U3 small nucleolar ribonucleoprotein MPP10, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U3 small nucleolar ribonucleoprotein protein MPP10, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X283_LEIDO

TriTrypDb:

LdBPK_290780.1 , LdCL_290012600 , LDHU3_29.1070

Length:

675

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005732	sno(s)RNA-containing ribonucleoprotein complex	3	9
GO:0032991	protein-containing complex	1	9
GO:0034457	Mpp10 complex	3	9
GO:0140513	nuclear protein-containing complex	2	9
GO:1990904	ribonucleoprotein complex	2	9
GO:0005730	nucleolus	5	1
GO:0030684	preribosome	3	1
GO:0032040	small-subunit processome	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X283

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X283

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006364	rRNA processing	8	9
GO:0006396	RNA processing	6	9
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016070	RNA metabolic process	5	9
GO:0016072	rRNA metabolic process	7	9
GO:0034470	ncRNA processing	7	9
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0034660	ncRNA metabolic process	6	9
GO:0043170	macromolecule metabolic process	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0046483	heterocycle metabolic process	3	9
GO:0071704	organic substance metabolic process	2	9
GO:0090304	nucleic acid metabolic process	4	9
GO:1901360	organic cyclic compound metabolic process	3	9

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.458
CLV_NRD_NRD_1	112	114	PF00675	0.395
CLV_NRD_NRD_1	134	136	PF00675	0.442
CLV_NRD_NRD_1	190	192	PF00675	0.447
CLV_NRD_NRD_1	193	195	PF00675	0.430
CLV_NRD_NRD_1	241	243	PF00675	0.438
CLV_NRD_NRD_1	265	267	PF00675	0.337
CLV_NRD_NRD_1	415	417	PF00675	0.367
CLV_NRD_NRD_1	46	48	PF00675	0.638
CLV_NRD_NRD_1	487	489	PF00675	0.395
CLV_NRD_NRD_1	644	646	PF00675	0.341
CLV_NRD_NRD_1	660	662	PF00675	0.583
CLV_NRD_NRD_1	81	83	PF00675	0.598
CLV_PCSK_FUR_1	236	240	PF00082	0.444
CLV_PCSK_KEX2_1	112	114	PF00082	0.369
CLV_PCSK_KEX2_1	190	192	PF00082	0.448
CLV_PCSK_KEX2_1	238	240	PF00082	0.438
CLV_PCSK_KEX2_1	241	243	PF00082	0.438
CLV_PCSK_KEX2_1	265	267	PF00082	0.339
CLV_PCSK_KEX2_1	421	423	PF00082	0.397
CLV_PCSK_KEX2_1	438	440	PF00082	0.277
CLV_PCSK_KEX2_1	46	48	PF00082	0.638
CLV_PCSK_KEX2_1	487	489	PF00082	0.451
CLV_PCSK_KEX2_1	644	646	PF00082	0.349
CLV_PCSK_KEX2_1	662	664	PF00082	0.650
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.440
CLV_PCSK_PC1ET2_1	421	423	PF00082	0.430
CLV_PCSK_PC1ET2_1	438	440	PF00082	0.277
CLV_PCSK_PC1ET2_1	487	489	PF00082	0.478
CLV_PCSK_PC1ET2_1	662	664	PF00082	0.650
CLV_PCSK_PC7_1	236	242	PF00082	0.492
CLV_PCSK_PC7_1	640	646	PF00082	0.357
CLV_PCSK_SKI1_1	101	105	PF00082	0.357
CLV_PCSK_SKI1_1	161	165	PF00082	0.438
CLV_PCSK_SKI1_1	195	199	PF00082	0.389
CLV_PCSK_SKI1_1	209	213	PF00082	0.319
CLV_PCSK_SKI1_1	28	32	PF00082	0.613
CLV_PCSK_SKI1_1	421	425	PF00082	0.438
