Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X253_LEIDO

TriTrypDb:

LdBPK_290480.1 , LdCL_290009600 , LDHU3_29.0680

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7X253

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X253

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	234	238	PF00656	0.694
CLV_C14_Caspase3-7	279	283	PF00656	0.742
CLV_C14_Caspase3-7	289	293	PF00656	0.749
CLV_C14_Caspase3-7	294	298	PF00656	0.782
CLV_C14_Caspase3-7	401	405	PF00656	0.715
CLV_C14_Caspase3-7	91	95	PF00656	0.733
CLV_NRD_NRD_1	217	219	PF00675	0.444
CLV_NRD_NRD_1	225	227	PF00675	0.459
CLV_PCSK_KEX2_1	101	103	PF00082	0.477
CLV_PCSK_KEX2_1	216	218	PF00082	0.451
CLV_PCSK_KEX2_1	225	227	PF00082	0.434
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.477
CLV_PCSK_SKI1_1	102	106	PF00082	0.479
CLV_PCSK_SKI1_1	225	229	PF00082	0.517
CLV_PCSK_SKI1_1	23	27	PF00082	0.474
CLV_PCSK_SKI1_1	420	424	PF00082	0.529
DEG_Nend_UBRbox_3	1	3	PF02207	0.781
DOC_CYCLIN_RxL_1	99	109	PF00134	0.673
DOC_MAPK_MEF2A_6	347	354	PF00069	0.808
DOC_MAPK_MEF2A_6	58	65	PF00069	0.633
DOC_USP7_MATH_1	100	104	PF00917	0.646
DOC_USP7_MATH_1	178	182	PF00917	0.545
DOC_USP7_MATH_1	190	194	PF00917	0.338
DOC_USP7_MATH_1	260	264	PF00917	0.698
DOC_USP7_MATH_1	369	373	PF00917	0.750
DOC_USP7_MATH_1	45	49	PF00917	0.684
DOC_USP7_MATH_1	95	99	PF00917	0.626
DOC_WW_Pin1_4	225	230	PF00397	0.639
DOC_WW_Pin1_4	248	253	PF00397	0.776
DOC_WW_Pin1_4	311	316	PF00397	0.746
DOC_WW_Pin1_4	346	351	PF00397	0.710
DOC_WW_Pin1_4	35	40	PF00397	0.669
LIG_14-3-3_CanoR_1	149	153	PF00244	0.671
LIG_14-3-3_CanoR_1	218	227	PF00244	0.646
LIG_14-3-3_CanoR_1	67	71	PF00244	0.670
LIG_14-3-3_CanoR_1	7	16	PF00244	0.745
LIG_APCC_ABBAyCdc20_2	358	364	PF00400	0.664
LIG_deltaCOP1_diTrp_1	302	309	PF00928	0.757
LIG_FHA_1	121	127	PF00498	0.617
LIG_FHA_1	130	136	PF00498	0.607
LIG_FHA_1	315	321	PF00498	0.761
LIG_FHA_1	36	42	PF00498	0.695
LIG_FHA_1	8	14	PF00498	0.708
LIG_FHA_1	91	97	PF00498	0.661
LIG_FHA_2	287	293	PF00498	0.829
LIG_FHA_2	408	414	PF00498	0.819
LIG_FHA_2	424	430	PF00498	0.544
LIG_LIR_Gen_1	161	171	PF02991	0.513
LIG_LIR_Gen_1	303	310	PF02991	0.758
LIG_LIR_Nem_3	103	108	PF02991	0.745
LIG_LIR_Nem_3	161	167	PF02991	0.411
LIG_LIR_Nem_3	189	194	PF02991	0.438
LIG_LIR_Nem_3	303	309	PF02991	0.758
LIG_NRBOX	75	81	PF00104	0.651
LIG_PDZ_Class_2	443	448	PF00595	0.761
LIG_SH2_CRK	164	168	PF00017	0.411
LIG_SH2_NCK_1	164	168	PF00017	0.513
LIG_SH2_SRC	202	205	PF00017	0.411
LIG_SH2_STAT5	164	167	PF00017	0.411
LIG_SH2_STAT5	19	22	PF00017	0.663
LIG_SH2_STAT5	202	205	PF00017	0.364
LIG_SH2_STAT5	206	209	PF00017	0.539
LIG_SH2_STAT5	421	424	PF00017	0.682
LIG_SH3_3	249	255	PF00018	0.755
LIG_Sin3_3	25	32	PF02671	0.731
LIG_SUMO_SIM_anti_2	10	18	PF11976	0.766
LIG_SUMO_SIM_anti_2	351	356	PF11976	0.809
LIG_SUMO_SIM_par_1	316	324	PF11976	0.778
LIG_TRAF2_1	243	246	PF00917	0.702
