Exonuclease, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exonuclease, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X257_LEIDO

TriTrypDb:

LdBPK_290560.1 , LdCL_290010400 , LDHU3_29.0790

Length:

880

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X257

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X257

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003824	catalytic activity	1	2
GO:0004518	nuclease activity	4	2
GO:0004527	exonuclease activity	5	2
GO:0005488	binding	1	7
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	453	457	PF00656	0.710
CLV_NRD_NRD_1	552	554	PF00675	0.533
CLV_PCSK_FUR_1	679	683	PF00082	0.313
CLV_PCSK_KEX2_1	551	553	PF00082	0.530
CLV_PCSK_KEX2_1	681	683	PF00082	0.313
CLV_PCSK_PC1ET2_1	681	683	PF00082	0.313
CLV_PCSK_PC7_1	677	683	PF00082	0.313
CLV_PCSK_SKI1_1	725	729	PF00082	0.268
CLV_PCSK_SKI1_1	778	782	PF00082	0.352
CLV_Separin_Metazoa	268	272	PF03568	0.466
CLV_Separin_Metazoa	548	552	PF03568	0.537
DEG_SCF_FBW7_2	506	512	PF00400	0.604
DEG_SPOP_SBC_1	373	377	PF00917	0.667
DEG_SPOP_SBC_1	388	392	PF00917	0.528
DEG_SPOP_SBC_1	457	461	PF00917	0.650
DOC_ANK_TNKS_1	87	94	PF00023	0.684
DOC_CKS1_1	295	300	PF01111	0.617
DOC_CKS1_1	345	350	PF01111	0.583
DOC_CKS1_1	506	511	PF01111	0.601
DOC_CKS1_1	92	97	PF01111	0.688
DOC_CYCLIN_RxL_1	149	160	PF00134	0.594
DOC_CYCLIN_RxL_1	266	279	PF00134	0.420
DOC_CYCLIN_yClb1_LxF_4	821	826	PF00134	0.483
DOC_CYCLIN_yCln2_LP_2	332	338	PF00134	0.577
DOC_CYCLIN_yCln2_LP_2	625	631	PF00134	0.454
DOC_CYCLIN_yCln2_LP_2	844	847	PF00134	0.594
DOC_MAPK_gen_1	776	783	PF00069	0.460
DOC_MAPK_MEF2A_6	800	809	PF00069	0.468
DOC_PP2B_LxvP_1	332	335	PF13499	0.575
DOC_PP2B_LxvP_1	784	787	PF13499	0.459
DOC_PP2B_LxvP_1	843	846	PF13499	0.579
DOC_PP4_FxxP_1	675	678	PF00568	0.468
DOC_USP7_MATH_1	135	139	PF00917	0.788
DOC_USP7_MATH_1	146	150	PF00917	0.760
DOC_USP7_MATH_1	188	192	PF00917	0.609
DOC_USP7_MATH_1	246	250	PF00917	0.653
DOC_USP7_MATH_1	316	320	PF00917	0.674
DOC_USP7_MATH_1	339	343	PF00917	0.782
DOC_USP7_MATH_1	357	361	PF00917	0.508
DOC_USP7_MATH_1	373	377	PF00917	0.634
DOC_USP7_MATH_1	378	382	PF00917	0.600
DOC_USP7_MATH_1	419	423	PF00917	0.638
DOC_USP7_MATH_1	457	461	PF00917	0.674
DOC_USP7_MATH_1	519	523	PF00917	0.681
DOC_USP7_MATH_1	533	537	PF00917	0.613
DOC_USP7_MATH_1	562	566	PF00917	0.643
DOC_USP7_MATH_1	614	618	PF00917	0.581
DOC_USP7_MATH_1	851	855	PF00917	0.695
DOC_WW_Pin1_4	111	116	PF00397	0.734
DOC_WW_Pin1_4	29	34	PF00397	0.607
DOC_WW_Pin1_4	294	299	PF00397	0.641
DOC_WW_Pin1_4	312	317	PF00397	0.485
DOC_WW_Pin1_4	344	349	PF00397	0.580
DOC_WW_Pin1_4	352	357	PF00397	0.605
DOC_WW_Pin1_4	369	374	PF00397	0.524
DOC_WW_Pin1_4	382	387	PF00397	0.726
DOC_WW_Pin1_4	407	412	PF00397	0.730
DOC_WW_Pin1_4	423	428	PF00397	0.578
DOC_WW_Pin1_4	446	451	PF00397	0.623
DOC_WW_Pin1_4	470	475	PF00397	0.629
DOC_WW_Pin1_4	484	489	PF00397	0.728
DOC_WW_Pin1_4	505	510	PF00397	0.634
DOC_WW_Pin1_4	524	529	PF00397	0.803
DOC_WW_Pin1_4	579	584	PF00397	0.595
DOC_WW_Pin1_4	610	615	PF00397	0.744
DOC_WW_Pin1_4	617	622	PF00397	0.544
DOC_WW_Pin1_4	64	69	PF00397	0.586
DOC_WW_Pin1_4	682	687	PF00397	0.463
DOC_WW_Pin1_4	860	865	PF00397	0.579
DOC_WW_Pin1_4	91	96	PF00397	0.632
LIG_14-3-3_CanoR_1	143	151	PF00244	0.613
LIG_14-3-3_CanoR_1	18	22	PF00244	0.509
LIG_14-3-3_CanoR_1	293	298	PF00244	0.719
LIG_14-3-3_CanoR_1	434	439	PF00244	0.724
LIG_14-3-3_CanoR_1	551	560	PF00244	0.557
LIG_14-3-3_CanoR_1	567	576	PF00244	0.599
LIG_14-3-3_CanoR_1	584	593	PF00244	0.552
LIG_14-3-3_CanoR_1	714	722	PF00244	0.513
LIG_14-3-3_CanoR_1	771	777	PF00244	0.483
LIG_14-3-3_CanoR_1	83	92	PF00244	0.752
LIG_14-3-3_CanoR_1	858	864	PF00244	0.577
LIG_Actin_WH2_2	180	198	PF00022	0.556
LIG_BIR_II_1	1	5	PF00653	0.670
LIG_BIR_III_2	199	203	PF00653	0.614
LIG_BRCT_BRCA1_1	190	194	PF00533	0.611
LIG_BRCT_BRCA1_1	434	438	PF00533	0.665
LIG_BRCT_BRCA1_1	537	541	PF00533	0.625
LIG_BRCT_BRCA1_1	618	622	PF00533	0.507
LIG_Clathr_ClatBox_1	632	636	PF01394	0.365
LIG_CtBP_PxDLS_1	733	737	PF00389	0.468
LIG_deltaCOP1_diTrp_1	256	267	PF00928	0.501
LIG_FHA_1	104	110	PF00498	0.497
LIG_FHA_1	159	165	PF00498	0.467
LIG_FHA_1	203	209	PF00498	0.579
LIG_FHA_1	214	220	PF00498	0.541
LIG_FHA_1	279	285	PF00498	0.629
LIG_FHA_1	398	404	PF00498	0.684
LIG_FHA_1	568	574	PF00498	0.588
LIG_FHA_1	57	63	PF00498	0.664
LIG_FHA_1	85	91	PF00498	0.791
LIG_FHA_1	92	98	PF00498	0.678
LIG_FHA_2	253	259	PF00498	0.505
LIG_FHA_2	295	301	PF00498	0.698
LIG_FHA_2	451	457	PF00498	0.681
LIG_FHA_2	492	498	PF00498	0.739
LIG_FHA_2	543	549	PF00498	0.628
LIG_FHA_2	638	644	PF00498	0.468
LIG_Integrin_isoDGR_2	81	83	PF01839	0.632
LIG_LIR_Apic_2	617	621	PF02991	0.542
LIG_LIR_Gen_1	257	267	PF02991	0.434
LIG_LIR_Gen_1	630	639	PF02991	0.303
LIG_LIR_Gen_1	671	680	PF02991	0.468
LIG_LIR_Gen_1	754	762	PF02991	0.496
LIG_LIR_Gen_1	765	770	PF02991	0.458
LIG_LIR_Gen_1	815	824	PF02991	0.430
LIG_LIR_Nem_3	257	263	PF02991	0.457
LIG_LIR_Nem_3	291	295	PF02991	0.517
LIG_LIR_Nem_3	619	625	PF02991	0.560
LIG_LIR_Nem_3	630	634	PF02991	0.307
LIG_LIR_Nem_3	655	659	PF02991	0.468
LIG_LIR_Nem_3	671	675	PF02991	0.468
LIG_LIR_Nem_3	738	742	PF02991	0.483
LIG_LIR_Nem_3	754	760	PF02991	0.416
LIG_LIR_Nem_3	765	769	PF02991	0.458
LIG_LIR_Nem_3	815	819	PF02991	0.404
LIG_MYND_1	842	846	PF01753	0.599
LIG_NRBOX	166	172	PF00104	0.531
LIG_PCNA_yPIPBox_3	771	781	PF02747	0.483
LIG_Pex14_2	752	756	PF04695	0.468
LIG_Pex14_2	766	770	PF04695	0.468
LIG_PTAP_UEV_1	147	152	PF05743	0.631
LIG_REV1ctd_RIR_1	767	775	PF16727	0.483
LIG_SH2_CRK	561	565	PF00017	0.563
LIG_SH2_CRK	618	622	PF00017	0.543
LIG_SH2_CRK	629	633	PF00017	0.333
LIG_SH2_CRK	742	746	PF00017	0.483
LIG_SH2_NCK_1	561	565	PF00017	0.563
LIG_SH2_NCK_1	618	622	PF00017	0.507
LIG_SH2_NCK_1	651	655	PF00017	0.454
LIG_SH2_SRC	304	307	PF00017	0.637
LIG_SH2_SRC	517	520	PF00017	0.674
LIG_SH2_SRC	651	654	PF00017	0.454
LIG_SH2_STAP1	629	633	PF00017	0.333
LIG_SH2_STAT5	631	634	PF00017	0.307
LIG_SH2_STAT5	649	652	PF00017	0.468
LIG_SH3_1	608	614	PF00018	0.555
LIG_SH3_3	109	115	PF00018	0.563
LIG_SH3_3	145	151	PF00018	0.636
LIG_SH3_3	292	298	PF00018	0.543
LIG_SH3_3	342	348	PF00018	0.583
LIG_SH3_3	353	359	PF00018	0.598
LIG_SH3_3	427	433	PF00018	0.611
LIG_SH3_3	45	51	PF00018	0.678
LIG_SH3_3	503	509	PF00018	0.608
LIG_SH3_3	513	519	PF00018	0.598
LIG_SH3_3	570	576	PF00018	0.723
LIG_SH3_3	590	596	PF00018	0.517
LIG_SH3_3	608	614	PF00018	0.472
LIG_SH3_3	89	95	PF00018	0.626
LIG_SUMO_SIM_anti_2	630	636	PF11976	0.303
LIG_SUMO_SIM_par_1	105	110	PF11976	0.611
LIG_SUMO_SIM_par_1	25	32	PF11976	0.603
LIG_SUMO_SIM_par_1	630	636	PF11976	0.303
LIG_SUMO_SIM_par_1	655	662	PF11976	0.474
LIG_TRAF2_1	255	258	PF00917	0.535
LIG_TRAF2_1	303	306	PF00917	0.808
LIG_TRAF2_1	545	548	PF00917	0.586
LIG_TRAF2_1	640	643	PF00917	0.468
LIG_TRAF2_1	704	707	PF00917	0.468
LIG_TYR_ITIM	755	760	PF00017	0.468
LIG_WW_1	646	649	PF00397	0.454
MOD_CDK_SPK_2	369	374	PF00069	0.568
MOD_CDK_SPK_2	579	584	PF00069	0.559
MOD_CK1_1	103	109	PF00069	0.769
MOD_CK1_1	129	135	PF00069	0.610
MOD_CK1_1	138	144	PF00069	0.706
MOD_CK1_1	177	183	PF00069	0.596
MOD_CK1_1	229	235	PF00069	0.779
MOD_CK1_1	38	44	PF00069	0.698
MOD_CK1_1	382	388	PF00069	0.612
MOD_CK1_1	392	398	PF00069	0.573
MOD_CK1_1	407	413	PF00069	0.564
MOD_CK1_1	437	443	PF00069	0.559
MOD_CK1_1	466	472	PF00069	0.754
MOD_CK1_1	57	63	PF00069	0.656
MOD_CK1_1	578	584	PF00069	0.698
MOD_CK1_1	617	623	PF00069	0.538
MOD_CK1_1	67	73	PF00069	0.495
MOD_CK1_1	854	860	PF00069	0.710
MOD_CK2_1	252	258	PF00069	0.520
MOD_CK2_1	491	497	PF00069	0.770
MOD_CK2_1	542	548	PF00069	0.611
