Nodulin-like/Major Facilitator Superfamily, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

major facilitator superfamily, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X2G0_LEIDO

TriTrypDb:

LdBPK_291610.1 , LdCL_290021800 , LDHU3_29.2340

Length:

656

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 36

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 110
NetGPI	no	yes: 0, no: 110

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	104
GO:0110165	cellular anatomical entity	1	104
GO:0005737	cytoplasm	2	3

Expansion

Sequence features

A0A3S7X2G0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2G0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	52
GO:0022857	transmembrane transporter activity	2	52

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	167	169	PF00675	0.565
CLV_NRD_NRD_1	216	218	PF00675	0.257
CLV_NRD_NRD_1	617	619	PF00675	0.344
CLV_NRD_NRD_1	636	638	PF00675	0.344
CLV_PCSK_FUR_1	615	619	PF00082	0.432
CLV_PCSK_KEX2_1	215	217	PF00082	0.246
CLV_PCSK_KEX2_1	316	318	PF00082	0.597
CLV_PCSK_KEX2_1	399	401	PF00082	0.369
CLV_PCSK_KEX2_1	617	619	PF00082	0.346
CLV_PCSK_KEX2_1	636	638	PF00082	0.327
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.405
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.427
CLV_PCSK_SKI1_1	149	153	PF00082	0.364
CLV_PCSK_SKI1_1	216	220	PF00082	0.326
CLV_PCSK_SKI1_1	316	320	PF00082	0.610
CLV_PCSK_SKI1_1	528	532	PF00082	0.278
CLV_PCSK_SKI1_1	564	568	PF00082	0.569
CLV_PCSK_SKI1_1	618	622	PF00082	0.349
DOC_CYCLIN_RxL_1	525	534	PF00134	0.379
DOC_MAPK_DCC_7	105	113	PF00069	0.180
DOC_MAPK_gen_1	205	214	PF00069	0.495
DOC_MAPK_gen_1	399	405	PF00069	0.485
DOC_MAPK_MEF2A_6	105	113	PF00069	0.310
DOC_MAPK_MEF2A_6	264	273	PF00069	0.290
DOC_PP2B_LxvP_1	496	499	PF13499	0.385
DOC_PP2B_PxIxI_1	474	480	PF00149	0.506
DOC_SPAK_OSR1_1	14	18	PF12202	0.516
DOC_USP7_MATH_1	257	261	PF00917	0.334
DOC_USP7_MATH_1	421	425	PF00917	0.519
DOC_USP7_MATH_1	482	486	PF00917	0.375
DOC_USP7_MATH_1	499	503	PF00917	0.399
DOC_USP7_UBL2_3	293	297	PF12436	0.687
DOC_USP7_UBL2_3	347	351	PF12436	0.595
DOC_USP7_UBL2_3	435	439	PF12436	0.271
DOC_USP7_UBL2_3	533	537	PF12436	0.484
DOC_WW_Pin1_4	576	581	PF00397	0.449
LIG_14-3-3_CanoR_1	168	176	PF00244	0.356
LIG_14-3-3_CanoR_1	215	224	PF00244	0.505
LIG_14-3-3_CanoR_1	264	270	PF00244	0.341
LIG_14-3-3_CanoR_1	380	390	PF00244	0.688
LIG_14-3-3_CanoR_1	456	460	PF00244	0.309
LIG_14-3-3_CanoR_1	8	16	PF00244	0.528
LIG_AP2alpha_1	510	514	PF02296	0.196
LIG_deltaCOP1_diTrp_1	402	408	PF00928	0.363
LIG_EH1_1	175	183	PF00400	0.438
LIG_FHA_1	108	114	PF00498	0.315
LIG_FHA_1	125	131	PF00498	0.311
LIG_FHA_1	185	191	PF00498	0.375
LIG_FHA_1	266	272	PF00498	0.391
LIG_FHA_1	471	477	PF00498	0.591
LIG_FHA_1	55	61	PF00498	0.331
LIG_FHA_1	602	608	PF00498	0.393
LIG_FHA_2	320	326	PF00498	0.775
LIG_FHA_2	46	52	PF00498	0.263
LIG_GBD_Chelix_1	272	280	PF00786	0.346
LIG_LIR_Gen_1	13	22	PF02991	0.480
LIG_LIR_Gen_1	171	182	PF02991	0.293
LIG_LIR_Gen_1	245	254	PF02991	0.333
LIG_LIR_Gen_1	392	403	PF02991	0.508
LIG_LIR_Gen_1	442	451	PF02991	0.312
