5-histidylcysteine_sulfoxide_synthase_putative/Ge neDB:LmjF.29.0940

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X2D6_LEIDO

TriTrypDb:

LdBPK_291030.1 , LdCL_290014500 , LDHU3_29.1400

Length:

757

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X2D6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2D6

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	3
GO:0010035	response to inorganic substance	3	1
GO:0010038	response to metal ion	4	1
GO:0010039	response to iron ion	5	1
GO:0010040	response to iron(II) ion	6	1
GO:0018158	protein oxidation	5	1
GO:0018171	peptidyl-cysteine oxidation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0042221	response to chemical	2	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0050896	response to stimulus	1	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:0032259	methylation	2	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005506	iron ion binding	6	1
GO:0008198	ferrous iron binding	7	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.438
CLV_C14_Caspase3-7	689	693	PF00656	0.630
CLV_NRD_NRD_1	143	145	PF00675	0.360
CLV_NRD_NRD_1	476	478	PF00675	0.281
CLV_NRD_NRD_1	536	538	PF00675	0.424
CLV_NRD_NRD_1	579	581	PF00675	0.425
CLV_NRD_NRD_1	754	756	PF00675	0.351
CLV_PCSK_KEX2_1	143	145	PF00082	0.360
CLV_PCSK_KEX2_1	361	363	PF00082	0.287
CLV_PCSK_KEX2_1	476	478	PF00082	0.281
CLV_PCSK_KEX2_1	536	538	PF00082	0.432
CLV_PCSK_KEX2_1	579	581	PF00082	0.383
CLV_PCSK_KEX2_1	622	624	PF00082	0.469
CLV_PCSK_PC1ET2_1	361	363	PF00082	0.287
CLV_PCSK_PC1ET2_1	622	624	PF00082	0.475
CLV_PCSK_PC7_1	472	478	PF00082	0.281
CLV_PCSK_SKI1_1	19	23	PF00082	0.436
CLV_PCSK_SKI1_1	24	28	PF00082	0.376
CLV_PCSK_SKI1_1	364	368	PF00082	0.293
CLV_PCSK_SKI1_1	472	476	PF00082	0.266
CLV_PCSK_SKI1_1	477	481	PF00082	0.266
CLV_PCSK_SKI1_1	536	540	PF00082	0.390
CLV_PCSK_SKI1_1	559	563	PF00082	0.417
CLV_PCSK_SKI1_1	622	626	PF00082	0.466
CLV_PCSK_SKI1_1	666	670	PF00082	0.439
DEG_Nend_UBRbox_1	1	4	PF02207	0.552
DOC_CKS1_1	20	25	PF01111	0.484
DOC_CYCLIN_RxL_1	19	28	PF00134	0.354
DOC_CYCLIN_yClb3_PxF_3	308	316	PF00134	0.281
DOC_CYCLIN_yCln2_LP_2	161	167	PF00134	0.340
DOC_CYCLIN_yCln2_LP_2	71	74	PF00134	0.372
DOC_CYCLIN_yCln2_LP_2	78	84	PF00134	0.264
DOC_MAPK_gen_1	666	675	PF00069	0.359
DOC_MAPK_gen_1	77	84	PF00069	0.308
DOC_MAPK_MEF2A_6	158	167	PF00069	0.343
DOC_PP1_RVXF_1	188	194	PF00149	0.297
DOC_PP1_RVXF_1	299	306	PF00149	0.325
