Tubulin-tyrosine ligase family, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tubulin-tyrosine ligase family, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X261_LEIDO

TriTrypDb:

LdBPK_290270.1 , LdCL_290007500 , LDHU3_29.0360

Length:

617

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A0A3S7X261

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X261

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	15
GO:0008152	metabolic process	1	15
GO:0019538	protein metabolic process	3	15
GO:0036211	protein modification process	4	15
GO:0043170	macromolecule metabolic process	3	15
GO:0043412	macromolecule modification	4	15
GO:0044238	primary metabolic process	2	15
GO:0071704	organic substance metabolic process	2	15
GO:1901564	organonitrogen compound metabolic process	3	15
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0018095	protein polyglutamylation	7	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018200	peptidyl-glutamic acid modification	6	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016874	ligase activity	2	7
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	3
GO:0016881	acid-amino acid ligase activity	4	3
GO:0070739	protein-glutamic acid ligase activity	3	1
GO:0070740	tubulin-glutamic acid ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	3
GO:0004835	tubulin-tyrosine ligase activity	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	143	145	PF00675	0.264
CLV_NRD_NRD_1	150	152	PF00675	0.264
CLV_NRD_NRD_1	210	212	PF00675	0.322
CLV_NRD_NRD_1	256	258	PF00675	0.327
CLV_NRD_NRD_1	277	279	PF00675	0.284
CLV_NRD_NRD_1	298	300	PF00675	0.598
CLV_NRD_NRD_1	435	437	PF00675	0.337
CLV_NRD_NRD_1	454	456	PF00675	0.256
CLV_NRD_NRD_1	571	573	PF00675	0.471
CLV_NRD_NRD_1	614	616	PF00675	0.529
CLV_PCSK_FUR_1	165	169	PF00082	0.272
CLV_PCSK_FUR_1	433	437	PF00082	0.333
CLV_PCSK_KEX2_1	150	152	PF00082	0.270
CLV_PCSK_KEX2_1	167	169	PF00082	0.298
CLV_PCSK_KEX2_1	21	23	PF00082	0.745
CLV_PCSK_KEX2_1	210	212	PF00082	0.322
CLV_PCSK_KEX2_1	256	258	PF00082	0.334
CLV_PCSK_KEX2_1	260	262	PF00082	0.314
CLV_PCSK_KEX2_1	298	300	PF00082	0.597
CLV_PCSK_KEX2_1	435	437	PF00082	0.358
CLV_PCSK_KEX2_1	454	456	PF00082	0.249
CLV_PCSK_KEX2_1	571	573	PF00082	0.471
CLV_PCSK_KEX2_1	614	616	PF00082	0.529
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.330
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.745
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.327
CLV_PCSK_PC7_1	256	262	PF00082	0.327
CLV_PCSK_PC7_1	294	300	PF00082	0.491
CLV_PCSK_SKI1_1	102	106	PF00082	0.538
CLV_PCSK_SKI1_1	144	148	PF00082	0.227
CLV_PCSK_SKI1_1	224	228	PF00082	0.320
CLV_PCSK_SKI1_1	271	275	PF00082	0.327
CLV_PCSK_SKI1_1	365	369	PF00082	0.327
CLV_PCSK_SKI1_1	571	575	PF00082	0.444
CLV_Separin_Metazoa	451	455	PF03568	0.367
DEG_APCC_DBOX_1	12	20	PF00400	0.510
DEG_APCC_DBOX_1	340	348	PF00400	0.498
DEG_Nend_UBRbox_4	1	3	PF02207	0.445
DOC_CKS1_1	103	108	PF01111	0.427
DOC_CYCLIN_RxL_1	184	192	PF00134	0.428
DOC_CYCLIN_yCln2_LP_2	191	197	PF00134	0.458
DOC_CYCLIN_yCln2_LP_2	378	384	PF00134	0.343
DOC_MAPK_DCC_7	484	493	PF00069	0.527