CLV_PCSK_SKI1_1	441	445	PF00082	0.162
CLV_PCSK_SKI1_1	522	526	PF00082	0.438
CLV_PCSK_SKI1_1	640	644	PF00082	0.339
CLV_PCSK_SKI1_1	85	89	PF00082	0.562
DEG_APCC_DBOX_1	100	108	PF00400	0.438
DEG_APCC_DBOX_1	440	448	PF00400	0.438
DEG_APCC_DBOX_1	53	61	PF00400	0.511
DEG_MDM2_SWIB_1	424	431	PF02201	0.492
DEG_SCF_TRCP1_1	231	237	PF00400	0.279
DOC_MAPK_gen_1	438	447	PF00069	0.438
DOC_MAPK_gen_1	511	519	PF00069	0.357
DOC_MAPK_MEF2A_6	66	74	PF00069	0.620
DOC_USP7_MATH_1	2	6	PF00917	0.709
DOC_USP7_MATH_1	366	370	PF00917	0.279
DOC_USP7_MATH_1	509	513	PF00917	0.420
DOC_USP7_UBL2_3	186	190	PF12436	0.395
DOC_USP7_UBL2_3	195	199	PF12436	0.333
DOC_USP7_UBL2_3	417	421	PF12436	0.492
DOC_USP7_UBL2_3	648	652	PF12436	0.412
DOC_WW_Pin1_4	258	263	PF00397	0.279
DOC_WW_Pin1_4	573	578	PF00397	0.357
DOC_WW_Pin1_4	633	638	PF00397	0.438
DOC_WW_Pin1_4	66	71	PF00397	0.601
DOC_WW_Pin1_4	7	12	PF00397	0.756
LIG_14-3-3_CanoR_1	33	43	PF00244	0.654
LIG_14-3-3_CanoR_1	422	431	PF00244	0.438
LIG_14-3-3_CanoR_1	488	493	PF00244	0.335
LIG_14-3-3_CanoR_1	621	630	PF00244	0.475
LIG_14-3-3_CanoR_1	85	93	PF00244	0.383
LIG_Actin_WH2_2	542	557	PF00022	0.333
LIG_Actin_WH2_2	60	75	PF00022	0.601
LIG_BIR_III_4	277	281	PF00653	0.201
LIG_BIR_III_4	328	332	PF00653	0.376
LIG_BRCT_BRCA1_1	623	627	PF00533	0.438
LIG_Clathr_ClatBox_1	444	448	PF01394	0.438
LIG_deltaCOP1_diTrp_1	205	212	PF00928	0.361
LIG_FHA_1	166	172	PF00498	0.391
LIG_FHA_1	465	471	PF00498	0.363
LIG_FHA_1	630	636	PF00498	0.422
LIG_FHA_1	87	93	PF00498	0.391
LIG_FHA_2	259	265	PF00498	0.279
LIG_FHA_2	492	498	PF00498	0.358
LIG_FHA_2	545	551	PF00498	0.357
LIG_FHA_2	606	612	PF00498	0.391
LIG_FHA_2	634	640	PF00498	0.438
LIG_FHA_2	79	85	PF00498	0.632
LIG_LIR_Gen_1	426	436	PF02991	0.486
LIG_LIR_Gen_1	624	635	PF02991	0.391
LIG_LIR_Nem_3	426	431	PF02991	0.486
LIG_LIR_Nem_3	480	486	PF02991	0.357
LIG_LIR_Nem_3	624	630	PF02991	0.391
LIG_LIR_Nem_3	90	96	PF02991	0.391
LIG_Pex14_1	208	212	PF04695	0.357
LIG_Pex14_2	424	428	PF04695	0.391
LIG_PTB_Apo_2	446	453	PF02174	0.492
LIG_PTB_Apo_2	569	576	PF02174	0.357
LIG_PTB_Phospho_1	569	575	PF10480	0.438
LIG_SH2_NCK_1	61	65	PF00017	0.547
LIG_SH2_SRC	483	486	PF00017	0.438
LIG_SH2_STAP1	503	507	PF00017	0.438
LIG_SH2_STAP1	520	524	PF00017	0.162
LIG_SH2_STAT3	334	337	PF00017	0.415
LIG_SH2_STAT5	341	344	PF00017	0.391
LIG_SH2_STAT5	575	578	PF00017	0.438
LIG_SH3_3	12	18	PF00018	0.726
LIG_SH3_3	535	541	PF00018	0.422
LIG_SH3_4	578	585	PF00018	0.391
LIG_SUMO_SIM_par_1	442	448	PF11976	0.438
LIG_TRAF2_1	217	220	PF00917	0.438
LIG_TRAF2_1	245	248	PF00917	0.415
LIG_TRAF2_1	284	287	PF00917	0.355
LIG_UBA3_1	516	522	PF00899	0.357
MOD_CDC14_SPxK_1	10	13	PF00782	0.800
MOD_CDK_SPK_2	573	578	PF00069	0.357
MOD_CDK_SPK_2	633	638	PF00069	0.438
MOD_CDK_SPxK_1	7	13	PF00069	0.805
MOD_CDK_SPxxK_3	258	265	PF00069	0.279
MOD_CDK_SPxxK_3	633	640	PF00069	0.438
MOD_CDK_SPxxK_3	66	73	PF00069	0.618