LIG_TRAF2_1	268	271	PF00917	0.716
LIG_TRAF2_1	375	378	PF00917	0.747
LIG_TRAF2_1	426	429	PF00917	0.680
LIG_WRC_WIRS_1	108	113	PF05994	0.747
MOD_CDK_SPxK_1	225	231	PF00069	0.638
MOD_CK1_1	11	17	PF00069	0.721
MOD_CK1_1	116	122	PF00069	0.676
MOD_CK1_1	148	154	PF00069	0.684
MOD_CK1_1	162	168	PF00069	0.308
MOD_CK1_1	324	330	PF00069	0.839
MOD_CK1_1	371	377	PF00069	0.769
MOD_CK1_1	391	397	PF00069	0.695
MOD_CK1_1	48	54	PF00069	0.677
MOD_CK2_1	240	246	PF00069	0.697
MOD_CK2_1	316	322	PF00069	0.830
MOD_CK2_1	372	378	PF00069	0.767
MOD_CK2_1	407	413	PF00069	0.817
MOD_CK2_1	422	428	PF00069	0.565
MOD_DYRK1A_RPxSP_1	311	315	PF00069	0.751
MOD_GlcNHglycan	115	118	PF01048	0.440
MOD_GlcNHglycan	256	259	PF01048	0.482
MOD_GlcNHglycan	277	281	PF01048	0.609
MOD_GlcNHglycan	30	33	PF01048	0.486
MOD_GlcNHglycan	322	326	PF01048	0.555
MOD_GlcNHglycan	366	369	PF01048	0.541
MOD_GlcNHglycan	371	374	PF01048	0.550
MOD_GlcNHglycan	382	385	PF01048	0.571
MOD_GlcNHglycan	393	396	PF01048	0.499
MOD_GlcNHglycan	90	93	PF01048	0.477
MOD_GSK3_1	11	18	PF00069	0.664
MOD_GSK3_1	116	123	PF00069	0.634
MOD_GSK3_1	131	138	PF00069	0.564
MOD_GSK3_1	158	165	PF00069	0.543
MOD_GSK3_1	186	193	PF00069	0.478
MOD_GSK3_1	272	279	PF00069	0.775
MOD_GSK3_1	286	293	PF00069	0.759
MOD_GSK3_1	3	10	PF00069	0.696
MOD_GSK3_1	314	321	PF00069	0.767
MOD_GSK3_1	353	360	PF00069	0.706
MOD_GSK3_1	364	371	PF00069	0.719
MOD_GSK3_1	387	394	PF00069	0.733
MOD_GSK3_1	86	93	PF00069	0.660
MOD_NEK2_1	113	118	PF00069	0.754
MOD_NEK2_1	135	140	PF00069	0.648
MOD_NEK2_1	15	20	PF00069	0.687
MOD_NEK2_1	159	164	PF00069	0.411
MOD_NEK2_1	320	325	PF00069	0.815
MOD_NEK2_1	341	346	PF00069	0.820
MOD_NEK2_1	388	393	PF00069	0.725
MOD_NEK2_1	46	51	PF00069	0.703
MOD_NEK2_2	100	105	PF00069	0.749
MOD_PIKK_1	232	238	PF00454	0.624
MOD_PIKK_1	334	340	PF00454	0.738
MOD_PK_1	357	363	PF00069	0.692
MOD_PKA_1	357	363	PF00069	0.734
MOD_PKA_2	148	154	PF00069	0.669
MOD_PKA_2	66	72	PF00069	0.666
MOD_Plk_4	11	17	PF00069	0.758
MOD_Plk_4	131	137	PF00069	0.646
MOD_Plk_4	159	165	PF00069	0.411
MOD_Plk_4	178	184	PF00069	0.545
MOD_Plk_4	190	196	PF00069	0.333
MOD_ProDKin_1	225	231	PF00069	0.638
MOD_ProDKin_1	248	254	PF00069	0.774
MOD_ProDKin_1	311	317	PF00069	0.749
MOD_ProDKin_1	346	352	PF00069	0.710
MOD_ProDKin_1	35	41	PF00069	0.666
MOD_SUMO_rev_2	322	330	PF00179	0.785
TRG_DiLeu_BaEn_1	59	64	PF01217	0.744
TRG_DiLeu_LyEn_5	59	64	PF01217	0.744
TRG_ENDOCYTIC_2	157	160	PF00928	0.625
TRG_ENDOCYTIC_2	164	167	PF00928	0.411
TRG_ER_diArg_1	216	218	PF00400	0.651
TRG_ER_diArg_1	224	226	PF00400	0.675
TRG_Pf-PMV_PEXEL_1	102	107	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7G2	Leptomonas seymouri	62%	100%
A4HH48	Leishmania braziliensis	74%	98%
A4I492	Leishmania infantum	100%	100%
E9ADP8	Leishmania major	94%	100%
E9AM32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%