Proteasome/cyclosome repeat family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome regulatory non-ATPase subunit, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X246_LEIDO

TriTrypDb:

LdBPK_290120.1 , LdCL_290006100 , LDHU3_29.0180

Length:

909

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000502	proteasome complex	3	11
GO:0032991	protein-containing complex	1	12
GO:0140535	intracellular protein-containing complex	2	11
GO:1902494	catalytic complex	2	11
GO:1905368	peptidase complex	3	11
GO:1905369	endopeptidase complex	4	11
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0008540	proteasome regulatory particle, base subcomplex	2	1
GO:0034515	proteasome storage granule	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X246

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X246

Function

Biological processes
Term	Name	Level	Count
GO:0009894	regulation of catabolic process	4	12
GO:0019222	regulation of metabolic process	3	12
GO:0042176	regulation of protein catabolic process	5	12
GO:0050789	regulation of biological process	2	12
GO:0051171	regulation of nitrogen compound metabolic process	4	12
GO:0051246	regulation of protein metabolic process	5	12
GO:0060255	regulation of macromolecule metabolic process	4	12
GO:0065007	biological regulation	1	12
GO:0080090	regulation of primary metabolic process	4	12
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0030234	enzyme regulator activity	2	12
GO:0098772	molecular function regulator activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	559	563	PF00656	0.493
CLV_MEL_PAP_1	844	850	PF00089	0.472
CLV_NRD_NRD_1	111	113	PF00675	0.442
CLV_NRD_NRD_1	476	478	PF00675	0.496
CLV_PCSK_KEX2_1	111	113	PF00082	0.444
CLV_PCSK_KEX2_1	220	222	PF00082	0.369
CLV_PCSK_KEX2_1	664	666	PF00082	0.473
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.496
CLV_PCSK_PC1ET2_1	664	666	PF00082	0.473
CLV_PCSK_SKI1_1	131	135	PF00082	0.414
CLV_PCSK_SKI1_1	19	23	PF00082	0.695
CLV_PCSK_SKI1_1	231	235	PF00082	0.360
CLV_PCSK_SKI1_1	295	299	PF00082	0.438
CLV_PCSK_SKI1_1	482	486	PF00082	0.369
CLV_PCSK_SKI1_1	739	743	PF00082	0.544
CLV_PCSK_SKI1_1	753	757	PF00082	0.528
CLV_PCSK_SKI1_1	862	866	PF00082	0.354
DEG_APCC_KENBOX_2	28	32	PF00400	0.738
DEG_SCF_FBW7_1	822	827	PF00400	0.522
DOC_CKS1_1	870	875	PF01111	0.414
DOC_CYCLIN_RxL_1	206	217	PF00134	0.434
DOC_CYCLIN_yCln2_LP_2	484	490	PF00134	0.388
DOC_MAPK_gen_1	111	119	PF00069	0.429
DOC_MAPK_gen_1	281	289	PF00069	0.408
DOC_MAPK_gen_1	293	300	PF00069	0.369
DOC_MAPK_gen_1	41	50	PF00069	0.588
DOC_MAPK_HePTP_8	639	651	PF00069	0.471
DOC_MAPK_JIP1_4	281	287	PF00069	0.496
DOC_MAPK_MEF2A_6	4	12	PF00069	0.688
DOC_MAPK_MEF2A_6	41	50	PF00069	0.533
DOC_MAPK_MEF2A_6	440	449	PF00069	0.612
DOC_MAPK_MEF2A_6	642	651	PF00069	0.441
DOC_PP2B_LxvP_1	484	487	PF13499	0.369
DOC_USP7_MATH_1	100	104	PF00917	0.467
DOC_USP7_MATH_1	107	111	PF00917	0.423
DOC_USP7_MATH_1	236	240	PF00917	0.408
DOC_USP7_MATH_1	360	364	PF00917	0.465
