Hsp70_protein/TPR_repeat/Tetratricopeptide_repeat _putative/Pfam:PF00012/Pfam:PF13414/Pfam:PF13371/Pfam:PF077 19/Pfam:PF00515/Pfam:PF13181

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Hsp70 protein/TPR repeat, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X2D2_LEIDO

TriTrypDb:

LdBPK_291330.1 , LdCL_290018400 , LDHU3_29.1820

Length:

725

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 3
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3S7X2D2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2D2

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	1
GO:0006457	protein folding	2	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018208	peptidyl-proline modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0061077	chaperone-mediated protein folding	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0044183	protein folding chaperone	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140657	ATP-dependent activity	1	12
GO:0140662	ATP-dependent protein folding chaperone	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	1
GO:0003824	catalytic activity	1	1
GO:0016853	isomerase activity	2	1
GO:0016859	cis-trans isomerase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	424	428	PF00656	0.515
CLV_C14_Caspase3-7	455	459	PF00656	0.519
CLV_NRD_NRD_1	258	260	PF00675	0.423
CLV_NRD_NRD_1	265	267	PF00675	0.386
CLV_NRD_NRD_1	387	389	PF00675	0.552
CLV_NRD_NRD_1	548	550	PF00675	0.554
CLV_NRD_NRD_1	581	583	PF00675	0.484
CLV_NRD_NRD_1	667	669	PF00675	0.374
CLV_PCSK_KEX2_1	387	389	PF00082	0.471
CLV_PCSK_KEX2_1	548	550	PF00082	0.550
CLV_PCSK_KEX2_1	580	582	PF00082	0.556
CLV_PCSK_KEX2_1	623	625	PF00082	0.499
CLV_PCSK_KEX2_1	667	669	PF00082	0.400
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.550
CLV_PCSK_PC1ET2_1	580	582	PF00082	0.612
CLV_PCSK_PC1ET2_1	623	625	PF00082	0.499
CLV_PCSK_PC7_1	544	550	PF00082	0.586
CLV_PCSK_PC7_1	576	582	PF00082	0.582
CLV_PCSK_SKI1_1	112	116	PF00082	0.406
CLV_PCSK_SKI1_1	12	16	PF00082	0.464
CLV_PCSK_SKI1_1	259	263	PF00082	0.458
CLV_PCSK_SKI1_1	266	270	PF00082	0.451
CLV_PCSK_SKI1_1	312	316	PF00082	0.483
CLV_PCSK_SKI1_1	358	362	PF00082	0.422
CLV_PCSK_SKI1_1	387	391	PF00082	0.485
CLV_PCSK_SKI1_1	41	45	PF00082	0.454
CLV_PCSK_SKI1_1	442	446	PF00082	0.478
CLV_PCSK_SKI1_1	663	667	PF00082	0.454
CLV_PCSK_SKI1_1	706	710	PF00082	0.556
CLV_PCSK_SKI1_1	717	721	PF00082	0.512
DEG_APCC_DBOX_1	311	319	PF00400	0.458
DEG_Nend_UBRbox_2	1	3	PF02207	0.585
DOC_ANK_TNKS_1	339	346	PF00023	0.462
DOC_CYCLIN_yCln2_LP_2	100	106	PF00134	0.410
DOC_MAPK_gen_1	442	450	PF00069	0.423
DOC_MAPK_gen_1	548	557	PF00069	0.551
DOC_MAPK_gen_1	620	628	PF00069	0.507
DOC_MAPK_MEF2A_6	125	133	PF00069	0.410
DOC_MAPK_MEF2A_6	68	76	PF00069	0.500
DOC_PP2B_LxvP_1	131	134	PF13499	0.462
DOC_USP7_MATH_1	132	136	PF00917	0.436
DOC_USP7_MATH_1	377	381	PF00917	0.477
DOC_USP7_MATH_1	408	412	PF00917	0.617
DOC_USP7_MATH_1	486	490	PF00917	0.718
DOC_USP7_MATH_1	635	639	PF00917	0.490
DOC_USP7_UBL2_3	256	260	PF12436	0.402