DOC_PP1_RVXF_1	557	563	PF00149	0.313
DOC_PP2B_LxvP_1	161	164	PF13499	0.351
DOC_PP2B_LxvP_1	71	74	PF13499	0.400
DOC_PP4_FxxP_1	443	446	PF00568	0.250
DOC_PP4_FxxP_1	70	73	PF00568	0.348
DOC_SPAK_OSR1_1	272	276	PF12202	0.210
DOC_USP7_MATH_1	350	354	PF00917	0.411
DOC_USP7_UBL2_3	158	162	PF12436	0.366
DOC_WW_Pin1_4	104	109	PF00397	0.303
DOC_WW_Pin1_4	19	24	PF00397	0.416
LIG_14-3-3_CanoR_1	24	34	PF00244	0.323
LIG_14-3-3_CanoR_1	327	336	PF00244	0.330
LIG_14-3-3_CanoR_1	364	373	PF00244	0.344
LIG_14-3-3_CanoR_1	605	611	PF00244	0.455
LIG_14-3-3_CanoR_1	623	627	PF00244	0.256
LIG_AP2alpha_1	439	443	PF02296	0.277
LIG_AP2alpha_1	517	521	PF02296	0.482
LIG_APCC_ABBA_1	436	441	PF00400	0.225
LIG_BRCT_BRCA1_1	155	159	PF00533	0.450
LIG_BRCT_BRCA1_1	611	615	PF00533	0.416
LIG_deltaCOP1_diTrp_1	296	305	PF00928	0.270
LIG_deltaCOP1_diTrp_1	309	314	PF00928	0.360
LIG_deltaCOP1_diTrp_1	334	339	PF00928	0.266
LIG_deltaCOP1_diTrp_1	368	375	PF00928	0.281
LIG_eIF4E_1	576	582	PF01652	0.475
LIG_eIF4E_1	66	72	PF01652	0.384
LIG_eIF4E_1	698	704	PF01652	0.523
LIG_FHA_1	101	107	PF00498	0.468
LIG_FHA_1	193	199	PF00498	0.299
LIG_FHA_1	328	334	PF00498	0.281
LIG_FHA_1	51	57	PF00498	0.297
LIG_FHA_1	698	704	PF00498	0.559
LIG_FHA_1	741	747	PF00498	0.501
LIG_FHA_2	136	142	PF00498	0.327
LIG_FHA_2	169	175	PF00498	0.418
LIG_FHA_2	365	371	PF00498	0.266
LIG_LIR_Apic_2	128	134	PF02991	0.360
LIG_LIR_Apic_2	334	340	PF02991	0.266
LIG_LIR_Apic_2	441	446	PF02991	0.367
LIG_LIR_Apic_2	67	73	PF02991	0.341
LIG_LIR_Gen_1	120	131	PF02991	0.410
LIG_LIR_Gen_1	279	289	PF02991	0.266
LIG_LIR_Gen_1	368	379	PF02991	0.266
LIG_LIR_Gen_1	412	420	PF02991	0.360
LIG_LIR_Gen_1	55	65	PF02991	0.314
LIG_LIR_Gen_1	565	576	PF02991	0.328
LIG_LIR_Gen_1	678	688	PF02991	0.524
LIG_LIR_Gen_1	713	723	PF02991	0.333
LIG_LIR_LC3C_4	640	645	PF02991	0.438
LIG_LIR_Nem_3	120	126	PF02991	0.407
LIG_LIR_Nem_3	132	136	PF02991	0.424
LIG_LIR_Nem_3	279	283	PF02991	0.266
LIG_LIR_Nem_3	297	303	PF02991	0.276
LIG_LIR_Nem_3	309	315	PF02991	0.379
LIG_LIR_Nem_3	368	374	PF02991	0.266
LIG_LIR_Nem_3	412	417	PF02991	0.360
LIG_LIR_Nem_3	519	524	PF02991	0.412
LIG_LIR_Nem_3	55	60	PF02991	0.292
LIG_LIR_Nem_3	565	571	PF02991	0.318
LIG_LIR_Nem_3	678	684	PF02991	0.476
LIG_LIR_Nem_3	713	718	PF02991	0.345
LIG_PCNA_yPIPBox_3	218	232	PF02747	0.502
LIG_PCNA_yPIPBox_3	707	718	PF02747	0.428
LIG_Pex14_1	252	256	PF04695	0.266
LIG_Pex14_1	371	375	PF04695	0.411
LIG_Pex14_2	439	443	PF04695	0.259
LIG_Pex14_2	475	479	PF04695	0.266
LIG_Pex14_2	517	521	PF04695	0.396
LIG_Pex14_2	57	61	PF04695	0.358
LIG_PTB_Apo_2	274	281	PF02174	0.281
LIG_PTB_Apo_2	511	518	PF02174	0.260
LIG_SH2_CRK	414	418	PF00017	0.360
LIG_SH2_GRB2like	256	259	PF00017	0.360
LIG_SH2_GRB2like	93	96	PF00017	0.305
LIG_SH2_NCK_1	414	418	PF00017	0.360
LIG_SH2_PTP2	482	485	PF00017	0.300
LIG_SH2_SRC	487	490	PF00017	0.302
LIG_SH2_SRC	654	657	PF00017	0.357
LIG_SH2_SRC	66	69	PF00017	0.516
LIG_SH2_STAP1	534	538	PF00017	0.328
LIG_SH2_STAP1	66	70	PF00017	0.378
LIG_SH2_STAT3	142	145	PF00017	0.384
LIG_SH2_STAT3	289	292	PF00017	0.266
LIG_SH2_STAT3	595	598	PF00017	0.420
LIG_SH2_STAT3	9	12	PF00017	0.473
LIG_SH2_STAT5	207	210	PF00017	0.455
LIG_SH2_STAT5	256	259	PF00017	0.243
LIG_SH2_STAT5	378	381	PF00017	0.281
LIG_SH2_STAT5	482	485	PF00017	0.300
LIG_SH2_STAT5	487	490	PF00017	0.341
LIG_SH2_STAT5	49	52	PF00017	0.296
LIG_SH2_STAT5	576	579	PF00017	0.436
LIG_SH2_STAT5	698	701	PF00017	0.559
LIG_SH2_STAT5	93	96	PF00017	0.305
LIG_SH3_3	305	311	PF00018	0.266
LIG_SH3_3	485	491	PF00018	0.411
LIG_SH3_3	728	734	PF00018	0.364
LIG_SUMO_SIM_anti_2	639	645	PF11976	0.295
LIG_SxIP_EBH_1	652	665	PF03271	0.390
LIG_TRAF2_1	10	13	PF00917	0.398
LIG_TRAF2_1	367	370	PF00917	0.287
LIG_TRAF2_1	65	68	PF00917	0.389
LIG_WRC_WIRS_1	280	285	PF05994	0.352
LIG_WRC_WIRS_1	351	356	PF05994	0.360
LIG_WRC_WIRS_1	445	450	PF05994	0.266
LIG_WRC_WIRS_1	703	708	PF05994	0.382
MOD_CDK_SPK_2	104	109	PF00069	0.303
MOD_CDK_SPK_2	19	24	PF00069	0.465
MOD_CK1_1	132	138	PF00069	0.435
MOD_CK1_1	353	359	PF00069	0.334
MOD_CK1_1	444	450	PF00069	0.288
MOD_CK1_1	629	635	PF00069	0.461
MOD_CK1_1	636	642	PF00069	0.364
MOD_CK2_1	135	141	PF00069	0.353
MOD_CK2_1	273	279	PF00069	0.269
MOD_CK2_1	364	370	PF00069	0.266
MOD_CK2_1	7	13	PF00069	0.348
MOD_CMANNOS	302	305	PF00535	0.266
MOD_Cter_Amidation	359	362	PF01082	0.325
MOD_GlcNHglycan	155	158	PF01048	0.383
MOD_GlcNHglycan	321	324	PF01048	0.331
MOD_GlcNHglycan	35	38	PF01048	0.591
MOD_GlcNHglycan	599	602	PF01048	0.570
MOD_GlcNHglycan	656	659	PF01048	0.420
MOD_GlcNHglycan	686	689	PF01048	0.594
MOD_GlcNHglycan	9	12	PF01048	0.427
MOD_GSK3_1	100	107	PF00069	0.289
MOD_GSK3_1	163	170	PF00069	0.384
MOD_GSK3_1	206	213	PF00069	0.541
MOD_GSK3_1	399	406	PF00069	0.265
MOD_GSK3_1	456	463	PF00069	0.397
MOD_GSK3_1	593	600	PF00069	0.454
MOD_GSK3_1	622	629	PF00069	0.410
MOD_GSK3_1	650	657	PF00069	0.351
MOD_LATS_1	5	11	PF00433	0.305
MOD_N-GLC_1	168	173	PF02516	0.376
MOD_N-GLC_2	112	114	PF02516	0.370
MOD_N-GLC_2	258	260	PF02516	0.287
MOD_N-GLC_2	514	516	PF02516	0.381
MOD_N-GLC_2	526	528	PF02516	0.304
MOD_NEK2_1	153	158	PF00069	0.362
MOD_NEK2_1	268	273	PF00069	0.310
MOD_NEK2_1	517	522	PF00069	0.383
MOD_NEK2_1	562	567	PF00069	0.318
MOD_NEK2_1	650	655	PF00069	0.346
MOD_NEK2_2	350	355	PF00069	0.360
MOD_NEK2_2	702	707	PF00069	0.364
MOD_PIKK_1	221	227	PF00454	0.370
MOD_PIKK_1	25	31	PF00454	0.485
MOD_PIKK_1	327	333	PF00454	0.265
MOD_PKA_1	622	628	PF00069	0.472
MOD_PKA_2	319	325	PF00069	0.452
MOD_PKA_2	517	523	PF00069	0.362
MOD_PKA_2	622	628	PF00069	0.381
MOD_PKB_1	362	370	PF00069	0.287
MOD_Plk_1	119	125	PF00069	0.386
MOD_Plk_1	369	375	PF00069	0.387
MOD_Plk_1	441	447	PF00069	0.266
MOD_Plk_1	639	645	PF00069	0.304
MOD_Plk_1	650	656	PF00069	0.313
MOD_Plk_1	66	72	PF00069	0.384
MOD_Plk_1	694	700	PF00069	0.555
MOD_Plk_2-3	119	125	PF00069	0.386
MOD_Plk_4	207	213	PF00069	0.456
MOD_Plk_4	622	628	PF00069	0.404
MOD_Plk_4	639	645	PF00069	0.355
MOD_Plk_4	66	72	PF00069	0.401
MOD_Plk_4	694	700	PF00069	0.582
MOD_ProDKin_1	104	110	PF00069	0.297
MOD_ProDKin_1	19	25	PF00069	0.417
MOD_SUMO_for_1	354	357	PF00179	0.281
MOD_SUMO_for_1	41	44	PF00179	0.503
MOD_SUMO_for_1	610	613	PF00179	0.391
MOD_SUMO_for_1	738	741	PF00179	0.376
TRG_DiLeu_BaEn_1	369	374	PF01217	0.264
TRG_DiLeu_BaEn_1	67	72	PF01217	0.382
TRG_DiLeu_BaEn_1	713	718	PF01217	0.337
TRG_DiLeu_BaEn_2	278	284	PF01217	0.266
TRG_DiLeu_BaEn_4	15	21	PF01217	0.437
TRG_DiLeu_BaLyEn_6	699	704	PF01217	0.378
TRG_ENDOCYTIC_2	414	417	PF00928	0.354
TRG_ENDOCYTIC_2	440	443	PF00928	0.279
TRG_ENDOCYTIC_2	482	485	PF00928	0.300
TRG_ER_diArg_1	142	144	PF00400	0.342
TRG_ER_diArg_1	362	365	PF00400	0.287
TRG_ER_diArg_1	475	477	PF00400	0.281
TRG_ER_diArg_1	536	538	PF00400	0.439
TRG_ER_diArg_1	579	581	PF00400	0.383
TRG_NES_CRM1_1	44	58	PF08389	0.321
TRG_NES_CRM1_1	563	575	PF08389	0.327
TRG_Pf-PMV_PEXEL_1	24	29	PF00026	0.402
TRG_Pf-PMV_PEXEL_1	364	368	PF00026	0.300

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMA1	Leptomonas seymouri	78%	100%
A0A0S4JIK4	Bodo saltans	57%	100%
A0A1X0NZP4	Trypanosomatidae	62%	100%
A0A422NF05	Trypanosoma rangeli	60%	100%
A4HHA6	Leishmania braziliensis	86%	100%
A4I4F2	Leishmania infantum	100%	100%
C9ZLK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9ADV2	Leishmania major	96%	100%
E9ALX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BR85	Trypanosoma cruzi	61%	100%