Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X251_LEIDO

TriTrypDb:

LdBPK_290200.1 , LdCL_290006800 , LDHU3_29.0270

Length:

1015

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X251

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X251

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.666
CLV_C14_Caspase3-7	197	201	PF00656	0.535
CLV_C14_Caspase3-7	795	799	PF00656	0.426
CLV_NRD_NRD_1	177	179	PF00675	0.624
CLV_NRD_NRD_1	538	540	PF00675	0.554
CLV_NRD_NRD_1	678	680	PF00675	0.488
CLV_NRD_NRD_1	810	812	PF00675	0.587
CLV_NRD_NRD_1	849	851	PF00675	0.665
CLV_NRD_NRD_1	962	964	PF00675	0.525
CLV_NRD_NRD_1	984	986	PF00675	0.522
CLV_PCSK_KEX2_1	177	179	PF00082	0.624
CLV_PCSK_KEX2_1	232	234	PF00082	0.822
CLV_PCSK_KEX2_1	538	540	PF00082	0.554
CLV_PCSK_KEX2_1	582	584	PF00082	0.803
CLV_PCSK_KEX2_1	678	680	PF00082	0.488
CLV_PCSK_KEX2_1	810	812	PF00082	0.517
CLV_PCSK_KEX2_1	849	851	PF00082	0.648
CLV_PCSK_KEX2_1	961	963	PF00082	0.548
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.700
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.654
CLV_PCSK_SKI1_1	227	231	PF00082	0.664
CLV_PCSK_SKI1_1	386	390	PF00082	0.601
CLV_PCSK_SKI1_1	446	450	PF00082	0.593
CLV_PCSK_SKI1_1	669	673	PF00082	0.464
CLV_PCSK_SKI1_1	674	678	PF00082	0.475
CLV_PCSK_SKI1_1	679	683	PF00082	0.505
CLV_PCSK_SKI1_1	700	704	PF00082	0.413
CLV_PCSK_SKI1_1	810	814	PF00082	0.539
DEG_APCC_DBOX_1	176	184	PF00400	0.604
DEG_Nend_UBRbox_2	1	3	PF02207	0.648
DEG_ODPH_VHL_1	773	784	PF01847	0.471
DEG_SCF_FBW7_1	835	842	PF00400	0.527
DEG_SPOP_SBC_1	24	28	PF00917	0.685
DOC_ANK_TNKS_1	467	474	PF00023	0.657
DOC_ANK_TNKS_1	508	515	PF00023	0.612
DOC_CKS1_1	166	171	PF01111	0.531
DOC_CKS1_1	319	324	PF01111	0.597
DOC_CKS1_1	372	377	PF01111	0.691
DOC_CKS1_1	730	735	PF01111	0.559
DOC_CKS1_1	836	841	PF01111	0.556
DOC_CYCLIN_yCln2_LP_2	349	355	PF00134	0.656
DOC_CYCLIN_yCln2_LP_2	418	424	PF00134	0.702
DOC_CYCLIN_yCln2_LP_2	71	77	PF00134	0.683
DOC_CYCLIN_yCln2_LP_2	833	836	PF00134	0.584
DOC_MAPK_DCC_7	731	741	PF00069	0.415
DOC_MAPK_gen_1	177	185	PF00069	0.601
DOC_MAPK_gen_1	489	499	PF00069	0.723
DOC_PP1_RVXF_1	119	126	PF00149	0.556
DOC_PP2B_LxvP_1	349	352	PF13499	0.621
DOC_PP2B_LxvP_1	354	357	PF13499	0.557
DOC_PP2B_LxvP_1	418	421	PF13499	0.615
DOC_PP2B_LxvP_1	71	74	PF13499	0.683
DOC_PP2B_LxvP_1	833	836	PF13499	0.588
DOC_PP4_FxxP_1	221	224	PF00568	0.591
DOC_PP4_FxxP_1	895	898	PF00568	0.604
DOC_USP7_MATH_1	116	120	PF00917	0.591
DOC_USP7_MATH_1	133	137	PF00917	0.575
DOC_USP7_MATH_1	173	177	PF00917	0.734
DOC_USP7_MATH_1	249	253	PF00917	0.666
DOC_USP7_MATH_1	254	258	PF00917	0.666
DOC_USP7_MATH_1	278	282	PF00917	0.610
DOC_USP7_MATH_1	309	313	PF00917	0.777
DOC_USP7_MATH_1	345	349	PF00917	0.579
DOC_USP7_MATH_1	522	526	PF00917	0.632
DOC_USP7_MATH_1	527	531	PF00917	0.655
DOC_USP7_MATH_1	532	536	PF00917	0.645
DOC_USP7_MATH_1	586	590	PF00917	0.598
DOC_USP7_MATH_1	692	696	PF00917	0.566
DOC_USP7_MATH_1	856	860	PF00917	0.610
DOC_USP7_MATH_1	979	983	PF00917	0.552
DOC_WW_Pin1_4	165	170	PF00397	0.527
DOC_WW_Pin1_4	220	225	PF00397	0.724
DOC_WW_Pin1_4	236	241	PF00397	0.532
DOC_WW_Pin1_4	318	323	PF00397	0.611
DOC_WW_Pin1_4	337	342	PF00397	0.575
DOC_WW_Pin1_4	371	376	PF00397	0.712
DOC_WW_Pin1_4	402	407	PF00397	0.607
DOC_WW_Pin1_4	62	67	PF00397	0.653
DOC_WW_Pin1_4	729	734	PF00397	0.594
DOC_WW_Pin1_4	75	80	PF00397	0.640
DOC_WW_Pin1_4	815	820	PF00397	0.595
DOC_WW_Pin1_4	835	840	PF00397	0.570
DOC_WW_Pin1_4	89	94	PF00397	0.657
LIG_14-3-3_CanoR_1	139	144	PF00244	0.658
LIG_14-3-3_CanoR_1	209	214	PF00244	0.678
LIG_14-3-3_CanoR_1	433	438	PF00244	0.548
LIG_14-3-3_CanoR_1	492	498	PF00244	0.648
LIG_14-3-3_CanoR_1	700	708	PF00244	0.562
LIG_Actin_WH2_2	665	680	PF00022	0.443
LIG_BIR_III_2	727	731	PF00653	0.566
LIG_BIR_III_4	38	42	PF00653	0.541
LIG_BRCT_BRCA1_1	279	283	PF00533	0.560
LIG_BRCT_BRCA1_1	637	641	PF00533	0.587
LIG_FHA_1	19	25	PF00498	0.685
LIG_FHA_1	494	500	PF00498	0.631
LIG_FHA_1	836	842	PF00498	0.580
LIG_FHA_1	9	15	PF00498	0.752
LIG_FHA_1	911	917	PF00498	0.509
LIG_FHA_2	11	17	PF00498	0.633
LIG_FHA_2	151	157	PF00498	0.651
LIG_FHA_2	166	172	PF00498	0.624
LIG_FHA_2	405	411	PF00498	0.796
LIG_FHA_2	680	686	PF00498	0.473
LIG_FHA_2	793	799	PF00498	0.370
LIG_FHA_2	801	807	PF00498	0.378
LIG_FHA_2	824	830	PF00498	0.494
LIG_FHA_2	930	936	PF00498	0.727
LIG_FHA_2	944	950	PF00498	0.468
LIG_GBD_Chelix_1	1001	1009	PF00786	0.526
LIG_GSK3_LRP6_1	835	840	PF00069	0.541
LIG_Integrin_RGD_1	744	746	PF01839	0.470
LIG_LIR_Apic_2	219	224	PF02991	0.593
LIG_LIR_Apic_2	893	898	PF02991	0.619
LIG_LIR_Gen_1	184	193	PF02991	0.540
LIG_LIR_Gen_1	280	290	PF02991	0.571
LIG_LIR_Gen_1	663	672	PF02991	0.453
LIG_LIR_Gen_1	67	77	PF02991	0.597
LIG_LIR_Nem_3	184	188	PF02991	0.549
LIG_LIR_Nem_3	189	194	PF02991	0.572
LIG_LIR_Nem_3	280	286	PF02991	0.559
LIG_LIR_Nem_3	663	668	PF02991	0.466
LIG_LIR_Nem_3	67	73	PF02991	0.598
LIG_LIR_Nem_3	734	740	PF02991	0.475
LIG_LIR_Nem_3	870	874	PF02991	0.652
LIG_LIR_Nem_3	934	939	PF02991	0.654
LIG_LYPXL_S_1	736	740	PF13949	0.542
LIG_LYPXL_yS_3	737	740	PF13949	0.533
LIG_LYPXL_yS_3	936	939	PF13949	0.562
LIG_MAD2	831	839	PF02301	0.520
LIG_MYND_1	352	356	PF01753	0.676
LIG_MYND_1	416	420	PF01753	0.622
LIG_PCNA_APIM_2	672	678	PF02747	0.466
LIG_SH2_CRK	665	669	PF00017	0.487
LIG_SH2_CRK	871	875	PF00017	0.655
LIG_SH2_GRB2like	634	637	PF00017	0.601
LIG_SH2_NCK_1	597	601	PF00017	0.646
LIG_SH2_NCK_1	726	730	PF00017	0.579
LIG_SH2_SRC	4	7	PF00017	0.583
LIG_SH2_SRC	422	425	PF00017	0.676
LIG_SH2_STAP1	4	8	PF00017	0.585
LIG_SH2_STAT5	634	637	PF00017	0.667
LIG_SH2_STAT5	675	678	PF00017	0.374
LIG_SH2_STAT5	70	73	PF00017	0.600
LIG_SH3_1	813	819	PF00018	0.418
LIG_SH3_3	163	169	PF00018	0.529
LIG_SH3_3	311	317	PF00018	0.630
LIG_SH3_3	324	330	PF00018	0.725
LIG_SH3_3	331	337	PF00018	0.659
LIG_SH3_3	349	355	PF00018	0.632
LIG_SH3_3	413	419	PF00018	0.624
LIG_SH3_3	507	513	PF00018	0.682
LIG_SH3_3	531	537	PF00018	0.572
LIG_SH3_3	691	697	PF00018	0.758
LIG_SH3_3	727	733	PF00018	0.623
LIG_SH3_3	73	79	PF00018	0.608
LIG_SH3_3	81	87	PF00018	0.594
LIG_SH3_3	813	819	PF00018	0.418
LIG_SH3_3	829	835	PF00018	0.612
LIG_SH3_4	294	301	PF00018	0.686
LIG_Sin3_3	707	714	PF02671	0.386
LIG_SUMO_SIM_par_1	53	60	PF11976	0.595
LIG_TRAF2_1	748	751	PF00917	0.453
LIG_WW_1	419	422	PF00397	0.624
LIG_WW_2	416	419	PF00397	0.657
MOD_CDK_SPK_2	236	241	PF00069	0.619
MOD_CDK_SPxxK_3	220	227	PF00069	0.601
MOD_CDK_SPxxK_3	402	409	PF00069	0.546
MOD_CDK_SPxxK_3	62	69	PF00069	0.584
MOD_CK1_1	109	115	PF00069	0.443
MOD_CK1_1	23	29	PF00069	0.554
MOD_CK1_1	252	258	PF00069	0.724
MOD_CK1_1	281	287	PF00069	0.566
MOD_CK1_1	318	324	PF00069	0.727
MOD_CK1_1	33	39	PF00069	0.594
MOD_CK1_1	360	366	PF00069	0.763
MOD_CK1_1	505	511	PF00069	0.616
MOD_CK1_1	517	523	PF00069	0.624
MOD_CK1_1	60	66	PF00069	0.682
MOD_CK1_1	618	624	PF00069	0.780
MOD_CK1_1	7	13	PF00069	0.643
MOD_CK1_1	859	865	PF00069	0.597
MOD_CK1_1	887	893	PF00069	0.556
MOD_CK1_1	910	916	PF00069	0.569
MOD_CK1_1	918	924	PF00069	0.604
MOD_CK1_1	92	98	PF00069	0.769
MOD_CK1_1	929	935	PF00069	0.429
MOD_CK2_1	150	156	PF00069	0.645
MOD_CK2_1	236	242	PF00069	0.611
MOD_CK2_1	404	410	PF00069	0.794
MOD_CK2_1	433	439	PF00069	0.498
MOD_CK2_1	474	480	PF00069	0.602
MOD_CK2_1	541	547	PF00069	0.563
MOD_CK2_1	566	572	PF00069	0.655
MOD_CK2_1	679	685	PF00069	0.489
MOD_CK2_1	800	806	PF00069	0.402