LIG_LIR_Gen_1	609	619	PF02991	0.366
LIG_LIR_Nem_3	13	18	PF02991	0.503
LIG_LIR_Nem_3	150	154	PF02991	0.341
LIG_LIR_Nem_3	171	177	PF02991	0.260
LIG_LIR_Nem_3	231	237	PF02991	0.517
LIG_LIR_Nem_3	245	249	PF02991	0.313
LIG_LIR_Nem_3	29	34	PF02991	0.335
LIG_LIR_Nem_3	392	398	PF02991	0.517
LIG_LIR_Nem_3	442	447	PF02991	0.344
LIG_LIR_Nem_3	609	614	PF02991	0.329
LIG_LIR_Nem_3	66	72	PF02991	0.311
LIG_LYPXL_yS_3	227	230	PF13949	0.387
LIG_NRBOX	491	497	PF00104	0.410
LIG_NRBOX	90	96	PF00104	0.292
LIG_Pex14_2	233	237	PF04695	0.324
LIG_Pex14_2	510	514	PF04695	0.337
LIG_PTB_Apo_2	160	167	PF02174	0.307
LIG_PTB_Apo_2	430	437	PF02174	0.342
LIG_PTB_Phospho_1	430	436	PF10480	0.395
LIG_REV1ctd_RIR_1	164	173	PF16727	0.279
LIG_SH2_CRK	256	260	PF00017	0.332
LIG_SH2_CRK	428	432	PF00017	0.294
LIG_SH2_CRK	444	448	PF00017	0.409
LIG_SH2_GRB2like	256	259	PF00017	0.350
LIG_SH2_NCK_1	256	260	PF00017	0.327
LIG_SH2_NCK_1	96	100	PF00017	0.445
LIG_SH2_SRC	256	259	PF00017	0.368
LIG_SH2_STAP1	444	448	PF00017	0.400
LIG_SH2_STAP1	562	566	PF00017	0.306
LIG_SH2_STAP1	96	100	PF00017	0.390
LIG_SH2_STAT3	223	226	PF00017	0.444
LIG_SH2_STAT3	562	565	PF00017	0.361
LIG_SH2_STAT5	223	226	PF00017	0.458
LIG_SH2_STAT5	234	237	PF00017	0.317
LIG_SH2_STAT5	246	249	PF00017	0.302
LIG_SH2_STAT5	337	340	PF00017	0.545
LIG_SH2_STAT5	543	546	PF00017	0.387
LIG_SH3_1	297	303	PF00018	0.642
LIG_SH3_3	297	303	PF00018	0.633
LIG_SH3_3	315	321	PF00018	0.799
LIG_SH3_3	577	583	PF00018	0.368
LIG_SUMO_SIM_anti_2	157	163	PF11976	0.432
LIG_SUMO_SIM_anti_2	187	192	PF11976	0.373
LIG_SUMO_SIM_anti_2	268	274	PF11976	0.305
LIG_SUMO_SIM_par_1	239	245	PF11976	0.287
LIG_SUMO_SIM_par_1	445	452	PF11976	0.367
LIG_TRAF2_1	322	325	PF00917	0.767
LIG_TYR_ITIM	244	249	PF00017	0.388
LIG_TYR_ITSM	440	447	PF00017	0.349
LIG_UBA3_1	495	503	PF00899	0.388
LIG_WRC_WIRS_1	148	153	PF05994	0.373
LIG_WRC_WIRS_1	249	254	PF05994	0.373
LIG_WRC_WIRS_1	28	33	PF05994	0.442
LIG_WRC_WIRS_1	307	312	PF05994	0.484
LIG_WRC_WIRS_1	511	516	PF05994	0.387
MOD_CK1_1	10	16	PF00069	0.440
MOD_CK1_1	107	113	PF00069	0.331
MOD_CK1_1	124	130	PF00069	0.343
MOD_CK1_1	353	359	PF00069	0.786
MOD_CK1_1	449	455	PF00069	0.332
MOD_CK2_1	319	325	PF00069	0.746
MOD_CK2_1	352	358	PF00069	0.669
MOD_CMANNOS	404	407	PF00535	0.353
MOD_Cter_Amidation	348	351	PF01082	0.502
MOD_Cter_Amidation	586	589	PF01082	0.469
MOD_GlcNHglycan	261	264	PF01048	0.399
MOD_GlcNHglycan	423	426	PF01048	0.379
MOD_GlcNHglycan	444	447	PF01048	0.317
MOD_GlcNHglycan	451	454	PF01048	0.306
MOD_GSK3_1	120	127	PF00069	0.339
MOD_GSK3_1	133	140	PF00069	0.315
MOD_GSK3_1	22	29	PF00069	0.339
MOD_GSK3_1	349	356	PF00069	0.694
MOD_GSK3_1	390	397	PF00069	0.472
MOD_GSK3_1	442	449	PF00069	0.380
MOD_GSK3_1	50	57	PF00069	0.315
MOD_GSK3_1	516	523	PF00069	0.349
MOD_N-GLC_1	162	167	PF02516	0.339
MOD_N-GLC_1	45	50	PF02516	0.370
MOD_N-GLC_1	601	606	PF02516	0.289
MOD_NEK2_1	120	125	PF00069	0.330
MOD_NEK2_1	154	159	PF00069	0.371
MOD_NEK2_1	265	270	PF00069	0.318
MOD_NEK2_1	394	399	PF00069	0.418
MOD_NEK2_1	45	50	PF00069	0.328
MOD_NEK2_1	510	515	PF00069	0.349
MOD_NEK2_2	27	32	PF00069	0.328
MOD_PIKK_1	222	228	PF00454	0.377
