LeishMANIAdb
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C3H1-type domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
C3H1-type domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X275_LEIDO
TriTrypDb:
LdBPK_290430.1 , LdCL_290009100 , LDHU3_29.0580
Length:
404

Annotations

Annotations by Jardim et al.

Metal Binding, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X275
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X275

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 6
GO:0043167 ion binding 2 6
GO:0043169 cation binding 3 6
GO:0046872 metal ion binding 4 6
GO:0003676 nucleic acid binding 3 1
GO:0003723 RNA binding 4 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 186 190 PF00656 0.619
CLV_C14_Caspase3-7 275 279 PF00656 0.632
CLV_NRD_NRD_1 333 335 PF00675 0.569
CLV_NRD_NRD_1 57 59 PF00675 0.537
CLV_PCSK_KEX2_1 333 335 PF00082 0.574
CLV_PCSK_KEX2_1 57 59 PF00082 0.537
CLV_PCSK_SKI1_1 15 19 PF00082 0.642
CLV_PCSK_SKI1_1 219 223 PF00082 0.546
CLV_PCSK_SKI1_1 232 236 PF00082 0.437
CLV_PCSK_SKI1_1 300 304 PF00082 0.708
CLV_PCSK_SKI1_1 333 337 PF00082 0.448
DEG_APCC_DBOX_1 218 226 PF00400 0.541
DEG_SPOP_SBC_1 137 141 PF00917 0.647
DOC_CKS1_1 102 107 PF01111 0.695
DOC_CYCLIN_RxL_1 297 305 PF00134 0.559
DOC_CYCLIN_RxL_1 9 22 PF00134 0.641
DOC_MAPK_gen_1 5 13 PF00069 0.729
DOC_MAPK_gen_1 57 68 PF00069 0.537
DOC_MAPK_MEF2A_6 61 70 PF00069 0.531
DOC_PP4_FxxP_1 253 256 PF00568 0.594
DOC_USP7_MATH_1 113 117 PF00917 0.654
DOC_USP7_MATH_1 137 141 PF00917 0.634
DOC_USP7_MATH_1 169 173 PF00917 0.649
DOC_USP7_MATH_1 211 215 PF00917 0.589
DOC_USP7_MATH_1 298 302 PF00917 0.546
DOC_USP7_MATH_1 328 332 PF00917 0.531
DOC_USP7_MATH_1 338 342 PF00917 0.499
DOC_USP7_MATH_1 81 85 PF00917 0.527
DOC_USP7_UBL2_3 5 9 PF12436 0.655
DOC_WW_Pin1_4 146 151 PF00397 0.648
DOC_WW_Pin1_4 361 366 PF00397 0.539
DOC_WW_Pin1_4 395 400 PF00397 0.562
DOC_WW_Pin1_4 42 47 PF00397 0.528
DOC_WW_Pin1_4 98 103 PF00397 0.678
LIG_14-3-3_CanoR_1 273 283 PF00244 0.646
LIG_14-3-3_CanoR_1 357 363 PF00244 0.645
LIG_BIR_III_4 367 371 PF00653 0.610
LIG_BRCT_BRCA1_1 115 119 PF00533 0.546
LIG_FHA_1 12 18 PF00498 0.649
LIG_FHA_1 191 197 PF00498 0.665
LIG_FHA_1 22 28 PF00498 0.544
LIG_FHA_1 224 230 PF00498 0.673
LIG_FHA_2 243 249 PF00498 0.621
LIG_FHA_2 273 279 PF00498 0.650
LIG_FHA_2 362 368 PF00498 0.633
LIG_FHA_2 377 383 PF00498 0.522
LIG_LIR_Apic_2 250 256 PF02991 0.603
LIG_LIR_Apic_2 282 286 PF02991 0.625
LIG_LIR_Gen_1 293 302 PF02991 0.502
LIG_LIR_Gen_1 315 324 PF02991 0.493
LIG_LIR_Gen_1 84 92 PF02991 0.636
LIG_LIR_Nem_3 293 297 PF02991 0.547
LIG_LIR_Nem_3 315 320 PF02991 0.531
LIG_LIR_Nem_3 84 88 PF02991 0.615
LIG_NRBOX 379 385 PF00104 0.630
LIG_SH2_CRK 317 321 PF00017 0.531
LIG_SH2_NCK_1 121 125 PF00017 0.630
LIG_SH2_STAP1 121 125 PF00017 0.630
LIG_SH2_STAT3 281 284 PF00017 0.638
LIG_SH2_STAT5 152 155 PF00017 0.624
LIG_SH2_STAT5 91 94 PF00017 0.560
LIG_SH3_2 102 107 PF14604 0.695
LIG_SH3_3 144 150 PF00018 0.568
LIG_SH3_3 396 402 PF00018 0.636
LIG_SH3_3 99 105 PF00018 0.821
LIG_SH3_4 5 12 PF00018 0.656
LIG_SUMO_SIM_anti_2 379 387 PF11976 0.630
LIG_SUMO_SIM_par_1 220 226 PF11976 0.523
LIG_SUMO_SIM_par_1 376 382 PF11976 0.582
LIG_TRAF2_1 268 271 PF00917 0.596
LIG_TRAF2_1 343 346 PF00917 0.548
LIG_TYR_ITIM 89 94 PF00017 0.551
MOD_CDK_SPxK_1 101 107 PF00069 0.697
MOD_CK1_1 139 145 PF00069 0.633
MOD_CK1_1 176 182 PF00069 0.620
MOD_CK1_1 190 196 PF00069 0.583
MOD_CK1_1 203 209 PF00069 0.601
MOD_CK2_1 287 293 PF00069 0.576
MOD_GlcNHglycan 114 118 PF01048 0.714
MOD_GlcNHglycan 122 125 PF01048 0.723
MOD_GlcNHglycan 171 174 PF01048 0.663
MOD_GlcNHglycan 175 178 PF01048 0.614
MOD_GlcNHglycan 205 208 PF01048 0.762
MOD_GlcNHglycan 213 216 PF01048 0.647
MOD_GlcNHglycan 310 314 PF01048 0.572
MOD_GSK3_1 113 120 PF00069 0.581
MOD_GSK3_1 146 153 PF00069 0.646
MOD_GSK3_1 169 176 PF00069 0.679
MOD_GSK3_1 195 202 PF00069 0.667
MOD_GSK3_1 217 224 PF00069 0.491
MOD_GSK3_1 357 364 PF00069 0.613
MOD_N-GLC_1 203 208 PF02516 0.653
MOD_NEK2_1 119 124 PF00069 0.623
MOD_NEK2_1 287 292 PF00069 0.576
MOD_NEK2_1 316 321 PF00069 0.527
MOD_NEK2_1 62 67 PF00069 0.617
MOD_NEK2_2 328 333 PF00069 0.510
MOD_PIKK_1 251 257 PF00454 0.639
MOD_PIKK_1 338 344 PF00454 0.589
MOD_PIKK_1 44 50 PF00454 0.526
MOD_PKA_2 272 278 PF00069 0.646
MOD_PKA_2 322 328 PF00069 0.512
MOD_Plk_1 163 169 PF00069 0.805
MOD_Plk_1 309 315 PF00069 0.451
MOD_Plk_1 62 68 PF00069 0.596
MOD_Plk_2-3 272 278 PF00069 0.646
MOD_Plk_4 13 19 PF00069 0.645
MOD_Plk_4 298 304 PF00069 0.553
MOD_Plk_4 376 382 PF00069 0.628
MOD_ProDKin_1 146 152 PF00069 0.651
MOD_ProDKin_1 361 367 PF00069 0.543
MOD_ProDKin_1 395 401 PF00069 0.559
MOD_ProDKin_1 42 48 PF00069 0.535
MOD_ProDKin_1 98 104 PF00069 0.681
MOD_SUMO_for_1 183 186 PF00179 0.680
MOD_SUMO_rev_2 162 167 PF00179 0.699
TRG_DiLeu_BaEn_4 271 277 PF01217 0.617
TRG_DiLeu_BaLyEn_6 331 336 PF01217 0.444
TRG_ENDOCYTIC_2 317 320 PF00928 0.533
TRG_ENDOCYTIC_2 91 94 PF00928 0.560
TRG_ER_diArg_1 332 334 PF00400 0.574
TRG_ER_diArg_1 56 58 PF00400 0.537
TRG_Pf-PMV_PEXEL_1 333 337 PF00026 0.448

Homologs

Protein Taxonomy Sequence identity Coverage
A4HH43 Leishmania braziliensis 68% 100%
A4I496 Leishmania infantum 100% 100%
E9ADP3 Leishmania major 94% 100%
E9AM37 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS