Aurora kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Aurora kinase

Gene product:

serine/threonine-protein kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X2F1_LEIDO

TriTrypDb:

LdBPK_291420.1 , LdCL_290019300 , LDHU3_29.1930

Length:

587

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X2F1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2F1

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0019538	protein metabolic process	3	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:0007165	signal transduction	2	1
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0035556	intracellular signal transduction	3	1
GO:0046777	protein autophosphorylation	6	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0004674	protein serine/threonine kinase activity	4	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140096	catalytic activity, acting on a protein	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6
GO:0004683	calmodulin-dependent protein kinase activity	5	1
GO:0005515	protein binding	2	1
GO:0005516	calmodulin binding	3	1
GO:0009931	calcium-dependent protein serine/threonine kinase activity	5	1
GO:0010857	calcium-dependent protein kinase activity	4	1
GO:0106310	protein serine kinase activity	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	264	266	PF00675	0.505
CLV_NRD_NRD_1	457	459	PF00675	0.505
CLV_PCSK_KEX2_1	264	266	PF00082	0.505
CLV_PCSK_KEX2_1	457	459	PF00082	0.505
CLV_PCSK_KEX2_1	86	88	PF00082	0.832
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.832
CLV_PCSK_SKI1_1	374	378	PF00082	0.366
CLV_PCSK_SKI1_1	387	391	PF00082	0.429
DEG_SPOP_SBC_1	6	10	PF00917	0.765
DOC_CKS1_1	330	335	PF01111	0.505
DOC_CYCLIN_yCln2_LP_2	37	43	PF00134	0.598
DOC_CYCLIN_yCln2_LP_2	546	552	PF00134	0.505
DOC_MAPK_gen_1	316	326	PF00069	0.505
DOC_MAPK_gen_1	387	396	PF00069	0.505
DOC_PP1_RVXF_1	296	302	PF00149	0.505
DOC_PP2B_LxvP_1	37	40	PF13499	0.608
DOC_PP4_FxxP_1	330	333	PF00568	0.344
DOC_USP7_MATH_1	158	162	PF00917	0.742
DOC_USP7_MATH_1	193	197	PF00917	0.703
DOC_USP7_MATH_1	228	232	PF00917	0.713
DOC_USP7_MATH_1	245	249	PF00917	0.556
DOC_USP7_MATH_1	4	8	PF00917	0.791
DOC_USP7_MATH_1	419	423	PF00917	0.311
DOC_USP7_MATH_1	436	440	PF00917	0.328
DOC_USP7_MATH_1	55	59	PF00917	0.779
DOC_USP7_MATH_1	71	75	PF00917	0.546
DOC_USP7_MATH_1	90	94	PF00917	0.544
DOC_WW_Pin1_4	130	135	PF00397	0.706
DOC_WW_Pin1_4	19	24	PF00397	0.660
DOC_WW_Pin1_4	191	196	PF00397	0.802
DOC_WW_Pin1_4	198	203	PF00397	0.662
DOC_WW_Pin1_4	241	246	PF00397	0.768
DOC_WW_Pin1_4	329	334	PF00397	0.505
DOC_WW_Pin1_4	465	470	PF00397	0.505
DOC_WW_Pin1_4	494	499	PF00397	0.427
DOC_WW_Pin1_4	7	12	PF00397	0.783
LIG_14-3-3_CanoR_1	136	146	PF00244	0.731
LIG_14-3-3_CanoR_1	219	225	PF00244	0.796
LIG_14-3-3_CanoR_1	325	330	PF00244	0.505
LIG_14-3-3_CanoR_1	457	461	PF00244	0.505
LIG_APCC_ABBA_1	43	48	PF00400	0.665
LIG_APCC_ABBAyCdc20_2	42	48	PF00400	0.667
LIG_BIR_III_4	397	401	PF00653	0.344
LIG_CtBP_PxDLS_1	516	520	PF00389	0.505
LIG_FHA_1	15	21	PF00498	0.753
LIG_FHA_1	185	191	PF00498	0.737
LIG_FHA_1	367	373	PF00498	0.505
LIG_FHA_1	448	454	PF00498	0.399
LIG_FHA_1	537	543	PF00498	0.330
LIG_FHA_2	426	432	PF00498	0.505
LIG_FHA_2	442	448	PF00498	0.505
LIG_FHA_2	543	549	PF00498	0.407
LIG_FHA_2	571	577	PF00498	0.466
LIG_LIR_Apic_2	328	333	PF02991	0.505
LIG_LIR_Apic_2	406	412	PF02991	0.407
LIG_LIR_Apic_2	463	469	PF02991	0.505
LIG_LIR_Gen_1	271	280	PF02991	0.353
LIG_LIR_Nem_3	133	138	PF02991	0.780
LIG_LIR_Nem_3	205	211	PF02991	0.670
LIG_LIR_Nem_3	271	277	PF02991	0.353
LIG_LYPXL_yS_3	208	211	PF13949	0.666
LIG_MAD2	219	227	PF02301	0.657
LIG_NRP_CendR_1	585	587	PF00754	0.508
LIG_SH2_CRK	274	278	PF00017	0.344
LIG_SH2_NCK_1	274	278	PF00017	0.505
LIG_SH2_STAP1	327	331	PF00017	0.395
LIG_SH2_STAP1	368	372	PF00017	0.505
LIG_SH2_STAT3	510	513	PF00017	0.427
LIG_SH2_STAT5	329	332	PF00017	0.506
LIG_SH2_STAT5	342	345	PF00017	0.290
LIG_SH2_STAT5	368	371	PF00017	0.505
LIG_SH2_STAT5	466	469	PF00017	0.505
LIG_SH2_STAT5	501	504	PF00017	0.381
LIG_SH3_2	247	252	PF14604	0.663
LIG_SH3_2	416	421	PF14604	0.330
LIG_SH3_3	152	158	PF00018	0.743
LIG_SH3_3	196	202	PF00018	0.785
LIG_SH3_3	244	250	PF00018	0.700
LIG_SH3_3	410	416	PF00018	0.505
LIG_SH3_3	65	71	PF00018	0.715
LIG_SUMO_SIM_anti_2	334	341	PF11976	0.427
LIG_SUMO_SIM_par_1	275	281	PF11976	0.505
LIG_SUMO_SIM_par_1	547	553	PF11976	0.501
LIG_TRAF2_1	573	576	PF00917	0.291
LIG_UBA3_1	559	566	PF00899	0.505
LIG_WW_1	498	501	PF00397	0.505
LIG_WW_2	68	71	PF00397	0.680
MOD_CDC14_SPxK_1	133	136	PF00782	0.664
MOD_CDC14_SPxK_1	22	25	PF00782	0.834
MOD_CDK_SPxK_1	130	136	PF00069	0.668
MOD_CDK_SPxK_1	19	25	PF00069	0.837
MOD_CK1_1	124	130	PF00069	0.692
MOD_CK1_1	15	21	PF00069	0.714
MOD_CK1_1	160	166	PF00069	0.723
MOD_CK1_1	176	182	PF00069	0.631
MOD_CK1_1	194	200	PF00069	0.487
MOD_CK1_1	210	216	PF00069	0.514
MOD_CK1_1	229	235	PF00069	0.468
MOD_CK1_1	241	247	PF00069	0.563
MOD_CK1_1	275	281	PF00069	0.505
MOD_CK1_1	344	350	PF00069	0.505
MOD_CK1_1	366	372	PF00069	0.505
MOD_CK1_1	422	428	PF00069	0.451
MOD_CK1_1	478	484	PF00069	0.364
MOD_CK1_1	534	540	PF00069	0.448
MOD_CK1_1	7	13	PF00069	0.793
MOD_CK2_1	435	441	PF00069	0.435
MOD_CK2_1	542	548	PF00069	0.407
MOD_CK2_1	570	576	PF00069	0.466
MOD_Cter_Amidation	455	458	PF01082	0.505
MOD_GlcNHglycan	107	110	PF01048	0.760
MOD_GlcNHglycan	160	163	PF01048	0.776
MOD_GlcNHglycan	165	169	PF01048	0.732
MOD_GlcNHglycan	17	20	PF01048	0.734
MOD_GlcNHglycan	178	181	PF01048	0.540
MOD_GlcNHglycan	196	199	PF01048	0.535
MOD_GlcNHglycan	204	207	PF01048	0.708
MOD_GlcNHglycan	212	215	PF01048	0.667
MOD_GlcNHglycan	228	231	PF01048	0.506
MOD_GlcNHglycan	239	243	PF01048	0.605
MOD_GlcNHglycan	284	287	PF01048	0.505
MOD_GlcNHglycan	343	346	PF01048	0.505
MOD_GlcNHglycan	421	424	PF01048	0.504
MOD_GlcNHglycan	438	441	PF01048	0.210
MOD_GlcNHglycan	472	475	PF01048	0.395
MOD_GlcNHglycan	477	480	PF01048	0.338
MOD_GlcNHglycan	533	536	PF01048	0.437
MOD_GlcNHglycan	552	555	PF01048	0.191
MOD_GlcNHglycan	56	60	PF01048	0.675