DOC_USP7_UBL2_3	713	717	PF12436	0.529
DOC_USP7_UBL2_3	718	722	PF12436	0.561
DOC_WW_Pin1_4	124	129	PF00397	0.438
DOC_WW_Pin1_4	427	432	PF00397	0.537
DOC_WW_Pin1_4	75	80	PF00397	0.462
LIG_14-3-3_CanoR_1	312	322	PF00244	0.407
LIG_14-3-3_CanoR_1	365	371	PF00244	0.443
LIG_14-3-3_CanoR_1	434	441	PF00244	0.618
LIG_Actin_WH2_2	209	224	PF00022	0.478
LIG_Clathr_ClatBox_1	420	424	PF01394	0.524
LIG_deltaCOP1_diTrp_1	591	601	PF00928	0.498
LIG_EH1_1	108	116	PF00400	0.438
LIG_FHA_1	124	130	PF00498	0.481
LIG_FHA_1	18	24	PF00498	0.462
LIG_FHA_1	513	519	PF00498	0.487
LIG_FHA_1	597	603	PF00498	0.474
LIG_FHA_1	650	656	PF00498	0.543
LIG_FHA_1	82	88	PF00498	0.525
LIG_FHA_2	272	278	PF00498	0.432
LIG_FHA_2	401	407	PF00498	0.771
LIG_FHA_2	47	53	PF00498	0.405
LIG_FHA_2	59	65	PF00498	0.462
LIG_FHA_2	612	618	PF00498	0.545
LIG_Integrin_RGD_1	252	254	PF01839	0.462
LIG_LIR_Gen_1	141	150	PF02991	0.471
LIG_LIR_Gen_1	234	244	PF02991	0.438
LIG_LIR_Gen_1	446	454	PF02991	0.624
LIG_LIR_Gen_1	530	540	PF02991	0.602
LIG_LIR_Gen_1	629	639	PF02991	0.495
LIG_LIR_Nem_3	141	145	PF02991	0.471
LIG_LIR_Nem_3	234	240	PF02991	0.484
LIG_LIR_Nem_3	257	261	PF02991	0.407
LIG_LIR_Nem_3	446	450	PF02991	0.631
LIG_LIR_Nem_3	530	536	PF02991	0.525
LIG_LIR_Nem_3	537	543	PF02991	0.565
LIG_LIR_Nem_3	629	634	PF02991	0.500
LIG_Pex14_1	56	60	PF04695	0.462
LIG_Pex14_2	720	724	PF04695	0.575
LIG_Rb_pABgroove_1	606	614	PF01858	0.536
LIG_RPA_C_Fungi	465	477	PF08784	0.457
LIG_RPA_C_Fungi	663	675	PF08784	0.462
LIG_SH2_CRK	177	181	PF00017	0.462
LIG_SH2_CRK	672	676	PF00017	0.410
LIG_SH2_GRB2like	631	634	PF00017	0.498
LIG_SH2_SRC	631	634	PF00017	0.476
LIG_SH2_SRC	678	681	PF00017	0.378
LIG_SH2_STAP1	678	682	PF00017	0.378
LIG_SH2_STAT3	474	477	PF00017	0.480
LIG_SH2_STAT5	110	113	PF00017	0.469
LIG_SH2_STAT5	171	174	PF00017	0.462
LIG_SH2_STAT5	227	230	PF00017	0.469
LIG_SH2_STAT5	474	477	PF00017	0.480
LIG_SH2_STAT5	498	501	PF00017	0.564
LIG_SH2_STAT5	505	508	PF00017	0.587
LIG_SH2_STAT5	60	63	PF00017	0.462
LIG_SH2_STAT5	631	634	PF00017	0.498
LIG_SH3_3	656	662	PF00018	0.505
LIG_SH3_3	73	79	PF00018	0.470
LIG_SUMO_SIM_anti_2	288	294	PF11976	0.462
LIG_SUMO_SIM_par_1	189	195	PF11976	0.410
LIG_SUMO_SIM_par_1	290	296	PF11976	0.488
LIG_TRAF2_1	615	618	PF00917	0.626
LIG_TYR_ITIM	175	180	PF00017	0.410
LIG_UBA3_1	114	121	PF00899	0.378
LIG_UBA3_1	314	321	PF00899	0.410
LIG_WRC_WIRS_1	23	28	PF05994	0.462
LIG_WRC_WIRS_1	255	260	PF05994	0.462
LIG_WW_3	337	341	PF00397	0.378
MOD_CDK_SPxxK_3	427	434	PF00069	0.489
MOD_CK1_1	201	207	PF00069	0.471
MOD_CK1_1	430	436	PF00069	0.498
MOD_CK1_1	542	548	PF00069	0.551
MOD_CK1_1	78	84	PF00069	0.463
MOD_CK2_1	271	277	PF00069	0.432
MOD_CK2_1	30	36	PF00069	0.496
MOD_CK2_1	372	378	PF00069	0.545
MOD_CK2_1	408	414	PF00069	0.658
MOD_CK2_1	511	517	PF00069	0.626
MOD_CK2_1	531	537	PF00069	0.542
MOD_CK2_1	58	64	PF00069	0.475
MOD_CK2_1	611	617	PF00069	0.639
MOD_Cter_Amidation	240	243	PF01082	0.378
MOD_GlcNHglycan	134	137	PF01048	0.433
MOD_GlcNHglycan	285	288	PF01048	0.532