DOC_MAPK_gen_1	11	19	PF00069	0.506
DOC_MAPK_gen_1	256	267	PF00069	0.499
DOC_MAPK_gen_1	278	286	PF00069	0.482
DOC_MAPK_MEF2A_6	260	269	PF00069	0.477
DOC_MAPK_MEF2A_6	278	286	PF00069	0.353
DOC_MAPK_MEF2A_6	330	339	PF00069	0.308
DOC_MAPK_NFAT4_5	279	287	PF00069	0.458
DOC_PP1_RVXF_1	143	150	PF00149	0.436
DOC_PP1_RVXF_1	222	229	PF00149	0.458
DOC_PP1_RVXF_1	71	78	PF00149	0.440
DOC_PP2B_LxvP_1	191	194	PF13499	0.458
DOC_PP2B_LxvP_1	378	381	PF13499	0.425
DOC_PP2B_LxvP_1	425	428	PF13499	0.368
DOC_USP7_MATH_1	217	221	PF00917	0.566
DOC_USP7_MATH_1	304	308	PF00917	0.685
DOC_USP7_MATH_1	41	45	PF00917	0.749
DOC_USP7_MATH_1	417	421	PF00917	0.487
DOC_USP7_MATH_1	510	514	PF00917	0.543
DOC_WW_Pin1_4	1	6	PF00397	0.469
DOC_WW_Pin1_4	102	107	PF00397	0.569
DOC_WW_Pin1_4	215	220	PF00397	0.533
DOC_WW_Pin1_4	243	248	PF00397	0.438
DOC_WW_Pin1_4	300	305	PF00397	0.747
DOC_WW_Pin1_4	394	399	PF00397	0.562
DOC_WW_Pin1_4	495	500	PF00397	0.416
DOC_WW_Pin1_4	96	101	PF00397	0.454
LIG_14-3-3_CanoR_1	242	247	PF00244	0.527
LIG_14-3-3_CanoR_1	298	304	PF00244	0.613
LIG_14-3-3_CanoR_1	374	379	PF00244	0.506
LIG_14-3-3_CanoR_1	433	439	PF00244	0.354
LIG_Actin_WH2_2	470	486	PF00022	0.474
LIG_Actin_WH2_2	504	519	PF00022	0.495
LIG_APCC_ABBA_1	265	270	PF00400	0.527
LIG_APCC_ABBA_1	337	342	PF00400	0.464
LIG_Clathr_ClatBox_1	476	480	PF01394	0.464
LIG_eIF4E_1	268	274	PF01652	0.525
LIG_EVH1_2	88	92	PF00568	0.385
LIG_FHA_1	373	379	PF00498	0.565
LIG_FHA_1	441	447	PF00498	0.490
LIG_FHA_1	517	523	PF00498	0.527
LIG_FHA_1	584	590	PF00498	0.642
LIG_FHA_2	232	238	PF00498	0.527
LIG_FHA_2	243	249	PF00498	0.455
LIG_FHA_2	250	256	PF00498	0.365
LIG_FHA_2	503	509	PF00498	0.467
LIG_FHA_2	561	567	PF00498	0.574
LIG_FHA_2	76	82	PF00498	0.571
LIG_LIR_Gen_1	186	195	PF02991	0.552
LIG_LIR_Gen_1	196	203	PF02991	0.492
LIG_LIR_Gen_1	472	482	PF02991	0.529
LIG_LIR_Gen_1	62	72	PF02991	0.364
LIG_LIR_Nem_3	186	191	PF02991	0.552
LIG_LIR_Nem_3	196	200	PF02991	0.492
LIG_LIR_Nem_3	472	477	PF02991	0.458
LIG_LIR_Nem_3	518	523	PF02991	0.434
LIG_LIR_Nem_3	62	68	PF02991	0.365
LIG_LIR_Nem_3	76	80	PF02991	0.436
LIG_NRBOX	283	289	PF00104	0.458
LIG_REV1ctd_RIR_1	225	231	PF16727	0.467
LIG_SH2_CRK	130	134	PF00017	0.550
LIG_SH2_CRK	352	356	PF00017	0.425
LIG_SH2_CRK	65	69	PF00017	0.300
LIG_SH2_GRB2like	322	325	PF00017	0.481
LIG_SH2_NCK_1	352	356	PF00017	0.425
LIG_SH2_PTP2	285	288	PF00017	0.504
LIG_SH2_SRC	379	382	PF00017	0.419
LIG_SH2_STAP1	540	544	PF00017	0.415
LIG_SH2_STAT5	268	271	PF00017	0.466
LIG_SH2_STAT5	285	288	PF00017	0.464
LIG_SH2_STAT5	338	341	PF00017	0.518
LIG_SH2_STAT5	379	382	PF00017	0.419
LIG_SH3_3	100	106	PF00018	0.500
LIG_SH3_3	266	272	PF00018	0.436
LIG_SH3_3	37	43	PF00018	0.524
LIG_SH3_3	395	401	PF00018	0.567
LIG_SUMO_SIM_anti_2	443	448	PF11976	0.317
LIG_SUMO_SIM_par_1	285	291	PF11976	0.537
LIG_SUMO_SIM_par_1	442	448	PF11976	0.275
LIG_SUMO_SIM_par_1	608	613	PF11976	0.390
LIG_TRAF2_1	25	28	PF00917	0.498
LIG_TYR_ITSM	61	68	PF00017	0.352
LIG_WRC_WIRS_1	418	423	PF05994	0.451
MOD_CDC14_SPxK_1	99	102	PF00782	0.503
MOD_CDK_SPxK_1	96	102	PF00069	0.465
MOD_CK1_1	196	202	PF00069	0.429
