PF00082 0.691
CLV_PCSK_KEX2_1 151 153 PF00082 0.460
CLV_PCSK_KEX2_1 207 209 PF00082 0.584
CLV_PCSK_KEX2_1 286 288 PF00082 0.677
CLV_PCSK_KEX2_1 361 363 PF00082 0.644
CLV_PCSK_KEX2_1 440 442 PF00082 0.610
CLV_PCSK_KEX2_1 58 60 PF00082 0.432
CLV_PCSK_KEX2_1 591 593 PF00082 0.604
CLV_PCSK_KEX2_1 709 711 PF00082 0.398
CLV_PCSK_SKI1_1 14 18 PF00082 0.459
CLV_PCSK_SKI1_1 151 155 PF00082 0.431
CLV_PCSK_SKI1_1 414 418 PF00082 0.615
CLV_PCSK_SKI1_1 441 445 PF00082 0.664
DEG_APCC_DBOX_1 150 158 PF00400 0.620
DEG_APCC_DBOX_1 206 214 PF00400 0.429
DEG_SPOP_SBC_1 197 201 PF00917 0.503
DEG_SPOP_SBC_1 326 330 PF00917 0.501
DEG_SPOP_SBC_1 485 489 PF00917 0.508
DEG_SPOP_SBC_1 654 658 PF00917 0.519
DEG_SPOP_SBC_1 87 91 PF00917 0.727
DOC_CYCLIN_RxL_1 348 357 PF00134 0.365
DOC_CYCLIN_yCln2_LP_2 409 415 PF00134 0.414
DOC_CYCLIN_yCln2_LP_2 662 668 PF00134 0.491
DOC_CYCLIN_yCln2_LP_2 694 700 PF00134 0.480
DOC_MAPK_gen_1 207 218 PF00069 0.371
DOC_MAPK_gen_1 644 652 PF00069 0.424
DOC_MAPK_MEF2A_6 58 67 PF00069 0.669
DOC_MAPK_MEF2A_6 689 698 PF00069 0.376
DOC_MAPK_RevD_3 694 710 PF00069 0.305
DOC_PP1_RVXF_1 439 446 PF00149 0.460
DOC_PP1_RVXF_1 503 509 PF00149 0.377
DOC_PP1_RVXF_1 687 693 PF00149 0.353
DOC_PP2B_LxvP_1 32 35 PF13499 0.600
DOC_PP2B_LxvP_1 409 412 PF13499 0.414
DOC_PP2B_LxvP_1 662 665 PF13499 0.432
DOC_PP2B_LxvP_1 694 697 PF13499 0.474
DOC_PP4_FxxP_1 175 178 PF00568 0.465
DOC_PP4_FxxP_1 60 63 PF00568 0.688
DOC_USP7_MATH_1 178 182 PF00917 0.540
DOC_USP7_MATH_1 188 192 PF00917 0.480
DOC_USP7_MATH_1 198 202 PF00917 0.564
DOC_USP7_MATH_1 297 301 PF00917 0.386
DOC_USP7_MATH_1 320 324 PF00917 0.464
DOC_USP7_MATH_1 326 330 PF00917 0.493
DOC_USP7_MATH_1 396 400 PF00917 0.489
DOC_USP7_MATH_1 466 470 PF00917 0.349
DOC_USP7_MATH_1 485 489 PF00917 0.476
DOC_USP7_MATH_1 520 524 PF00917 0.412
DOC_USP7_MATH_1 585 589 PF00917 0.425
DOC_USP7_MATH_1 605 609 PF00917 0.335
DOC_USP7_MATH_1 639 643 PF00917 0.566
DOC_USP7_MATH_1 87 91 PF00917 0.781
DOC_USP7_UBL2_3 223 227 PF12436 0.378
DOC_WW_Pin1_4 327 332 PF00397 0.450
DOC_WW_Pin1_4 33 38 PF00397 0.528
DOC_WW_Pin1_4 581 586 PF00397 0.453
DOC_WW_Pin1_4 6 11 PF00397 0.787
DOC_WW_Pin1_4 637 642 PF00397 0.571
DOC_WW_Pin1_4 657 662 PF00397 0.508
LIG_14-3-3_CanoR_1 290 298 PF00244 0.450
LIG_14-3-3_CanoR_1 366 375 PF00244 0.516
LIG_14-3-3_CanoR_1 440 446 PF00244 0.448
LIG_14-3-3_CanoR_1 538 544 PF00244 0.496
LIG_14-3-3_CanoR_1 632 641 PF00244 0.529
LIG_14-3-3_CanoR_1 655 661 PF00244 0.498
LIG_14-3-3_CanoR_1 70 75 PF00244 0.646
LIG_Actin_WH2_2 335 352 PF00022 0.386
LIG_Actin_WH2_2 408 423 PF00022 0.415
LIG_Actin_WH2_2 550 567 PF00022 0.433
LIG_Actin_WH2_2 674 691 PF00022 0.474
LIG_APCC_ABBA_1 524 529 PF00400 0.414
LIG_BIR_II_1 1 5 PF00653 0.779
LIG_BIR_III_2 96 100 PF00653 0.565
LIG_BRCT_BRCA1_1 659 663 PF00533 0.450
LIG_FHA_1 250 256 PF00498 0.402
LIG_FHA_1 350 356 PF00498 0.320
