Triple RNA binding domain protein 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Triple RNA binding domain protein 3

Species:

Leishmania donovani

UniProt:

A0A3S7X2A3_LEIDO

TriTrypDb:

LdBPK_290710.1 , LdCL_290011800 , LDHU3_29.0980

Length:

774

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3S7X2A3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2A3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	407	411	PF00656	0.491
CLV_C14_Caspase3-7	682	686	PF00656	0.651
CLV_NRD_NRD_1	102	104	PF00675	0.633
CLV_NRD_NRD_1	156	158	PF00675	0.567
CLV_NRD_NRD_1	312	314	PF00675	0.429
CLV_NRD_NRD_1	389	391	PF00675	0.436
CLV_NRD_NRD_1	417	419	PF00675	0.432
CLV_NRD_NRD_1	490	492	PF00675	0.678
CLV_NRD_NRD_1	550	552	PF00675	0.297
CLV_NRD_NRD_1	634	636	PF00675	0.562
CLV_NRD_NRD_1	753	755	PF00675	0.692
CLV_NRD_NRD_1	83	85	PF00675	0.716
CLV_PCSK_FUR_1	40	44	PF00082	0.606
CLV_PCSK_KEX2_1	102	104	PF00082	0.633
CLV_PCSK_KEX2_1	156	158	PF00082	0.567
CLV_PCSK_KEX2_1	417	419	PF00082	0.432
CLV_PCSK_KEX2_1	42	44	PF00082	0.684
CLV_PCSK_KEX2_1	490	492	PF00082	0.678
CLV_PCSK_KEX2_1	634	636	PF00082	0.688
CLV_PCSK_KEX2_1	680	682	PF00082	0.711
CLV_PCSK_KEX2_1	698	700	PF00082	0.487
CLV_PCSK_KEX2_1	750	752	PF00082	0.603
CLV_PCSK_KEX2_1	76	78	PF00082	0.673
CLV_PCSK_KEX2_1	83	85	PF00082	0.699
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.684
CLV_PCSK_PC1ET2_1	634	636	PF00082	0.688
CLV_PCSK_PC1ET2_1	680	682	PF00082	0.711
CLV_PCSK_PC1ET2_1	698	700	PF00082	0.487
CLV_PCSK_PC1ET2_1	750	752	PF00082	0.603
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.570
CLV_PCSK_SKI1_1	227	231	PF00082	0.561
CLV_PCSK_SKI1_1	283	287	PF00082	0.435
CLV_PCSK_SKI1_1	313	317	PF00082	0.454
CLV_PCSK_SKI1_1	349	353	PF00082	0.360
CLV_PCSK_SKI1_1	366	370	PF00082	0.401
CLV_PCSK_SKI1_1	390	394	PF00082	0.392
CLV_PCSK_SKI1_1	636	640	PF00082	0.607
CLV_PCSK_SKI1_1	710	714	PF00082	0.555
CLV_PCSK_SKI1_1	769	773	PF00082	0.703
CLV_Separin_Metazoa	367	371	PF03568	0.407
DEG_APCC_DBOX_1	365	373	PF00400	0.404
DEG_SCF_FBW7_1	402	407	PF00400	0.406
DOC_CKS1_1	61	66	PF01111	0.590
DOC_MAPK_gen_1	241	249	PF00069	0.479
DOC_MAPK_gen_1	390	396	PF00069	0.387
DOC_MAPK_gen_1	551	557	PF00069	0.521
DOC_MAPK_gen_1	589	597	PF00069	0.521
DOC_MAPK_RevD_3	404	418	PF00069	0.491
DOC_PP4_FxxP_1	116	119	PF00568	0.699
DOC_PP4_FxxP_1	572	575	PF00568	0.454
DOC_USP7_MATH_1	173	177	PF00917	0.639
DOC_USP7_MATH_1	19	23	PF00917	0.694
DOC_USP7_MATH_1	33	37	PF00917	0.671
DOC_USP7_MATH_1	447	451	PF00917	0.670
DOC_USP7_MATH_1	456	460	PF00917	0.608
DOC_USP7_MATH_1	50	54	PF00917	0.610
DOC_USP7_MATH_1	718	722	PF00917	0.645
DOC_USP7_MATH_1	741	745	PF00917	0.679
DOC_USP7_UBL2_3	242	246	PF12436	0.505
DOC_USP7_UBL2_3	340	344	PF12436	0.540
DOC_USP7_UBL2_3	632	636	PF12436	0.533
DOC_USP7_UBL2_3	765	769	PF12436	0.679
DOC_WW_Pin1_4	183	188	PF00397	0.687
DOC_WW_Pin1_4	296	301	PF00397	0.406
DOC_WW_Pin1_4	400	405	PF00397	0.403
