Solute carrier family 35 member F6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic protein of unknown function (DUF914), putative

Species:

Leishmania donovani

UniProt:

A0A3S7X2D4_LEIDO

TriTrypDb:

LdBPK_290970.1 , LdCL_290015100 , LDHU3_29.1340

Length:

452

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A0A3S7X2D4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2D4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	12
GO:0022857	transmembrane transporter activity	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	398	402	PF00656	0.564
CLV_PCSK_KEX2_1	17	19	PF00082	0.346
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.388
CLV_PCSK_PC7_1	13	19	PF00082	0.300
CLV_PCSK_SKI1_1	13	17	PF00082	0.268
CLV_PCSK_SKI1_1	18	22	PF00082	0.322
CLV_PCSK_SKI1_1	203	207	PF00082	0.694
CLV_PCSK_SKI1_1	285	289	PF00082	0.336
CLV_PCSK_SKI1_1	353	357	PF00082	0.423
DEG_APCC_DBOX_1	12	20	PF00400	0.506
DEG_APCC_KENBOX_2	391	395	PF00400	0.559
DOC_CYCLIN_yClb1_LxF_4	351	356	PF00134	0.536
DOC_MAPK_gen_1	86	95	PF00069	0.474
DOC_MAPK_MEF2A_6	253	260	PF00069	0.416
DOC_PP1_RVXF_1	351	357	PF00149	0.536
DOC_PP2B_PxIxI_1	316	322	PF00149	0.236
DOC_PP4_FxxP_1	122	125	PF00568	0.316
DOC_PP4_FxxP_1	198	201	PF00568	0.261
DOC_PP4_FxxP_1	61	64	PF00568	0.370
DOC_USP7_MATH_1	226	230	PF00917	0.547
DOC_USP7_MATH_1	265	269	PF00917	0.399
DOC_USP7_MATH_1	289	293	PF00917	0.519
DOC_USP7_MATH_1	3	7	PF00917	0.548
DOC_WW_Pin1_4	224	229	PF00397	0.522
DOC_WW_Pin1_4	417	422	PF00397	0.503
LIG_14-3-3_CanoR_1	291	295	PF00244	0.536
LIG_AP2alpha_2	389	391	PF02296	0.511
LIG_BIR_II_1	1	5	PF00653	0.654
LIG_BIR_III_4	161	165	PF00653	0.250
LIG_BRCT_BRCA1_1	235	239	PF00533	0.400
LIG_BRCT_BRCA1_1	323	327	PF00533	0.250
LIG_BRCT_BRCA1_1	5	9	PF00533	0.694
LIG_Clathr_ClatBox_1	157	161	PF01394	0.303
LIG_deltaCOP1_diTrp_1	283	287	PF00928	0.461
LIG_deltaCOP1_diTrp_1	298	305	PF00928	0.461
LIG_EH1_1	304	312	PF00400	0.450
LIG_eIF4E_1	62	68	PF01652	0.337
LIG_FHA_1	109	115	PF00498	0.259
LIG_FHA_1	140	146	PF00498	0.334
LIG_FHA_1	188	194	PF00498	0.291
LIG_FHA_1	306	312	PF00498	0.450
LIG_FHA_1	332	338	PF00498	0.380
LIG_FHA_1	34	40	PF00498	0.294
LIG_FHA_1	370	376	PF00498	0.559
LIG_FHA_1	436	442	PF00498	0.536
LIG_FHA_2	293	299	PF00498	0.476
LIG_FHA_2	396	402	PF00498	0.583
LIG_FHA_2	9	15	PF00498	0.555
LIG_LIR_Apic_2	195	201	PF02991	0.264
LIG_LIR_Gen_1	268	277	PF02991	0.388
