Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X2F4_LEIDO

TriTrypDb:

LdBPK_291200.1 , LdCL_290017100 , LDHU3_29.1660

Length:

625

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X2F4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2F4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	254	258	PF00656	0.497
CLV_C14_Caspase3-7	31	35	PF00656	0.682
CLV_C14_Caspase3-7	314	318	PF00656	0.508
CLV_C14_Caspase3-7	96	100	PF00656	0.561
CLV_NRD_NRD_1	129	131	PF00675	0.530
CLV_NRD_NRD_1	301	303	PF00675	0.509
CLV_NRD_NRD_1	370	372	PF00675	0.396
CLV_NRD_NRD_1	593	595	PF00675	0.594
CLV_PCSK_KEX2_1	129	131	PF00082	0.558
CLV_PCSK_KEX2_1	136	138	PF00082	0.506
CLV_PCSK_KEX2_1	298	300	PF00082	0.527
CLV_PCSK_KEX2_1	370	372	PF00082	0.481
CLV_PCSK_KEX2_1	593	595	PF00082	0.607
CLV_PCSK_KEX2_1	599	601	PF00082	0.620
CLV_PCSK_KEX2_1	82	84	PF00082	0.514
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.621
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.447
CLV_PCSK_PC1ET2_1	599	601	PF00082	0.631
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.514
CLV_PCSK_PC7_1	125	131	PF00082	0.522
CLV_PCSK_SKI1_1	125	129	PF00082	0.581
CLV_PCSK_SKI1_1	130	134	PF00082	0.546
CLV_PCSK_SKI1_1	346	350	PF00082	0.538
CLV_PCSK_SKI1_1	53	57	PF00082	0.524
DEG_Nend_UBRbox_2	1	3	PF02207	0.688
DEG_SPOP_SBC_1	147	151	PF00917	0.686
DOC_CDC14_PxL_1	188	196	PF14671	0.670
DOC_MAPK_DCC_7	406	416	PF00069	0.481
DOC_MAPK_gen_1	240	250	PF00069	0.643
DOC_MAPK_gen_1	283	293	PF00069	0.497
DOC_MAPK_gen_1	370	376	PF00069	0.395
DOC_MAPK_MEF2A_6	240	248	PF00069	0.622
DOC_PP2B_LxvP_1	336	339	PF13499	0.356
DOC_USP7_MATH_1	147	151	PF00917	0.579
DOC_USP7_MATH_1	156	160	PF00917	0.594
DOC_USP7_MATH_1	23	27	PF00917	0.660
DOC_USP7_MATH_1	466	470	PF00917	0.579
DOC_USP7_MATH_1	531	535	PF00917	0.560
DOC_USP7_MATH_1	580	584	PF00917	0.718
DOC_USP7_MATH_1	587	591	PF00917	0.747
DOC_USP7_MATH_1	611	615	PF00917	0.735
LIG_14-3-3_CanoR_1	199	209	PF00244	0.518
LIG_14-3-3_CanoR_1	217	223	PF00244	0.556
LIG_14-3-3_CanoR_1	276	284	PF00244	0.484
LIG_14-3-3_CanoR_1	354	363	PF00244	0.387
LIG_14-3-3_CanoR_1	401	407	PF00244	0.623
LIG_14-3-3_CanoR_1	498	507	PF00244	0.523
LIG_14-3-3_CanoR_1	59	65	PF00244	0.608
LIG_Actin_WH2_2	392	410	PF00022	0.535
LIG_Actin_WH2_2	484	500	PF00022	0.598
LIG_APCC_ABBA_1	570	575	PF00400	0.569
LIG_BIR_III_4	34	38	PF00653	0.714
LIG_BRCT_BRCA1_1	311	315	PF00533	0.490
LIG_CaM_IQ_9	290	305	PF13499	0.371
LIG_eIF4E_1	202	208	PF01652	0.533
LIG_FHA_1	101	107	PF00498	0.618
LIG_FHA_1	233	239	PF00498	0.656
LIG_FHA_1	259	265	PF00498	0.379
LIG_FHA_1	283	289	PF00498	0.392
LIG_FHA_1	331	337	PF00498	0.548
LIG_FHA_1	351	357	PF00498	0.197
LIG_FHA_1	384	390	PF00498	0.579
LIG_FHA_1	561	567	PF00498	0.624
LIG_FHA_1	86	92	PF00498	0.648
LIG_FHA_2	232	238	PF00498	0.664
LIG_FHA_2	312	318	PF00498	0.533
LIG_FHA_2	389	395	PF00498	0.543
LIG_FHA_2	400	406	PF00498	0.653
LIG_Integrin_RGD_1	32	34	PF01839	0.592
LIG_LIR_Apic_2	60	65	PF02991	0.537
LIG_LIR_Gen_1	257	268	PF02991	0.437
LIG_LIR_Gen_1	485	495	PF02991	0.542
LIG_LIR_Gen_1	504	515	PF02991	0.571
LIG_LIR_Gen_1	567	577	PF02991	0.496
LIG_LIR_Gen_1	616	622	PF02991	0.779
LIG_LIR_Nem_3	2	6	PF02991	0.631
LIG_LIR_Nem_3	257	263	PF02991	0.464
LIG_LIR_Nem_3	342	348	PF02991	0.427
LIG_LIR_Nem_3	44	48	PF02991	0.565
LIG_LIR_Nem_3	485	491	PF02991	0.609
LIG_LIR_Nem_3	504	510	PF02991	0.473
LIG_LIR_Nem_3	540	546	PF02991	0.624
LIG_LIR_Nem_3	616	621	PF02991	0.781
LIG_LIR_Nem_3	63	69	PF02991	0.469
LIG_LYPXL_yS_3	66	69	PF13949	0.665
LIG_NRBOX	287	293	PF00104	0.426
LIG_Pex14_1	289	293	PF04695	0.366
LIG_Pex14_1	62	66	PF04695	0.550
LIG_Pex14_2	311	315	PF04695	0.465
LIG_PTB_Apo_2	406	413	PF02174	0.540
LIG_PTB_Phospho_1	406	412	PF10480	0.547
LIG_SH2_CRK	507	511	PF00017	0.622
LIG_SH2_CRK	546	550	PF00017	0.481
LIG_SH2_GRB2like	390	393	PF00017	0.536
LIG_SH2_NCK_1	202	206	PF00017	0.618
LIG_SH2_NCK_1	390	394	PF00017	0.535
LIG_SH2_NCK_1	546	550	PF00017	0.575
LIG_SH2_STAP1	341	345	PF00017	0.460
LIG_SH2_STAP1	352	356	PF00017	0.330
LIG_SH2_STAP1	359	363	PF00017	0.304
LIG_SH2_STAP1	499	503	PF00017	0.458
LIG_SH2_STAT5	202	205	PF00017	0.525
LIG_SH2_STAT5	352	355	PF00017	0.330
LIG_SH2_STAT5	385	388	PF00017	0.563
LIG_SH2_STAT5	390	393	PF00017	0.517
LIG_SH2_STAT5	520	523	PF00017	0.505
LIG_SH2_STAT5	543	546	PF00017	0.607
LIG_SH2_STAT5	569	572	PF00017	0.484
LIG_SH3_3	112	118	PF00018	0.596
LIG_SH3_3	194	200	PF00018	0.668
LIG_SH3_3	415	421	PF00018	0.467
LIG_SH3_3	453	459	PF00018	0.510
LIG_SH3_3	61	67	PF00018	0.513
LIG_SUMO_SIM_par_1	346	351	PF11976	0.483
LIG_SUMO_SIM_par_1	4	11	PF11976	0.700
LIG_TRAF2_1	209	212	PF00917	0.630
LIG_TRAF2_1	234	237	PF00917	0.710
LIG_TRAF2_1	7	10	PF00917	0.708
LIG_TRFH_1	114	118	PF08558	0.553
LIG_TYR_ITIM	111	116	PF00017	0.543
LIG_TYR_ITIM	544	549	PF00017	0.584
LIG_TYR_ITIM	64	69	PF00017	0.633
MOD_CK1_1	11	17	PF00069	0.699
MOD_CK1_1	149	155	PF00069	0.671
MOD_CK1_1	258	264	PF00069	0.342
MOD_CK1_1	277	283	PF00069	0.449
MOD_CK1_1	313	319	PF00069	0.578
MOD_CK2_1	231	237	PF00069	0.655
MOD_CK2_1	388	394	PF00069	0.520
MOD_CK2_1	4	10	PF00069	0.698
MOD_GlcNHglycan	153	156	PF01048	0.736
MOD_GlcNHglycan	25	28	PF01048	0.636