MOD_CK2_1	637	643	PF00069	0.468
MOD_CK2_1	701	707	PF00069	0.513
MOD_CK2_1	71	77	PF00069	0.562
MOD_CK2_1	812	818	PF00069	0.388
MOD_CK2_1	869	875	PF00069	0.580
MOD_GlcNHglycan	1	4	PF01048	0.762
MOD_GlcNHglycan	102	105	PF01048	0.620
MOD_GlcNHglycan	109	112	PF01048	0.768
MOD_GlcNHglycan	128	131	PF01048	0.527
MOD_GlcNHglycan	144	147	PF01048	0.580
MOD_GlcNHglycan	148	151	PF01048	0.522
MOD_GlcNHglycan	190	193	PF01048	0.592
MOD_GlcNHglycan	211	214	PF01048	0.734
MOD_GlcNHglycan	228	231	PF01048	0.625
MOD_GlcNHglycan	235	238	PF01048	0.663
MOD_GlcNHglycan	312	315	PF01048	0.580
MOD_GlcNHglycan	318	321	PF01048	0.618
MOD_GlcNHglycan	381	384	PF01048	0.621
MOD_GlcNHglycan	406	409	PF01048	0.718
MOD_GlcNHglycan	417	420	PF01048	0.797
MOD_GlcNHglycan	434	437	PF01048	0.545
MOD_GlcNHglycan	439	442	PF01048	0.618
MOD_GlcNHglycan	519	522	PF01048	0.699
MOD_GlcNHglycan	537	540	PF01048	0.777
MOD_GlcNHglycan	553	556	PF01048	0.503
MOD_GlcNHglycan	577	580	PF01048	0.696
MOD_GlcNHglycan	793	796	PF01048	0.268
MOD_GlcNHglycan	837	840	PF01048	0.595
MOD_GlcNHglycan	867	870	PF01048	0.674
MOD_GSK3_1	107	114	PF00069	0.592
MOD_GSK3_1	129	136	PF00069	0.612
MOD_GSK3_1	138	145	PF00069	0.669
MOD_GSK3_1	156	163	PF00069	0.371
MOD_GSK3_1	209	216	PF00069	0.573
MOD_GSK3_1	222	229	PF00069	0.703
MOD_GSK3_1	238	245	PF00069	0.672
MOD_GSK3_1	25	32	PF00069	0.565
MOD_GSK3_1	312	319	PF00069	0.653
MOD_GSK3_1	369	376	PF00069	0.594
MOD_GSK3_1	378	385	PF00069	0.600
MOD_GSK3_1	38	45	PF00069	0.762
MOD_GSK3_1	388	395	PF00069	0.541
MOD_GSK3_1	407	414	PF00069	0.511
MOD_GSK3_1	415	422	PF00069	0.604
MOD_GSK3_1	446	453	PF00069	0.621
MOD_GSK3_1	463	470	PF00069	0.767
MOD_GSK3_1	504	511	PF00069	0.615
MOD_GSK3_1	519	526	PF00069	0.732
MOD_GSK3_1	531	538	PF00069	0.609
MOD_GSK3_1	562	569	PF00069	0.587
MOD_GSK3_1	575	582	PF00069	0.756
MOD_GSK3_1	606	613	PF00069	0.671
MOD_GSK3_1	67	74	PF00069	0.654
MOD_GSK3_1	829	836	PF00069	0.566
MOD_GSK3_1	856	863	PF00069	0.783
MOD_GSK3_1	865	872	PF00069	0.775
MOD_GSK3_1	96	103	PF00069	0.710
MOD_N-GLC_1	397	402	PF02516	0.671
MOD_N-GLC_1	524	529	PF02516	0.652
MOD_N-GLC_1	531	536	PF02516	0.579
MOD_NEK2_1	27	32	PF00069	0.615
MOD_NEK2_1	415	420	PF00069	0.595
MOD_NEK2_1	465	470	PF00069	0.604
MOD_NEK2_1	523	528	PF00069	0.743
MOD_NEK2_1	560	565	PF00069	0.599
MOD_NEK2_1	586	591	PF00069	0.625
MOD_NEK2_1	616	621	PF00069	0.546
MOD_NEK2_1	71	76	PF00069	0.563
MOD_NEK2_1	716	721	PF00069	0.468
MOD_NEK2_1	770	775	PF00069	0.468
MOD_NEK2_1	829	834	PF00069	0.616
