Scavenger mRNA decapping enzyme C-term binding/HIT domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Scavenger mRNA decapping enzyme C-term binding, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X266_LEIDO

TriTrypDb:

LdBPK_290670.1 , LdCL_290011400 , LDHU3_29.0940

Length:

264

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A0A3S7X266

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X266

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006259	DNA metabolic process	4	11
GO:0006281	DNA repair	5	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0006950	response to stress	2	11
GO:0006974	DNA damage response	4	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0033554	cellular response to stress	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0046483	heterocycle metabolic process	3	11
GO:0050896	response to stimulus	1	11
GO:0051716	cellular response to stimulus	2	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0003824	catalytic activity	1	11
GO:0004518	nuclease activity	4	11
GO:0004527	exonuclease activity	5	11
GO:0004529	DNA exonuclease activity	5	11
GO:0004536	DNA nuclease activity	4	11
GO:0005488	binding	1	11
GO:0008409	5'-3' exonuclease activity	6	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	11
GO:0016895	DNA exonuclease activity, producing 5'-phosphomonoesters	6	11
GO:0033699	DNA 5'-adenosine monophosphate hydrolase activity	8	11
GO:0035312	5'-3' DNA exonuclease activity	7	11
GO:0097159	organic cyclic compound binding	2	11
GO:0140097	catalytic activity, acting on DNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.490
CLV_NRD_NRD_1	13	15	PF00675	0.641
CLV_NRD_NRD_1	156	158	PF00675	0.331
CLV_PCSK_KEX2_1	13	15	PF00082	0.648
CLV_PCSK_KEX2_1	156	158	PF00082	0.331
CLV_PCSK_SKI1_1	132	136	PF00082	0.340
CLV_PCSK_SKI1_1	143	147	PF00082	0.286
DEG_APCC_DBOX_1	24	32	PF00400	0.438
DEG_Nend_UBRbox_3	1	3	PF02207	0.685
DEG_SCF_FBW7_1	46	53	PF00400	0.571
DEG_SPOP_SBC_1	51	55	PF00917	0.653
DOC_CDC14_PxL_1	162	170	PF14671	0.445
DOC_CDC14_PxL_1	68	76	PF14671	0.462
DOC_CYCLIN_yCln2_LP_2	109	115	PF00134	0.470
DOC_MAPK_gen_1	25	34	PF00069	0.510
DOC_MAPK_MEF2A_6	90	97	PF00069	0.537
DOC_PP2B_LxvP_1	109	112	PF13499	0.445
DOC_USP7_MATH_1	16	20	PF00917	0.539
DOC_USP7_MATH_1	164	168	PF00917	0.470
DOC_USP7_MATH_1	240	244	PF00917	0.456
DOC_USP7_MATH_1	246	250	PF00917	0.424
DOC_USP7_MATH_1	38	42	PF00917	0.532
DOC_USP7_MATH_1	51	55	PF00917	0.623
DOC_USP7_MATH_1	82	86	PF00917	0.352
DOC_USP7_UBL2_3	258	262	PF12436	0.538
DOC_USP7_UBL2_3	36	40	PF12436	0.513
DOC_WW_Pin1_4	1	6	PF00397	0.624
DOC_WW_Pin1_4	179	184	PF00397	0.467
DOC_WW_Pin1_4	46	51	PF00397	0.636
DOC_WW_Pin1_4	72	77	PF00397	0.531
LIG_14-3-3_CanoR_1	116	121	PF00244	0.537
LIG_14-3-3_CanoR_1	13	20	PF00244	0.595
LIG_14-3-3_CanoR_1	143	149	PF00244	0.527
LIG_14-3-3_CanoR_1	214	218	PF00244	0.443
LIG_Actin_WH2_2	130	148	PF00022	0.531
LIG_BIR_III_2	99	103	PF00653	0.445
LIG_CtBP_PxDLS_1	112	116	PF00389	0.470
LIG_DLG_GKlike_1	116	123	PF00625	0.531
LIG_FHA_1	47	53	PF00498	0.698
LIG_FHA_2	122	128	PF00498	0.495
LIG_FHA_2	176	182	PF00498	0.490
LIG_LIR_Gen_1	193	200	PF02991	0.418
LIG_LIR_Nem_3	139	144	PF02991	0.470
LIG_LIR_Nem_3	193	197	PF02991	0.401
LIG_LIR_Nem_3	201	206	PF02991	0.363
LIG_LYPXL_yS_3	71	74	PF13949	0.446
LIG_MYND_1	72	76	PF01753	0.528
LIG_Pex14_2	158	162	PF04695	0.452
LIG_Pex14_2	194	198	PF04695	0.297
LIG_PTB_Apo_2	95	102	PF02174	0.445
LIG_SH2_STAT5	141	144	PF00017	0.441
LIG_SH2_STAT5	153	156	PF00017	0.461
LIG_SH3_3	163	169	PF00018	0.437
LIG_SH3_3	239	245	PF00018	0.361
LIG_SH3_3	42	48	PF00018	0.563
LIG_WRC_WIRS_1	191	196	PF05994	0.316
LIG_WRPW_2	68	71	PF00400	0.471
MOD_CDK_SPxxK_3	179	186	PF00069	0.471
MOD_CK1_1	19	25	PF00069	0.602
MOD_CK1_1	193	199	PF00069	0.313
MOD_CK1_1	41	47	PF00069	0.478
MOD_CK1_1	54	60	PF00069	0.572
MOD_CK2_1	54	60	PF00069	0.666
MOD_CK2_1	72	78	PF00069	0.531
MOD_GlcNHglycan	40	43	PF01048	0.497
MOD_GSK3_1	12	19	PF00069	0.598
MOD_GSK3_1	175	182	PF00069	0.490
MOD_GSK3_1	236	243	PF00069	0.367
MOD_GSK3_1	246	253	PF00069	0.353
MOD_GSK3_1	46	53	PF00069	0.573
MOD_GSK3_1	72	79	PF00069	0.542
MOD_NEK2_1	198	203	PF00069	0.237
MOD_NEK2_1	52	57	PF00069	0.699
MOD_PKA_2	12	18	PF00069	0.620
MOD_PKA_2	213	219	PF00069	0.443
MOD_Plk_1	219	225	PF00069	0.401
MOD_Plk_4	101	107	PF00069	0.445
MOD_Plk_4	144	150	PF00069	0.416
MOD_Plk_4	193	199	PF00069	0.418
MOD_Plk_4	41	47	PF00069	0.550
MOD_Plk_4	83	89	PF00069	0.395
MOD_ProDKin_1	1	7	PF00069	0.624
MOD_ProDKin_1	179	185	PF00069	0.467
MOD_ProDKin_1	46	52	PF00069	0.640
MOD_ProDKin_1	72	78	PF00069	0.528
MOD_SUMO_rev_2	228	235	PF00179	0.361
MOD_SUMO_rev_2	75	82	PF00179	0.578
TRG_DiLeu_BaLyEn_6	126	131	PF01217	0.486
TRG_DiLeu_BaLyEn_6	69	74	PF01217	0.519
TRG_ENDOCYTIC_2	191	194	PF00928	0.310
TRG_ENDOCYTIC_2	203	206	PF00928	0.237
TRG_ENDOCYTIC_2	71	74	PF00928	0.435
TRG_ER_diArg_1	12	14	PF00400	0.664
TRG_ER_diArg_1	156	158	PF00400	0.531
TRG_ER_diArg_1	24	27	PF00400	0.420
TRG_NES_CRM1_1	127	140	PF08389	0.495
TRG_Pf-PMV_PEXEL_1	204	208	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IB39	Leptomonas seymouri	70%	100%
A0A0S4IR98	Bodo saltans	40%	100%
A0A0S4JC46	Bodo saltans	31%	84%
A0A0S4JGA0	Bodo saltans	38%	100%
A0A1X0NZZ4	Trypanosomatidae	51%	100%
A4HH71	Leishmania braziliensis	84%	100%
A4I4B7	Leishmania infantum	100%	100%
C9ZL51	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AM14	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O74859	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
P61797	Canis lupus familiaris	33%	77%
P61801	Xenopus tropicalis	34%	76%
Q08702	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
Q7Z2E3	Homo sapiens	36%	74%
V5BUM6	Trypanosoma cruzi	49%	100%