LIG_FHA_1 415 421 PF00498 0.397
LIG_FHA_1 548 554 PF00498 0.395
LIG_FHA_1 676 682 PF00498 0.460
LIG_FHA_2 198 204 PF00498 0.506
LIG_FHA_2 377 383 PF00498 0.578
LIG_FHA_2 401 407 PF00498 0.366
LIG_FHA_2 507 513 PF00498 0.333
LIG_HP1_1 697 701 PF01393 0.402
LIG_LIR_Apic_2 300 304 PF02991 0.367
LIG_LIR_Apic_2 625 631 PF02991 0.501
LIG_LIR_Gen_1 168 175 PF02991 0.329
LIG_LIR_Gen_1 36 46 PF02991 0.579
LIG_LIR_Gen_1 444 453 PF02991 0.471
LIG_LIR_Gen_1 493 504 PF02991 0.430
LIG_LIR_LC3C_4 340 344 PF02991 0.340
LIG_LIR_Nem_3 118 124 PF02991 0.598
LIG_LIR_Nem_3 168 172 PF02991 0.314
LIG_LIR_Nem_3 36 42 PF02991 0.577
LIG_LIR_Nem_3 444 448 PF02991 0.464
LIG_LIR_Nem_3 493 499 PF02991 0.461
LIG_LYPXL_yS_3 593 596 PF13949 0.459
LIG_PTB_Apo_2 469 476 PF02174 0.332
LIG_PTB_Phospho_1 469 475 PF10480 0.335
LIG_SH2_CRK 39 43 PF00017 0.574
LIG_SH2_CRK 467 471 PF00017 0.374
LIG_SH2_CRK 628 632 PF00017 0.540
LIG_SH2_NCK_1 39 43 PF00017 0.611
LIG_SH2_NCK_1 467 471 PF00017 0.384
LIG_SH2_SRC 475 478 PF00017 0.419
LIG_SH2_STAP1 267 271 PF00017 0.470
LIG_SH2_STAP1 39 43 PF00017 0.596
LIG_SH2_STAP1 535 539 PF00017 0.478
LIG_SH2_STAT3 209 212 PF00017 0.420
LIG_SH2_STAT3 271 274 PF00017 0.498
LIG_SH2_STAT5 209 212 PF00017 0.420
LIG_SH2_STAT5 267 270 PF00017 0.496
LIG_SH2_STAT5 364 367 PF00017 0.546
LIG_SH2_STAT5 39 42 PF00017 0.516
LIG_SH2_STAT5 475 478 PF00017 0.419
LIG_SH2_STAT5 527 530 PF00017 0.465
LIG_SH3_1 628 634 PF00018 0.496
LIG_SH3_3 31 37 PF00018 0.559
LIG_SH3_3 628 634 PF00018 0.535
LIG_SH3_3 658 664 PF00018 0.409
LIG_SH3_CIN85_PxpxPR_1 627 632 PF14604 0.477
LIG_SUMO_SIM_par_1 235 240 PF11976 0.432
LIG_SUMO_SIM_par_1 351 357 PF11976 0.405
LIG_TRAF2_1 127 130 PF00917 0.610
LIG_TRAF2_1 374 377 PF00917 0.568
LIG_UBA3_1 408 414 PF00899 0.563
LIG_WRC_WIRS_1 100 105 PF05994 0.545
LIG_WRC_WIRS_1 166 171 PF05994 0.441
MOD_CDC14_SPxK_1 584 587 PF00782 0.596
MOD_CDK_SPK_2 327 332 PF00069 0.570
MOD_CDK_SPxK_1 581 587 PF00069 0.580
MOD_CDK_SPxxK_3 637 644 PF00069 0.759
MOD_CK1_1 135 141 PF00069 0.659
MOD_CK1_1 183 189 PF00069 0.806
MOD_CK1_1 192 198 PF00069 0.658
MOD_CK1_1 327 333 PF00069 0.717
MOD_CK1_1 390 396 PF00069 0.657
MOD_CK1_1 489 495 PF00069 0.642
MOD_CK1_1 635 641 PF00069 0.676
MOD_CK1_1 642 648 PF00069 0.623
MOD_CK1_1 656 662 PF00069 0.614
MOD_CK1_1 73 79 PF00069 0.585
MOD_CK2_1 124 130 PF00069 0.470
MOD_CK2_1 376 382 PF00069 0.728
MOD_CK2_1 400 406 PF00069 0.520
MOD_Cter_Amidation 56 59 PF01082 0.524
MOD_GlcNHglycan 125 129 PF01048 0.638
MOD_GlcNHglycan 134 137 PF01048 0.729
MOD_GlcNHglycan 187 191 PF01048 0.735
MOD_GlcNHglycan 194 197 PF01048 0.580
MOD_GlcNHglycan 200 203 PF01048 0.637
MOD_GlcNHglycan 279 282 PF01048 0.725
MOD_GlcNHglycan 372 375 PF01048 0.682
MOD_GlcNHglycan 539 542 PF01048 0.620
MOD_GlcNHglycan 613 616 PF01048 0.484
MOD_GlcNHglycan 635 638 PF01048 0.618
MOD_GlcNHglycan 669 672 PF01048 0.676
MOD_GlcNHglycan 75 78 PF01048 0.628
