Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X2E5_LEIDO

TriTrypDb:

LdBPK_291090.1 , LdCL_290015800 , LDHU3_29.1490

Length:

628

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X2E5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2E5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	139	145	PF00089	0.471
CLV_MEL_PAP_1	339	345	PF00089	0.562
CLV_NRD_NRD_1	172	174	PF00675	0.512
CLV_NRD_NRD_1	341	343	PF00675	0.532
CLV_NRD_NRD_1	459	461	PF00675	0.642
CLV_NRD_NRD_1	473	475	PF00675	0.592
CLV_NRD_NRD_1	506	508	PF00675	0.647
CLV_PCSK_KEX2_1	172	174	PF00082	0.512
CLV_PCSK_KEX2_1	291	293	PF00082	0.724
CLV_PCSK_KEX2_1	341	343	PF00082	0.532
CLV_PCSK_KEX2_1	459	461	PF00082	0.698
CLV_PCSK_KEX2_1	472	474	PF00082	0.605
CLV_PCSK_KEX2_1	506	508	PF00082	0.661
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.724
CLV_PCSK_SKI1_1	188	192	PF00082	0.595
CLV_PCSK_SKI1_1	207	211	PF00082	0.406
CLV_PCSK_SKI1_1	416	420	PF00082	0.636
CLV_PCSK_SKI1_1	517	521	PF00082	0.526
CLV_PCSK_SKI1_1	597	601	PF00082	0.556
CLV_Separin_Metazoa	204	208	PF03568	0.423
CLV_Separin_Metazoa	456	460	PF03568	0.645
DEG_APCC_DBOX_1	47	55	PF00400	0.559
DEG_APCC_DBOX_1	505	513	PF00400	0.460
DEG_COP1_1	5	14	PF00400	0.568
DEG_SPOP_SBC_1	601	605	PF00917	0.600
DOC_CYCLIN_yCln2_LP_2	595	601	PF00134	0.626
DOC_MAPK_gen_1	186	193	PF00069	0.555
DOC_MAPK_gen_1	472	479	PF00069	0.694
DOC_MAPK_MEF2A_6	25	34	PF00069	0.404
DOC_MAPK_MEF2A_6	450	457	PF00069	0.522
DOC_MAPK_MEF2A_6	472	479	PF00069	0.674
DOC_PP2B_LxvP_1	191	194	PF13499	0.445
DOC_PP2B_PxIxI_1	1	7	PF00149	0.624
DOC_PP4_FxxP_1	585	588	PF00568	0.700
DOC_USP7_MATH_1	220	224	PF00917	0.499
DOC_USP7_MATH_1	226	230	PF00917	0.474
DOC_USP7_MATH_1	245	249	PF00917	0.394
DOC_USP7_MATH_1	275	279	PF00917	0.608
DOC_USP7_MATH_1	515	519	PF00917	0.551
DOC_USP7_MATH_1	546	550	PF00917	0.644
DOC_WW_Pin1_4	357	362	PF00397	0.665
DOC_WW_Pin1_4	429	434	PF00397	0.685
DOC_WW_Pin1_4	618	623	PF00397	0.692
LIG_14-3-3_CanoR_1	129	133	PF00244	0.575
LIG_14-3-3_CanoR_1	142	150	PF00244	0.441
LIG_14-3-3_CanoR_1	172	179	PF00244	0.642
LIG_14-3-3_CanoR_1	188	194	PF00244	0.372
LIG_14-3-3_CanoR_1	227	235	PF00244	0.483
LIG_14-3-3_CanoR_1	25	33	PF00244	0.498
LIG_14-3-3_CanoR_1	313	318	PF00244	0.485
LIG_14-3-3_CanoR_1	341	346	PF00244	0.498
LIG_14-3-3_CanoR_1	355	361	PF00244	0.605
LIG_14-3-3_CanoR_1	472	478	PF00244	0.677
LIG_14-3-3_CanoR_1	562	570	PF00244	0.697
LIG_14-3-3_CanoR_1	587	595	PF00244	0.703
LIG_DLG_GKlike_1	230	238	PF00625	0.544
LIG_eIF4E_1	553	559	PF01652	0.647
