Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X2C7_LEIDO

TriTrypDb:

LdBPK_290870.1 , LdCL_290013500 , LDHU3_29.1180

Length:

484

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A0A3S7X2C7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2C7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	39	43	PF00656	0.606
CLV_C14_Caspase3-7	84	88	PF00656	0.490
CLV_NRD_NRD_1	245	247	PF00675	0.674
CLV_NRD_NRD_1	474	476	PF00675	0.540
CLV_PCSK_KEX2_1	245	247	PF00082	0.670
CLV_PCSK_KEX2_1	361	363	PF00082	0.787
CLV_PCSK_PC1ET2_1	361	363	PF00082	0.683
CLV_PCSK_SKI1_1	208	212	PF00082	0.577
CLV_PCSK_SKI1_1	228	232	PF00082	0.440
CLV_PCSK_SKI1_1	237	241	PF00082	0.613
CLV_PCSK_SKI1_1	26	30	PF00082	0.813
DEG_Nend_UBRbox_2	1	3	PF02207	0.616
DEG_SPOP_SBC_1	13	17	PF00917	0.540
DEG_SPOP_SBC_1	144	148	PF00917	0.460
DOC_CDC14_PxL_1	272	280	PF14671	0.443
DOC_CDC14_PxL_1	342	350	PF14671	0.528
DOC_MAPK_gen_1	215	223	PF00069	0.410
DOC_MAPK_gen_1	384	394	PF00069	0.535
DOC_MAPK_HePTP_8	450	462	PF00069	0.351
DOC_MAPK_MEF2A_6	213	221	PF00069	0.400
DOC_MAPK_MEF2A_6	453	462	PF00069	0.424
DOC_USP7_MATH_1	138	142	PF00917	0.591
DOC_USP7_MATH_1	144	148	PF00917	0.402
DOC_USP7_MATH_1	235	239	PF00917	0.446
DOC_USP7_MATH_1	259	263	PF00917	0.482
DOC_USP7_MATH_1	356	360	PF00917	0.618
DOC_USP7_MATH_1	411	415	PF00917	0.555
DOC_USP7_MATH_1	9	13	PF00917	0.579
DOC_USP7_MATH_2	22	28	PF00917	0.532
DOC_USP7_UBL2_3	179	183	PF12436	0.528
DOC_WW_Pin1_4	346	351	PF00397	0.510
DOC_WW_Pin1_4	37	42	PF00397	0.627
DOC_WW_Pin1_4	426	431	PF00397	0.548
DOC_WW_Pin1_4	445	450	PF00397	0.562
DOC_WW_Pin1_4	94	99	PF00397	0.486
LIG_14-3-3_CanoR_1	158	166	PF00244	0.391
LIG_14-3-3_CanoR_1	169	174	PF00244	0.396
LIG_14-3-3_CanoR_1	453	458	PF00244	0.424
LIG_Actin_WH2_2	264	281	PF00022	0.396
LIG_BIR_III_4	87	91	PF00653	0.492
LIG_deltaCOP1_diTrp_1	298	308	PF00928	0.507
LIG_FHA_2	258	264	PF00498	0.463
LIG_FHA_2	82	88	PF00498	0.543
LIG_Integrin_RGD_1	327	329	PF01839	0.720
LIG_Integrin_RGD_1	368	370	PF01839	0.679
LIG_LIR_Apic_2	399	405	PF02991	0.504
LIG_LIR_Gen_1	214	223	PF02991	0.375
LIG_LIR_Nem_3	214	219	PF02991	0.377
LIG_LIR_Nem_3	269	275	PF02991	0.436
LIG_LIR_Nem_3	319	325	PF02991	0.462
LIG_LIR_Nem_3	451	455	PF02991	0.401
LIG_MYND_1	346	350	PF01753	0.532
LIG_NRBOX	454	460	PF00104	0.426
LIG_SH2_CRK	452	456	PF00017	0.351
LIG_SH2_PTP2	402	405	PF00017	0.558
LIG_SH2_SRC	173	176	PF00017	0.494
LIG_SH2_STAT5	173	176	PF00017	0.414
LIG_SH2_STAT5	282	285	PF00017	0.430
LIG_SH2_STAT5	331	334	PF00017	0.558
LIG_SH2_STAT5	402	405	PF00017	0.528
LIG_SH3_2	335	340	PF14604	0.530
LIG_SH3_3	134	140	PF00018	0.505
LIG_SH3_3	220	226	PF00018	0.417
LIG_SH3_3	270	276	PF00018	0.439
LIG_SH3_3	332	338	PF00018	0.508
LIG_SH3_3	347	353	PF00018	0.510
LIG_SH3_3	424	430	PF00018	0.566
LIG_SUMO_SIM_anti_2	456	462	PF11976	0.350
LIG_SUMO_SIM_par_1	145	154	PF11976	0.526
LIG_SUMO_SIM_par_1	9	17	PF11976	0.554
LIG_TRAF2_1	119	122	PF00917	0.554
LIG_TRAF2_1	124	127	PF00917	0.568
LIG_TRAF2_1	46	49	PF00917	0.452
LIG_TRAF2_1	91	94	PF00917	0.644
LIG_TRAF2_1	97	100	PF00917	0.537
LIG_TRAF2_2	353	358	PF00917	0.618
LIG_TYR_ITIM	450	455	PF00017	0.531
MOD_CDK_SPxK_1	346	352	PF00069	0.530
MOD_CDK_SPxxK_3	37	44	PF00069	0.491
MOD_CK1_1	12	18	PF00069	0.612
MOD_CK1_1	145	151	PF00069	0.495
MOD_CK1_1	40	46	PF00069	0.582
MOD_CK1_1	406	412	PF00069	0.614
MOD_CK1_1	414	420	PF00069	0.568
MOD_CK2_1	418	424	PF00069	0.487
MOD_CK2_1	94	100	PF00069	0.556
MOD_GlcNHglycan	139	143	PF01048	0.780
MOD_GlcNHglycan	162	165	PF01048	0.669
MOD_GlcNHglycan	408	411	PF01048	0.760
MOD_GlcNHglycan	420	423	PF01048	0.717
MOD_GSK3_1	138	145	PF00069	0.629
MOD_GSK3_1	300	307	PF00069	0.509
MOD_GSK3_1	311	318	PF00069	0.503
MOD_GSK3_1	33	40	PF00069	0.646
MOD_GSK3_1	411	418	PF00069	0.544
MOD_GSK3_1	474	481	PF00069	0.731
MOD_GSK3_1	56	63	PF00069	0.611
MOD_GSK3_1	9	16	PF00069	0.573
MOD_N-GLC_1	329	334	PF02516	0.809
MOD_NEK2_1	151	156	PF00069	0.481
MOD_NEK2_1	203	208	PF00069	0.393
MOD_NEK2_1	467	472	PF00069	0.472
MOD_NEK2_1	60	65	PF00069	0.596
MOD_NEK2_2	235	240	PF00069	0.438
MOD_PIKK_1	300	306	PF00454	0.490
MOD_PIKK_1	403	409	PF00454	0.598
MOD_PK_1	453	459	PF00069	0.424
MOD_PKA_2	309	315	PF00069	0.453
MOD_PKA_2	383	389	PF00069	0.532
MOD_PKA_2	418	424	PF00069	0.585
MOD_PKA_2	474	480	PF00069	0.699
MOD_Plk_1	56	62	PF00069	0.631
MOD_Plk_2-3	56	62	PF00069	0.604
MOD_Plk_4	169	175	PF00069	0.457
MOD_Plk_4	193	199	PF00069	0.439
MOD_Plk_4	453	459	PF00069	0.372
MOD_ProDKin_1	346	352	PF00069	0.507
MOD_ProDKin_1	37	43	PF00069	0.628
MOD_ProDKin_1	426	432	PF00069	0.548
MOD_ProDKin_1	445	451	PF00069	0.556
MOD_ProDKin_1	94	100	PF00069	0.488
MOD_SUMO_for_1	296	299	PF00179	0.479
TRG_ENDOCYTIC_2	452	455	PF00928	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Q7	Leptomonas seymouri	57%	96%
A4HH91	Leishmania braziliensis	72%	99%
A4I4D7	Leishmania infantum	100%	100%
C9ZL27	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	99%
E9ADT6	Leishmania major	91%	100%
E9ALZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%