DOC_WW_Pin1_4	436	441	PF00397	0.629
DOC_WW_Pin1_4	452	457	PF00397	0.775
DOC_WW_Pin1_4	60	65	PF00397	0.590
LIG_14-3-3_CanoR_1	227	233	PF00244	0.548
LIG_14-3-3_CanoR_1	40	46	PF00244	0.673
LIG_14-3-3_CanoR_1	67	72	PF00244	0.625
LIG_AP2alpha_1	408	412	PF02296	0.425
LIG_APCC_ABBA_1	555	560	PF00400	0.521
LIG_BIR_III_2	93	97	PF00653	0.674
LIG_BRCT_BRCA1_1	112	116	PF00533	0.836
LIG_DLG_GKlike_1	67	75	PF00625	0.564
LIG_FHA_1	224	230	PF00498	0.606
LIG_FHA_1	317	323	PF00498	0.519
LIG_FHA_1	331	337	PF00498	0.573
LIG_FHA_1	346	352	PF00498	0.437
LIG_FHA_1	401	407	PF00498	0.401
LIG_FHA_1	711	717	PF00498	0.555
LIG_FHA_1	733	739	PF00498	0.676
LIG_FHA_2	105	111	PF00498	0.507
LIG_FHA_2	262	268	PF00498	0.572
LIG_FHA_2	358	364	PF00498	0.345
LIG_FHA_2	396	402	PF00498	0.448
LIG_FHA_2	405	411	PF00498	0.400
LIG_FHA_2	84	90	PF00498	0.650
LIG_Integrin_isoDGR_2	311	313	PF01839	0.418
LIG_LIR_Apic_2	113	119	PF02991	0.641
LIG_LIR_Apic_2	571	575	PF02991	0.482
LIG_LIR_Gen_1	410	419	PF02991	0.434
LIG_LIR_Gen_1	513	523	PF02991	0.549
LIG_LIR_Nem_3	410	415	PF02991	0.426
LIG_LIR_Nem_3	513	519	PF02991	0.575
LIG_NRP_CendR_1	772	774	PF00754	0.765
LIG_Pex14_2	272	276	PF04695	0.417
LIG_Pex14_2	408	412	PF04695	0.425
LIG_RPA_C_Fungi	413	425	PF08784	0.438
LIG_SH2_STAP1	254	258	PF00017	0.577
LIG_SH2_STAP1	577	581	PF00017	0.291
LIG_SH2_STAP1	620	624	PF00017	0.609
LIG_SH2_STAT5	254	257	PF00017	0.535
LIG_SH2_STAT5	527	530	PF00017	0.325
LIG_SH2_STAT5	637	640	PF00017	0.571
LIG_SH3_2	187	192	PF14604	0.584
LIG_SH3_3	184	190	PF00018	0.583
LIG_SH3_3	257	263	PF00018	0.603
LIG_SH3_3	275	281	PF00018	0.348
LIG_SH3_3	319	325	PF00018	0.421
LIG_SH3_3	356	362	PF00018	0.428
LIG_SH3_3	44	50	PF00018	0.681
LIG_SH3_3	450	456	PF00018	0.570
LIG_SH3_3	55	61	PF00018	0.693
LIG_SUMO_SIM_anti_2	467	476	PF11976	0.677
LIG_SUMO_SIM_par_1	95	100	PF11976	0.666
LIG_TRAF2_1	108	111	PF00917	0.692
LIG_TRAF2_1	209	212	PF00917	0.692
LIG_TRAF2_1	264	267	PF00917	0.565
LIG_TRAF2_1	612	615	PF00917	0.583
LIG_UBA3_1	352	358	PF00899	0.379
LIG_WRC_WIRS_1	393	398	PF05994	0.417
MOD_CDC14_SPxK_1	189	192	PF00782	0.650
MOD_CDK_SPK_2	436	441	PF00069	0.531
MOD_CDK_SPxK_1	186	192	PF00069	0.646
MOD_CDK_SPxxK_3	60	67	PF00069	0.548
MOD_CK1_1	167	173	PF00069	0.669
MOD_CK1_1	186	192	PF00069	0.646
MOD_CK1_1	197	203	PF00069	0.733
MOD_CK1_1	299	305	PF00069	0.403
MOD_CK1_1	486	492	PF00069	0.591
MOD_CK1_1	507	513	PF00069	0.569
MOD_CK1_1	745	751	PF00069	0.654
MOD_CK1_1	9	15	PF00069	0.693
MOD_CK2_1	104	110	PF00069	0.571
MOD_CK2_1	206	212	PF00069	0.723
MOD_CK2_1	261	267	PF00069	0.586
MOD_CK2_1	357	363	PF00069	0.408
MOD_CK2_1	395	401	PF00069	0.482
MOD_CK2_1	490	496	PF00069	0.522
MOD_CK2_1	657	663	PF00069	0.815
MOD_Cter_Amidation	311	314	PF01082	0.426
MOD_Cter_Amidation	415	418	PF01082	0.459
MOD_Cter_Amidation	678	681	PF01082	0.719
MOD_Cter_Amidation	81	84	PF01082	0.631
MOD_GlcNHglycan	110	115	PF01048	0.720
MOD_GlcNHglycan	142	145	PF01048	0.555
