Exonuclease_putative/Pfam:PF00929

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exonuclease, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X262_LEIDO

TriTrypDb:

LdBPK_290550.1 , LdCL_290010300 , LDHU3_29.0780

Length:

502

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X262

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X262

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003824	catalytic activity	1	3
GO:0004518	nuclease activity	4	3
GO:0004527	exonuclease activity	5	3
GO:0005488	binding	1	8
GO:0016787	hydrolase activity	2	3
GO:0016788	hydrolase activity, acting on ester bonds	3	3
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.705
CLV_C14_Caspase3-7	135	139	PF00656	0.672
CLV_C14_Caspase3-7	341	345	PF00656	0.517
CLV_NRD_NRD_1	142	144	PF00675	0.636
CLV_NRD_NRD_1	147	149	PF00675	0.640
CLV_NRD_NRD_1	335	337	PF00675	0.332
CLV_NRD_NRD_1	367	369	PF00675	0.293
CLV_NRD_NRD_1	421	423	PF00675	0.297
CLV_NRD_NRD_1	45	47	PF00675	0.648
CLV_PCSK_KEX2_1	213	215	PF00082	0.526
CLV_PCSK_KEX2_1	335	337	PF00082	0.265
CLV_PCSK_KEX2_1	367	369	PF00082	0.333
CLV_PCSK_KEX2_1	421	423	PF00082	0.306
CLV_PCSK_KEX2_1	500	502	PF00082	0.671
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.481
CLV_PCSK_PC1ET2_1	500	502	PF00082	0.641
CLV_PCSK_PC7_1	209	215	PF00082	0.578
CLV_PCSK_SKI1_1	148	152	PF00082	0.660
CLV_PCSK_SKI1_1	213	217	PF00082	0.504
CLV_PCSK_SKI1_1	40	44	PF00082	0.744
CLV_PCSK_SKI1_1	403	407	PF00082	0.296
CLV_PCSK_SKI1_1	485	489	PF00082	0.734
CLV_PCSK_SKI1_1	497	501	PF00082	0.636
DEG_APCC_DBOX_1	116	124	PF00400	0.606
DEG_SPOP_SBC_1	163	167	PF00917	0.569
DEG_SPOP_SBC_1	78	82	PF00917	0.690
DEG_SPOP_SBC_1	83	87	PF00917	0.651
DOC_ANK_TNKS_1	174	181	PF00023	0.567
DOC_CYCLIN_yCln2_LP_2	216	222	PF00134	0.406
DOC_MAPK_gen_1	412	418	PF00069	0.448
DOC_PP4_FxxP_1	99	102	PF00568	0.597
DOC_SPAK_OSR1_1	127	131	PF12202	0.593
DOC_USP7_MATH_1	153	157	PF00917	0.703
DOC_USP7_MATH_1	178	182	PF00917	0.707
DOC_USP7_MATH_1	233	237	PF00917	0.466
DOC_USP7_MATH_1	348	352	PF00917	0.517
DOC_USP7_MATH_1	38	42	PF00917	0.635
DOC_USP7_MATH_1	51	55	PF00917	0.619
DOC_USP7_MATH_1	77	81	PF00917	0.672
DOC_USP7_MATH_1	83	87	PF00917	0.637
DOC_WW_Pin1_4	19	24	PF00397	0.618
DOC_WW_Pin1_4	53	58	PF00397	0.683
DOC_WW_Pin1_4	79	84	PF00397	0.736
LIG_14-3-3_CanoR_1	115	121	PF00244	0.614
LIG_14-3-3_CanoR_1	3	8	PF00244	0.587
LIG_14-3-3_CanoR_1	393	397	PF00244	0.463
LIG_14-3-3_CanoR_1	40	48	PF00244	0.622
LIG_Actin_WH2_2	243	259	PF00022	0.506
LIG_Actin_WH2_2	363	379	PF00022	0.517
LIG_APCC_ABBAyCdc20_2	335	341	PF00400	0.506
LIG_BIR_III_4	177	181	PF00653	0.568
LIG_BRCT_BRCA1_1	396	400	PF00533	0.517
LIG_BRCT_BRCA1_1	414	418	PF00533	0.385
LIG_deltaCOP1_diTrp_1	361	369	PF00928	0.463
LIG_FHA_1	251	257	PF00498	0.475
LIG_FHA_1	406	412	PF00498	0.463
LIG_FHA_1	427	433	PF00498	0.506
LIG_FHA_2	348	354	PF00498	0.550
LIG_FHA_2	69	75	PF00498	0.637
LIG_HP1_1	247	251	PF01393	0.506
LIG_Integrin_RGD_1	175	177	PF01839	0.584
LIG_Integrin_RGD_1	457	459	PF01839	0.552
LIG_LIR_Apic_2	96	102	PF02991	0.593
LIG_LIR_Gen_1	126	132	PF02991	0.592
LIG_LIR_Nem_3	126	131	PF02991	0.591
LIG_LIR_Nem_3	245	249	PF02991	0.463
LIG_LIR_Nem_3	261	265	PF02991	0.463
LIG_LIR_Nem_3	381	385	PF02991	0.498
LIG_PCNA_yPIPBox_3	401	411	PF02747	0.506
LIG_Pex14_1	317	321	PF04695	0.506
LIG_SH2_CRK	387	391	PF00017	0.506
LIG_SH2_GRB2like	389	392	PF00017	0.506
LIG_SH2_PTP2	265	268	PF00017	0.463
LIG_SH2_PTP2	389	392	PF00017	0.506
LIG_SH2_SRC	339	342	PF00017	0.483
LIG_SH2_SRC	389	392	PF00017	0.506
LIG_SH2_STAP1	396	400	PF00017	0.506
LIG_SH2_STAT5	265	268	PF00017	0.463
LIG_SH2_STAT5	389	392	PF00017	0.506
LIG_SH3_3	193	199	PF00018	0.672
LIG_SH3_3	20	26	PF00018	0.642
LIG_SH3_3	204	210	PF00018	0.543
LIG_SH3_3	234	240	PF00018	0.506
LIG_SH3_3	288	294	PF00018	0.496
LIG_SH3_3	377	383	PF00018	0.517
LIG_SH3_3	45	51	PF00018	0.668
LIG_SUMO_SIM_par_1	245	253	PF11976	0.506
LIG_SUMO_SIM_par_1	287	293	PF11976	0.527
LIG_SxIP_EBH_1	199	213	PF03271	0.602
LIG_TRAF2_1	168	171	PF00917	0.613
LIG_TRAF2_1	467	470	PF00917	0.569
LIG_TYR_ITIM	385	390	PF00017	0.463
LIG_WW_3	24	28	PF00397	0.640
MOD_CDK_SPK_2	53	58	PF00069	0.680
MOD_CK1_1	105	111	PF00069	0.626
MOD_CK1_1	116	122	PF00069	0.586
MOD_CK1_1	41	47	PF00069	0.720
MOD_CK1_1	52	58	PF00069	0.755
MOD_CK1_1	82	88	PF00069	0.729
MOD_CK2_1	179	185	PF00069	0.691
MOD_CK2_1	347	353	PF00069	0.550
MOD_CK2_1	68	74	PF00069	0.819
MOD_Cter_Amidation	419	422	PF01082	0.306
MOD_GlcNHglycan	155	158	PF01048	0.683
MOD_GlcNHglycan	203	206	PF01048	0.603
MOD_GlcNHglycan	233	236	PF01048	0.263
MOD_GlcNHglycan	29	32	PF01048	0.774
MOD_GlcNHglycan	350	353	PF01048	0.317
MOD_GlcNHglycan	40	43	PF01048	0.643
MOD_GlcNHglycan	423	426	PF01048	0.263
MOD_GlcNHglycan	96	99	PF01048	0.737
MOD_GSK3_1	119	126	PF00069	0.700
MOD_GSK3_1	162	169	PF00069	0.759
MOD_GSK3_1	201	208	PF00069	0.609
MOD_GSK3_1	272	279	PF00069	0.477
MOD_GSK3_1	36	43	PF00069	0.686
MOD_GSK3_1	481	488	PF00069	0.569
MOD_GSK3_1	49	56	PF00069	0.763
MOD_GSK3_1	78	85	PF00069	0.714
MOD_N-GLC_1	348	353	PF02516	0.317
MOD_NEK2_1	104	109	PF00069	0.639
MOD_NEK2_1	123	128	PF00069	0.625
MOD_NEK2_1	132	137	PF00069	0.595
MOD_NEK2_1	200	205	PF00069	0.625
MOD_NEK2_1	228	233	PF00069	0.506
MOD_NEK2_2	233	238	PF00069	0.506
MOD_OFUCOSY	226	232	PF10250	0.263
MOD_PIKK_1	142	148	PF00454	0.677
MOD_PIKK_1	166	172	PF00454	0.703
MOD_PIKK_1	282	288	PF00454	0.463
MOD_PKA_1	148	154	PF00069	0.793
MOD_PKA_1	412	418	PF00069	0.487
MOD_PKA_1	421	427	PF00069	0.468
MOD_PKA_2	102	108	PF00069	0.625
MOD_PKA_2	116	122	PF00069	0.608
MOD_PKA_2	142	148	PF00069	0.647
MOD_PKA_2	324	330	PF00069	0.489
MOD_PKA_2	392	398	PF00069	0.463
MOD_PKA_2	421	427	PF00069	0.493
MOD_Plk_1	371	377	PF00069	0.444
MOD_Plk_2-3	179	185	PF00069	0.641
MOD_Plk_4	116	122	PF00069	0.608
MOD_Plk_4	179	185	PF00069	0.702
MOD_Plk_4	294	300	PF00069	0.483
MOD_Plk_4	371	377	PF00069	0.463
MOD_ProDKin_1	19	25	PF00069	0.621
MOD_ProDKin_1	53	59	PF00069	0.683
MOD_ProDKin_1	79	85	PF00069	0.738
MOD_SUMO_for_1	306	309	PF00179	0.483
MOD_SUMO_for_1	330	333	PF00179	0.506
TRG_DiLeu_BaEn_1	179	184	PF01217	0.642
TRG_DiLeu_BaEn_2	332	338	PF01217	0.506
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.546
TRG_ENDOCYTIC_2	387	390	PF00928	0.463
TRG_ER_diArg_1	335	337	PF00400	0.517
TRG_ER_diArg_1	366	368	PF00400	0.533
TRG_Pf-PMV_PEXEL_1	12	17	PF00026	0.577
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	434	438	PF00026	0.263
TRG_Pf-PMV_PEXEL_1	5	10	PF00026	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7G3	Leptomonas seymouri	61%	95%
A0A3R7M512	Trypanosoma rangeli	50%	100%
A4HH55	Leishmania braziliensis	79%	100%
A4I4A6	Leishmania infantum	100%	100%
E9ADQ5	Leishmania major	94%	100%
E9AM25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%