MOD_CK1_1	165	171	PF00069	0.391
MOD_CK1_1	3	9	PF00069	0.688
MOD_CK1_1	512	518	PF00069	0.397
MOD_CK1_1	53	59	PF00069	0.522
MOD_CK1_1	62	68	PF00069	0.516
MOD_CK2_1	281	287	PF00069	0.426
MOD_CK2_1	397	403	PF00069	0.406
MOD_CK2_1	544	550	PF00069	0.371
MOD_CK2_1	605	611	PF00069	0.391
MOD_CK2_1	633	639	PF00069	0.401
MOD_CK2_1	643	649	PF00069	0.419
MOD_CK2_1	78	84	PF00069	0.672
MOD_Cter_Amidation	650	653	PF01082	0.438
MOD_GlcNHglycan	120	123	PF01048	0.481
MOD_GlcNHglycan	125	128	PF01048	0.484
MOD_GlcNHglycan	140	143	PF01048	0.213
MOD_GlcNHglycan	149	152	PF01048	0.398
MOD_GlcNHglycan	2	5	PF01048	0.755
MOD_GlcNHglycan	230	234	PF01048	0.448
MOD_GlcNHglycan	368	371	PF01048	0.448
MOD_GlcNHglycan	6	9	PF01048	0.751
MOD_GSK3_1	118	125	PF00069	0.472
MOD_GSK3_1	162	169	PF00069	0.393
MOD_GSK3_1	2	9	PF00069	0.676
MOD_GSK3_1	460	467	PF00069	0.359
MOD_GSK3_1	487	494	PF00069	0.369
MOD_GSK3_1	62	69	PF00069	0.483
MOD_GSK3_1	629	636	PF00069	0.431
MOD_GSK3_1	665	672	PF00069	0.709
MOD_NEK2_1	24	29	PF00069	0.662
MOD_NEK2_1	34	39	PF00069	0.583
MOD_NEK2_1	42	47	PF00069	0.521
MOD_NEK2_1	643	648	PF00069	0.492
MOD_PKA_1	487	493	PF00069	0.425
MOD_PKA_2	166	172	PF00069	0.438
MOD_PKA_2	24	30	PF00069	0.621
MOD_PKA_2	32	38	PF00069	0.588
MOD_PKA_2	487	493	PF00069	0.339
MOD_PKA_2	53	59	PF00069	0.580
MOD_PKA_2	620	626	PF00069	0.374
MOD_PKA_2	643	649	PF00069	0.469
MOD_Plk_1	204	210	PF00069	0.416
MOD_Plk_1	426	432	PF00069	0.436
MOD_Plk_2-3	397	403	PF00069	0.492
MOD_Plk_2-3	544	550	PF00069	0.357
MOD_Plk_2-3	629	635	PF00069	0.422
MOD_Plk_4	337	343	PF00069	0.376
MOD_Plk_4	512	518	PF00069	0.357
MOD_ProDKin_1	258	264	PF00069	0.279
MOD_ProDKin_1	573	579	PF00069	0.357
MOD_ProDKin_1	633	639	PF00069	0.438
MOD_ProDKin_1	66	72	PF00069	0.608
MOD_ProDKin_1	7	13	PF00069	0.757
MOD_SUMO_for_1	468	471	PF00179	0.391
MOD_SUMO_for_1	541	544	PF00179	0.415
TRG_DiLeu_BaEn_1	179	184	PF01217	0.391
TRG_DiLeu_BaEn_4	286	292	PF01217	0.355
TRG_DiLeu_BaEn_4	317	323	PF01217	0.492
TRG_ENDOCYTIC_2	483	486	PF00928	0.438
TRG_ER_diArg_1	111	113	PF00400	0.459
TRG_ER_diArg_1	236	239	PF00400	0.444
TRG_ER_diArg_1	240	242	PF00400	0.431
TRG_ER_diArg_1	265	268	PF00400	0.341
TRG_ER_diArg_1	527	530	PF00400	0.422
TRG_ER_diArg_1	643	645	PF00400	0.364
TRG_ER_diArg_1	660	663	PF00400	0.593
TRG_NLS_Bipartite_1	644	666	PF00514	0.420
TRG_NLS_MonoCore_2	660	665	PF00514	0.671
TRG_NLS_MonoExtC_3	189	194	PF00514	0.395
TRG_NLS_MonoExtN_4	190	195	PF00514	0.343
TRG_NLS_MonoExtN_4	661	666	PF00514	0.679
TRG_Pf-PMV_PEXEL_1	191	196	PF00026	0.356
TRG_Pf-PMV_PEXEL_1	292	297	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Q4	Leptomonas seymouri	70%	99%
A0A0S4JKJ8	Bodo saltans	44%	100%
A4HH82	Leishmania braziliensis	82%	100%
A4I4C8	Leishmania infantum	100%	100%
C9ZL36	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ADS7	Leishmania major	93%	100%
E9AM03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%