LIG_LIR_Gen_1	298	309	PF02991	0.484
LIG_LIR_Gen_1	324	335	PF02991	0.254
LIG_LIR_Gen_1	358	367	PF02991	0.336
LIG_LIR_Gen_1	53	63	PF02991	0.301
LIG_LIR_Gen_1	99	110	PF02991	0.336
LIG_LIR_Nem_3	131	135	PF02991	0.325
LIG_LIR_Nem_3	268	273	PF02991	0.377
LIG_LIR_Nem_3	276	282	PF02991	0.322
LIG_LIR_Nem_3	283	287	PF02991	0.435
LIG_LIR_Nem_3	298	304	PF02991	0.450
LIG_LIR_Nem_3	324	330	PF02991	0.244
LIG_LIR_Nem_3	345	350	PF02991	0.329
LIG_LIR_Nem_3	358	362	PF02991	0.296
LIG_LIR_Nem_3	45	49	PF02991	0.245
LIG_LIR_Nem_3	53	58	PF02991	0.293
LIG_LIR_Nem_3	6	12	PF02991	0.671
LIG_LIR_Nem_3	79	84	PF02991	0.472
LIG_LIR_Nem_3	99	105	PF02991	0.217
LIG_LYPXL_yS_3	46	49	PF13949	0.275
LIG_Pex14_2	270	274	PF04695	0.348
LIG_Pex14_2	280	284	PF04695	0.250
LIG_Pex14_2	301	305	PF04695	0.388
LIG_Pex14_2	379	383	PF04695	0.459
LIG_Pex14_2	57	61	PF04695	0.386
LIG_Pex14_2	83	87	PF04695	0.477
LIG_PTB_Apo_2	77	84	PF02174	0.491
LIG_REV1ctd_RIR_1	130	140	PF16727	0.360
LIG_SH2_CRK	55	59	PF00017	0.330
LIG_SH2_CRK	90	94	PF00017	0.337
LIG_SH2_GRB2like	110	113	PF00017	0.336
LIG_SH2_PTP2	102	105	PF00017	0.386
LIG_SH2_PTP2	359	362	PF00017	0.280
LIG_SH2_SRC	338	341	PF00017	0.352
LIG_SH2_SRC	359	362	PF00017	0.327
LIG_SH2_SRC	62	65	PF00017	0.411
LIG_SH2_STAP1	110	114	PF00017	0.119
LIG_SH2_STAP1	338	342	PF00017	0.314
LIG_SH2_STAP1	55	59	PF00017	0.337
LIG_SH2_STAP1	90	94	PF00017	0.388
LIG_SH2_STAT5	102	105	PF00017	0.325
LIG_SH2_STAT5	110	113	PF00017	0.240
LIG_SH2_STAT5	313	316	PF00017	0.303
LIG_SH2_STAT5	359	362	PF00017	0.280
LIG_SH2_STAT5	62	65	PF00017	0.346
LIG_SH3_3	198	204	PF00018	0.344
LIG_SH3_3	253	259	PF00018	0.382
LIG_SH3_3	372	378	PF00018	0.480
LIG_SUMO_SIM_par_1	156	161	PF11976	0.305
LIG_SUMO_SIM_par_1	308	314	PF11976	0.388
LIG_SUMO_SIM_par_1	91	97	PF11976	0.388
LIG_TYR_ITIM	357	362	PF00017	0.360
LIG_TYR_ITSM	51	58	PF00017	0.303
LIG_UBA3_1	346	353	PF00899	0.404
LIG_UBA3_1	67	72	PF00899	0.423
LIG_WRC_WIRS_1	129	134	PF05994	0.337
LIG_WRC_WIRS_1	267	272	PF05994	0.450
MOD_CK1_1	227	233	PF00069	0.509
MOD_CK1_1	292	298	PF00069	0.504
MOD_CK1_1	331	337	PF00069	0.320
MOD_CK1_1	42	48	PF00069	0.300
MOD_CK1_1	422	428	PF00069	0.581
MOD_CK2_1	163	169	PF00069	0.330
MOD_CK2_1	397	403	PF00069	0.554
MOD_CK2_1	8	14	PF00069	0.618
MOD_GlcNHglycan	215	218	PF01048	0.719
MOD_GlcNHglycan	323	326	PF01048	0.450
MOD_GlcNHglycan	424	427	PF01048	0.802
MOD_GSK3_1	108	115	PF00069	0.250
MOD_GSK3_1	165	172	PF00069	0.303
MOD_GSK3_1	183	190	PF00069	0.241
MOD_GSK3_1	29	36	PF00069	0.297
MOD_GSK3_1	431	438	PF00069	0.549
MOD_N-GLC_1	213	218	PF02516	0.674
MOD_N-GLC_1	289	294	PF02516	0.325
MOD_N-GLC_1	328	333	PF02516	0.298
MOD_N-GLC_1	342	347	PF02516	0.303
MOD_N-GLC_1	369	374	PF02516	0.543
MOD_N-GLC_1	395	400	PF02516	0.651
MOD_N-GLC_1	42	47	PF02516	0.461
MOD_N-GLC_1	422	427	PF02516	0.766
MOD_N-GLC_2	209	211	PF02516	0.677
MOD_NEK2_1	128	133	PF00069	0.314
MOD_NEK2_1	139	144	PF00069	0.439
MOD_NEK2_1	182	187	PF00069	0.260
MOD_NEK2_1	266	271	PF00069	0.383
MOD_NEK2_1	27	32	PF00069	0.324
MOD_NEK2_1	272	277	PF00069	0.413
MOD_NEK2_1	305	310	PF00069	0.312
MOD_NEK2_1	311	316	PF00069	0.264
MOD_NEK2_1	320	325	PF00069	0.305
MOD_NEK2_1	355	360	PF00069	0.318
MOD_NEK2_1	39	44	PF00069	0.250
MOD_NEK2_2	342	347	PF00069	0.318
MOD_NEK2_2	8	13	PF00069	0.641
MOD_PIKK_1	169	175	PF00454	0.335
MOD_PIKK_1	221	227	PF00454	0.516
MOD_PIKK_1	440	446	PF00454	0.559
MOD_PKA_2	169	175	PF00069	0.333
MOD_PKA_2	290	296	PF00069	0.511
MOD_PKA_2	76	82	PF00069	0.500
MOD_Plk_1	289	295	PF00069	0.486
MOD_Plk_1	328	334	PF00069	0.303
MOD_Plk_1	342	348	PF00069	0.303
MOD_Plk_1	42	48	PF00069	0.250
MOD_Plk_2-3	397	403	PF00069	0.505
MOD_Plk_4	128	134	PF00069	0.293
MOD_Plk_4	183	189	PF00069	0.310
MOD_Plk_4	234	240	PF00069	0.561
MOD_Plk_4	305	311	PF00069	0.317
MOD_Plk_4	342	348	PF00069	0.362
MOD_Plk_4	355	361	PF00069	0.362
MOD_ProDKin_1	224	230	PF00069	0.521
MOD_ProDKin_1	417	423	PF00069	0.505
MOD_SUMO_for_1	219	222	PF00179	0.491
TRG_ENDOCYTIC_2	102	105	PF00928	0.289
TRG_ENDOCYTIC_2	110	113	PF00928	0.119
TRG_ENDOCYTIC_2	313	316	PF00928	0.388
TRG_ENDOCYTIC_2	338	341	PF00928	0.298
TRG_ENDOCYTIC_2	359	362	PF00928	0.303
TRG_ENDOCYTIC_2	46	49	PF00928	0.257
TRG_ENDOCYTIC_2	55	58	PF00928	0.279
TRG_ENDOCYTIC_2	90	93	PF00928	0.322

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8D2	Leptomonas seymouri	64%	100%
A0A0S4ISV7	Bodo saltans	41%	100%
A0A1X0PAA4	Trypanosomatidae	53%	100%
A0A422NJ67	Trypanosoma rangeli	50%	100%
A4HHA0	Leishmania braziliensis	79%	100%
A4I4E6	Leishmania infantum	100%	100%
C9ZLM2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ADU6	Leishmania major	92%	100%
E9ALY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O59785	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	90%
V5BCU4	Trypanosoma cruzi	46%	100%