DOC_USP7_MATH_1	53	57	PF00917	0.415
DOC_USP7_MATH_1	713	717	PF00917	0.647
DOC_USP7_MATH_1	732	736	PF00917	0.368
DOC_USP7_MATH_1	840	844	PF00917	0.567
DOC_USP7_UBL2_3	15	19	PF12436	0.715
DOC_USP7_UBL2_3	347	351	PF12436	0.726
DOC_USP7_UBL2_3	478	482	PF12436	0.414
DOC_WW_Pin1_4	340	345	PF00397	0.645
DOC_WW_Pin1_4	376	381	PF00397	0.617
DOC_WW_Pin1_4	820	825	PF00397	0.445
DOC_WW_Pin1_4	869	874	PF00397	0.359
LIG_14-3-3_CanoR_1	322	328	PF00244	0.395
LIG_14-3-3_CanoR_1	390	400	PF00244	0.426
LIG_14-3-3_CanoR_1	573	579	PF00244	0.445
LIG_14-3-3_CanoR_1	73	80	PF00244	0.451
LIG_Actin_WH2_2	86	104	PF00022	0.388
LIG_BIR_III_4	310	314	PF00653	0.496
LIG_BRCT_BRCA1_1	580	584	PF00533	0.568
LIG_Clathr_ClatBox_1	201	205	PF01394	0.369
LIG_CtBP_PxDLS_1	659	664	PF00389	0.494
LIG_EH_1	440	444	PF12763	0.548
LIG_FHA_1	172	178	PF00498	0.380
LIG_FHA_1	206	212	PF00498	0.384
LIG_FHA_1	393	399	PF00498	0.436
LIG_FHA_1	405	411	PF00498	0.453
LIG_FHA_1	506	512	PF00498	0.516
LIG_FHA_1	562	568	PF00498	0.495
LIG_FHA_1	573	579	PF00498	0.428
LIG_FHA_1	585	591	PF00498	0.435
LIG_FHA_1	634	640	PF00498	0.727
LIG_FHA_1	720	726	PF00498	0.589
LIG_FHA_1	758	764	PF00498	0.572
LIG_FHA_1	821	827	PF00498	0.484
LIG_FHA_1	852	858	PF00498	0.360
LIG_FHA_1	870	876	PF00498	0.354
LIG_FHA_1	877	883	PF00498	0.355
LIG_FHA_2	130	136	PF00498	0.408
LIG_FHA_2	139	145	PF00498	0.328
LIG_FHA_2	194	200	PF00498	0.380
LIG_FHA_2	20	26	PF00498	0.748
LIG_FHA_2	242	248	PF00498	0.478
LIG_FHA_2	322	328	PF00498	0.404
LIG_FHA_2	333	339	PF00498	0.313
LIG_FHA_2	474	480	PF00498	0.388
LIG_FHA_2	557	563	PF00498	0.489
LIG_FHA_2	892	898	PF00498	0.447
LIG_LIR_Apic_2	748	754	PF02991	0.566
LIG_LIR_Gen_1	118	126	PF02991	0.354
LIG_LIR_Gen_1	151	160	PF02991	0.354
LIG_LIR_Gen_1	327	336	PF02991	0.384
LIG_LIR_Gen_1	595	601	PF02991	0.618
LIG_LIR_Gen_1	767	777	PF02991	0.552
LIG_LIR_Nem_3	151	155	PF02991	0.354
LIG_LIR_Nem_3	217	222	PF02991	0.450
LIG_LIR_Nem_3	244	249	PF02991	0.416
LIG_LIR_Nem_3	536	541	PF02991	0.464
LIG_LIR_Nem_3	595	600	PF02991	0.608
LIG_LIR_Nem_3	814	820	PF02991	0.591
LIG_LIR_Nem_3	886	892	PF02991	0.414
LIG_LYPXL_S_1	93	97	PF13949	0.434
LIG_LYPXL_yS_3	94	97	PF13949	0.434
LIG_NRBOX	112	118	PF00104	0.496
LIG_NRBOX	67	73	PF00104	0.354
LIG_PCNA_yPIPBox_3	314	322	PF02747	0.354
LIG_PCNA_yPIPBox_3	351	362	PF02747	0.624
LIG_Pex14_1	148	152	PF04695	0.354
LIG_PTB_Apo_2	364	371	PF02174	0.430
LIG_PTB_Phospho_1	364	370	PF10480	0.520
LIG_REV1ctd_RIR_1	381	391	PF16727	0.643
LIG_SH2_CRK	219	223	PF00017	0.447
LIG_SH2_CRK	693	697	PF00017	0.434
LIG_SH2_CRK	751	755	PF00017	0.585
LIG_SH2_NCK_1	504	508	PF00017	0.524
LIG_SH2_PTP2	889	892	PF00017	0.434
LIG_SH2_SRC	471	474	PF00017	0.369
LIG_SH2_SRC	889	892	PF00017	0.384
LIG_SH2_STAP1	574	578	PF00017	0.419
LIG_SH2_STAT5	152	155	PF00017	0.354
LIG_SH2_STAT5	225	228	PF00017	0.354
LIG_SH2_STAT5	232	235	PF00017	0.354
LIG_SH2_STAT5	416	419	PF00017	0.465
LIG_SH2_STAT5	423	426	PF00017	0.427
LIG_SH2_STAT5	538	541	PF00017	0.449
LIG_SH2_STAT5	574	577	PF00017	0.435
LIG_SH2_STAT5	889	892	PF00017	0.434
LIG_SH3_3	436	442	PF00018	0.465
LIG_SH3_3	698	704	PF00018	0.530
LIG_SH3_3	7	13	PF00018	0.739
LIG_SH3_3	80	86	PF00018	0.369
LIG_SH3_3	845	851	PF00018	0.480
LIG_SH3_3	852	858	PF00018	0.369
LIG_SUMO_SIM_anti_2	196	203	PF11976	0.356
LIG_SUMO_SIM_anti_2	44	51	PF11976	0.389
LIG_SUMO_SIM_par_1	589	595	PF11976	0.599
LIG_SUMO_SIM_par_1	650	657	PF11976	0.445
LIG_SUMO_SIM_par_1	872	877	PF11976	0.373
LIG_TRAF2_1	324	327	PF00917	0.472
LIG_TRAF2_1	335	338	PF00917	0.407
LIG_TRAF2_1	623	626	PF00917	0.848
LIG_TRAF2_1	631	634	PF00917	0.838
LIG_TYR_ITIM	539	544	PF00017	0.451
LIG_TYR_ITIM	691	696	PF00017	0.430
LIG_TYR_ITIM	887	892	PF00017	0.384
LIG_WRC_WIRS_1	116	121	PF05994	0.354
MOD_CDK_SPK_2	824	829	PF00069	0.471
MOD_CDK_SPxxK_3	340	347	PF00069	0.613
MOD_CK1_1	118	124	PF00069	0.491
MOD_CK1_1	170	176	PF00069	0.339
MOD_CK1_1	419	425	PF00069	0.548
MOD_CK1_1	746	752	PF00069	0.595
MOD_CK1_1	76	82	PF00069	0.364
MOD_CK2_1	129	135	PF00069	0.496
MOD_CK2_1	19	25	PF00069	0.745
MOD_CK2_1	234	240	PF00069	0.426
MOD_CK2_1	277	283	PF00069	0.479
MOD_CK2_1	321	327	PF00069	0.447
MOD_CK2_1	332	338	PF00069	0.447
MOD_CK2_1	340	346	PF00069	0.672
MOD_CK2_1	473	479	PF00069	0.388
MOD_CK2_1	510	516	PF00069	0.458
MOD_CK2_1	891	897	PF00069	0.414
MOD_GlcNHglycan	345	350	PF01048	0.732
MOD_GlcNHglycan	362	365	PF01048	0.352
MOD_GlcNHglycan	431	434	PF01048	0.547
MOD_GlcNHglycan	512	515	PF01048	0.474
MOD_GlcNHglycan	683	686	PF01048	0.511
MOD_GlcNHglycan	696	699	PF01048	0.435
MOD_GlcNHglycan	76	79	PF01048	0.442
MOD_GlcNHglycan	876	879	PF01048	0.403
MOD_GSK3_1	101	108	PF00069	0.388
MOD_GSK3_1	167	174	PF00069	0.404
MOD_GSK3_1	227	234	PF00069	0.369
MOD_GSK3_1	273	280	PF00069	0.426
MOD_GSK3_1	713	720	PF00069	0.534
MOD_GSK3_1	72	79	PF00069	0.474
MOD_GSK3_1	739	746	PF00069	0.624
MOD_GSK3_1	796	803	PF00069	0.594
MOD_GSK3_1	820	827	PF00069	0.451
MOD_GSK3_1	862	869	PF00069	0.354
MOD_N-GLC_1	313	318	PF02516	0.297
MOD_N-GLC_1	621	626	PF02516	0.880
MOD_N-GLC_1	783	788	PF02516	0.507
MOD_N-GLC_1	789	794	PF02516	0.418
MOD_NEK2_1	101	106	PF00069	0.384
MOD_NEK2_1	138	143	PF00069	0.539
MOD_NEK2_1	315	320	PF00069	0.395
MOD_NEK2_1	48	53	PF00069	0.339
MOD_NEK2_1	561	566	PF00069	0.481
MOD_NEK2_1	584	589	PF00069	0.537
MOD_NEK2_1	660	665	PF00069	0.571
MOD_NEK2_1	672	677	PF00069	0.547
MOD_NEK2_1	71	76	PF00069	0.381
MOD_NEK2_1	777	782	PF00069	0.574
MOD_NEK2_1	800	805	PF00069	0.452
MOD_NEK2_1	807	812	PF00069	0.493
MOD_NEK2_2	241	246	PF00069	0.496
MOD_NEK2_2	505	510	PF00069	0.545
MOD_PIKK_1	101	107	PF00454	0.434
MOD_PIKK_1	315	321	PF00454	0.369
MOD_PIKK_1	866	872	PF00454	0.447
MOD_PKA_2	234	240	PF00069	0.506
MOD_PKA_2	321	327	PF00069	0.419
MOD_PKA_2	456	462	PF00069	0.540
MOD_PKA_2	572	578	PF00069	0.468
MOD_PKA_2	72	78	PF00069	0.487
MOD_PKB_1	165	173	PF00069	0.297
MOD_Plk_1	19	25	PF00069	0.834
MOD_Plk_1	193	199	PF00069	0.474
MOD_Plk_1	313	319	PF00069	0.297
MOD_Plk_1	419	425	PF00069	0.548
MOD_Plk_1	789	795	PF00069	0.478
MOD_Plk_2-3	299	305	PF00069	0.297
MOD_Plk_4	115	121	PF00069	0.354
MOD_Plk_4	183	189	PF00069	0.359
MOD_Plk_4	419	425	PF00069	0.548
MOD_Plk_4	505	511	PF00069	0.465
MOD_Plk_4	518	524	PF00069	0.416
MOD_Plk_4	556	562	PF00069	0.487
MOD_Plk_4	592	598	PF00069	0.596
MOD_Plk_4	667	673	PF00069	0.606
MOD_Plk_4	746	752	PF00069	0.476
MOD_Plk_4	796	802	PF00069	0.487
MOD_Plk_4	807	813	PF00069	0.430
MOD_Plk_4	840	846	PF00069	0.597
MOD_Plk_4	891	897	PF00069	0.423
MOD_ProDKin_1	340	346	PF00069	0.640
MOD_ProDKin_1	376	382	PF00069	0.612
MOD_ProDKin_1	820	826	PF00069	0.444
MOD_ProDKin_1	869	875	PF00069	0.359
MOD_SUMO_for_1	42	45	PF00179	0.677
MOD_SUMO_for_1	629	632	PF00179	0.783
MOD_SUMO_rev_2	273	280	PF00179	0.384
MOD_SUMO_rev_2	30	36	PF00179	0.769
MOD_SUMO_rev_2	343	348	PF00179	0.731
MOD_SUMO_rev_2	479	484	PF00179	0.426
MOD_SUMO_rev_2	491	497	PF00179	0.570
MOD_SUMO_rev_2	528	534	PF00179	0.581
MOD_SUMO_rev_2	632	637	PF00179	0.809
MOD_SUMO_rev_2	880	890	PF00179	0.434
TRG_DiLeu_BaEn_1	303	308	PF01217	0.388
TRG_DiLeu_BaEn_1	44	49	PF01217	0.620
TRG_DiLeu_BaEn_1	493	498	PF01217	0.625
TRG_DiLeu_BaEn_2	150	156	PF01217	0.354
TRG_DiLeu_BaEn_4	303	309	PF01217	0.369
TRG_DiLeu_BaLyEn_6	484	489	PF01217	0.496
TRG_ENDOCYTIC_2	152	155	PF00928	0.354
TRG_ENDOCYTIC_2	219	222	PF00928	0.447
TRG_ENDOCYTIC_2	249	252	PF00928	0.354
TRG_ENDOCYTIC_2	541	544	PF00928	0.425
TRG_ENDOCYTIC_2	574	577	PF00928	0.420
TRG_ENDOCYTIC_2	693	696	PF00928	0.430
TRG_ENDOCYTIC_2	889	892	PF00928	0.388
TRG_ENDOCYTIC_2	94	97	PF00928	0.369
TRG_ER_diArg_1	111	113	PF00400	0.447
TRG_NES_CRM1_1	115	125	PF08389	0.447
TRG_NES_CRM1_1	203	215	PF08389	0.434
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.222
TRG_Pf-PMV_PEXEL_1	131	135	PF00026	0.222
TRG_Pf-PMV_PEXEL_1	268	273	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	334	338	PF00026	0.485
TRG_Pf-PMV_PEXEL_1	91	96	PF00026	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCY7	Leptomonas seymouri	85%	100%
A0A0S4KJP7	Bodo saltans	50%	98%
A0A1X0NZE4	Trypanosomatidae	61%	100%
A0A422NUV0	Trypanosoma rangeli	60%	100%
A4HH20	Leishmania braziliensis	92%	100%
A4I449	Leishmania infantum	100%	100%
C9ZKR3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9ADL4	Leishmania major	98%	100%
E9AM67	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
P38764	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	92%
P56701	Bos taurus	36%	100%
P87048	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%
Q13200	Homo sapiens	36%	100%
Q4FZT9	Rattus norvegicus	36%	100%
Q54BC6	Dictyostelium discoideum	36%	100%
Q5R9I6	Pongo abelii	36%	100%
Q6FPV6	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	33%	92%
Q6XJG8	Arabidopsis thaliana	37%	100%
Q7S8R8	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	34%	100%
Q8SS65	Encephalitozoon cuniculi (strain GB-M1)	23%	100%
Q8VDM4	Mus musculus	36%	100%
Q9SIV2	Arabidopsis thaliana	36%	100%
V5DLC9	Trypanosoma cruzi	60%	100%