MOD_CK2_1	887	893	PF00069	0.558
MOD_CK2_1	943	949	PF00069	0.556
MOD_Cter_Amidation	847	850	PF01082	0.604
MOD_GlcNHglycan	102	105	PF01048	0.534
MOD_GlcNHglycan	137	142	PF01048	0.663
MOD_GlcNHglycan	145	148	PF01048	0.683
MOD_GlcNHglycan	196	199	PF01048	0.583
MOD_GlcNHglycan	258	261	PF01048	0.678
MOD_GlcNHglycan	311	314	PF01048	0.696
MOD_GlcNHglycan	32	35	PF01048	0.692
MOD_GlcNHglycan	46	49	PF01048	0.475
MOD_GlcNHglycan	486	489	PF01048	0.725
MOD_GlcNHglycan	516	519	PF01048	0.655
MOD_GlcNHglycan	524	527	PF01048	0.576
MOD_GlcNHglycan	534	537	PF01048	0.662
MOD_GlcNHglycan	568	571	PF01048	0.751
MOD_GlcNHglycan	59	62	PF01048	0.547
MOD_GlcNHglycan	625	628	PF01048	0.779
MOD_GlcNHglycan	638	641	PF01048	0.615
MOD_GlcNHglycan	647	650	PF01048	0.643
MOD_GlcNHglycan	659	662	PF01048	0.444
MOD_GlcNHglycan	694	697	PF01048	0.627
MOD_GlcNHglycan	733	736	PF01048	0.610
MOD_GlcNHglycan	767	770	PF01048	0.638
MOD_GlcNHglycan	886	889	PF01048	0.740
MOD_GlcNHglycan	927	931	PF01048	0.623
MOD_GlcNHglycan	94	97	PF01048	0.739
MOD_GSK3_1	105	112	PF00069	0.739
MOD_GSK3_1	133	140	PF00069	0.668
MOD_GSK3_1	151	158	PF00069	0.516
MOD_GSK3_1	194	201	PF00069	0.587
MOD_GSK3_1	20	27	PF00069	0.727
MOD_GSK3_1	204	211	PF00069	0.614
MOD_GSK3_1	252	259	PF00069	0.736
MOD_GSK3_1	269	276	PF00069	0.523
MOD_GSK3_1	277	284	PF00069	0.563
MOD_GSK3_1	29	36	PF00069	0.638
MOD_GSK3_1	321	328	PF00069	0.666
MOD_GSK3_1	4	11	PF00069	0.553
MOD_GSK3_1	425	432	PF00069	0.583
MOD_GSK3_1	50	57	PF00069	0.788
MOD_GSK3_1	517	524	PF00069	0.602
MOD_GSK3_1	562	569	PF00069	0.717
MOD_GSK3_1	578	585	PF00069	0.579
MOD_GSK3_1	60	67	PF00069	0.535
MOD_GSK3_1	765	772	PF00069	0.536
MOD_GSK3_1	835	842	PF00069	0.659
MOD_GSK3_1	85	92	PF00069	0.754
MOD_GSK3_1	856	863	PF00069	0.701
MOD_GSK3_1	907	914	PF00069	0.483
MOD_GSK3_1	915	922	PF00069	0.636
MOD_GSK3_1	941	948	PF00069	0.572
MOD_N-GLC_1	366	371	PF02516	0.651
MOD_N-GLC_1	635	640	PF02516	0.535
MOD_N-GLC_1	765	770	PF02516	0.535
MOD_N-GLC_2	716	718	PF02516	0.366
MOD_NEK2_1	105	110	PF00069	0.663
MOD_NEK2_1	143	148	PF00069	0.792
MOD_NEK2_1	155	160	PF00069	0.540
MOD_NEK2_1	194	199	PF00069	0.609
MOD_NEK2_1	521	526	PF00069	0.587
MOD_NEK2_1	56	61	PF00069	0.596
MOD_NEK2_1	635	640	PF00069	0.645
MOD_NEK2_1	645	650	PF00069	0.677
MOD_NEK2_1	765	770	PF00069	0.546
MOD_NEK2_1	8	13	PF00069	0.553
MOD_NEK2_1	800	805	PF00069	0.371
MOD_NEK2_1	978	983	PF00069	0.493
MOD_NEK2_2	278	283	PF00069	0.631