MOD_CK1_1	218	224	PF00069	0.377
MOD_CK1_1	297	303	PF00069	0.700
MOD_CK1_1	323	329	PF00069	0.501
MOD_CK1_1	96	102	PF00069	0.578
MOD_CK2_1	180	186	PF00069	0.569
MOD_CK2_1	231	237	PF00069	0.563
MOD_CK2_1	242	248	PF00069	0.475
MOD_CK2_1	249	255	PF00069	0.379
MOD_CK2_1	417	423	PF00069	0.475
MOD_CK2_1	434	440	PF00069	0.384
MOD_CK2_1	445	451	PF00069	0.305
MOD_CK2_1	469	475	PF00069	0.458
MOD_CK2_1	560	566	PF00069	0.370
MOD_CK2_1	79	85	PF00069	0.604
MOD_Cter_Amidation	276	279	PF01082	0.325
MOD_DYRK1A_RPxSP_1	102	106	PF00069	0.465
MOD_GlcNHglycan	159	162	PF01048	0.296
MOD_GlcNHglycan	43	46	PF01048	0.724
MOD_GlcNHglycan	447	450	PF01048	0.281
MOD_GlcNHglycan	51	55	PF01048	0.602
MOD_GlcNHglycan	512	515	PF01048	0.289
MOD_GlcNHglycan	577	580	PF01048	0.495
MOD_GSK3_1	115	122	PF00069	0.415
MOD_GSK3_1	153	160	PF00069	0.503
MOD_GSK3_1	189	196	PF00069	0.443
MOD_GSK3_1	294	301	PF00069	0.637
MOD_GSK3_1	3	10	PF00069	0.514
MOD_GSK3_1	318	325	PF00069	0.629
MOD_GSK3_1	361	368	PF00069	0.504
MOD_GSK3_1	407	414	PF00069	0.520
MOD_GSK3_1	417	424	PF00069	0.466
MOD_GSK3_1	75	82	PF00069	0.447
MOD_N-GLC_1	318	323	PF02516	0.679
MOD_N-GLC_1	372	377	PF02516	0.299
MOD_N-GLC_1	495	500	PF02516	0.225
MOD_NEK2_1	153	158	PF00069	0.482
MOD_NEK2_1	189	194	PF00069	0.515
MOD_NEK2_1	288	293	PF00069	0.459
MOD_NEK2_1	421	426	PF00069	0.497
MOD_NEK2_1	502	507	PF00069	0.436
MOD_NEK2_1	516	521	PF00069	0.436
MOD_NEK2_1	522	527	PF00069	0.333
MOD_NEK2_1	560	565	PF00069	0.523
MOD_PKA_1	298	304	PF00069	0.613
MOD_PKA_2	241	247	PF00069	0.527
MOD_PKA_2	297	303	PF00069	0.600
MOD_PKA_2	373	379	PF00069	0.444
MOD_PKA_2	434	440	PF00069	0.313
MOD_PKA_2	516	522	PF00069	0.491
MOD_PKA_2	560	566	PF00069	0.550
MOD_PKA_2	60	66	PF00069	0.384
MOD_Plk_1	115	121	PF00069	0.352
MOD_Plk_1	181	187	PF00069	0.428
MOD_Plk_1	318	324	PF00069	0.516
MOD_Plk_1	75	81	PF00069	0.566
MOD_Plk_2-3	81	87	PF00069	0.559
MOD_Plk_4	115	121	PF00069	0.404
MOD_Plk_4	374	380	PF00069	0.458
MOD_Plk_4	417	423	PF00069	0.469
MOD_Plk_4	442	448	PF00069	0.336
MOD_Plk_4	497	503	PF00069	0.425
MOD_ProDKin_1	1	7	PF00069	0.465
MOD_ProDKin_1	215	221	PF00069	0.533
MOD_ProDKin_1	243	249	PF00069	0.438
MOD_ProDKin_1	300	306	PF00069	0.747
MOD_ProDKin_1	394	400	PF00069	0.558
MOD_ProDKin_1	495	501	PF00069	0.416
MOD_ProDKin_1	96	102	PF00069	0.465
MOD_SUMO_rev_2	541	550	PF00179	0.436
TRG_DiLeu_BaEn_3	553	559	PF01217	0.360
TRG_DiLeu_BaLyEn_6	269	274	PF01217	0.525
TRG_DiLeu_BaLyEn_6	518	523	PF01217	0.449
TRG_DiLeu_BaLyEn_6	569	574	PF01217	0.472
TRG_ENDOCYTIC_2	130	133	PF00928	0.528
TRG_ENDOCYTIC_2	136	139	PF00928	0.520
TRG_ENDOCYTIC_2	285	288	PF00928	0.464
TRG_ENDOCYTIC_2	65	68	PF00928	0.326
TRG_ER_diArg_1	120	123	PF00400	0.380
TRG_ER_diArg_1	149	151	PF00400	0.507
TRG_ER_diArg_1	209	211	PF00400	0.522
TRG_ER_diArg_1	432	435	PF00400	0.391
TRG_ER_diArg_1	453	455	PF00400	0.425
TRG_ER_diArg_1	570	572	PF00400	0.468
TRG_ER_diArg_1	614	616	PF00400	0.424
TRG_NES_CRM1_1	440	456	PF08389	0.344
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.303
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.244
TRG_Pf-PMV_PEXEL_1	436	440	PF00026	0.450

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAP5	Leptomonas seymouri	25%	83%
A0A0N1IH77	Leptomonas seymouri	56%	100%
A0A0S4J7C9	Bodo saltans	25%	93%
A0A0S4JH38	Bodo saltans	33%	100%
A0A0S4KQK8	Bodo saltans	26%	94%
A0A1X0P0Y5	Trypanosomatidae	37%	100%
A0A1X0P6A0	Trypanosomatidae	26%	93%
A0A3Q8IDL7	Leishmania donovani	24%	100%
A0A3Q8III2	Leishmania donovani	27%	85%
A0A422N064	Trypanosoma rangeli	42%	100%
A0A422N932	Trypanosoma rangeli	25%	100%
A0A422P136	Trypanosoma rangeli	25%	94%
A4HH59	Leishmania braziliensis	76%	100%
A4HYN9	Leishmania infantum	24%	100%
A4I479	Leishmania infantum	100%	100%
A4IC28	Leishmania infantum	27%	85%
A4Q9E8	Mus musculus	26%	75%
A4Q9F6	Mus musculus	24%	77%
A6NNM8	Homo sapiens	25%	76%
A8CVX7	Danio rerio	27%	79%
B6DTF7	Bodo saltans	22%	100%
C9ZI96	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	90%
C9ZKP9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZPR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZYH1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	94%
D0A044	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
E9ADM8	Leishmania major	93%	100%
E9AFW7	Leishmania major	26%	85%
E9AID0	Leishmania braziliensis	25%	100%
E9AM52	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9B720	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	85%
Q8N841	Homo sapiens	25%	73%
V5ARK1	Trypanosoma cruzi	26%	100%
V5B4U2	Trypanosoma cruzi	42%	100%