Cytochrome_b5-like_Heme/Steroid_binding_domain_co ntaining_protein_putative/Pfam:PF00173

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome b5-like Heme/Steroid binding domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X2B2_LEIDO

TriTrypDb:

LdBPK_290930.1 , LdCL_290015600 , LDHU3_29.1260

Length:

168

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X2B2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2B2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0020037	heme binding	4	1
GO:0046906	tetrapyrrole binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	156	158	PF00675	0.691
CLV_NRD_NRD_1	29	31	PF00675	0.300
CLV_NRD_NRD_1	59	61	PF00675	0.309
CLV_NRD_NRD_1	79	81	PF00675	0.415
CLV_NRD_NRD_1	84	86	PF00675	0.418
CLV_PCSK_KEX2_1	13	15	PF00082	0.549
CLV_PCSK_KEX2_1	156	158	PF00082	0.689
CLV_PCSK_KEX2_1	29	31	PF00082	0.218
CLV_PCSK_KEX2_1	59	61	PF00082	0.309
CLV_PCSK_KEX2_1	79	81	PF00082	0.407
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.493
CLV_PCSK_SKI1_1	111	115	PF00082	0.600
DEG_APCC_DBOX_1	28	36	PF00400	0.309
DEG_Nend_Nbox_1	1	3	PF02207	0.569
DOC_CYCLIN_yClb1_LxF_4	2	8	PF00134	0.493
DOC_PP2B_LxvP_1	98	101	PF13499	0.505
DOC_WW_Pin1_4	117	122	PF00397	0.730
DOC_WW_Pin1_4	147	152	PF00397	0.586
DOC_WW_Pin1_4	158	163	PF00397	0.578
DOC_WW_Pin1_4	88	93	PF00397	0.379
LIG_14-3-3_CanoR_1	156	164	PF00244	0.611
LIG_14-3-3_CanoR_1	29	33	PF00244	0.309
LIG_FHA_1	136	142	PF00498	0.583
LIG_FHA_1	42	48	PF00498	0.309
LIG_FHA_1	89	95	PF00498	0.413
LIG_NRBOX	1	7	PF00104	0.564
LIG_NRP_CendR_1	166	168	PF00754	0.593
LIG_Pex14_2	7	11	PF04695	0.485
LIG_SH2_STAT5	71	74	PF00017	0.420
LIG_TRAF2_1	105	108	PF00917	0.583
LIG_TRAF2_1	132	135	PF00917	0.669
LIG_TRAF2_1	19	22	PF00917	0.299
LIG_UBA3_1	5	13	PF00899	0.514
LIG_WW_3	99	103	PF00397	0.545
MOD_CK1_1	36	42	PF00069	0.360
MOD_CK2_1	129	135	PF00069	0.674
MOD_CK2_1	16	22	PF00069	0.312
MOD_GlcNHglycan	131	134	PF01048	0.704
MOD_GlcNHglycan	35	38	PF01048	0.309
MOD_GlcNHglycan	8	11	PF01048	0.500
MOD_GSK3_1	129	136	PF00069	0.769
MOD_GSK3_1	140	147	PF00069	0.616
MOD_NEK2_1	25	30	PF00069	0.366
MOD_NEK2_1	6	11	PF00069	0.516
MOD_NEK2_2	69	74	PF00069	0.418
MOD_PKA_2	155	161	PF00069	0.617
MOD_PKA_2	28	34	PF00069	0.309
MOD_Plk_1	69	75	PF00069	0.418
MOD_Plk_4	36	42	PF00069	0.309
MOD_ProDKin_1	117	123	PF00069	0.731
MOD_ProDKin_1	147	153	PF00069	0.587
MOD_ProDKin_1	158	164	PF00069	0.574
MOD_ProDKin_1	88	94	PF00069	0.376
TRG_ER_diArg_1	155	157	PF00400	0.716
TRG_ER_diArg_1	58	60	PF00400	0.350
TRG_NLS_MonoExtC_3	11	16	PF00514	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMH0	Leptomonas seymouri	65%	98%
A4HH96	Leishmania braziliensis	85%	100%
A4I4E2	Leishmania infantum	100%	100%
E9ADU2	Leishmania major	96%	100%
E9ALY8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%