Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X240_LEIDO

TriTrypDb:

LdBPK_290490.1 , LdCL_290009700 , LDHU3_29.0690

Length:

318

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X240

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X240

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.537
CLV_NRD_NRD_1	182	184	PF00675	0.500
CLV_NRD_NRD_1	187	189	PF00675	0.482
CLV_NRD_NRD_1	206	208	PF00675	0.517
CLV_NRD_NRD_1	275	277	PF00675	0.621
CLV_NRD_NRD_1	290	292	PF00675	0.525
CLV_NRD_NRD_1	306	308	PF00675	0.535
CLV_PCSK_FUR_1	304	308	PF00082	0.530
CLV_PCSK_KEX2_1	187	189	PF00082	0.473
CLV_PCSK_KEX2_1	205	207	PF00082	0.511
CLV_PCSK_KEX2_1	275	277	PF00082	0.554
CLV_PCSK_KEX2_1	290	292	PF00082	0.433
CLV_PCSK_KEX2_1	306	308	PF00082	0.535
CLV_PCSK_PC7_1	183	189	PF00082	0.413
CLV_PCSK_PC7_1	201	207	PF00082	0.496
CLV_PCSK_SKI1_1	242	246	PF00082	0.548
DEG_Nend_UBRbox_1	1	4	PF02207	0.524
DEG_SPOP_SBC_1	64	68	PF00917	0.634
DOC_MAPK_gen_1	10	17	PF00069	0.565
DOC_MAPK_gen_1	288	295	PF00069	0.536
DOC_MAPK_MEF2A_6	206	215	PF00069	0.594
DOC_PP2B_LxvP_1	101	104	PF13499	0.632
DOC_PP2B_LxvP_1	224	227	PF13499	0.574
DOC_USP7_MATH_1	150	154	PF00917	0.487
DOC_WW_Pin1_4	175	180	PF00397	0.612
DOC_WW_Pin1_4	306	311	PF00397	0.549
LIG_14-3-3_CanoR_1	106	113	PF00244	0.609
LIG_14-3-3_CanoR_1	28	35	PF00244	0.607
LIG_14-3-3_CanoR_1	42	46	PF00244	0.492
LIG_14-3-3_CanoR_1	63	73	PF00244	0.641
LIG_14-3-3_CanoR_1	98	102	PF00244	0.668
LIG_eIF4E_1	230	236	PF01652	0.511
LIG_FHA_1	115	121	PF00498	0.691
LIG_FHA_1	137	143	PF00498	0.614
LIG_FHA_2	176	182	PF00498	0.555
LIG_FHA_2	45	51	PF00498	0.569
LIG_LIR_Gen_1	210	220	PF02991	0.581
LIG_LIR_LC3C_4	221	226	PF02991	0.489
LIG_LIR_Nem_3	210	215	PF02991	0.585
LIG_SH2_PTP2	212	215	PF00017	0.578
LIG_SH2_STAT3	190	193	PF00017	0.526
LIG_SH2_STAT5	212	215	PF00017	0.580
LIG_SH2_STAT5	230	233	PF00017	0.541
LIG_SH2_STAT5	284	287	PF00017	0.444
LIG_SH3_3	205	211	PF00018	0.547
MOD_CK1_1	105	111	PF00069	0.623
MOD_CK1_1	65	71	PF00069	0.682
MOD_CK1_1	97	103	PF00069	0.666
MOD_CK2_1	175	181	PF00069	0.564
MOD_GlcNHglycan	22	26	PF01048	0.435
MOD_GlcNHglycan	67	70	PF01048	0.668
MOD_GSK3_1	102	109	PF00069	0.604
MOD_GSK3_1	136	143	PF00069	0.575
MOD_GSK3_1	54	61	PF00069	0.676
MOD_NEK2_1	62	67	PF00069	0.649
MOD_NEK2_1	72	77	PF00069	0.578
MOD_NEK2_1	96	101	PF00069	0.688
MOD_NEK2_2	150	155	PF00069	0.484
MOD_PIKK_1	106	112	PF00454	0.581
MOD_PKA_2	105	111	PF00069	0.590
MOD_PKA_2	41	47	PF00069	0.570
MOD_PKA_2	62	68	PF00069	0.659
MOD_PKA_2	97	103	PF00069	0.653
MOD_Plk_1	168	174	PF00069	0.620
MOD_Plk_1	199	205	PF00069	0.513
MOD_ProDKin_1	175	181	PF00069	0.606
MOD_ProDKin_1	306	312	PF00069	0.554
TRG_DiLeu_BaLyEn_6	124	129	PF01217	0.687
TRG_DiLeu_BaLyEn_6	91	96	PF01217	0.587
TRG_ENDOCYTIC_2	212	215	PF00928	0.580
TRG_ER_diArg_1	1	4	PF00400	0.524
TRG_ER_diArg_1	204	207	PF00400	0.550
TRG_ER_diArg_1	304	307	PF00400	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7Y3	Leptomonas seymouri	55%	100%
A0A1X0NZJ3	Trypanosomatidae	37%	100%
A4HH49	Leishmania braziliensis	69%	97%
A4I4A0	Leishmania infantum	100%	100%
E9ADP9	Leishmania major	90%	100%
E9AM31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%