MOD_GlcNHglycan	166	169	PF01048	0.688
MOD_GlcNHglycan	196	200	PF01048	0.752
MOD_GlcNHglycan	221	224	PF01048	0.656
MOD_GlcNHglycan	273	276	PF01048	0.496
MOD_GlcNHglycan	35	38	PF01048	0.714
MOD_GlcNHglycan	419	422	PF01048	0.380
MOD_GlcNHglycan	458	461	PF01048	0.691
MOD_GlcNHglycan	485	488	PF01048	0.674
MOD_GlcNHglycan	498	501	PF01048	0.660
MOD_GlcNHglycan	603	606	PF01048	0.557
MOD_GlcNHglycan	64	67	PF01048	0.706
MOD_GlcNHglycan	99	102	PF01048	0.805
MOD_GSK3_1	106	113	PF00069	0.675
MOD_GSK3_1	219	226	PF00069	0.612
MOD_GSK3_1	230	237	PF00069	0.556
MOD_GSK3_1	29	36	PF00069	0.623
MOD_GSK3_1	400	407	PF00069	0.493
MOD_GSK3_1	426	433	PF00069	0.531
MOD_GSK3_1	448	455	PF00069	0.613
MOD_GSK3_1	479	486	PF00069	0.590
MOD_GSK3_1	496	503	PF00069	0.758
MOD_GSK3_1	558	565	PF00069	0.333
MOD_GSK3_1	741	748	PF00069	0.798
MOD_N-GLC_1	140	145	PF02516	0.553
MOD_N-GLC_1	234	239	PF02516	0.550
MOD_N-GLC_1	496	501	PF02516	0.687
MOD_N-GLC_1	507	512	PF02516	0.539
MOD_N-GLC_1	671	676	PF02516	0.691
MOD_N-GLC_1	718	723	PF02516	0.711
MOD_NEK2_1	140	145	PF00069	0.553
MOD_NEK2_1	316	321	PF00069	0.472
MOD_NEK2_1	638	643	PF00069	0.534
MOD_NEK2_2	749	754	PF00069	0.582
MOD_PIKK_1	118	124	PF00454	0.578
MOD_PIKK_1	357	363	PF00454	0.408
MOD_PIKK_1	384	390	PF00454	0.547
MOD_PIKK_1	672	678	PF00454	0.563
MOD_PK_1	639	645	PF00069	0.545
MOD_PKA_1	417	423	PF00069	0.433
MOD_PKA_1	490	496	PF00069	0.522
MOD_PKA_1	83	89	PF00069	0.567
MOD_PKA_2	417	423	PF00069	0.433
MOD_PKA_2	490	496	PF00069	0.663
MOD_PKA_2	6	12	PF00069	0.682
MOD_PKA_2	82	88	PF00069	0.702
MOD_PKB_1	225	233	PF00069	0.566
MOD_Plk_1	470	476	PF00069	0.650
MOD_Plk_1	536	542	PF00069	0.234
MOD_Plk_2-3	657	663	PF00069	0.632
MOD_Plk_4	470	476	PF00069	0.650
MOD_ProDKin_1	183	189	PF00069	0.685
MOD_ProDKin_1	296	302	PF00069	0.401
MOD_ProDKin_1	400	406	PF00069	0.402
MOD_ProDKin_1	436	442	PF00069	0.629
MOD_ProDKin_1	452	458	PF00069	0.778
MOD_ProDKin_1	60	66	PF00069	0.592
MOD_SUMO_rev_2	323	327	PF00179	0.555
MOD_SUMO_rev_2	371	380	PF00179	0.455
MOD_SUMO_rev_2	682	689	PF00179	0.644
TRG_DiLeu_BaEn_1	514	519	PF01217	0.569
TRG_DiLeu_BaEn_3	111	117	PF01217	0.655
TRG_DiLeu_BaLyEn_6	280	285	PF01217	0.451
TRG_ENDOCYTIC_2	516	519	PF00928	0.563
TRG_ER_diArg_1	155	157	PF00400	0.662
TRG_ER_diArg_1	224	227	PF00400	0.607
TRG_ER_diArg_1	417	419	PF00400	0.432
TRG_ER_diLys_1	770	774	PF00400	0.716
TRG_NES_CRM1_1	238	250	PF08389	0.498
TRG_NLS_Bipartite_1	680	702	PF00514	0.691
TRG_NLS_Bipartite_1	754	773	PF00514	0.685
TRG_NLS_MonoExtC_3	697	703	PF00514	0.643
TRG_NLS_MonoExtC_3	768	773	PF00514	0.707
TRG_Pf-PMV_PEXEL_1	318	323	PF00026	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8C3	Leptomonas seymouri	61%	100%
A0A0S4JB85	Bodo saltans	45%	100%
A4HH75	Leishmania braziliensis	73%	95%
A4I4C1	Leishmania infantum	99%	100%
C9ZL47	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9ADS0	Leishmania major	85%	100%
E9AM10	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%