Nucleoporin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Nucleoporin

Gene product:

Nucleoporin NUP53b

Species:

Leishmania donovani

UniProt:

A0A3S7X2B5_LEIDO

TriTrypDb:

LdBPK_290830.1 , LdCL_290013100 , LDHU3_29.1130

Length:

658

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	2
GO:0032991	protein-containing complex	1	2
GO:0044613	nuclear pore central transport channel	3	1
GO:0140513	nuclear protein-containing complex	2	2

Expansion

Sequence features

A0A3S7X2B5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2B5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	257	259	PF00675	0.558
CLV_NRD_NRD_1	290	292	PF00675	0.703
CLV_NRD_NRD_1	356	358	PF00675	0.587
CLV_NRD_NRD_1	463	465	PF00675	0.671
CLV_PCSK_KEX2_1	290	292	PF00082	0.706
CLV_PCSK_KEX2_1	356	358	PF00082	0.587
CLV_PCSK_KEX2_1	463	465	PF00082	0.671
CLV_PCSK_SKI1_1	18	22	PF00082	0.610
CLV_PCSK_SKI1_1	258	262	PF00082	0.662
CLV_PCSK_SKI1_1	433	437	PF00082	0.565
DEG_APCC_DBOX_1	257	265	PF00400	0.592
DEG_APCC_DBOX_1	289	297	PF00400	0.574
DEG_SPOP_SBC_1	252	256	PF00917	0.605
DEG_SPOP_SBC_1	486	490	PF00917	0.690
DOC_CDC14_PxL_1	470	478	PF14671	0.681
DOC_CDC14_PxL_1	66	74	PF14671	0.522
DOC_CYCLIN_yCln2_LP_2	372	375	PF00134	0.621
DOC_MAPK_gen_1	221	227	PF00069	0.569
DOC_PP1_RVXF_1	180	187	PF00149	0.577
DOC_PP2B_LxvP_1	372	375	PF13499	0.621
DOC_PP4_FxxP_1	143	146	PF00568	0.531
DOC_PP4_FxxP_1	471	474	PF00568	0.678
DOC_PP4_FxxP_1	537	540	PF00568	0.679
DOC_USP7_MATH_1	121	125	PF00917	0.628
DOC_USP7_MATH_1	130	134	PF00917	0.579
DOC_USP7_MATH_1	244	248	PF00917	0.673
DOC_USP7_MATH_1	252	256	PF00917	0.524
DOC_USP7_MATH_1	27	31	PF00917	0.611
DOC_USP7_MATH_1	337	341	PF00917	0.705
DOC_USP7_MATH_1	346	350	PF00917	0.568
DOC_USP7_MATH_1	375	379	PF00917	0.714
DOC_USP7_MATH_1	465	469	PF00917	0.663
DOC_USP7_MATH_1	592	596	PF00917	0.687
DOC_USP7_MATH_1	641	645	PF00917	0.682
DOC_WW_Pin1_4	25	30	PF00397	0.674
DOC_WW_Pin1_4	342	347	PF00397	0.610
DOC_WW_Pin1_4	463	468	PF00397	0.668
LIG_14-3-3_CanoR_1	428	436	PF00244	0.434
LIG_Actin_WH2_2	365	382	PF00022	0.632
LIG_APCC_ABBAyCdc20_2	210	216	PF00400	0.545
LIG_BIR_II_1	1	5	PF00653	0.648
LIG_BRCT_BRCA1_1	123	127	PF00533	0.603
LIG_BRCT_BRCA1_1	467	471	PF00533	0.674
LIG_FHA_1	130	136	PF00498	0.665
LIG_FHA_1	188	194	PF00498	0.554
LIG_FHA_1	502	508	PF00498	0.626
LIG_FHA_2	364	370	PF00498	0.590
LIG_FHA_2	429	435	PF00498	0.432
LIG_FHA_2	467	473	PF00498	0.673
LIG_GBD_Chelix_1	350	358	PF00786	0.636
LIG_LIR_Apic_2	468	474	PF02991	0.677
LIG_LIR_Apic_2	534	540	PF02991	0.679
LIG_LIR_Gen_1	183	193	PF02991	0.512
LIG_LIR_Gen_1	345	354	PF02991	0.578
LIG_LIR_Nem_3	183	189	PF02991	0.574
LIG_LIR_Nem_3	2	6	PF02991	0.595
LIG_LIR_Nem_3	254	260	PF02991	0.599
LIG_LIR_Nem_3	345	350	PF02991	0.590
LIG_LIR_Nem_3	468	473	PF02991	0.677
LIG_LIR_Nem_3	83	89	PF02991	0.541
LIG_LYPXL_yS_3	166	169	PF13949	0.585
LIG_MLH1_MIPbox_1	467	471	PF16413	0.674
LIG_NRP_CendR_1	656	658	PF00754	0.728
LIG_PTAP_UEV_1	606	611	PF05743	0.657
LIG_REV1ctd_RIR_1	433	442	PF16727	0.454
LIG_SH2_CRK	257	261	PF00017	0.595
LIG_SH2_GRB2like	226	229	PF00017	0.587
LIG_SH2_STAP1	306	310	PF00017	0.511
LIG_SH2_STAT5	168	171	PF00017	0.484
LIG_SH2_STAT5	224	227	PF00017	0.578
LIG_SH2_STAT5	470	473	PF00017	0.679
LIG_SH3_3	155	161	PF00018	0.664
LIG_SH3_3	307	313	PF00018	0.558
LIG_SH3_3	471	477	PF00018	0.679
LIG_SH3_3	604	610	PF00018	0.708
LIG_SH3_3	611	617	PF00018	0.637
LIG_UBA3_1	260	268	PF00899	0.589
LIG_WRC_WIRS_1	209	214	PF05994	0.594
LIG_WW_2	474	477	PF00397	0.679
MOD_CK1_1	129	135	PF00069	0.695
MOD_CK1_1	187	193	PF00069	0.584
MOD_CK1_1	248	254	PF00069	0.585
MOD_CK1_1	363	369	PF00069	0.505
MOD_CK1_1	466	472	PF00069	0.673
MOD_CK1_1	525	531	PF00069	0.543
MOD_CK1_1	595	601	PF00069	0.592
MOD_CK1_1	608	614	PF00069	0.640
MOD_CK2_1	346	352	PF00069	0.542
MOD_CK2_1	363	369	PF00069	0.448
MOD_CK2_1	428	434	PF00069	0.431
MOD_GlcNHglycan	123	126	PF01048	0.727
MOD_GlcNHglycan	128	131	PF01048	0.633
MOD_GlcNHglycan	132	135	PF01048	0.584
MOD_GlcNHglycan	154	157	PF01048	0.718
MOD_GlcNHglycan	242	245	PF01048	0.653
MOD_GlcNHglycan	247	250	PF01048	0.586
MOD_GlcNHglycan	325	328	PF01048	0.686
MOD_GlcNHglycan	362	365	PF01048	0.563
MOD_GlcNHglycan	384	387	PF01048	0.645
MOD_GlcNHglycan	393	396	PF01048	0.548
MOD_GlcNHglycan	41	44	PF01048	0.622
MOD_GlcNHglycan	490	493	PF01048	0.662
MOD_GlcNHglycan	504	507	PF01048	0.552
MOD_GlcNHglycan	514	517	PF01048	0.572
MOD_GlcNHglycan	524	527	PF01048	0.471
MOD_GlcNHglycan	566	569	PF01048	0.587
MOD_GlcNHglycan	592	595	PF01048	0.676
MOD_GlcNHglycan	607	610	PF01048	0.569
MOD_GlcNHglycan	643	646	PF01048	0.679
MOD_GSK3_1	117	124	PF00069	0.671
MOD_GSK3_1	126	133	PF00069	0.635
MOD_GSK3_1	148	155	PF00069	0.672
MOD_GSK3_1	240	247	PF00069	0.699
MOD_GSK3_1	248	255	PF00069	0.556
MOD_GSK3_1	28	35	PF00069	0.654
MOD_GSK3_1	319	326	PF00069	0.727
MOD_GSK3_1	342	349	PF00069	0.550
MOD_GSK3_1	359	366	PF00069	0.419
MOD_GSK3_1	375	382	PF00069	0.591
MOD_GSK3_1	424	431	PF00069	0.446
MOD_GSK3_1	521	528	PF00069	0.652
MOD_GSK3_1	590	597	PF00069	0.615
MOD_LATS_1	426	432	PF00433	0.432
MOD_N-GLC_1	175	180	PF02516	0.586
MOD_N-GLC_1	227	232	PF02516	0.588
MOD_N-GLC_1	391	396	PF02516	0.631
MOD_N-GLC_1	456	461	PF02516	0.506
MOD_NEK2_1	149	154	PF00069	0.775
MOD_NEK2_1	323	328	PF00069	0.697
MOD_NEK2_1	368	373	PF00069	0.609
MOD_NEK2_1	379	384	PF00069	0.582
MOD_NEK2_1	415	420	PF00069	0.651
MOD_NEK2_1	511	516	PF00069	0.624
MOD_NEK2_2	375	380	PF00069	0.572
MOD_PIKK_1	184	190	PF00454	0.569
MOD_PIKK_1	651	657	PF00454	0.678
MOD_PKA_2	379	385	PF00069	0.550
MOD_PKA_2	651	657	PF00069	0.726
MOD_Plk_1	175	181	PF00069	0.585
MOD_Plk_1	184	190	PF00069	0.569
MOD_Plk_1	368	374	PF00069	0.581
MOD_Plk_1	416	422	PF00069	0.600
MOD_Plk_4	346	352	PF00069	0.681
MOD_Plk_4	368	374	PF00069	0.556
MOD_Plk_4	466	472	PF00069	0.651
MOD_ProDKin_1	25	31	PF00069	0.675
MOD_ProDKin_1	342	348	PF00069	0.607
MOD_ProDKin_1	463	469	PF00069	0.668
TRG_DiLeu_BaEn_2	207	213	PF01217	0.557
TRG_DiLeu_BaLyEn_6	310	315	PF01217	0.566
TRG_ENDOCYTIC_2	166	169	PF00928	0.628
TRG_ENDOCYTIC_2	224	227	PF00928	0.578
TRG_ENDOCYTIC_2	257	260	PF00928	0.601
TRG_ENDOCYTIC_2	470	473	PF00928	0.647
TRG_ER_diArg_1	356	358	PF00400	0.579
TRG_ER_diArg_1	462	464	PF00400	0.673
TRG_Pf-PMV_PEXEL_1	258	263	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HH87	Leishmania braziliensis	81%	100%
A4I4D3	Leishmania infantum	100%	100%
C9ZMH1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	91%
E9ADT2	Leishmania major	88%	100%
E9ALZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%