LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X2B4_LEIDO
TriTrypDb:
LdBPK_290800.1 , LdCL_290012800 , LDHU3_29.1090
Length:
191

Annotations

LeishMANIAdb annotations

Seems to form a single continuous helix according to predictions. Kinetoplastid-only protein.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 1
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9
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Expansion

Sequence features

A0A3S7X2B4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2B4

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 14 18 PF00656 0.677
CLV_NRD_NRD_1 108 110 PF00675 0.422
CLV_NRD_NRD_1 143 145 PF00675 0.686
CLV_NRD_NRD_1 53 55 PF00675 0.397
CLV_NRD_NRD_1 70 72 PF00675 0.406
CLV_PCSK_FUR_1 141 145 PF00082 0.604
CLV_PCSK_FUR_1 94 98 PF00082 0.494
CLV_PCSK_KEX2_1 143 145 PF00082 0.689
CLV_PCSK_KEX2_1 187 189 PF00082 0.666
CLV_PCSK_KEX2_1 53 55 PF00082 0.367
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P8C6 Leptomonas seymouri 63% 98%
A0A0S4ISL6 Bodo saltans 41% 100%
A0A1X0NZL1 Trypanosomatidae 47% 100%
A4HH84 Leishmania braziliensis 71% 100%
A4I4D0 Leishmania infantum 99% 100%
C9ZL34 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
E9ADS9 Leishmania major 88% 100%
E9AM01 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS