Phosphate transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphate transporter, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X2A5_LEIDO

TriTrypDb:

LdBPK_290680.1 , LdCL_290011500 , LDHU3_29.0950

Length:

709

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A0A3S7X2A5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2A5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	8
GO:0006811	monoatomic ion transport	4	8
GO:0006817	phosphate ion transport	7	8
GO:0006820	monoatomic anion transport	5	8
GO:0015698	inorganic anion transport	6	8
GO:0051179	localization	1	8
GO:0051234	establishment of localization	2	8
GO:0009987	cellular process	1	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0035435	phosphate ion transmembrane transport	6	1
GO:0055085	transmembrane transport	2	1
GO:0098656	monoatomic anion transmembrane transport	4	1
GO:0098660	inorganic ion transmembrane transport	4	1
GO:0098661	inorganic anion transmembrane transport	5	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	8
GO:0005315	inorganic phosphate transmembrane transporter activity	4	8
GO:0015291	secondary active transmembrane transporter activity	4	8
GO:0015293	symporter activity	5	8
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	8
GO:0022804	active transmembrane transporter activity	3	8
GO:0022857	transmembrane transporter activity	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	340	344	PF00656	0.431
CLV_C14_Caspase3-7	401	405	PF00656	0.486
CLV_NRD_NRD_1	175	177	PF00675	0.239
CLV_NRD_NRD_1	358	360	PF00675	0.237
CLV_PCSK_KEX2_1	175	177	PF00082	0.239
CLV_PCSK_KEX2_1	358	360	PF00082	0.237
CLV_PCSK_SKI1_1	176	180	PF00082	0.237
CLV_PCSK_SKI1_1	444	448	PF00082	0.285
CLV_PCSK_SKI1_1	680	684	PF00082	0.282
DEG_APCC_DBOX_1	269	277	PF00400	0.397
DOC_CYCLIN_yCln2_LP_2	157	163	PF00134	0.315
DOC_CYCLIN_yCln2_LP_2	533	539	PF00134	0.461
DOC_MAPK_DCC_7	79	88	PF00069	0.272
DOC_MAPK_gen_1	182	190	PF00069	0.485
DOC_MAPK_gen_1	492	500	PF00069	0.437
DOC_MAPK_MEF2A_6	145	154	PF00069	0.233
DOC_MAPK_MEF2A_6	184	192	PF00069	0.446
DOC_MAPK_MEF2A_6	92	99	PF00069	0.236
DOC_PIKK_1	277	285	PF02985	0.397
DOC_PP1_RVXF_1	284	291	PF00149	0.454
DOC_PP2B_LxvP_1	157	160	PF13499	0.315
DOC_PP2B_LxvP_1	336	339	PF13499	0.486
DOC_PP4_FxxP_1	116	119	PF00568	0.430
DOC_PP4_FxxP_1	290	293	PF00568	0.447
DOC_USP7_MATH_1	214	218	PF00917	0.280
DOC_USP7_MATH_1	255	259	PF00917	0.454
DOC_USP7_MATH_1	378	382	PF00917	0.519
DOC_USP7_MATH_1	402	406	PF00917	0.558
DOC_WW_Pin1_4	380	385	PF00397	0.530
DOC_WW_Pin1_4	422	427	PF00397	0.431
DOC_WW_Pin1_4	500	505	PF00397	0.450
DOC_WW_Pin1_4	622	627	PF00397	0.437
LIG_BRCT_BRCA1_1	112	116	PF00533	0.263
LIG_BRCT_BRCA1_1	37	41	PF00533	0.430
LIG_CaM_NSCaTE_8	630	637	PF13499	0.295
LIG_Clathr_ClatBox_1	273	277	PF01394	0.397
LIG_CtBP_PxDLS_1	649	653	PF00389	0.230
LIG_FHA_1	12	18	PF00498	0.230
LIG_FHA_1	121	127	PF00498	0.321