LIG_FHA_1	185	191	PF00498	0.506
LIG_FHA_1	25	31	PF00498	0.476
LIG_FHA_1	452	458	PF00498	0.725
LIG_FHA_1	590	596	PF00498	0.646
LIG_FHA_1	77	83	PF00498	0.554
LIG_FHA_1	98	104	PF00498	0.466
LIG_FHA_2	294	300	PF00498	0.624
LIG_FHA_2	422	428	PF00498	0.576
LIG_FHA_2	488	494	PF00498	0.469
LIG_FHA_2	78	84	PF00498	0.596
LIG_Integrin_isoDGR_2	567	569	PF01839	0.538
LIG_Integrin_RGD_1	581	583	PF01839	0.628
LIG_LIR_Apic_2	550	556	PF02991	0.648
LIG_LIR_Apic_2	583	588	PF02991	0.671
LIG_LIR_Gen_1	195	203	PF02991	0.416
LIG_LIR_Gen_1	20	30	PF02991	0.397
LIG_LIR_Nem_3	195	199	PF02991	0.401
LIG_LIR_Nem_3	20	26	PF02991	0.396
LIG_MYND_1	556	560	PF01753	0.694
LIG_MYND_3	273	277	PF01753	0.628
LIG_NRBOX	205	211	PF00104	0.522
LIG_NRBOX	313	319	PF00104	0.600
LIG_Pex14_2	156	160	PF04695	0.385
LIG_RPA_C_Fungi	225	237	PF08784	0.528
LIG_SH2_CRK	23	27	PF00017	0.392
LIG_SH2_CRK	553	557	PF00017	0.648
LIG_SH2_NCK_1	553	557	PF00017	0.648
LIG_SH2_NCK_1	570	574	PF00017	0.498
LIG_SH2_STAP1	113	117	PF00017	0.442
LIG_SH2_STAT5	189	192	PF00017	0.382
LIG_SH2_STAT5	234	237	PF00017	0.694
LIG_SH2_STAT5	608	611	PF00017	0.593
LIG_SH3_2	557	562	PF14604	0.603
LIG_SH3_3	428	434	PF00018	0.685
LIG_SH3_3	554	560	PF00018	0.615
LIG_SUMO_SIM_anti_2	454	459	PF11976	0.642
LIG_SUMO_SIM_par_1	189	195	PF11976	0.440
LIG_TRAF2_1	74	77	PF00917	0.590
LIG_TYR_ITIM	21	26	PF00017	0.393
LIG_WRC_WIRS_1	193	198	PF05994	0.438
MOD_CK1_1	192	198	PF00069	0.442
MOD_CK1_1	24	30	PF00069	0.453
MOD_CK1_1	420	426	PF00069	0.694
MOD_CK1_1	439	445	PF00069	0.510
MOD_CK1_1	586	592	PF00069	0.702
MOD_CK1_1	603	609	PF00069	0.525
MOD_CK2_1	141	147	PF00069	0.509
MOD_CK2_1	291	297	PF00069	0.651
MOD_CK2_1	341	347	PF00069	0.504
MOD_CK2_1	421	427	PF00069	0.571
MOD_CK2_1	487	493	PF00069	0.519
MOD_CK2_1	515	521	PF00069	0.488
MOD_CK2_1	568	574	PF00069	0.592
MOD_CK2_1	77	83	PF00069	0.603
MOD_Cter_Amidation	170	173	PF01082	0.558
MOD_GlcNHglycan	143	146	PF01048	0.417
MOD_GlcNHglycan	246	250	PF01048	0.610
MOD_GlcNHglycan	277	280	PF01048	0.607
MOD_GlcNHglycan	293	296	PF01048	0.626
MOD_GlcNHglycan	401	404	PF01048	0.662
MOD_GlcNHglycan	419	422	PF01048	0.545
MOD_GlcNHglycan	517	520	PF01048	0.484
MOD_GlcNHglycan	550	553	PF01048	0.643
MOD_GlcNHglycan	564	567	PF01048	0.641
MOD_GlcNHglycan	57	61	PF01048	0.482
MOD_GlcNHglycan	589	592	PF01048	0.690
MOD_GSK3_1	17	24	PF00069	0.405
MOD_GSK3_1	226	233	PF00069	0.506
MOD_GSK3_1	356	363	PF00069	0.655
MOD_GSK3_1	417	424	PF00069	0.564
MOD_GSK3_1	437	444	PF00069	0.553
MOD_GSK3_1	515	522	PF00069	0.615
MOD_GSK3_1	52	59	PF00069	0.455
MOD_GSK3_1	583	590	PF00069	0.646
MOD_GSK3_1	616	623	PF00069	0.574
MOD_N-GLC_1	616	621	PF02516	0.610
MOD_NEK2_1	128	133	PF00069	0.610
MOD_NEK2_1	179	184	PF00069	0.439
MOD_NEK2_1	19	24	PF00069	0.399
MOD_NEK2_1	318	323	PF00069	0.630
MOD_NEK2_1	419	424	PF00069	0.633
MOD_NEK2_1	437	442	PF00069	0.608
MOD_NEK2_1	487	492	PF00069	0.626
MOD_NEK2_1	520	525	PF00069	0.564
MOD_NEK2_1	600	605	PF00069	0.603
MOD_NEK2_1	85	90	PF00069	0.572
MOD_PIKK_1	461	467	PF00454	0.673
MOD_PIKK_1	487	493	PF00454	0.541
MOD_PIKK_1	52	58	PF00454	0.429
MOD_PK_1	404	410	PF00069	0.517
MOD_PK_1	473	479	PF00069	0.639
MOD_PKA_1	291	297	PF00069	0.571
MOD_PKA_1	341	347	PF00069	0.538
MOD_PKA_1	473	479	PF00069	0.639
MOD_PKA_2	128	134	PF00069	0.575
MOD_PKA_2	141	147	PF00069	0.607
MOD_PKA_2	171	177	PF00069	0.646
MOD_PKA_2	226	232	PF00069	0.457
MOD_PKA_2	24	30	PF00069	0.453
MOD_PKA_2	291	297	PF00069	0.571
MOD_PKA_2	341	347	PF00069	0.590
MOD_PKA_2	390	396	PF00069	0.780
MOD_PKA_2	473	479	PF00069	0.690
MOD_PKA_2	487	493	PF00069	0.569
MOD_PKA_2	568	574	PF00069	0.615
MOD_PKA_2	586	592	PF00069	0.730
MOD_Plk_1	146	152	PF00069	0.517
MOD_Plk_1	179	185	PF00069	0.532
MOD_Plk_1	346	352	PF00069	0.656
MOD_Plk_1	56	62	PF00069	0.394
MOD_Plk_1	6	12	PF00069	0.499
MOD_Plk_1	616	622	PF00069	0.666
MOD_Plk_2-3	118	124	PF00069	0.378
MOD_Plk_2-3	451	457	PF00069	0.576
MOD_Plk_2-3	7	13	PF00069	0.458
MOD_Plk_4	179	185	PF00069	0.559
MOD_Plk_4	230	236	PF00069	0.596
MOD_Plk_4	313	319	PF00069	0.600
MOD_Plk_4	341	347	PF00069	0.538
MOD_Plk_4	603	609	PF00069	0.652
MOD_ProDKin_1	357	363	PF00069	0.664
MOD_ProDKin_1	429	435	PF00069	0.679
MOD_ProDKin_1	618	624	PF00069	0.694
MOD_SUMO_rev_2	83	88	PF00179	0.523
TRG_DiLeu_BaEn_3	493	499	PF01217	0.509
TRG_DiLeu_BaEn_4	201	207	PF01217	0.459
TRG_ENDOCYTIC_2	23	26	PF00928	0.392
TRG_ER_diArg_1	186	189	PF00400	0.451
TRG_ER_diArg_1	341	343	PF00400	0.585
TRG_ER_diArg_1	458	460	PF00400	0.699
TRG_ER_diArg_1	472	474	PF00400	0.589
TRG_ER_diArg_1	485	488	PF00400	0.411
TRG_Pf-PMV_PEXEL_1	207	211	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	259	263	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	507	511	PF00026	0.677

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IB58	Leptomonas seymouri	54%	100%
A0A1X0P0W9	Trypanosomatidae	31%	100%
A0A3R7MKA9	Trypanosoma rangeli	27%	100%
A4HHB2	Leishmania braziliensis	77%	99%
A4I4F8	Leishmania infantum	97%	100%
E9ADV8	Leishmania major	91%	100%
E9ALX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BH56	Trypanosoma cruzi	29%	100%