Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X227_LEIDO

TriTrypDb:

LdBPK_290240.1 , LdCL_290007200 , LDHU3_29.0310

Length:

215

Annotations

LeishMANIAdb annotations

Possibly part of a larger transporter.

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7X227

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X227

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	35	39	PF00656	0.664
CLV_NRD_NRD_1	155	157	PF00675	0.410
CLV_NRD_NRD_1	180	182	PF00675	0.457
CLV_NRD_NRD_1	197	199	PF00675	0.488
CLV_NRD_NRD_1	35	37	PF00675	0.482
CLV_NRD_NRD_1	48	50	PF00675	0.367
CLV_PCSK_KEX2_1	180	182	PF00082	0.459
CLV_PCSK_KEX2_1	47	49	PF00082	0.419
CLV_PCSK_PC7_1	43	49	PF00082	0.419
CLV_PCSK_SKI1_1	71	75	PF00082	0.402
CLV_PCSK_SKI1_1	8	12	PF00082	0.452
DEG_Nend_Nbox_1	1	3	PF02207	0.626
DOC_MAPK_gen_1	36	44	PF00069	0.661
DOC_MAPK_gen_1	47	56	PF00069	0.563
DOC_MAPK_MEF2A_6	49	58	PF00069	0.594
DOC_PP1_RVXF_1	154	161	PF00149	0.672
DOC_PP1_RVXF_1	6	12	PF00149	0.658
DOC_PP2B_LxvP_1	100	103	PF13499	0.489
DOC_PP4_FxxP_1	161	164	PF00568	0.546
DOC_USP7_MATH_1	165	169	PF00917	0.651
DOC_WW_Pin1_4	209	214	PF00397	0.719
LIG_14-3-3_CanoR_1	114	119	PF00244	0.406
LIG_14-3-3_CanoR_1	13	19	PF00244	0.593
LIG_14-3-3_CanoR_1	3	11	PF00244	0.589
LIG_14-3-3_CterR_2	211	215	PF00244	0.729
LIG_AP2alpha_2	207	209	PF02296	0.631
LIG_FHA_1	102	108	PF00498	0.455
LIG_FHA_1	61	67	PF00498	0.629
LIG_FHA_1	76	82	PF00498	0.222
LIG_FHA_1	95	101	PF00498	0.464
LIG_FHA_2	25	31	PF00498	0.657
LIG_GBD_Chelix_1	125	133	PF00786	0.365
LIG_LIR_Gen_1	110	118	PF02991	0.405
LIG_LIR_Gen_1	119	129	PF02991	0.228
LIG_LIR_Gen_1	52	61	PF02991	0.639
LIG_LIR_Gen_1	97	107	PF02991	0.355
LIG_LIR_Nem_3	119	124	PF02991	0.282
LIG_LIR_Nem_3	139	144	PF02991	0.623
LIG_LIR_Nem_3	52	56	PF02991	0.640
LIG_LIR_Nem_3	69	73	PF02991	0.616
LIG_LIR_Nem_3	97	102	PF02991	0.363
LIG_SH2_CRK	155	159	PF00017	0.631
LIG_SH2_STAP1	109	113	PF00017	0.449
LIG_SH2_STAP1	136	140	PF00017	0.271
LIG_SH2_STAT5	112	115	PF00017	0.451
LIG_SH2_STAT5	149	152	PF00017	0.599
LIG_SH2_STAT5	53	56	PF00017	0.610
LIG_SH2_STAT5	93	96	PF00017	0.512
LIG_SH2_STAT5	99	102	PF00017	0.414
LIG_SH3_3	147	153	PF00018	0.581
LIG_SH3_3	55	61	PF00018	0.615
LIG_SH3_3	78	84	PF00018	0.425
LIG_TRFH_1	149	153	PF08558	0.624
LIG_TRFH_1	99	103	PF08558	0.454
LIG_TYR_ITIM	51	56	PF00017	0.619
LIG_TYR_ITSM	95	102	PF00017	0.428
LIG_UBA3_1	10	18	PF00899	0.547
LIG_WRC_WIRS_1	115	120	PF05994	0.478
MOD_CDK_SPK_2	209	214	PF00069	0.713
MOD_CK2_1	24	30	PF00069	0.673
MOD_GSK3_1	14	21	PF00069	0.677
MOD_NEK2_1	14	19	PF00069	0.614
MOD_NEK2_1	2	7	PF00069	0.593
MOD_NEK2_1	24	29	PF00069	0.667
MOD_NEK2_2	136	141	PF00069	0.475
MOD_PIKK_1	12	18	PF00454	0.642
MOD_PIKK_1	3	9	PF00454	0.677
MOD_PKA_2	12	18	PF00069	0.590
MOD_PKA_2	2	8	PF00069	0.608
MOD_Plk_1	136	142	PF00069	0.567
MOD_Plk_4	136	142	PF00069	0.473
MOD_Plk_4	94	100	PF00069	0.464
MOD_ProDKin_1	209	215	PF00069	0.722
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.652
TRG_ENDOCYTIC_2	112	115	PF00928	0.383
TRG_ENDOCYTIC_2	144	147	PF00928	0.585
TRG_ENDOCYTIC_2	155	158	PF00928	0.598
TRG_ENDOCYTIC_2	53	56	PF00928	0.618
TRG_ENDOCYTIC_2	98	101	PF00928	0.407
TRG_ER_diArg_1	180	182	PF00400	0.654
TRG_ER_diArg_1	47	49	PF00400	0.619
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTZ2	Leptomonas seymouri	79%	100%
A0A0S4ISU9	Bodo saltans	37%	100%
A0A1X0NZD9	Trypanosomatidae	52%	96%
A0A422NUT7	Trypanosoma rangeli	56%	87%
A4HH31	Leishmania braziliensis	85%	100%
A4I476	Leishmania infantum	100%	100%
C9ZKQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9ADM5	Leishmania major	95%	100%
E9AM56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BPX2	Trypanosoma cruzi	60%	86%