MOD_PKA_1	216	222	PF00069	0.442
MOD_PKA_1	350	356	PF00069	0.482
MOD_PKA_2	167	173	PF00069	0.421
MOD_PKA_2	216	222	PF00069	0.337
MOD_PKA_2	455	461	PF00069	0.337
MOD_PKA_2	7	13	PF00069	0.387
MOD_Plk_1	10	16	PF00069	0.527
MOD_Plk_1	162	168	PF00069	0.373
MOD_Plk_1	203	209	PF00069	0.466
MOD_Plk_1	50	56	PF00069	0.309
MOD_Plk_1	601	607	PF00069	0.304
MOD_Plk_2-3	306	312	PF00069	0.700
MOD_Plk_4	126	132	PF00069	0.319
MOD_Plk_4	154	160	PF00069	0.361
MOD_Plk_4	162	168	PF00069	0.369
MOD_Plk_4	242	248	PF00069	0.318
MOD_Plk_4	265	271	PF00069	0.347
MOD_Plk_4	27	33	PF00069	0.312
MOD_Plk_4	390	396	PF00069	0.406
MOD_Plk_4	439	445	PF00069	0.273
MOD_Plk_4	607	613	PF00069	0.274
MOD_ProDKin_1	576	582	PF00069	0.568
MOD_SUMO_rev_2	309	318	PF00179	0.707
MOD_SUMO_rev_2	374	379	PF00179	0.597
MOD_SUMO_rev_2	432	440	PF00179	0.491
TRG_DiLeu_BaEn_2	10	16	PF01217	0.433
TRG_ENDOCYTIC_2	164	167	PF00928	0.331
TRG_ENDOCYTIC_2	174	177	PF00928	0.274
TRG_ENDOCYTIC_2	198	201	PF00928	0.347
TRG_ENDOCYTIC_2	227	230	PF00928	0.395
TRG_ENDOCYTIC_2	234	237	PF00928	0.359
TRG_ENDOCYTIC_2	246	249	PF00928	0.322
TRG_ENDOCYTIC_2	428	431	PF00928	0.345
TRG_ENDOCYTIC_2	444	447	PF00928	0.321
TRG_ENDOCYTIC_2	539	542	PF00928	0.333
TRG_ENDOCYTIC_2	558	561	PF00928	0.500
TRG_ENDOCYTIC_2	616	619	PF00928	0.388
TRG_ER_diArg_1	214	217	PF00400	0.313
TRG_ER_diArg_1	616	618	PF00400	0.437
TRG_ER_diArg_1	636	638	PF00400	0.410
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	636	640	PF00026	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G0	Leptomonas seymouri	28%	100%
A0A0N1HZC2	Leptomonas seymouri	30%	100%
A0A0N1IKC5	Leptomonas seymouri	32%	100%
A0A0N1PB63	Leptomonas seymouri	26%	99%
A0A0N1PD04	Leptomonas seymouri	25%	100%
A0A0N1PFR4	Leptomonas seymouri	32%	99%
A0A1X0NKK0	Trypanosomatidae	30%	100%
A0A1X0NM09	Trypanosomatidae	29%	100%
A0A1X0NRW5	Trypanosomatidae	27%	94%
A0A1X0NV13	Trypanosomatidae	32%	100%
A0A1X0NV19	Trypanosomatidae	33%	100%
A0A1X0NV27	Trypanosomatidae	32%	100%
A0A1X0NVF9	Trypanosomatidae	22%	98%
A0A1X0NVH8	Trypanosomatidae	31%	99%
A0A1X0NVM7	Trypanosomatidae	30%	100%
A0A1X0NWQ1	Trypanosomatidae	33%	100%
A0A1X0NZE6	Trypanosomatidae	29%	100%
A0A1X0NZU2	Trypanosomatidae	33%	100%
A0A1X0NZU5	Trypanosomatidae	55%	100%
A0A1X0NZW1	Trypanosomatidae	31%	100%
A0A1X0P0M7	Trypanosomatidae	28%	100%
A0A381MMW5	Leishmania infantum	100%	100%
A0A3Q8IEC4	Leishmania donovani	100%	100%
A0A3Q8IF95	Leishmania donovani	28%	100%
A0A3Q8IIT5	Leishmania donovani	31%	100%
A0A3Q8ISY9	Leishmania donovani	28%	100%
A0A3R7KKN8	Trypanosoma rangeli	32%	100%
A0A3R7MAQ7	Trypanosoma rangeli	27%	93%
A0A3R7N3S6	Trypanosoma rangeli	25%	100%
A0A3R7N415	Trypanosoma rangeli	31%	100%
A0A3R7N921	Trypanosoma rangeli	29%	100%
A0A3R7R443	Trypanosoma rangeli	31%	100%
A0A3S7WRJ4	Leishmania donovani	30%	100%
A0A3S7WRJ5	Leishmania donovani	32%	100%
A0A3S7WRS3	Leishmania donovani	25%	100%
A0A3S7WSR4	Leishmania donovani	32%	99%
A0A3S7WWU1	Leishmania donovani	26%	100%
A0A3S7X2K5	Leishmania donovani	98%	100%
A0A3S7XB11	Leishmania donovani	30%	100%
A0A422MSE4	Trypanosoma rangeli	34%	100%