MOD_NEK2_2	42	47	PF00069	0.661
MOD_NEK2_2	458	463	PF00069	0.682
MOD_NEK2_2	851	856	PF00069	0.583
MOD_PIKK_1	35	41	PF00454	0.604
MOD_PIKK_1	419	425	PF00454	0.618
MOD_PIKK_1	472	478	PF00454	0.618
MOD_PIKK_1	491	497	PF00454	0.747
MOD_PIKK_1	770	776	PF00454	0.513
MOD_PKA_1	551	557	PF00069	0.544
MOD_PKA_2	142	148	PF00069	0.623
MOD_PKA_2	17	23	PF00069	0.527
MOD_PKA_2	195	201	PF00069	0.610
MOD_PKA_2	373	379	PF00069	0.671
MOD_PKA_2	419	425	PF00069	0.595
MOD_PKA_2	483	489	PF00069	0.640
MOD_PKA_2	551	557	PF00069	0.544
MOD_PKA_2	566	572	PF00069	0.593
MOD_PKA_2	770	776	PF00069	0.483
MOD_PKA_2	857	863	PF00069	0.584
MOD_Plk_1	54	60	PF00069	0.650
MOD_Plk_4	166	172	PF00069	0.465
MOD_Plk_4	190	196	PF00069	0.616
MOD_Plk_4	22	28	PF00069	0.509
MOD_Plk_4	327	333	PF00069	0.651
MOD_Plk_4	434	440	PF00069	0.566
MOD_Plk_4	519	525	PF00069	0.684
MOD_Plk_4	71	77	PF00069	0.600
MOD_Plk_4	751	757	PF00069	0.483
MOD_Plk_4	801	807	PF00069	0.468
MOD_ProDKin_1	111	117	PF00069	0.736
MOD_ProDKin_1	29	35	PF00069	0.609
MOD_ProDKin_1	294	300	PF00069	0.646
MOD_ProDKin_1	312	318	PF00069	0.487
MOD_ProDKin_1	344	350	PF00069	0.577
MOD_ProDKin_1	352	358	PF00069	0.607
MOD_ProDKin_1	369	375	PF00069	0.524
MOD_ProDKin_1	382	388	PF00069	0.719
MOD_ProDKin_1	407	413	PF00069	0.733
MOD_ProDKin_1	423	429	PF00069	0.579
MOD_ProDKin_1	446	452	PF00069	0.626
MOD_ProDKin_1	470	476	PF00069	0.631
MOD_ProDKin_1	484	490	PF00069	0.724
MOD_ProDKin_1	505	511	PF00069	0.634
MOD_ProDKin_1	524	530	PF00069	0.804
MOD_ProDKin_1	579	585	PF00069	0.593
MOD_ProDKin_1	610	616	PF00069	0.569
MOD_ProDKin_1	617	623	PF00069	0.541
MOD_ProDKin_1	64	70	PF00069	0.582
MOD_ProDKin_1	682	688	PF00069	0.463
MOD_ProDKin_1	860	866	PF00069	0.581
MOD_ProDKin_1	91	97	PF00069	0.632
TRG_DiLeu_BaEn_1	22	27	PF01217	0.504
TRG_DiLeu_BaEn_2	670	676	PF01217	0.468
TRG_DiLeu_BaLyEn_6	839	844	PF01217	0.709
TRG_ENDOCYTIC_2	561	564	PF00928	0.588
TRG_ENDOCYTIC_2	629	632	PF00928	0.338
TRG_ENDOCYTIC_2	651	654	PF00928	0.454
TRG_ENDOCYTIC_2	742	745	PF00928	0.541
TRG_ENDOCYTIC_2	757	760	PF00928	0.428
TRG_ER_diArg_1	550	553	PF00400	0.535
TRG_ER_diArg_1	676	679	PF00400	0.468
TRG_NES_CRM1_1	279	291	PF08389	0.472
TRG_Pf-PMV_PEXEL_1	282	286	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	463	467	PF00026	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7U4	Leptomonas seymouri	50%	77%
A4HH56	Leishmania braziliensis	74%	100%
A4I4A7	Leishmania infantum	100%	100%
E9ADQ6	Leishmania major	90%	100%
E9AM24	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%