DNA-directed DNA polymerase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X2C1_LEIDO

TriTrypDb:

LdBPK_291110.1 , LdCL_290016200 , LDHU3_29.1540

Length:

724

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X2C1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2C1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.494
CLV_C14_Caspase3-7	228	232	PF00656	0.815
CLV_C14_Caspase3-7	527	531	PF00656	0.503
CLV_C14_Caspase3-7	658	662	PF00656	0.585
CLV_NRD_NRD_1	128	130	PF00675	0.732
CLV_NRD_NRD_1	25	27	PF00675	0.488
CLV_NRD_NRD_1	28	30	PF00675	0.479
CLV_NRD_NRD_1	325	327	PF00675	0.662
CLV_NRD_NRD_1	338	340	PF00675	0.610
CLV_NRD_NRD_1	354	356	PF00675	0.533
CLV_NRD_NRD_1	372	374	PF00675	0.517
CLV_NRD_NRD_1	45	47	PF00675	0.579
CLV_NRD_NRD_1	544	546	PF00675	0.638
CLV_NRD_NRD_1	683	685	PF00675	0.526
CLV_PCSK_FUR_1	26	30	PF00082	0.558
CLV_PCSK_KEX2_1	128	130	PF00082	0.734
CLV_PCSK_KEX2_1	24	26	PF00082	0.500
CLV_PCSK_KEX2_1	28	30	PF00082	0.479
CLV_PCSK_KEX2_1	324	326	PF00082	0.605
CLV_PCSK_KEX2_1	340	342	PF00082	0.657
CLV_PCSK_KEX2_1	353	355	PF00082	0.574
CLV_PCSK_KEX2_1	372	374	PF00082	0.504
CLV_PCSK_KEX2_1	44	46	PF00082	0.562
CLV_PCSK_KEX2_1	544	546	PF00082	0.638
CLV_PCSK_KEX2_1	639	641	PF00082	0.602
CLV_PCSK_KEX2_1	683	685	PF00082	0.526
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.636
CLV_PCSK_PC1ET2_1	639	641	PF00082	0.602
CLV_PCSK_PC7_1	24	30	PF00082	0.428
CLV_PCSK_PC7_1	350	356	PF00082	0.675
CLV_PCSK_PC7_1	368	374	PF00082	0.689
CLV_PCSK_SKI1_1	244	248	PF00082	0.621
CLV_PCSK_SKI1_1	420	424	PF00082	0.618
CLV_PCSK_SKI1_1	473	477	PF00082	0.475
CLV_Separin_Metazoa	109	113	PF03568	0.583
DEG_APCC_DBOX_1	104	112	PF00400	0.587
DEG_APCC_DBOX_1	23	31	PF00400	0.470
DEG_APCC_DBOX_1	43	51	PF00400	0.335
DEG_Nend_Nbox_1	1	3	PF02207	0.538
DEG_SPOP_SBC_1	60	64	PF00917	0.667
DOC_CKS1_1	287	292	PF01111	0.650
DOC_CKS1_1	421	426	PF01111	0.529
DOC_MAPK_gen_1	102	110	PF00069	0.472
DOC_MIT_MIM_1	20	31	PF04212	0.438
DOC_PP2B_LxvP_1	271	274	PF13499	0.599
DOC_PP4_FxxP_1	122	125	PF00568	0.663
DOC_PP4_FxxP_1	431	434	PF00568	0.631
DOC_PP4_FxxP_1	700	703	PF00568	0.611
DOC_USP7_MATH_1	177	181	PF00917	0.607
DOC_USP7_MATH_1	382	386	PF00917	0.700
DOC_USP7_MATH_1	441	445	PF00917	0.643
DOC_USP7_MATH_1	60	64	PF00917	0.678
DOC_USP7_MATH_1	663	667	PF00917	0.572
DOC_USP7_MATH_1	672	676	PF00917	0.447
DOC_WW_Pin1_4	121	126	PF00397	0.511
DOC_WW_Pin1_4	286	291	PF00397	0.730
DOC_WW_Pin1_4	412	417	PF00397	0.622
DOC_WW_Pin1_4	420	425	PF00397	0.544
DOC_WW_Pin1_4	462	467	PF00397	0.567
DOC_WW_Pin1_4	550	555	PF00397	0.595
LIG_14-3-3_CanoR_1	354	364	PF00244	0.754
LIG_14-3-3_CanoR_1	473	480	PF00244	0.575
LIG_14-3-3_CanoR_1	545	554	PF00244	0.706
LIG_14-3-3_CanoR_1	573	579	PF00244	0.664
LIG_BRCT_BRCA1_1	501	505	PF00533	0.502
LIG_CaM_IQ_9	38	54	PF13499	0.483
LIG_eIF4E_1	578	584	PF01652	0.399
LIG_FHA_1	474	480	PF00498	0.526
LIG_FHA_1	562	568	PF00498	0.591
LIG_FHA_1	575	581	PF00498	0.435
LIG_FHA_1	687	693	PF00498	0.553
LIG_FHA_1	713	719	PF00498	0.571
LIG_FHA_2	104	110	PF00498	0.469
LIG_FHA_2	150	156	PF00498	0.533
LIG_FHA_2	220	226	PF00498	0.647
LIG_FHA_2	287	293	PF00498	0.807
LIG_FHA_2	585	591	PF00498	0.556
LIG_Integrin_isoDGR_2	542	544	PF01839	0.555
LIG_IRF3_LxIS_1	94	99	PF10401	0.530
LIG_LIR_Apic_2	121	125	PF02991	0.658
LIG_LIR_Apic_2	697	703	PF02991	0.548
LIG_LIR_Gen_1	143	151	PF02991	0.534
LIG_LIR_Gen_1	153	164	PF02991	0.498
LIG_LIR_Gen_1	299	310	PF02991	0.573
LIG_LIR_Gen_1	500	507	PF02991	0.441
LIG_LIR_Gen_1	577	584	PF02991	0.448
LIG_LIR_Gen_1	590	599	PF02991	0.408
LIG_LIR_Nem_3	143	148	PF02991	0.583
LIG_LIR_Nem_3	153	159	PF02991	0.496
LIG_LIR_Nem_3	500	504	PF02991	0.398
LIG_LIR_Nem_3	577	581	PF02991	0.471
LIG_LIR_Nem_3	590	596	PF02991	0.444
LIG_LIR_Nem_3	697	702	PF02991	0.610
LIG_LYPXL_SIV_4	489	497	PF13949	0.430
LIG_MLH1_MIPbox_1	501	505	PF16413	0.502
LIG_MYND_1	430	434	PF01753	0.516
LIG_NRBOX	46	52	PF00104	0.573
LIG_Pex14_2	160	164	PF04695	0.452
LIG_Pex14_2	431	435	PF04695	0.535
LIG_Pex14_2	501	505	PF04695	0.388
LIG_SH2_PTP2	145	148	PF00017	0.495
LIG_SH2_STAP1	578	582	PF00017	0.442
LIG_SH2_STAT5	145	148	PF00017	0.495
LIG_SH2_STAT5	156	159	PF00017	0.454
LIG_SH2_STAT5	439	442	PF00017	0.485
LIG_SH2_STAT5	490	493	PF00017	0.555
LIG_SH2_STAT5	699	702	PF00017	0.586
LIG_SH2_STAT5	707	710	PF00017	0.511
LIG_SH3_3	165	171	PF00018	0.457
LIG_SH3_3	284	290	PF00018	0.700
LIG_SH3_3	457	463	PF00018	0.481
LIG_SH3_3	517	523	PF00018	0.509
LIG_SUMO_SIM_anti_2	106	112	PF11976	0.578
LIG_SUMO_SIM_anti_2	455	461	PF11976	0.510
LIG_SUMO_SIM_anti_2	579	588	PF11976	0.405
LIG_SUMO_SIM_par_1	579	588	PF11976	0.405
LIG_TRAF2_1	211	214	PF00917	0.555
LIG_TRAF2_1	222	225	PF00917	0.630
LIG_TRAF2_1	240	243	PF00917	0.500
LIG_TRAF2_1	385	388	PF00917	0.711
LIG_TRAF2_1	588	591	PF00917	0.558
LIG_TRAF2_1	635	638	PF00917	0.528
LIG_TYR_ITIM	154	159	PF00017	0.450
LIG_TYR_ITIM	576	581	PF00017	0.466
LIG_UBA3_1	306	313	PF00899	0.566
LIG_WRC_WIRS_1	119	124	PF05994	0.558
MOD_CDK_SPxxK_3	121	128	PF00069	0.630
MOD_CK1_1	121	127	PF00069	0.523
MOD_CK1_1	178	184	PF00069	0.581
MOD_CK1_1	319	325	PF00069	0.667
MOD_CK1_1	342	348	PF00069	0.532
MOD_CK1_1	412	418	PF00069	0.485
MOD_CK1_1	514	520	PF00069	0.496
MOD_CK1_1	546	552	PF00069	0.693
MOD_CK1_1	59	65	PF00069	0.547
MOD_CK1_1	695	701	PF00069	0.594
MOD_CK2_1	103	109	PF00069	0.483
MOD_CK2_1	149	155	PF00069	0.495
MOD_CK2_1	219	225	PF00069	0.645
MOD_CK2_1	382	388	PF00069	0.677
MOD_CK2_1	462	468	PF00069	0.515
MOD_CK2_1	550	556	PF00069	0.595
MOD_CK2_1	584	590	PF00069	0.546
MOD_CK2_1	632	638	PF00069	0.620
MOD_Cter_Amidation	370	373	PF01082	0.636
MOD_Cter_Amidation	542	545	PF01082	0.625
MOD_GlcNHglycan	170	174	PF01048	0.496
MOD_GlcNHglycan	177	180	PF01048	0.473
MOD_GlcNHglycan	184	187	PF01048	0.558
MOD_GlcNHglycan	260	263	PF01048	0.773
MOD_GlcNHglycan	318	321	PF01048	0.696
MOD_GlcNHglycan	344	347	PF01048	0.665
MOD_GlcNHglycan	394	397	PF01048	0.647
MOD_GlcNHglycan	500	504	PF01048	0.485
MOD_GlcNHglycan	513	516	PF01048	0.465
MOD_GlcNHglycan	548	551	PF01048	0.662
MOD_GlcNHglycan	56	59	PF01048	0.592
MOD_GlcNHglycan	602	605	PF01048	0.479
MOD_GlcNHglycan	64	67	PF01048	0.679
MOD_GlcNHglycan	674	677	PF01048	0.523
MOD_GlcNHglycan	68	71	PF01048	0.719
MOD_GlcNHglycan	694	697	PF01048	0.505
MOD_GSK3_1	114	121	PF00069	0.597
MOD_GSK3_1	175	182	PF00069	0.560
MOD_GSK3_1	196	203	PF00069	0.693
MOD_GSK3_1	315	322	PF00069	0.699
MOD_GSK3_1	378	385	PF00069	0.660
MOD_GSK3_1	407	414	PF00069	0.636
MOD_GSK3_1	469	476	PF00069	0.545
MOD_GSK3_1	54	61	PF00069	0.543
MOD_GSK3_1	546	553	PF00069	0.672
MOD_GSK3_1	585	592	PF00069	0.551
MOD_GSK3_1	62	69	PF00069	0.598
MOD_GSK3_1	701	708	PF00069	0.533
MOD_N-GLC_1	115	120	PF02516	0.595
MOD_N-GLC_1	448	453	PF02516	0.479
MOD_NEK2_1	1	6	PF00069	0.683
MOD_NEK2_1	114	119	PF00069	0.561
MOD_NEK2_1	175	180	PF00069	0.574
MOD_NEK2_1	30	35	PF00069	0.638
MOD_NEK2_1	301	306	PF00069	0.532
MOD_NEK2_1	315	320	PF00069	0.609
MOD_NEK2_1	469	474	PF00069	0.509
MOD_NEK2_1	583	588	PF00069	0.484
MOD_NEK2_1	589	594	PF00069	0.512
MOD_NEK2_2	19	24	PF00069	0.474
MOD_NEK2_2	543	548	PF00069	0.512
MOD_PIKK_1	232	238	PF00454	0.590
MOD_PIKK_1	409	415	PF00454	0.478
MOD_PIKK_1	533	539	PF00454	0.561
MOD_PK_1	386	392	PF00069	0.530
MOD_PKA_1	339	345	PF00069	0.786
MOD_PKA_2	12	18	PF00069	0.597
MOD_PKA_2	30	36	PF00069	0.436
MOD_PKA_2	367	373	PF00069	0.686
MOD_PKA_2	543	549	PF00069	0.730
MOD_PKB_1	337	345	PF00069	0.618
MOD_PKB_1	353	361	PF00069	0.487
MOD_Plk_1	115	121	PF00069	0.596
MOD_Plk_1	219	225	PF00069	0.727
MOD_Plk_1	269	275	PF00069	0.566
MOD_Plk_1	386	392	PF00069	0.530
MOD_Plk_1	441	447	PF00069	0.491
MOD_Plk_1	448	454	PF00069	0.455
MOD_Plk_1	499	505	PF00069	0.462
MOD_Plk_1	561	567	PF00069	0.611
MOD_Plk_1	589	595	PF00069	0.617
MOD_Plk_1	650	656	PF00069	0.739
MOD_Plk_2-3	103	109	PF00069	0.473
MOD_Plk_2-3	632	638	PF00069	0.562
MOD_Plk_4	115	121	PF00069	0.496
MOD_Plk_4	196	202	PF00069	0.624
MOD_Plk_4	3	9	PF00069	0.691
MOD_Plk_4	301	307	PF00069	0.644
MOD_Plk_4	442	448	PF00069	0.471
MOD_Plk_4	695	701	PF00069	0.546
MOD_ProDKin_1	121	127	PF00069	0.513
MOD_ProDKin_1	286	292	PF00069	0.731
MOD_ProDKin_1	412	418	PF00069	0.624
MOD_ProDKin_1	420	426	PF00069	0.543
MOD_ProDKin_1	462	468	PF00069	0.567
MOD_ProDKin_1	550	556	PF00069	0.595
MOD_SUMO_for_1	491	494	PF00179	0.554
MOD_SUMO_rev_2	131	137	PF00179	0.562
MOD_SUMO_rev_2	243	249	PF00179	0.640
MOD_SUMO_rev_2	401	406	PF00179	0.537
MOD_SUMO_rev_2	716	720	PF00179	0.627
TRG_DiLeu_BaEn_1	562	567	PF01217	0.657
TRG_DiLeu_BaEn_1	579	584	PF01217	0.308
TRG_DiLeu_LyEn_5	562	567	PF01217	0.554
TRG_ENDOCYTIC_2	145	148	PF00928	0.509
TRG_ENDOCYTIC_2	156	159	PF00928	0.442
TRG_ENDOCYTIC_2	490	493	PF00928	0.439
TRG_ENDOCYTIC_2	578	581	PF00928	0.470
TRG_ENDOCYTIC_2	699	702	PF00928	0.607
TRG_ER_diArg_1	10	13	PF00400	0.672
TRG_ER_diArg_1	128	130	PF00400	0.730
TRG_ER_diArg_1	23	26	PF00400	0.455
TRG_ER_diArg_1	27	29	PF00400	0.420
TRG_ER_diArg_1	324	326	PF00400	0.835
TRG_ER_diArg_1	334	337	PF00400	0.585
TRG_ER_diArg_1	352	355	PF00400	0.563
TRG_ER_diArg_1	372	375	PF00400	0.605
TRG_ER_diArg_1	44	46	PF00400	0.566
TRG_ER_diArg_1	563	566	PF00400	0.576
TRG_ER_diArg_1	682	684	PF00400	0.514
TRG_NLS_Bipartite_1	324	343	PF00514	0.711
TRG_NLS_MonoExtN_4	337	343	PF00514	0.670
TRG_Pf-PMV_PEXEL_1	28	32	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	363	367	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	478	483	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	565	569	PF00026	0.611

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7Y8	Leptomonas seymouri	53%	100%
A0A1X0NZR8	Trypanosomatidae	39%	100%
A0A3R7NBZ9	Trypanosoma rangeli	41%	100%
A4HHB4	Leishmania braziliensis	76%	100%
A4I4G1	Leishmania infantum	100%	100%
E9ADW0	Leishmania major	92%	100%
E9ALX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5DI40	Trypanosoma cruzi	42%	100%