A0A422MSP6	Trypanosoma rangeli	49%	100%
A0A422MST9	Trypanosoma rangeli	29%	100%
A0A422MU68	Trypanosoma rangeli	29%	100%
A4H6J0	Leishmania braziliensis	30%	100%
A4H6J1	Leishmania braziliensis	33%	100%
A4H6Q5	Leishmania braziliensis	26%	100%
A4HC19	Leishmania braziliensis	28%	100%
A4HHG2	Leishmania braziliensis	30%	100%
A4HHG3	Leishmania braziliensis	83%	100%
A4HHG4	Leishmania braziliensis	74%	100%
A4HJW3	Leishmania braziliensis	28%	100%
A4HPE2	Leishmania braziliensis	29%	99%
A4HUX5	Leishmania infantum	31%	100%
A4HUX6	Leishmania infantum	32%	100%
A4HV40	Leishmania infantum	25%	100%
A4HZF5	Leishmania infantum	28%	100%
A4HZJ4	Leishmania infantum	26%	100%
A4I4L2	Leishmania infantum	31%	100%
A4I7C5	Leishmania infantum	28%	100%
A4ICI3	Leishmania infantum	29%	99%
C9ZL97	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZL98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZL99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZLA0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZLA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZTR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZTR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZTR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZTR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZTR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZTS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZUT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
D0A7B1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A7H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0AAQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	96%
E8NHE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AE01	Leishmania major	92%	100%
E9AE09	Leishmania major	31%	100%
E9AE10	Leishmania major	31%	100%
E9AE11	Leishmania major	89%	100%
E9AGK5	Leishmania infantum	32%	99%
E9AHJ0	Leishmania infantum	100%	100%
E9AHJ1	Leishmania infantum	97%	100%
E9ALS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9ALS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9ANL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	98%
E9ANL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9ANS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9APJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	98%
E9AT53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	96%
E9AVF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	99%
E9AVF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B2B8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
Q4Q1E4	Leishmania major	29%	99%
Q4Q5T8	Leishmania major	27%	100%
Q4QC27	Leishmania major	26%	100%
Q4QC28	Leishmania major	27%	96%
Q4QFY5	Leishmania major	31%	99%
Q4QGU8	Leishmania major	26%	100%
Q4QH14	Leishmania major	31%	100%
Q4QH15	Leishmania major	30%	100%
V5B647	Trypanosoma cruzi	31%	100%
V5B983	Trypanosoma cruzi	47%	100%
V5BBB1	Trypanosoma cruzi	31%	100%
V5BFV8	Trypanosoma cruzi	32%	98%
V5BQY6	Trypanosoma cruzi	30%	93%
V5BVP0	Trypanosoma cruzi	30%	100%
V5BWJ7	Trypanosoma cruzi	22%	100%
V5DT25	Trypanosoma cruzi	31%	100%