LIG_FHA_1	136	142	PF00498	0.263
LIG_FHA_1	165	171	PF00498	0.263
LIG_FHA_1	269	275	PF00498	0.470
LIG_FHA_1	298	304	PF00498	0.484
LIG_FHA_1	323	329	PF00498	0.479
LIG_FHA_1	4	10	PF00498	0.315
LIG_FHA_1	482	488	PF00498	0.397
LIG_FHA_1	638	644	PF00498	0.263
LIG_FHA_1	677	683	PF00498	0.468
LIG_FHA_1	686	692	PF00498	0.308
LIG_FHA_1	693	699	PF00498	0.305
LIG_FHA_2	428	434	PF00498	0.501
LIG_FHA_2	578	584	PF00498	0.307
LIG_FHA_2	58	64	PF00498	0.263
LIG_GBD_Chelix_1	686	694	PF00786	0.294
LIG_Integrin_RGD_1	294	296	PF01839	0.254
LIG_IRF3_LxIS_1	686	692	PF10401	0.262
LIG_LIR_Apic_2	113	119	PF02991	0.430
LIG_LIR_Apic_2	142	146	PF02991	0.240
LIG_LIR_Apic_2	287	293	PF02991	0.451
LIG_LIR_Apic_2	372	378	PF02991	0.437
LIG_LIR_Gen_1	204	215	PF02991	0.273
LIG_LIR_Gen_1	38	45	PF02991	0.460
LIG_LIR_Gen_1	569	579	PF02991	0.270
LIG_LIR_Gen_1	590	600	PF02991	0.237
LIG_LIR_Gen_1	60	70	PF02991	0.263
LIG_LIR_Nem_3	204	210	PF02991	0.273
LIG_LIR_Nem_3	38	44	PF02991	0.460
LIG_LIR_Nem_3	542	548	PF02991	0.445
LIG_LIR_Nem_3	569	575	PF02991	0.270
LIG_LIR_Nem_3	590	596	PF02991	0.237
LIG_LIR_Nem_3	60	65	PF02991	0.263
LIG_LIR_Nem_3	674	678	PF02991	0.472
LIG_NRBOX	197	203	PF00104	0.341
LIG_PCNA_PIPBox_1	20	29	PF02747	0.216
LIG_REV1ctd_RIR_1	288	292	PF16727	0.480
LIG_SH2_CRK	375	379	PF00017	0.437
LIG_SH2_CRK	58	62	PF00017	0.263
LIG_SH2_PTP2	143	146	PF00017	0.237
LIG_SH2_PTP2	230	233	PF00017	0.279
LIG_SH2_STAT3	314	317	PF00017	0.397
LIG_SH2_STAT5	111	114	PF00017	0.263
LIG_SH2_STAT5	143	146	PF00017	0.230
LIG_SH2_STAT5	172	175	PF00017	0.265
LIG_SH2_STAT5	230	233	PF00017	0.317
LIG_SH2_STAT5	543	546	PF00017	0.500
LIG_SH2_STAT5	58	61	PF00017	0.263
LIG_SH3_2	523	528	PF14604	0.423
LIG_SH3_3	306	312	PF00018	0.486
LIG_SH3_3	325	331	PF00018	0.463
LIG_SH3_3	336	342	PF00018	0.405
LIG_SH3_3	495	501	PF00018	0.438
LIG_SH3_3	520	526	PF00018	0.437
LIG_SH3_3	533	539	PF00018	0.437
LIG_SUMO_SIM_anti_2	93	98	PF11976	0.318
LIG_SUMO_SIM_par_1	118	123	PF11976	0.430
LIG_SUMO_SIM_par_1	620	625	PF11976	0.447
LIG_SUMO_SIM_par_1	648	653	PF11976	0.230
LIG_SUMO_SIM_par_1	687	692	PF11976	0.263
LIG_TYR_ITIM	228	233	PF00017	0.252
LIG_TYR_ITIM	56	61	PF00017	0.263
LIG_WRC_WIRS_1	23	28	PF05994	0.263
LIG_WRC_WIRS_1	555	560	PF05994	0.273
LIG_WW_3	308	312	PF00397	0.454
MOD_CDK_SPxK_1	622	628	PF00069	0.437
MOD_CK1_1	258	264	PF00069	0.454
MOD_CK1_1	368	374	PF00069	0.509
MOD_CK1_1	398	404	PF00069	0.486
MOD_CK1_1	434	440	PF00069	0.512
MOD_CK1_1	480	486	PF00069	0.476
MOD_CK1_1	554	560	PF00069	0.281
MOD_CK1_1	591	597	PF00069	0.348
MOD_CK1_1	692	698	PF00069	0.285
MOD_CK2_1	427	433	PF00069	0.501
MOD_CK2_1	457	463	PF00069	0.534
MOD_CK2_1	506	512	PF00069	0.456
MOD_CK2_1	57	63	PF00069	0.263
MOD_CK2_1	577	583	PF00069	0.280
MOD_GlcNHglycan	112	115	PF01048	0.253
MOD_GlcNHglycan	146	149	PF01048	0.447
MOD_GlcNHglycan	257	260	PF01048	0.325
MOD_GlcNHglycan	296	300	PF01048	0.277
MOD_GlcNHglycan	303	306	PF01048	0.293
MOD_GlcNHglycan	36	40	PF01048	0.230
MOD_GlcNHglycan	400	403	PF01048	0.341
MOD_GlcNHglycan	452	455	PF01048	0.239
MOD_GlcNHglycan	46	49	PF01048	0.230
MOD_GlcNHglycan	471	474	PF01048	0.337
MOD_GlcNHglycan	487	490	PF01048	0.249
MOD_GlcNHglycan	569	572	PF01048	0.561
MOD_GlcNHglycan	691	694	PF01048	0.263
MOD_GlcNHglycan	79	82	PF01048	0.490
MOD_GSK3_1	118	125	PF00069	0.430
MOD_GSK3_1	135	142	PF00069	0.263
MOD_GSK3_1	297	304	PF00069	0.477
MOD_GSK3_1	365	372	PF00069	0.460
MOD_GSK3_1	376	383	PF00069	0.481
MOD_GSK3_1	391	398	PF00069	0.471
MOD_GSK3_1	418	425	PF00069	0.476
MOD_GSK3_1	427	434	PF00069	0.476
MOD_GSK3_1	469	476	PF00069	0.491
MOD_GSK3_1	477	484	PF00069	0.423
MOD_GSK3_1	587	594	PF00069	0.297
MOD_GSK3_1	609	616	PF00069	0.373
MOD_GSK3_1	637	644	PF00069	0.289
MOD_GSK3_1	676	683	PF00069	0.427
MOD_GSK3_1	685	692	PF00069	0.278
MOD_GSK3_1	702	709	PF00069	0.502
MOD_N-GLC_1	11	16	PF02516	0.472
MOD_N-GLC_1	391	396	PF02516	0.290
MOD_N-GLC_1	566	571	PF02516	0.437
MOD_NEK2_1	110	115	PF00069	0.263
MOD_NEK2_1	135	140	PF00069	0.318
MOD_NEK2_1	197	202	PF00069	0.258
MOD_NEK2_1	216	221	PF00069	0.237
MOD_NEK2_1	276	281	PF00069	0.465
MOD_NEK2_1	395	400	PF00069	0.480
MOD_NEK2_1	609	614	PF00069	0.281
MOD_NEK2_1	641	646	PF00069	0.255
MOD_NEK2_1	689	694	PF00069	0.272
MOD_NMyristoyl	1	7	PF02799	0.344
MOD_PIKK_1	214	220	PF00454	0.280
MOD_PIKK_1	588	594	PF00454	0.280
MOD_PIKK_1	650	656	PF00454	0.263
MOD_PIKK_1	86	92	PF00454	0.237
MOD_Plk_1	11	17	PF00069	0.272
MOD_Plk_1	276	282	PF00069	0.507
MOD_Plk_1	286	292	PF00069	0.459
MOD_Plk_1	391	397	PF00069	0.480
MOD_Plk_1	403	409	PF00069	0.480
MOD_Plk_2-3	352	358	PF00069	0.516
MOD_Plk_4	122	128	PF00069	0.316
MOD_Plk_4	139	145	PF00069	0.230
MOD_Plk_4	19	25	PF00069	0.263
MOD_Plk_4	197	203	PF00069	0.322
MOD_Plk_4	286	292	PF00069	0.463
MOD_Plk_4	391	397	PF00069	0.480
MOD_Plk_4	403	409	PF00069	0.480
MOD_Plk_4	554	560	PF00069	0.273
MOD_Plk_4	57	63	PF00069	0.263
MOD_Plk_4	609	615	PF00069	0.340
MOD_Plk_4	634	640	PF00069	0.275
MOD_Plk_4	685	691	PF00069	0.295
MOD_Plk_4	696	702	PF00069	0.270
MOD_ProDKin_1	380	386	PF00069	0.530
MOD_ProDKin_1	422	428	PF00069	0.431
MOD_ProDKin_1	500	506	PF00069	0.450
MOD_ProDKin_1	622	628	PF00069	0.437
MOD_SUMO_rev_2	278	288	PF00179	0.437
TRG_ENDOCYTIC_2	230	233	PF00928	0.267
TRG_ENDOCYTIC_2	576	579	PF00928	0.237
TRG_ENDOCYTIC_2	58	61	PF00928	0.263
TRG_ER_diArg_1	174	176	PF00400	0.437
TRG_NES_CRM1_1	272	284	PF08389	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8C5	Leptomonas seymouri	64%	100%
A0A1X0P0T2	Trypanosomatidae	54%	100%
A4HH72	Leishmania braziliensis	76%	100%
A4I4B8	Leishmania infantum	99%	100%
E9ADR7	Leishmania major	94%	100%
E9AM13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
O97596	Felis catus	24%	100%
Q5R9L5	Pongo abelii	22%	100%
Q5XHF9	Xenopus laevis	22%	100%
Q63488	Rattus norvegicus	24%	100%
Q80UP8	Mus musculus	23%	100%
Q95L97	Felis catus	23%	100%
Q9ES44	Cricetulus griseus	23%	100%