MOD_NEK2_2	778	783	PF00069	0.426
MOD_NEK2_2	839	844	PF00069	0.466
MOD_PIKK_1	252	258	PF00454	0.650
MOD_PIKK_1	284	290	PF00454	0.580
MOD_PIKK_1	628	634	PF00454	0.661
MOD_PIKK_1	786	792	PF00454	0.495
MOD_PK_1	209	215	PF00069	0.644
MOD_PK_1	273	279	PF00069	0.659
MOD_PK_1	698	704	PF00069	0.416
MOD_PKA_1	582	588	PF00069	0.607
MOD_PKA_2	208	214	PF00069	0.638
MOD_PKA_2	24	30	PF00069	0.695
MOD_PKA_2	425	431	PF00069	0.629
MOD_PKA_2	432	438	PF00069	0.541
MOD_PKA_2	499	505	PF00069	0.659
MOD_PKA_2	562	568	PF00069	0.655
MOD_PKA_2	578	584	PF00069	0.556
MOD_PKA_2	615	621	PF00069	0.640
MOD_PKB_1	698	706	PF00069	0.405
MOD_Plk_1	18	24	PF00069	0.611
MOD_Plk_1	4	10	PF00069	0.591
MOD_Plk_1	429	435	PF00069	0.504
MOD_Plk_1	926	932	PF00069	0.566
MOD_Plk_1	952	958	PF00069	0.576
MOD_Plk_2-3	541	547	PF00069	0.588
MOD_Plk_4	10	16	PF00069	0.748
MOD_Plk_4	106	112	PF00069	0.570
MOD_Plk_4	209	215	PF00069	0.660
MOD_Plk_4	278	284	PF00069	0.560
MOD_Plk_4	374	380	PF00069	0.615
MOD_Plk_4	907	913	PF00069	0.602
MOD_ProDKin_1	165	171	PF00069	0.530
MOD_ProDKin_1	220	226	PF00069	0.727
MOD_ProDKin_1	236	242	PF00069	0.532
MOD_ProDKin_1	318	324	PF00069	0.611
MOD_ProDKin_1	337	343	PF00069	0.570
MOD_ProDKin_1	371	377	PF00069	0.714
MOD_ProDKin_1	402	408	PF00069	0.608
MOD_ProDKin_1	62	68	PF00069	0.655
MOD_ProDKin_1	729	735	PF00069	0.595
MOD_ProDKin_1	75	81	PF00069	0.641
MOD_ProDKin_1	815	821	PF00069	0.600
MOD_ProDKin_1	835	841	PF00069	0.560
MOD_ProDKin_1	89	95	PF00069	0.658
MOD_SUMO_for_1	231	234	PF00179	0.560
TRG_ENDOCYTIC_2	457	460	PF00928	0.614
TRG_ENDOCYTIC_2	597	600	PF00928	0.656
TRG_ENDOCYTIC_2	665	668	PF00928	0.510
TRG_ENDOCYTIC_2	70	73	PF00928	0.600
TRG_ENDOCYTIC_2	737	740	PF00928	0.533
TRG_ENDOCYTIC_2	817	820	PF00928	0.487
TRG_ENDOCYTIC_2	871	874	PF00928	0.652
TRG_ENDOCYTIC_2	936	939	PF00928	0.650
TRG_ER_diArg_1	466	469	PF00400	0.631
TRG_ER_diArg_1	503	506	PF00400	0.644
TRG_ER_diArg_1	537	539	PF00400	0.552
TRG_ER_diArg_1	677	679	PF00400	0.525
TRG_ER_diArg_1	697	700	PF00400	0.548
TRG_ER_diArg_1	809	811	PF00400	0.560
TRG_ER_diArg_1	960	963	PF00400	0.512
TRG_Pf-PMV_PEXEL_1	468	472	PF00026	0.662

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4C6	Leptomonas seymouri	46%	100%
A0A1X0NZF9	Trypanosomatidae	27%	100%
A4HH27	Leishmania braziliensis	64%	98%
A4I472	Leishmania infantum	100%	100%
E9ADM1	Leishmania major	89%	100%
E9AM60	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5BPW9	Trypanosoma cruzi	28%	100%