MOD_GlcNHglycan	567	571	PF01048	0.388
MOD_GlcNHglycan	73	76	PF01048	0.558
MOD_GlcNHglycan	81	86	PF01048	0.645
MOD_GSK3_1	101	108	PF00069	0.777
MOD_GSK3_1	120	127	PF00069	0.502
MOD_GSK3_1	15	22	PF00069	0.799
MOD_GSK3_1	160	167	PF00069	0.708
MOD_GSK3_1	175	182	PF00069	0.662
MOD_GSK3_1	194	201	PF00069	0.536
MOD_GSK3_1	237	244	PF00069	0.631
MOD_GSK3_1	278	285	PF00069	0.505
MOD_GSK3_1	325	332	PF00069	0.395
MOD_GSK3_1	456	463	PF00069	0.427
MOD_GSK3_1	478	485	PF00069	0.505
MOD_GSK3_1	501	508	PF00069	0.505
MOD_GSK3_1	566	573	PF00069	0.442
MOD_LATS_1	181	187	PF00433	0.734
MOD_N-GLC_1	517	522	PF02516	0.381
MOD_N-GLC_2	541	543	PF02516	0.330
MOD_NEK2_1	12	17	PF00069	0.821
MOD_NEK2_1	120	125	PF00069	0.713
MOD_NEK2_1	137	142	PF00069	0.584
MOD_NEK2_1	175	180	PF00069	0.749
MOD_NEK2_1	204	209	PF00069	0.790
MOD_NEK2_1	314	319	PF00069	0.505
MOD_NEK2_1	407	412	PF00069	0.375
MOD_NEK2_1	531	536	PF00069	0.425
MOD_PIKK_1	502	508	PF00454	0.427
MOD_PIKK_1	60	66	PF00454	0.805
MOD_PKA_2	282	288	PF00069	0.505
MOD_PKA_2	358	364	PF00069	0.505
MOD_PKA_2	366	372	PF00069	0.372
MOD_PKA_2	456	462	PF00069	0.505
MOD_PKA_2	570	576	PF00069	0.466
MOD_Plk_1	100	106	PF00069	0.695
MOD_Plk_1	294	300	PF00069	0.505
MOD_Plk_4	207	213	PF00069	0.785
MOD_Plk_4	272	278	PF00069	0.344
MOD_Plk_4	325	331	PF00069	0.420
MOD_Plk_4	344	350	PF00069	0.198
MOD_Plk_4	505	511	PF00069	0.498
MOD_Plk_4	555	561	PF00069	0.403
MOD_ProDKin_1	130	136	PF00069	0.707
MOD_ProDKin_1	19	25	PF00069	0.662
MOD_ProDKin_1	191	197	PF00069	0.800
MOD_ProDKin_1	198	204	PF00069	0.665
MOD_ProDKin_1	241	247	PF00069	0.771
MOD_ProDKin_1	329	335	PF00069	0.505
MOD_ProDKin_1	465	471	PF00069	0.505
MOD_ProDKin_1	494	500	PF00069	0.427
MOD_ProDKin_1	7	13	PF00069	0.786
MOD_SUMO_for_1	389	392	PF00179	0.505
TRG_DiLeu_BaLyEn_6	116	121	PF01217	0.799
TRG_DiLeu_BaLyEn_6	8	13	PF01217	0.811
TRG_ENDOCYTIC_2	208	211	PF00928	0.666
TRG_ENDOCYTIC_2	274	277	PF00928	0.344
TRG_ENDOCYTIC_2	327	330	PF00928	0.476
TRG_ER_diArg_1	263	265	PF00400	0.505
TRG_ER_diArg_1	296	299	PF00400	0.505
TRG_ER_diArg_1	41	44	PF00400	0.772
TRG_Pf-PMV_PEXEL_1	302	307	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	387	392	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8INQ4	Leishmania donovani	26%	100%
A0A3S5H5G0	Leishmania donovani	27%	100%
A4H459	Leishmania braziliensis	27%	100%
A4HD79	Leishmania braziliensis	27%	100%
A4HED7	Leishmania braziliensis	28%	100%
A4HHE4	Leishmania braziliensis	74%	100%
A4HSE2	Leishmania infantum	27%	100%
A4I1T4	Leishmania infantum	26%	100%
E9ADZ1	Leishmania major	92%	100%
E9AHI7	Leishmania infantum	99%	100%
E9AKB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9ALU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9AXW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B5Y5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q09170	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q4Q9K2	Leishmania major	27%	100%
Q4QJJ0	Leishmania major	26%	100%
Q5MPA9	Rattus norvegicus	28%	77%
V5BFI8	Trypanosoma cruzi	25%	100%