MOD_GlcNHglycan 90 93 PF01048 0.766
MOD_GSK3_1 132 139 PF00069 0.699
MOD_GSK3_1 161 168 PF00069 0.428
MOD_GSK3_1 179 186 PF00069 0.523
MOD_GSK3_1 188 195 PF00069 0.602
MOD_GSK3_1 273 280 PF00069 0.640
MOD_GSK3_1 320 327 PF00069 0.664
MOD_GSK3_1 33 40 PF00069 0.471
MOD_GSK3_1 349 356 PF00069 0.413
MOD_GSK3_1 362 369 PF00069 0.559
MOD_GSK3_1 383 390 PF00069 0.818
MOD_GSK3_1 396 403 PF00069 0.604
MOD_GSK3_1 485 492 PF00069 0.615
MOD_GSK3_1 515 522 PF00069 0.491
MOD_GSK3_1 560 567 PF00069 0.511
MOD_GSK3_1 581 588 PF00069 0.525
MOD_GSK3_1 633 640 PF00069 0.651
MOD_GSK3_1 653 660 PF00069 0.632
MOD_N-GLC_1 349 354 PF02516 0.482
MOD_N-GLC_1 471 476 PF02516 0.409
MOD_N-GLC_1 585 590 PF02516 0.640
MOD_NEK2_1 124 129 PF00069 0.660
MOD_NEK2_1 349 354 PF00069 0.488
MOD_NEK2_1 415 420 PF00069 0.405
MOD_NEK2_1 486 491 PF00069 0.696
MOD_NEK2_1 673 678 PF00069 0.566
MOD_NEK2_1 705 710 PF00069 0.474
MOD_NEK2_2 560 565 PF00069 0.517
MOD_NEK2_2 684 689 PF00069 0.519
MOD_PIKK_1 180 186 PF00454 0.722
MOD_PKA_1 362 368 PF00069 0.590
MOD_PKA_1 441 447 PF00069 0.619
MOD_PKA_2 362 368 PF00069 0.575
MOD_PKA_2 441 447 PF00069 0.619
MOD_PKA_2 537 543 PF00069 0.641
MOD_PKA_2 564 570 PF00069 0.593
MOD_PKA_2 654 660 PF00069 0.647
MOD_Plk_1 308 314 PF00069 0.490
MOD_Plk_1 349 355 PF00069 0.385
MOD_Plk_1 471 477 PF00069 0.412
MOD_Plk_1 585 591 PF00069 0.569
MOD_Plk_4 117 123 PF00069 0.438
MOD_Plk_4 165 171 PF00069 0.402
MOD_Plk_4 349 355 PF00069 0.465
MOD_Plk_4 471 477 PF00069 0.426
MOD_ProDKin_1 327 333 PF00069 0.568
MOD_ProDKin_1 33 39 PF00069 0.402
MOD_ProDKin_1 581 587 PF00069 0.580
MOD_ProDKin_1 6 12 PF00069 0.760
MOD_ProDKin_1 637 643 PF00069 0.741
MOD_ProDKin_1 657 663 PF00069 0.639
MOD_SUMO_rev_2 125 133 PF00179 0.725
MOD_SUMO_rev_2 217 225 PF00179 0.486
MOD_SUMO_rev_2 382 390 PF00179 0.775
TRG_ENDOCYTIC_2 39 42 PF00928 0.464
TRG_ENDOCYTIC_2 467 470 PF00928 0.427
TRG_ENDOCYTIC_2 593 596 PF00928 0.584
TRG_ER_diArg_1 151 153 PF00400 0.585
TRG_ER_diArg_1 207 209 PF00400 0.475
TRG_ER_diArg_1 286 288 PF00400 0.608
TRG_ER_diArg_1 289 292 PF00400 0.559
TRG_ER_diArg_1 358 361 PF00400 0.493
TRG_ER_diArg_1 362 364 PF00400 0.565
TRG_ER_diArg_1 439 442 PF00400 0.522
TRG_ER_diArg_1 58 60 PF00400 0.564
TRG_ER_diArg_1 591 593 PF00400 0.630
TRG_ER_diArg_1 709 711 PF00400 0.604
TRG_Pf-PMV_PEXEL_1 208 212 PF00026 0.531
TRG_Pf-PMV_PEXEL_1 441 446 PF00026 0.509

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P9G4 Leptomonas seymouri 55% 98%
A0A1X0NZU7 Trypanosomatidae 31% 94%
A0A422NEG1 Trypanosoma rangeli 32% 100%
A4HHG5 Leishmania braziliensis 78% 100%
A4I4L4 Leishmania infantum 100% 100%
C9ZLA2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
E9AE12 Leishmania major 90% 100%
E9ALS1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 99%
V5ATS3 Trypanosoma cruzi 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS