Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X2B4_LEIDO

TriTrypDb:

LdBPK_290800.1 , LdCL_290012800 , LDHU3_29.1090

Length:

191

Annotations

LeishMANIAdb annotations

Seems to form a single continuous helix according to predictions. Kinetoplastid-only protein.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3S7X2B4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2B4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	14	18	PF00656	0.677
CLV_NRD_NRD_1	108	110	PF00675	0.422
CLV_NRD_NRD_1	143	145	PF00675	0.686
CLV_NRD_NRD_1	53	55	PF00675	0.397
CLV_NRD_NRD_1	70	72	PF00675	0.406
CLV_PCSK_FUR_1	141	145	PF00082	0.604
CLV_PCSK_FUR_1	94	98	PF00082	0.494
CLV_PCSK_KEX2_1	143	145	PF00082	0.689
CLV_PCSK_KEX2_1	187	189	PF00082	0.666
CLV_PCSK_KEX2_1	53	55	PF00082	0.367
CLV_PCSK_KEX2_1	96	98	PF00082	0.484
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.660
CLV_PCSK_PC1ET2_1	96	98	PF00082	0.484
DEG_APCC_DBOX_1	101	109	PF00400	0.695
DOC_MAPK_gen_1	109	117	PF00069	0.459
DOC_MAPK_MEF2A_6	109	117	PF00069	0.459
DOC_PP2B_LxvP_1	44	47	PF13499	0.696
DOC_USP7_MATH_1	152	156	PF00917	0.475
DOC_USP7_MATH_1	18	22	PF00917	0.639
DOC_USP7_UBL2_3	72	76	PF12436	0.680
LIG_14-3-3_CanoR_1	102	108	PF00244	0.698
LIG_14-3-3_CanoR_1	151	157	PF00244	0.473
LIG_14-3-3_CanoR_1	23	32	PF00244	0.597
LIG_BIR_II_1	1	5	PF00653	0.648
LIG_BRCT_BRCA1_1	69	73	PF00533	0.694
LIG_FHA_1	127	133	PF00498	0.401
LIG_FHA_1	24	30	PF00498	0.630
LIG_LIR_Apic_2	129	133	PF02991	0.245
LIG_SH2_NCK_1	149	153	PF00017	0.476
LIG_SH2_STAT5	130	133	PF00017	0.555
LIG_SH2_STAT5	135	138	PF00017	0.459
LIG_SH3_3	165	171	PF00018	0.388
MOD_CK1_1	66	72	PF00069	0.694
MOD_CK1_1	8	14	PF00069	0.715
MOD_GlcNHglycan	13	16	PF01048	0.508
MOD_GlcNHglycan	20	23	PF01048	0.500
MOD_GlcNHglycan	77	80	PF01048	0.437
MOD_GSK3_1	18	25	PF00069	0.608
MOD_GSK3_1	182	189	PF00069	0.443
MOD_GSK3_1	5	12	PF00069	0.698
MOD_GSK3_1	63	70	PF00069	0.696
MOD_N-GLC_1	103	108	PF02516	0.471
MOD_NEK2_1	10	15	PF00069	0.728
MOD_NEK2_1	126	131	PF00069	0.446
MOD_NEK2_1	186	191	PF00069	0.422
MOD_NEK2_2	182	187	PF00069	0.367
MOD_PKA_2	22	28	PF00069	0.677
MOD_Plk_1	103	109	PF00069	0.669
MOD_Plk_4	103	109	PF00069	0.671
MOD_Plk_4	126	132	PF00069	0.401
MOD_SUMO_rev_2	68	78	PF00179	0.628
TRG_ENDOCYTIC_2	135	138	PF00928	0.383
TRG_ER_diArg_1	141	144	PF00400	0.400
TRG_ER_diArg_1	53	56	PF00400	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8C6	Leptomonas seymouri	63%	98%
A0A0S4ISL6	Bodo saltans	41%	100%
A0A1X0NZL1	Trypanosomatidae	47%	100%
A4HH84	Leishmania braziliensis	71%	100%
A4I4D0	Leishmania infantum	99%	100%
C9ZL34	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9ADS9	Leishmania major	88%	100%
E9AM01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%