MOD_GlcNHglycan	378	382	PF01048	0.461
MOD_GlcNHglycan	61	64	PF01048	0.471
MOD_GlcNHglycan	672	675	PF01048	0.447
MOD_GSK3_1	161	168	PF00069	0.492
MOD_GSK3_1	18	25	PF00069	0.507
MOD_GSK3_1	227	234	PF00069	0.419
MOD_GSK3_1	271	278	PF00069	0.394
MOD_GSK3_1	325	332	PF00069	0.375
MOD_GSK3_1	400	407	PF00069	0.826
MOD_GSK3_1	430	437	PF00069	0.501
MOD_GSK3_1	486	493	PF00069	0.602
MOD_GSK3_1	527	534	PF00069	0.462
MOD_GSK3_1	563	570	PF00069	0.688
MOD_N-GLC_1	372	377	PF02516	0.410
MOD_N-GLC_1	618	623	PF02516	0.571
MOD_N-GLC_1	649	654	PF02516	0.527
MOD_N-GLC_2	649	651	PF02516	0.536
MOD_NEK2_1	123	128	PF00069	0.461
MOD_NEK2_1	231	236	PF00069	0.462
MOD_NEK2_1	361	366	PF00069	0.453
MOD_NEK2_1	58	63	PF00069	0.462
MOD_NEK2_1	611	616	PF00069	0.552
MOD_NEK2_2	217	222	PF00069	0.321
MOD_NEK2_2	539	544	PF00069	0.532
MOD_NEK2_2	635	640	PF00069	0.502
MOD_OFUCOSY	630	637	PF10250	0.431
MOD_PIKK_1	206	212	PF00454	0.450
MOD_PIKK_1	275	281	PF00454	0.457
MOD_PIKK_1	329	335	PF00454	0.378
MOD_PIKK_1	689	695	PF00454	0.546
MOD_PIKK_1	93	99	PF00454	0.431
MOD_PKA_1	387	393	PF00069	0.488
MOD_PKA_2	387	393	PF00069	0.616
MOD_Plk_1	156	162	PF00069	0.410
MOD_Plk_1	165	171	PF00069	0.597
MOD_Plk_1	275	281	PF00069	0.477
MOD_Plk_1	372	378	PF00069	0.561
MOD_Plk_1	624	630	PF00069	0.535
MOD_Plk_2-3	30	36	PF00069	0.423
MOD_Plk_2-3	531	537	PF00069	0.458
MOD_Plk_2-3	613	619	PF00069	0.564
MOD_Plk_4	110	116	PF00069	0.455
MOD_Plk_4	156	162	PF00069	0.469
MOD_Plk_4	19	25	PF00069	0.462
MOD_Plk_4	201	207	PF00069	0.451
MOD_Plk_4	227	233	PF00069	0.375
MOD_Plk_4	46	52	PF00069	0.486
MOD_Plk_4	470	476	PF00069	0.487
MOD_Plk_4	6	12	PF00069	0.445
MOD_Plk_4	603	609	PF00069	0.484
MOD_ProDKin_1	124	130	PF00069	0.438
MOD_ProDKin_1	427	433	PF00069	0.535
MOD_ProDKin_1	75	81	PF00069	0.462
MOD_SUMO_for_1	182	185	PF00179	0.321
MOD_SUMO_for_1	589	592	PF00179	0.510
MOD_SUMO_rev_2	249	258	PF00179	0.509
MOD_SUMO_rev_2	320	328	PF00179	0.321
MOD_SUMO_rev_2	488	493	PF00179	0.531
MOD_SUMO_rev_2	563	570	PF00179	0.652
MOD_SUMO_rev_2	613	621	PF00179	0.602
TRG_DiLeu_BaEn_4	552	558	PF01217	0.586
TRG_ENDOCYTIC_2	177	180	PF00928	0.462
TRG_ENDOCYTIC_2	237	240	PF00928	0.462
TRG_ENDOCYTIC_2	540	543	PF00928	0.621
TRG_ENDOCYTIC_2	631	634	PF00928	0.498
TRG_ENDOCYTIC_2	672	675	PF00928	0.410
TRG_ER_diArg_1	386	388	PF00400	0.370
TRG_ER_diArg_1	574	577	PF00400	0.596
TRG_ER_diArg_1	666	668	PF00400	0.400
TRG_ER_FFAT_1	673	684	PF00635	0.462
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	434	438	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	92	97	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6E2	Leptomonas seymouri	71%	94%
A0A0S4JRE7	Bodo saltans	41%	100%
A0A3S7X203	Leishmania donovani	23%	100%
A4HGY5	Leishmania braziliensis	24%	100%
A4HHD6	Leishmania braziliensis	86%	100%
A4I4I1	Leishmania infantum	100%	100%
E9ADY2	Leishmania major	94%	100%
E9ALU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9B0A4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
V5BI61	Trypanosoma cruzi	24%	100%