Exonuclease_putative/Pfam:PF00929

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exonuclease, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X264_LEIDO

TriTrypDb:

LdBPK_290580.1 , LdCL_290010600 , LDHU3_29.0810

Length:

405

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7X264

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X264

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003824	catalytic activity	1	2
GO:0004518	nuclease activity	4	2
GO:0004527	exonuclease activity	5	2
GO:0005488	binding	1	11
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.506
CLV_NRD_NRD_1	17	19	PF00675	0.516
CLV_NRD_NRD_1	227	229	PF00675	0.316
CLV_NRD_NRD_1	285	287	PF00675	0.381
CLV_NRD_NRD_1	342	344	PF00675	0.478
CLV_PCSK_KEX2_1	285	287	PF00082	0.391
CLV_PCSK_KEX2_1	303	305	PF00082	0.333
CLV_PCSK_KEX2_1	341	343	PF00082	0.486
CLV_PCSK_KEX2_1	6	8	PF00082	0.493
CLV_PCSK_PC1ET2_1	303	305	PF00082	0.393
CLV_PCSK_PC1ET2_1	341	343	PF00082	0.489
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.493
CLV_PCSK_SKI1_1	167	171	PF00082	0.288
DEG_SCF_FBW7_1	129	134	PF00400	0.516
DOC_MAPK_gen_1	228	234	PF00069	0.513
DOC_MAPK_gen_1	352	360	PF00069	0.571
DOC_MAPK_MEF2A_6	354	362	PF00069	0.502
DOC_PP4_FxxP_1	120	123	PF00568	0.530
DOC_USP7_MATH_1	146	150	PF00917	0.579
DOC_USP7_MATH_1	388	392	PF00917	0.419
DOC_USP7_MATH_1	399	403	PF00917	0.403
DOC_WW_Pin1_4	127	132	PF00397	0.521
LIG_14-3-3_CanoR_1	113	118	PF00244	0.485
LIG_14-3-3_CanoR_1	208	212	PF00244	0.482
LIG_14-3-3_CanoR_1	25	35	PF00244	0.721
LIG_14-3-3_CanoR_1	357	361	PF00244	0.419
LIG_BIR_II_1	1	5	PF00653	0.746
LIG_BIR_III_2	145	149	PF00653	0.562
LIG_Clathr_ClatBox_1	366	370	PF01394	0.305
LIG_deltaCOP1_diTrp_1	176	184	PF00928	0.460
LIG_FHA_1	106	112	PF00498	0.559
LIG_FHA_1	138	144	PF00498	0.591
LIG_FHA_1	149	155	PF00498	0.469
LIG_FHA_1	63	69	PF00498	0.645
LIG_FHA_2	59	65	PF00498	0.719
LIG_LIR_Apic_2	119	123	PF02991	0.482
LIG_LIR_Gen_1	116	123	PF02991	0.530
LIG_LIR_Gen_1	199	207	PF02991	0.496
LIG_LIR_Gen_1	74	83	PF02991	0.482
LIG_LIR_Nem_3	116	120	PF02991	0.511
LIG_LIR_Nem_3	180	184	PF02991	0.493
LIG_LIR_Nem_3	199	205	PF02991	0.403
LIG_LIR_Nem_3	309	313	PF02991	0.525
LIG_LIR_Nem_3	74	78	PF02991	0.505
LIG_NRBOX	362	368	PF00104	0.351
LIG_Pex14_2	120	124	PF04695	0.530
LIG_Pex14_2	197	201	PF04695	0.482
LIG_RPA_C_Fungi	374	386	PF08784	0.467
LIG_SH2_PTP2	75	78	PF00017	0.385
LIG_SH2_SRC	204	207	PF00017	0.402
LIG_SH2_SRC	75	78	PF00017	0.368
LIG_SH2_STAP1	373	377	PF00017	0.266
LIG_SH2_STAT3	373	376	PF00017	0.480
LIG_SH2_STAT5	204	207	PF00017	0.335
LIG_SH2_STAT5	310	313	PF00017	0.434
LIG_SH2_STAT5	35	38	PF00017	0.784
LIG_SH2_STAT5	46	49	PF00017	0.703
LIG_SH2_STAT5	75	78	PF00017	0.366
LIG_SH3_3	192	198	PF00018	0.355
LIG_Sin3_3	365	372	PF02671	0.404
LIG_SUMO_SIM_anti_2	74	80	PF11976	0.335
LIG_SUMO_SIM_par_1	102	108	PF11976	0.383
LIG_SUMO_SIM_par_1	365	370	PF11976	0.406
LIG_SUMO_SIM_par_1	74	80	PF11976	0.335
LIG_TYR_ITIM	200	205	PF00017	0.335
LIG_WRC_WIRS_1	117	122	PF05994	0.402
MOD_CK1_1	116	122	PF00069	0.332
MOD_CK1_1	127	133	PF00069	0.266
MOD_CK1_1	27	33	PF00069	0.684
MOD_CK1_1	393	399	PF00069	0.638
MOD_CK1_1	45	51	PF00069	0.782
MOD_CK2_1	146	152	PF00069	0.378
MOD_GlcNHglycan	287	292	PF01048	0.456
MOD_GlcNHglycan	386	389	PF01048	0.622
MOD_GlcNHglycan	397	400	PF01048	0.523
MOD_GlcNHglycan	51	54	PF01048	0.731
MOD_GSK3_1	127	134	PF00069	0.422
MOD_GSK3_1	27	34	PF00069	0.729
MOD_GSK3_1	384	391	PF00069	0.589
MOD_GSK3_1	393	400	PF00069	0.686
MOD_GSK3_1	42	49	PF00069	0.692
MOD_GSK3_1	58	65	PF00069	0.538
MOD_LATS_1	23	29	PF00433	0.709
MOD_LATS_1	328	334	PF00433	0.570
MOD_NEK2_2	168	173	PF00069	0.480
MOD_PIKK_1	131	137	PF00454	0.357
MOD_PIKK_1	399	405	PF00454	0.629
MOD_PKA_2	124	130	PF00069	0.395
MOD_PKA_2	161	167	PF00069	0.334
MOD_PKA_2	207	213	PF00069	0.335
MOD_PKA_2	24	30	PF00069	0.670
MOD_PKA_2	356	362	PF00069	0.412
MOD_Plk_4	116	122	PF00069	0.447
MOD_Plk_4	168	174	PF00069	0.461
MOD_Plk_4	196	202	PF00069	0.355
MOD_Plk_4	31	37	PF00069	0.791
MOD_Plk_4	356	362	PF00069	0.447
MOD_Plk_4	42	48	PF00069	0.693
MOD_ProDKin_1	127	133	PF00069	0.389
MOD_SUMO_rev_2	176	184	PF00179	0.335
TRG_ENDOCYTIC_2	202	205	PF00928	0.348
TRG_ENDOCYTIC_2	310	313	PF00928	0.413
TRG_ENDOCYTIC_2	75	78	PF00928	0.368
TRG_ER_diArg_1	284	286	PF00400	0.443
TRG_NES_CRM1_1	70	82	PF08389	0.380
TRG_NLS_MonoExtN_4	3	10	PF00514	0.734
TRG_Pf-PMV_PEXEL_1	346	351	PF00026	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILS5	Leptomonas seymouri	77%	99%
A0A1X0P115	Trypanosomatidae	58%	100%
A0A3R7MWK6	Trypanosoma rangeli	59%	100%
A4HH64	Leishmania braziliensis	87%	100%
A4I4A8	Leishmania infantum	100%	100%
C9ZKL9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	90%
E9ADQ8	Leishmania major	95%	100%
E9AM22	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BUL7	Trypanosoma cruzi	58%	100%