Solute carrier family 35 member F6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic protein of unknown function (DUF914), putative

Species:

Leishmania donovani

UniProt:

A0A3S7X2D4_LEIDO

TriTrypDb:

LdBPK_290970.1 , LdCL_290015100 , LDHU3_29.1340

Length:

452

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

A0A3S7X2D4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2D4

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	12
GO:0022857	transmembrane transporter activity	2	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	398	402	PF00656	0.564
CLV_PCSK_KEX2_1	17	19	PF00082	0.346
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.388
CLV_PCSK_PC7_1	13	19	PF00082	0.300
CLV_PCSK_SKI1_1	13	17	PF00082	0.268
CLV_PCSK_SKI1_1	18	22	PF00082	0.322
CLV_PCSK_SKI1_1	203	207	PF00082	0.694
CLV_PCSK_SKI1_1	285	289	PF00082	0.336
CLV_PCSK_SKI1_1	353	357	PF00082	0.423
DEG_APCC_DBOX_1	12	20	PF00400	0.506

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8D2	Leptomonas seymouri	64%	100%
A0A0S4ISV7	Bodo saltans	41%	100%
A0A1X0PAA4	Trypanosomatidae	53%	100%
A0A422NJ67	Trypanosoma rangeli	50%	100%
A4HHA0	Leishmania braziliensis	79%	100%
A4I4E6	Leishmania infantum	100%	100%
C9ZLM2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ADU6	Leishmania major	92%	100%
E9ALY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O59785	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	90%

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