Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X291_LEIDO

TriTrypDb:

LdBPK_290850.1 , LdCL_290013300 , LDHU3_29.1150

Length:

618

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S7X291

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X291

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	211	215	PF00656	0.724
CLV_C14_Caspase3-7	245	249	PF00656	0.666
CLV_C14_Caspase3-7	255	259	PF00656	0.657
CLV_C14_Caspase3-7	306	310	PF00656	0.720
CLV_C14_Caspase3-7	313	317	PF00656	0.758
CLV_C14_Caspase3-7	356	360	PF00656	0.770
CLV_NRD_NRD_1	155	157	PF00675	0.607
CLV_NRD_NRD_1	291	293	PF00675	0.449
CLV_NRD_NRD_1	469	471	PF00675	0.507
CLV_NRD_NRD_1	472	474	PF00675	0.507
CLV_NRD_NRD_1	532	534	PF00675	0.532
CLV_NRD_NRD_1	569	571	PF00675	0.476
CLV_NRD_NRD_1	578	580	PF00675	0.490
CLV_NRD_NRD_1	85	87	PF00675	0.730
CLV_PCSK_FUR_1	289	293	PF00082	0.441
CLV_PCSK_FUR_1	470	474	PF00082	0.581
CLV_PCSK_FUR_1	533	537	PF00082	0.517
CLV_PCSK_KEX2_1	291	293	PF00082	0.449
CLV_PCSK_KEX2_1	469	471	PF00082	0.507
CLV_PCSK_KEX2_1	472	474	PF00082	0.507
CLV_PCSK_KEX2_1	532	534	PF00082	0.530
CLV_PCSK_KEX2_1	535	537	PF00082	0.469
CLV_PCSK_KEX2_1	571	573	PF00082	0.470
CLV_PCSK_KEX2_1	578	580	PF00082	0.457
CLV_PCSK_KEX2_1	85	87	PF00082	0.730
CLV_PCSK_PC1ET2_1	535	537	PF00082	0.506
CLV_PCSK_PC1ET2_1	571	573	PF00082	0.396
CLV_PCSK_PC7_1	465	471	PF00082	0.580
CLV_PCSK_SKI1_1	169	173	PF00082	0.517
CLV_PCSK_SKI1_1	192	196	PF00082	0.403
CLV_PCSK_SKI1_1	540	544	PF00082	0.492
DEG_Nend_Nbox_1	1	3	PF02207	0.732
DOC_ANK_TNKS_1	400	407	PF00023	0.829
DOC_CYCLIN_RxL_1	189	198	PF00134	0.676
DOC_CYCLIN_RxL_1	535	544	PF00134	0.692
DOC_MAPK_gen_1	182	190	PF00069	0.693
DOC_USP7_MATH_1	130	134	PF00917	0.577
DOC_USP7_MATH_1	149	153	PF00917	0.624
DOC_USP7_MATH_1	304	308	PF00917	0.710
DOC_USP7_MATH_1	310	314	PF00917	0.753
DOC_USP7_UBL2_3	117	121	PF12436	0.506
DOC_WW_Pin1_4	300	305	PF00397	0.705
DOC_WW_Pin1_4	4	9	PF00397	0.714
LIG_14-3-3_CanoR_1	23	31	PF00244	0.787
LIG_14-3-3_CanoR_1	373	378	PF00244	0.801
LIG_14-3-3_CanoR_1	391	399	PF00244	0.594
LIG_APCC_ABBA_1	293	298	PF00400	0.664
LIG_APCC_ABBAyCdc20_2	292	298	PF00400	0.660
LIG_BIR_III_4	309	313	PF00653	0.683
LIG_deltaCOP1_diTrp_1	607	615	PF00928	0.831
LIG_FHA_1	135	141	PF00498	0.338
LIG_FHA_1	176	182	PF00498	0.666
LIG_FHA_1	26	32	PF00498	0.775
LIG_FHA_2	209	215	PF00498	0.732
LIG_FHA_2	224	230	PF00498	0.631
LIG_FHA_2	508	514	PF00498	0.828
LIG_LIR_Gen_1	185	195	PF02991	0.681
LIG_LIR_Gen_1	275	284	PF02991	0.606
LIG_LIR_Gen_1	541	550	PF02991	0.690
LIG_LIR_Gen_1	57	66	PF02991	0.745
LIG_LIR_Gen_1	78	87	PF02991	0.576
LIG_LIR_Nem_3	185	190	PF02991	0.690
LIG_LIR_Nem_3	241	246	PF02991	0.702
LIG_LIR_Nem_3	541	546	PF02991	0.609
LIG_LIR_Nem_3	57	63	PF02991	0.513
LIG_LIR_Nem_3	78	83	PF02991	0.573
LIG_PDZ_Class_3	613	618	PF00595	0.760
LIG_SH2_PTP2	187	190	PF00017	0.681
LIG_SH2_PTP2	60	63	PF00017	0.570
