U-box domain protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U-box domain protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X270_LEIDO

TriTrypDb:

LdBPK_290810.1 , LdCL_290012900 , LDHU3_29.1110

Length:

601

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X270

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X270

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004842	ubiquitin-protein transferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0019787	ubiquitin-like protein transferase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	278	282	PF00656	0.496
CLV_C14_Caspase3-7	32	36	PF00656	0.412
CLV_C14_Caspase3-7	514	518	PF00656	0.692
CLV_NRD_NRD_1	428	430	PF00675	0.606
CLV_NRD_NRD_1	50	52	PF00675	0.519
CLV_NRD_NRD_1	72	74	PF00675	0.516
CLV_PCSK_KEX2_1	428	430	PF00082	0.606
CLV_PCSK_KEX2_1	50	52	PF00082	0.466
CLV_PCSK_KEX2_1	72	74	PF00082	0.516
CLV_PCSK_SKI1_1	107	111	PF00082	0.611
CLV_PCSK_SKI1_1	428	432	PF00082	0.553
CLV_PCSK_SKI1_1	562	566	PF00082	0.458
DOC_CDC14_PxL_1	477	485	PF14671	0.727
DOC_CYCLIN_yClb1_LxF_4	368	374	PF00134	0.529
DOC_MAPK_gen_1	107	117	PF00069	0.591
DOC_MAPK_gen_1	484	493	PF00069	0.678
DOC_MAPK_gen_1	50	57	PF00069	0.551
DOC_MAPK_gen_1	72	81	PF00069	0.406
DOC_MAPK_MEF2A_6	123	132	PF00069	0.402
DOC_MAPK_MEF2A_6	209	218	PF00069	0.406
DOC_PP1_RVXF_1	207	213	PF00149	0.455
DOC_PP1_RVXF_1	89	96	PF00149	0.496
DOC_PP4_FxxP_1	185	188	PF00568	0.408
DOC_USP7_MATH_1	116	120	PF00917	0.658
DOC_USP7_MATH_1	233	237	PF00917	0.596
DOC_USP7_MATH_1	357	361	PF00917	0.560
DOC_USP7_MATH_1	399	403	PF00917	0.447
DOC_USP7_MATH_1	43	47	PF00917	0.451
DOC_USP7_MATH_1	437	441	PF00917	0.604
DOC_USP7_MATH_1	89	93	PF00917	0.493
DOC_USP7_UBL2_3	205	209	PF12436	0.525
DOC_USP7_UBL2_3	260	264	PF12436	0.519
DOC_WW_Pin1_4	532	537	PF00397	0.390
LIG_14-3-3_CanoR_1	123	131	PF00244	0.434
LIG_14-3-3_CanoR_1	336	342	PF00244	0.474
LIG_14-3-3_CanoR_1	401	405	PF00244	0.571
LIG_14-3-3_CanoR_1	428	436	PF00244	0.523
LIG_14-3-3_CanoR_1	475	483	PF00244	0.819
LIG_14-3-3_CanoR_1	562	571	PF00244	0.452
LIG_14-3-3_CanoR_1	585	589	PF00244	0.620
LIG_Actin_WH2_2	125	143	PF00022	0.414
LIG_Actin_WH2_2	385	403	PF00022	0.519
LIG_AP2alpha_1	342	346	PF02296	0.547
LIG_BIR_II_1	1	5	PF00653	0.469
LIG_BIR_III_4	378	382	PF00653	0.456
LIG_BRCT_BRCA1_1	314	318	PF00533	0.448
LIG_BRCT_BRCA1_1	439	443	PF00533	0.526
LIG_BRCT_BRCA1_1	91	95	PF00533	0.591
LIG_CaM_IQ_9	577	593	PF13499	0.497
LIG_deltaCOP1_diTrp_1	421	427	PF00928	0.571
LIG_EH1_1	154	162	PF00400	0.413
LIG_EH1_1	385	393	PF00400	0.669
LIG_eIF4E_1	386	392	PF01652	0.713
LIG_EVH1_2	168	172	PF00568	0.531
LIG_FHA_1	205	211	PF00498	0.456
LIG_FHA_1	275	281	PF00498	0.407
LIG_FHA_1	523	529	PF00498	0.421
LIG_FHA_1	588	594	PF00498	0.658
LIG_FHA_2	13	19	PF00498	0.648
LIG_FHA_2	276	282	PF00498	0.425
LIG_GBD_Chelix_1	291	299	PF00786	0.522
LIG_GBD_Chelix_1	306	314	PF00786	0.466
LIG_LIR_Gen_1	23	31	PF02991	0.529
LIG_LIR_Gen_1	340	350	PF02991	0.555
LIG_LIR_Gen_1	440	451	PF02991	0.422
LIG_LIR_Gen_1	75	84	PF02991	0.510
LIG_LIR_Gen_1	92	101	PF02991	0.587
LIG_LIR_Nem_3	317	323	PF02991	0.498
LIG_LIR_Nem_3	340	345	PF02991	0.514
LIG_LIR_Nem_3	421	427	PF02991	0.625
LIG_LIR_Nem_3	440	446	PF02991	0.350
LIG_LIR_Nem_3	75	80	PF02991	0.492
LIG_LIR_Nem_3	85	90	PF02991	0.514
LIG_LIR_Nem_3	92	98	PF02991	0.536
LIG_MYND_1	481	485	PF01753	0.785
LIG_NRBOX	160	166	PF00104	0.402
LIG_PDZ_Class_2	596	601	PF00595	0.616
LIG_Pex14_1	423	427	PF04695	0.539
LIG_Pex14_2	338	342	PF04695	0.554
LIG_Pex14_2	419	423	PF04695	0.481
LIG_SH2_CRK	87	91	PF00017	0.486
LIG_SH2_GRB2like	367	370	PF00017	0.528
LIG_SH2_GRB2like	60	63	PF00017	0.414
LIG_SH2_PTP2	367	370	PF00017	0.463
LIG_SH2_STAP1	170	174	PF00017	0.474
LIG_SH2_STAP1	541	545	PF00017	0.518
LIG_SH2_STAT5	10	13	PF00017	0.603
LIG_SH2_STAT5	287	290	PF00017	0.413
LIG_SH2_STAT5	367	370	PF00017	0.415
LIG_SH2_STAT5	60	63	PF00017	0.434
LIG_SH3_2	482	487	PF14604	0.683
LIG_SH3_3	381	387	PF00018	0.601
LIG_SH3_3	461	467	PF00018	0.657
LIG_SH3_3	479	485	PF00018	0.829
LIG_SH3_3	530	536	PF00018	0.375
LIG_SUMO_SIM_anti_2	125	132	PF11976	0.397
LIG_SxIP_EBH_1	473	484	PF03271	0.694
LIG_TRAF2_1	331	334	PF00917	0.518
LIG_TYR_ITIM	365	370	PF00017	0.471
LIG_UBA3_1	132	141	PF00899	0.518
LIG_UBA3_1	159	166	PF00899	0.402
LIG_UBA3_1	255	260	PF00899	0.568
LIG_WRC_WIRS_1	338	343	PF05994	0.545
MOD_CK1_1	236	242	PF00069	0.567
MOD_CK1_1	263	269	PF00069	0.507
MOD_CK1_1	29	35	PF00069	0.489
MOD_CK1_1	290	296	PF00069	0.476
MOD_CK1_1	455	461	PF00069	0.597
MOD_CK2_1	100	106	PF00069	0.516
MOD_CK2_1	259	265	PF00069	0.523
MOD_CK2_1	399	405	PF00069	0.612
MOD_GlcNHglycan	12	15	PF01048	0.659
MOD_GlcNHglycan	179	182	PF01048	0.496
MOD_GlcNHglycan	245	248	PF01048	0.494
MOD_GlcNHglycan	359	362	PF01048	0.486
MOD_GlcNHglycan	396	399	PF01048	0.553
MOD_GlcNHglycan	506	509	PF01048	0.734
MOD_GSK3_1	259	266	PF00069	0.443
MOD_GSK3_1	310	317	PF00069	0.548
MOD_GSK3_1	570	577	PF00069	0.552
MOD_N-GLC_1	248	253	PF02516	0.609
MOD_N-GLC_1	552	557	PF02516	0.409
MOD_N-GLC_1	82	87	PF02516	0.572
MOD_NEK2_1	105	110	PF00069	0.463
MOD_NEK2_1	183	188	PF00069	0.405
MOD_NEK2_1	243	248	PF00069	0.515
MOD_NEK2_1	259	264	PF00069	0.539
MOD_NEK2_1	274	279	PF00069	0.463
MOD_NEK2_1	280	285	PF00069	0.432
MOD_NEK2_1	295	300	PF00069	0.451
MOD_NEK2_1	310	315	PF00069	0.543
MOD_NEK2_1	346	351	PF00069	0.447
MOD_NEK2_2	445	450	PF00069	0.448
MOD_PIKK_1	150	156	PF00454	0.475
MOD_PIKK_1	183	189	PF00454	0.415
MOD_PIKK_1	264	270	PF00454	0.444
MOD_PIKK_1	329	335	PF00454	0.526
MOD_PIKK_1	452	458	PF00454	0.649
MOD_PIKK_1	587	593	PF00454	0.542
MOD_PK_1	509	515	PF00069	0.734
MOD_PKA_1	428	434	PF00069	0.608
MOD_PKA_1	50	56	PF00069	0.493
MOD_PKA_1	72	78	PF00069	0.498
MOD_PKA_2	122	128	PF00069	0.415
MOD_PKA_2	357	363	PF00069	0.580
MOD_PKA_2	400	406	PF00069	0.518
MOD_PKA_2	428	434	PF00069	0.531
MOD_PKA_2	50	56	PF00069	0.476
MOD_PKA_2	584	590	PF00069	0.578
MOD_PKA_2	72	78	PF00069	0.523
MOD_Plk_1	248	254	PF00069	0.569
MOD_Plk_1	264	270	PF00069	0.584
MOD_Plk_1	438	444	PF00069	0.583
MOD_Plk_1	82	88	PF00069	0.550
MOD_Plk_1	99	105	PF00069	0.489
MOD_Plk_2-3	100	106	PF00069	0.619
MOD_Plk_4	100	106	PF00069	0.615
MOD_Plk_4	251	257	PF00069	0.494
MOD_Plk_4	275	281	PF00069	0.433
MOD_Plk_4	314	320	PF00069	0.555
MOD_Plk_4	337	343	PF00069	0.547
MOD_Plk_4	431	437	PF00069	0.488
MOD_ProDKin_1	532	538	PF00069	0.390
MOD_SUMO_for_1	109	112	PF00179	0.524
MOD_SUMO_for_1	408	411	PF00179	0.525
MOD_SUMO_rev_2	13	22	PF00179	0.610
TRG_DiLeu_BaEn_2	207	213	PF01217	0.481
TRG_DiLeu_BaLyEn_6	472	477	PF01217	0.757
TRG_ENDOCYTIC_2	367	370	PF00928	0.401
TRG_ENDOCYTIC_2	424	427	PF00928	0.584
TRG_ENDOCYTIC_2	87	90	PF00928	0.493
TRG_ER_diArg_1	427	429	PF00400	0.585
TRG_ER_diArg_1	49	51	PF00400	0.562
TRG_ER_diArg_1	71	73	PF00400	0.523
TRG_NLS_MonoExtN_4	70	77	PF00514	0.508
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.679

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMG8	Leptomonas seymouri	73%	100%
A0A0S4IVT7	Bodo saltans	48%	98%
A0A1X0NZM7	Trypanosomatidae	44%	96%
A0A3R7MLP4	Trypanosoma rangeli	45%	99%
A4HH85	Leishmania braziliensis	89%	100%
A4I4D1	Leishmania infantum	100%	100%
C9ZL32	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	96%
E9ADT0	Leishmania major	97%	100%
E9AM00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5DLG6	Trypanosoma cruzi	45%	99%