MOD_GlcNHglycan	277	280	PF01048	0.446
MOD_GlcNHglycan	402	405	PF01048	0.713
MOD_GlcNHglycan	421	424	PF01048	0.540
MOD_GlcNHglycan	501	504	PF01048	0.652
MOD_GlcNHglycan	9	13	PF01048	0.719
MOD_GSK3_1	146	153	PF00069	0.607
MOD_GSK3_1	251	258	PF00069	0.551
MOD_GSK3_1	275	282	PF00069	0.481
MOD_GSK3_1	309	316	PF00069	0.377
MOD_GSK3_1	350	357	PF00069	0.421
MOD_GSK3_1	37	44	PF00069	0.602
MOD_GSK3_1	4	11	PF00069	0.704
MOD_GSK3_1	493	500	PF00069	0.512
MOD_GSK3_1	560	567	PF00069	0.644
MOD_N-GLC_1	156	161	PF02516	0.661
MOD_N-GLC_1	558	563	PF02516	0.580
MOD_NEK2_1	105	110	PF00069	0.494
MOD_NEK2_1	274	279	PF00069	0.471
MOD_NEK2_1	293	298	PF00069	0.432
MOD_NEK2_1	311	316	PF00069	0.326
MOD_NEK2_1	399	404	PF00069	0.592
MOD_NEK2_1	407	412	PF00069	0.567
MOD_NEK2_1	493	498	PF00069	0.507
MOD_NEK2_1	84	89	PF00069	0.557
MOD_PIKK_1	11	17	PF00454	0.713
MOD_PIKK_1	218	224	PF00454	0.607
MOD_PIKK_1	251	257	PF00454	0.618
MOD_PIKK_1	37	43	PF00454	0.676
MOD_PKA_2	275	281	PF00069	0.578
MOD_PKA_2	282	288	PF00069	0.508
MOD_PKA_2	330	336	PF00069	0.511
MOD_PKA_2	400	406	PF00069	0.586
MOD_PKA_2	497	503	PF00069	0.607
MOD_PKA_2	58	64	PF00069	0.605
MOD_Plk_1	258	264	PF00069	0.456
MOD_Plk_1	449	455	PF00069	0.568
MOD_Plk_1	503	509	PF00069	0.472
MOD_Plk_1	85	91	PF00069	0.566
MOD_Plk_4	407	413	PF00069	0.532
MOD_Plk_4	516	522	PF00069	0.523
MOD_SUMO_for_1	598	601	PF00179	0.658
MOD_SUMO_rev_2	394	400	PF00179	0.578
MOD_SUMO_rev_2	79	84	PF00179	0.551
TRG_DiLeu_BaEn_2	440	446	PF01217	0.582
TRG_DiLeu_BaEn_4	441	447	PF01217	0.584
TRG_DiLeu_BaLyEn_6	344	349	PF01217	0.479
TRG_ENDOCYTIC_2	113	116	PF00928	0.543
TRG_ENDOCYTIC_2	202	205	PF00928	0.525
TRG_ENDOCYTIC_2	390	393	PF00928	0.536
TRG_ENDOCYTIC_2	507	510	PF00928	0.617
TRG_ENDOCYTIC_2	546	549	PF00928	0.491
TRG_ENDOCYTIC_2	569	572	PF00928	0.489
TRG_ENDOCYTIC_2	66	69	PF00928	0.560
TRG_ENDOCYTIC_2	81	84	PF00928	0.516
TRG_ER_diArg_1	128	130	PF00400	0.629
TRG_ER_diArg_1	161	164	PF00400	0.725
TRG_ER_diArg_1	593	595	PF00400	0.762
TRG_Pf-PMV_PEXEL_1	199	204	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	346	351	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	379	383	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHI1	Leptomonas seymouri	67%	100%
A0A0S4JMH1	Bodo saltans	29%	100%
A0A1X0P058	Trypanosomatidae	34%	96%
A0A3R7M9T5	Trypanosoma rangeli	33%	98%
A4HHC1	Leishmania braziliensis	88%	100%
C9ZLL7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	97%
E9ADW9	Leishmania major	95%	100%
E9AHI6	Leishmania infantum	100%	100%
E9ALW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5DI43	Trypanosoma cruzi	34%	99%