LIG_SH2_STAP1	18	22	PF00017	0.816
LIG_SH2_STAT3	452	455	PF00017	0.718
LIG_SH2_STAT5	187	190	PF00017	0.681
LIG_SH2_STAT5	278	281	PF00017	0.605
LIG_SH2_STAT5	452	455	PF00017	0.718
LIG_SH2_STAT5	60	63	PF00017	0.570
LIG_SH3_1	410	416	PF00018	0.791
LIG_SH3_3	324	330	PF00018	0.747
LIG_SH3_3	410	416	PF00018	0.791
LIG_SH3_3	5	11	PF00018	0.778
LIG_TRAF2_1	464	467	PF00917	0.788
LIG_TRAF2_1	510	513	PF00917	0.801
LIG_TRAF2_1	518	521	PF00917	0.768
LIG_TYR_ITIM	58	63	PF00017	0.744
LIG_UBA3_1	542	551	PF00899	0.667
MOD_CK1_1	133	139	PF00069	0.351
MOD_CK1_1	209	215	PF00069	0.724
MOD_CK1_1	26	32	PF00069	0.755
MOD_CK1_1	3	9	PF00069	0.718
MOD_CK1_1	68	74	PF00069	0.527
MOD_CK1_1	78	84	PF00069	0.461
MOD_CK2_1	223	229	PF00069	0.639
MOD_CK2_1	362	368	PF00069	0.757
MOD_CK2_1	461	467	PF00069	0.718
MOD_CK2_1	493	499	PF00069	0.845
MOD_CK2_1	507	513	PF00069	0.640
MOD_GlcNHglycan	151	154	PF01048	0.448
MOD_GlcNHglycan	160	163	PF01048	0.494
MOD_GlcNHglycan	2	5	PF01048	0.600
MOD_GlcNHglycan	240	243	PF01048	0.473
MOD_GlcNHglycan	248	251	PF01048	0.474
MOD_GlcNHglycan	28	31	PF01048	0.557
MOD_GlcNHglycan	364	367	PF01048	0.547
MOD_GlcNHglycan	50	53	PF01048	0.513
MOD_GlcNHglycan	585	588	PF01048	0.557
MOD_GlcNHglycan	67	70	PF01048	0.601
MOD_GSK3_1	130	137	PF00069	0.571
MOD_GSK3_1	206	213	PF00069	0.737
MOD_GSK3_1	22	29	PF00069	0.817
MOD_GSK3_1	300	307	PF00069	0.708
MOD_GSK3_1	549	556	PF00069	0.646
MOD_GSK3_1	68	75	PF00069	0.560
MOD_NEK2_1	158	163	PF00069	0.734
MOD_NEK2_1	2	7	PF00069	0.726
MOD_NEK2_1	22	27	PF00069	0.572
MOD_NEK2_1	238	243	PF00069	0.656
MOD_NEK2_1	246	251	PF00069	0.730
MOD_NEK2_1	267	272	PF00069	0.604
MOD_NEK2_1	48	53	PF00069	0.459
MOD_NEK2_1	54	59	PF00069	0.401
MOD_NEK2_1	549	554	PF00069	0.647
MOD_PKA_2	22	28	PF00069	0.786
MOD_PKA_2	379	385	PF00069	0.777
MOD_PKB_1	86	94	PF00069	0.577
MOD_Plk_1	216	222	PF00069	0.655
MOD_Plk_1	394	400	PF00069	0.752
MOD_Plk_2-3	493	499	PF00069	0.845
MOD_Plk_4	170	176	PF00069	0.678
MOD_Plk_4	267	273	PF00069	0.604
MOD_Plk_4	373	379	PF00069	0.745
MOD_Plk_4	394	400	PF00069	0.826
MOD_Plk_4	54	60	PF00069	0.515
MOD_Plk_4	75	81	PF00069	0.514
MOD_ProDKin_1	300	306	PF00069	0.702
MOD_ProDKin_1	4	10	PF00069	0.714
MOD_SUMO_rev_2	108	116	PF00179	0.495
MOD_SUMO_rev_2	161	171	PF00179	0.740
TRG_DiLeu_BaEn_1	445	450	PF01217	0.795
TRG_ENDOCYTIC_2	187	190	PF00928	0.681
TRG_ENDOCYTIC_2	243	246	PF00928	0.699
TRG_ENDOCYTIC_2	278	281	PF00928	0.605
TRG_ENDOCYTIC_2	60	63	PF00928	0.745
TRG_ER_diArg_1	288	291	PF00400	0.608
TRG_ER_diArg_1	468	470	PF00400	0.776
TRG_ER_diArg_1	570	573	PF00400	0.650
TRG_ER_diArg_1	85	88	PF00400	0.511
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	401	405	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7X5	Leptomonas seymouri	45%	100%
A4HH89	Leishmania braziliensis	73%	100%
A4I4D5	Leishmania infantum	99%	100%
E9ADT4	Leishmania major	91%	100%
E9ALZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%